Disseminated Superficial Actinic Porokeratosis

Synonym
Porokeratosis, Mibelli
Porokeratosis, Palmar, Plantar, And Disseminated 1
Porokeratosis, Palmoplantar
Porokeratosis, Linear
Type 2 Punctate PPK
Porokeratosis Plantaris, Palmaris, Et Disseminata
Porokeratosis, Disseminated Superficial Actinic, 2
Disseminated Superficial Actinic Porokeratosis
Porokeratosis Plantaris Palmaris et Disseminata
Porokeratosis of Mibelli
Porokeratosis, Disseminated Superficial Actinic 2
Porokeratosis Palmaris et Plantaris Disseminata
Porokeratosis, Disseminated Superficial Actinic
Keratoderma Palmoplantar, Punctate Type 2
Porokeratosis, Punctate

Excerpt	Reference
"Disseminated superficial actinic porokeratosis is characterized by the development of numerous annular keratotic lesions on sun-exposed areas, accompanied by pathological evidence of cornoid lamellae."	( Kanekura, T; Kanzaki, T; Matsushita, S, 1997)
"Disseminated superficial actinic porokeratosis is characterized by multiple, brown, annular, keratotic lesions that develop predominantly on the extensor surfaces of the legs and arms during the third and fourth decades of life."	( Böhm, M; Bonsmann, G; Luger, TA, 1999)
"Porokeratosis of Mibelli is a rare genodermatosis characterized by a disorder of keratinization."	( García-Ramírez, V; Montes-De-Oca-Sánchez, G; Tirado-Sánchez, A, 2006)
"Disseminated superficial actinic porokeratosis is the clinical variant of porokeratosis that most frequently develops in immunosuppressive states."	( Cacharrón, JM; de las Heras, C; Durana, C; Ginarte, M; Labandeira, J; Monteagudo-Sánchez, B, 2006)
"A relationship with linear porokeratosis is not yet established; some consider it as a rare variant of porokeratosis involving the acrosyringium, whereas others consider it a separate entity based on distinctive clinical features and histologic accentuation within ostial structures."	( Chowdhury, SN; Gharami, RC; Ghosh, K; Kumar, P; Mondal, A; Mondal, AK, 2012)

Excerpt	Reference
"We examined a case of disseminated superficial actinic porokeratosis in a 40-year-old male who had undergone renal transplantation and was being treated with immunosuppressants."	( Kanekura, T; Kanzaki, T; Matsushita, S, 1997)
"No ideal treatment of disseminated superficial actinic porokeratosis has been found."	( Böhm, M; Bonsmann, G; Luger, TA, 1999)
"Three patients with classical disseminated superficial actinic porokeratosis had a small test area treated with topical aminolaevulinic acid PDT."	( Nayeemuddin, FA; Rhodes, LE; Wong, M; Yell, J, 2002)
"We report a case of a patient with disseminated superficial actinic porokeratosis displaying a comparable inflammatory process following therapy with systemic 5-fluorouracil used to manage a metastatic breast cancer."	( Badiavas, E; Danahy, JF; Donohue, KG; Falanga, V; Nahm, WK, 2003)
"A 77-year-old woman with a large porokeratosis of Mibelli on the left shin was successfully treated with topical 5% imiquimod cream applied to the entire lesion once daily without occlusion three times a week."	( Harrison, S; Sinclair, R, 2003)
"We describe the successful treatment of porokeratosis of Mibelli of the left calf in an 83-year-old man with topical 5 percent imiquimod and topical 5 percent 5-fluorouracil."	( LeLeux, TM; Orengo, I; Rosen, T; Venkatarajan, S; Yang, D, 2010)
"Although promising, reports of disseminated superficial actinic porokeratosis treated with vitamin D3 analogs are rare."	( Chokoeva, AA; Ivanova, B; Mangarov, H; Tchernev, G; Vidolova, NG, 2017)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	6 (3.41)	23.3326
1990's	20 (11.36)	12.5806
2000's	51 (28.98)	18.1394
2010's	70 (39.77)	28.8240
2020's	29 (16.48)	9.53

Drug	Relationship Strength	Studies	Trials
aminolevulinic acid	low	10	0
benzene	low	1	0
salicylic acid	low	5	0
lactic acid	low	1	0
dimethyl sulfoxide	low	1	0
glycolic acid	low	1	0
iodine	low	1	0
urea	low	4	0
azathioprine	low	2	0
clofazimine	low	1	0
diclofenac	medium	7	1
fluorouracil	low	18	0
hydroxychloroquine	low	1	0
hydroxyurea	low	2	0
hypericin	low	1	0
2-propanol	low	2	0
tazarotene	low	4	0
temozolomide	low	1	0
prednisolone	low	2	0
prednisone	low	5	0
cantharidin	low	1	0
isoprene	low	1	0
methylprednisolone	low	2	0
isopropyl myristate	low	1	0
perylene	low	1	0
thiazoles	low	1	0
betamethasone	low	1	0
gentian violet	low	2	0
congo red	low	1	0
betamethasone valerate	low	1	0
thioflavin t	low	1	0
neodymium	low	1	0
thorium	low	1	0
thulium	low	1	0
erbium	low	1	0
clodronic acid	low	1	0
paclitaxel	low	1	0
etoposide	low	1	0
lovastatin	medium	8	1
simvastatin	low	3	0
imiquimod	low	18	0
clobetasone butyrate	low	1	0
methotrexate	low	2	0
methyl 5-aminolevulinate	low	6	0
povidone-iodine	low	1	0
mevalonic acid	low	6	0
inositol 3-phosphate	low	1	0
tretinoin	low	11	0
retinol	low	5	0
tacrolimus	low	2	0
ferulic acid	low	1	0
alitretinoin	low	1	0
bromochloroacetic acid	low	5	0
calcitriol	low	6	0
cholecalciferol	low	1	0
etretinate	low	3	0
isotretinoin	low	3	0
phenylephrine hydrochloride	low	3	0
acitretin	low	13	0
clobetasol	low	3	0
halobetasol	low	1	0
involucrin	low	1	0
hoe 777	low	1	0
pep005	low	2	0
endothelin-1	medium	1	1
olaparib	low	1	0
calcipotriene	low	6	0
ascorbic acid	low	1	0
1 alpha,24-dihydroxyvitamin d3	low	3	0
cyclosporine	low	3	0
dacarbazine	low	2	0
aprepitant	low	1	0
somatomedin b	low	1	0

Protein Targets (721)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	18	0	0	18
RAR-related orphan receptor gamma	28	0	0	28
GLI family zinc finger 3	26	0	0	26
AR protein	41	0	0	41
aldehyde dehydrogenase 1 family, member A1	18	0	0	18
retinoic acid nuclear receptor alpha variant 1	30	0	0	30
retinoid X nuclear receptor alpha	25	0	0	25
estrogen nuclear receptor alpha	43	0	0	43
peroxisome proliferator-activated receptor delta	21	0	0	21
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	25	0	0	25
activating transcription factor 6	12	0	0	12
v-jun sarcoma virus 17 oncogene homolog (avian)	15	0	0	15
Histone H2A.x	15	0	0	15
thyroid hormone receptor beta isoform a	8	0	0	8
heat shock protein beta-1	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 1	30	0	0	30
lamin isoform A-delta10	18	0	0	18
Voltage-dependent calcium channel gamma-2 subunit	19	0	0	19
Glutamate receptor 2	19	0	0	19
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
Luciferase	11	0	0	11
USP1 protein, partial	14	0	0	14
TDP1 protein	30	0	0	30
Microtubule-associated protein tau	14	0	0	15
glucocorticoid receptor [Homo sapiens]	30	0	0	30
peroxisome proliferator activated receptor gamma	25	0	0	25
euchromatic histone-lysine N-methyltransferase 2	18	0	0	18
vitamin D3 receptor isoform VDRA	14	0	0	14
thyroid hormone receptor beta isoform 2	27	0	0	27
flap endonuclease 1	3	0	0	3
serine/threonine-protein kinase PLK1	3	0	0	3
eyes absent homolog 2 isoform a	2	0	0	2
DNA polymerase eta isoform 1	3	0	0	3
geminin	30	0	0	30
peripheral myelin protein 22	18	0	0	18
survival motor neuron protein isoform d	14	0	0	14
histone acetyltransferase KAT2A isoform 1	8	0	0	8
ATP-binding cassette sub-family C member 3	0	26	0	26
Multidrug resistance-associated protein 4	0	26	0	27
Bile salt export pump	0	5	0	5
Bile salt export pump	0	28	0	28
Rap guanine nucleotide exchange factor 3	2	0	0	2
Cellular tumor antigen p53	28	0	0	28
Rap guanine nucleotide exchange factor 4	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
nuclear receptor subfamily 1, group I, member 3	23	0	0	23
EWS/FLI fusion protein	12	0	0	12
estrogen-related nuclear receptor alpha	29	0	0	29
farnesoid X nuclear receptor	16	0	0	16
vitamin D (1,25- dihydroxyvitamin D3) receptor	20	0	0	20
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
Bloom syndrome protein isoform 1	9	0	0	9
nuclear receptor ROR-gamma isoform 1	12	0	0	12
60 kDa chaperonin	0	5	0	5
Retinoic acid receptor alpha	0	5	6	15
60 kDa heat shock protein, mitochondrial	0	5	0	5
Retinoic acid receptor beta	0	5	6	15
Retinoic acid receptor gamma	0	5	6	15
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Glycine receptor subunit alpha-1	0	0	2	2
Spike glycoprotein	13	0	1	14
10 kDa heat shock protein, mitochondrial	0	5	0	5
Thiosulfate sulfurtransferase	0	5	0	5
60 kDa chaperonin	0	5	0	5
10 kDa chaperonin	0	5	0	5
Canalicular multispecific organic anion transporter 1	0	26	0	27
ATP-dependent phosphofructokinase	6	0	0	6
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, Ferritin light chain	13	0	0	13
Chain A, Cruzipain	8	0	0	8
acetylcholinesterase	13	0	0	13
SMAD family member 2	11	0	0	11
SMAD family member 3	11	0	0	11
estrogen receptor 2 (ER beta)	16	0	0	16
progesterone receptor	18	0	0	18
pregnane X nuclear receptor	25	0	0	25
thyroid stimulating hormone receptor	16	0	0	16
retinoic acid receptor alpha isoform 1	0	1	0	1
retinoic acid receptor RXR-alpha isoform a	0	1	0	1
Renin	0	0	1	1
Cytochrome P450 1A2	0	4	1	6
Retinoic acid receptor alpha	0	3	3	6
Retinoic acid receptor gamma	0	2	3	5
Retinoic acid receptor RXR-alpha	0	4	5	11
Retinoic acid receptor beta	0	2	3	5
Nuclear receptor subfamily 4 group A member 1	0	0	1	1
Cellular retinoic acid-binding protein 2	0	0	3	3
Retinoic acid receptor RXR-alpha	0	3	4	7
Retinoic acid receptor RXR-beta	0	4	4	8
Retinoic acid receptor RXR-beta	0	2	4	6
Retinoic acid receptor RXR-gamma	0	2	4	6
Type-1 angiotensin II receptor	0	0	1	1
Cellular retinoic acid-binding protein 1	0	3	0	4
Retinoic acid receptor RXR-gamma	0	4	4	8
Type-2 angiotensin II receptor	0	0	1	1
Nuclear receptor ROR-gamma	7	1	2	10
Oxysterols receptor LXR-beta	0	0	1	1
Cellular retinoic acid-binding protein 1	0	0	3	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Oxysterols receptor LXR-alpha	0	0	1	1
Chain A, Beta-lactamase	8	0	0	8
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
Gamma-aminobutyric acid receptor subunit rho-1	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	1	1	0	2
Solute carrier family 15 member 1	0	1	0	1
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
GALC protein	3	0	0	3
caspase 7, apoptosis-related cysteine protease	5	0	0	5
cytochrome P450 family 3 subfamily A polypeptide 4	18	0	0	18
G	12	0	0	12
cytochrome P450 2D6	12	0	0	12
caspase-3	5	0	0	5
Interferon beta	16	0	0	16
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
Cytochrome P450 3A4	0	9	1	11
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	0	1
cGMP-dependent protein kinase 1	0	0	1	1
Substance-P receptor	0	1	0	1
Inositol hexakisphosphate kinase 1	12	0	0	12
cytochrome P450 2C9, partial	12	0	0	12
PPM1D protein	5	0	0	5
thioredoxin glutathione reductase	7	0	0	7
nuclear receptor subfamily 1, group I, member 2	10	0	0	10
Aromatase	0	3	0	3
Chain A, Hyaluronidase, phage associated	0	1	0	1
IDH1	10	0	0	10
chromobox protein homolog 1	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	13	0	0	13
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	3	0	0	3
Polyphenol oxidase 2	0	3	0	4
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	5	1	6
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
interleukin 8	6	0	0	6
thioredoxin reductase	9	0	0	9
phosphopantetheinyl transferase	9	0	0	9
ATAD5 protein, partial	4	0	0	4
Fumarate hydratase	3	0	0	3
polyprotein	3	0	0	3
P53	1	0	0	1
arylsulfatase A	2	0	0	2
aryl hydrocarbon receptor	15	0	0	15
peripheral myelin protein 22 isoform 1	4	0	0	4
hemoglobin subunit beta	2	0	0	2
cellular tumor antigen p53 isoform a	7	0	0	7
DNA polymerase iota isoform a (long)	6	0	0	6
cytochrome P450 3A4 isoform 1	8	0	0	8
M-phase phosphoprotein 8	3	0	0	3
muscleblind-like protein 1 isoform 1	5	0	0	5
muscarinic acetylcholine receptor M1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	8	0	0	8
Gamma-aminobutyric acid receptor subunit beta-1	8	0	0	8
Gamma-aminobutyric acid receptor subunit delta	8	0	0	8
Gamma-aminobutyric acid receptor subunit gamma-2	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-5	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-3	8	0	0	8
Gamma-aminobutyric acid receptor subunit gamma-1	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-2	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-4	8	0	0	8
Gamma-aminobutyric acid receptor subunit gamma-3	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-6	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-1	8	0	0	8
Gamma-aminobutyric acid receptor subunit beta-3	8	0	0	8
Gamma-aminobutyric acid receptor subunit beta-2	8	0	0	8
GABA theta subunit	8	0	0	8
ATPase family AAA domain-containing protein 5	10	0	0	10
Ataxin-2	10	0	0	10
Gamma-aminobutyric acid receptor subunit epsilon	8	0	0	8
Protein-arginine deiminase type-4	0	2	0	2
Chain A, Integrase	0	1	0	1
Chain A, Integrase	0	1	0	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, GCN4P1	0	0	1	1
Chain B, GCN4P1	0	0	1	1
Chain C, GCN4P1	0	0	1	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, Replicase polyprotein 1ab	0	1	0	1
Chain A, 3C-like proteinase	0	1	0	1
pregnane X receptor	9	0	0	9
thyroid stimulating hormone receptor	8	0	0	8
Endolysin	0	0	1	1
Integrin beta-3	6	1	0	7
Integrin alpha-IIb	6	0	0	6
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
ORF73	0	0	1	1
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
mitogen-activated protein kinase 1	6	0	0	6
Vitamin D-binding protein	0	0	1	1
Androgen receptor	0	3	0	3
Cytochrome P450 2D6	0	4	1	5
Vitamin D3 receptor	0	2	4	9
Cytochrome P450 2C9	0	6	1	9
Vitamin D3 receptor	0	1	1	3
Cytochrome P450 2C19	0	2	1	3
Kappa-type opioid receptor	0	0	1	1
Vitamin D3 receptor	0	0	2	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	9	0	0	9
Protein phosphatase 1B	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	4
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	0	1	0	1
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	0	1	0	1
Chain A, HADH2 protein	3	0	0	3
Chain B, HADH2 protein	3	0	0	3
15-lipoxygenase, partial	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
DNA polymerase kappa isoform 1	8	0	0	8
glp-1 receptor, partial	5	0	0	5
nonstructural protein 1	4	0	0	4
neuropeptide S receptor isoform A	1	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Type IV secretion-like conjugative transfer relaxase protein TraI	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	2	3
Matrix metalloproteinase-9	0	2	0	2
Macrophage metalloelastase	0	1	0	1
67.9K protein	8	0	0	8
cytochrome P450 2D6 isoform 1	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
transcriptional regulator ERG isoform 3	2	0	0	2
importin subunit beta-1 isoform 1	3	0	0	3
mitogen-activated protein kinase kinase kinase kinase 2 isoform 1	0	0	1	1
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
streptokinase A precursor	0	0	1	1
mitogen-activated protein kinase kinase kinase 3 isoform 1	0	0	1	1
Estrogen receptor	0	0	1	1
ATP-dependent translocase ABCB1	0	6	0	9
Spike glycoprotein	0	0	1	1
5-hydroxytryptamine receptor 1A	0	2	1	3
Cruzipain	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Estrogen receptor beta	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	4
B2 bradykinin receptor	0	1	0	1
Dihydrofolate reductase	0	3	0	5
Dihydrofolate reductase	0	2	0	2
Chymotrypsinogen A	0	0	0	1
Beta-lactamase	0	1	0	1
Amyloid-beta precursor protein	1	6	0	7
Beta-lactamase	0	0	0	1
5-hydroxytryptamine receptor 2A	0	1	0	2
Beta-galactosidase	0	1	0	2
Choline O-acetyltransferase	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
Inositol monophosphatase 1	4	0	0	4
Isocitrate lyase	0	1	0	1
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Cytochrome c oxidase subunit 2	0	1	0	1
Carbonic anhydrase 1	0	6	0	7
Carbonic anhydrase 2	0	8	1	11
Fatty acid-binding protein, liver	0	2	0	2
Transthyretin	0	0	1	3
Albumin	0	3	1	4
Prostaglandin G/H synthase 1	0	1	0	1
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	2	0	4
UDP-glucuronosyltransferase 1-6	0	3	0	3
UDP-glucuronosyltransferase 1A1	0	3	0	4
UDP-glucuronosyltransferase 1A4	0	2	0	3
Prostaglandin G/H synthase 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin G/H synthase 2	0	5	0	5
Prostaglandin G/H synthase 2	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
UDP-glucuronosyltransferase 2B10	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Cytochrome P450 2J2	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Carbonic anhydrase 9	0	7	0	9
Solute carrier family 22 member 6	0	2	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Cereblon isoform 4	0	2	0	2
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	2	0	2
Endothelin-1 receptor	0	1	0	1
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
urokinase-type plasminogen activator precursor	6	0	0	6
plasminogen precursor	6	0	0	6
urokinase plasminogen activator surface receptor precursor	6	0	0	6
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	2	0	2
Prothrombin	0	0	0	1
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Serum paraoxonase/arylesterase 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 1	0	0	0	1
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	1
Glutamate receptor ionotropic, NMDA 2B	0	0	0	1
Glutamate receptor ionotropic, NMDA 2C	0	0	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Glutamate receptor ionotropic, NMDA 2D	0	0	0	1
Tubulin beta-2B chain	0	1	1	4
Integrase	0	3	0	3
Similar to alpha-tubulin isoform 1	0	1	1	4
Similar to alpha-tubulin isoform 1	0	1	0	3
Glutamate receptor ionotropic, NMDA 3B	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Glutamate receptor ionotropic, NMDA 3A	0	0	0	1
ClpP	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Acetylcholinesterase	0	1	0	1
Carbonic anhydrase 12	0	4	0	5
Cholinesterase	0	3	0	3
Carbonic anhydrase 3	0	3	0	3
Pyruvate kinase PKM	0	1	0	1
Acetylcholinesterase	0	3	0	3
Carbonic anhydrase 4	0	4	0	5
Carbonic anhydrase 6	0	3	0	4
Adenosine receptor A1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	5	0	6
Alpha-synuclein	0	4	0	4
Carbonic anhydrase 7	0	3	0	4
Alpha-glucosidase MAL12	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Cholinesterase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Hyaluronidase-1	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Carbonic anhydrase 13	0	3	0	4
Carbonic anhydrase 14	0	3	0	4
Carbonic anhydrase 5B, mitochondrial	0	3	0	4
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
endonuclease IV	1	0	0	1
Skn7p	0	0	0	1
Thrombopoietin	1	0	0	1
huntingtin isoform 2	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
Vpr	2	0	0	2
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	3	0	3
Thymidylate synthase	0	3	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
thyrotropin-releasing hormone receptor	4	0	0	4
Solute carrier family 22 member 6	0	2	0	2
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
alpha synuclein, partial	1	0	0	1
hypothetical protein, conserved	1	0	0	1
glucocerebrosidase	1	0	0	1
luciferase	2	0	0	2
Caspase-7	3	0	0	3
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	3	0	0	3
caspase-3	3	0	0	3
histone deacetylase 9 isoform 3	2	0	0	2
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Solute carrier family 22 member 1	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Tyrosine-protein kinase Fyn	0	2	0	2
Muscarinic acetylcholine receptor M2	0	4	0	4
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Adenosine receptor A3	0	6	0	6
Muscarinic acetylcholine receptor M1	0	3	0	3
D(2) dopamine receptor	0	2	0	2
Androgen receptor	0	7	0	7
Alpha-1B adrenergic receptor	0	6	0	6
Alpha-2C adrenergic receptor	0	3	0	3
Muscarinic acetylcholine receptor M3	0	3	0	3
Substance-K receptor	0	6	0	6
D(1A) dopamine receptor	0	2	0	2
Glutamate receptor ionotropic, kainate 1	1	0	0	1
Histamine H2 receptor	0	4	0	4
Alpha-1D adrenergic receptor	0	6	0	6
5-hydroxytryptamine receptor 2A	0	2	0	2
Adenosine receptor A2a	0	4	0	4
Mu-type opioid receptor	0	2	0	2
D(3) dopamine receptor	0	3	0	3
Kappa-type opioid receptor	0	2	0	2
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Alpha-1A adrenergic receptor	0	6	0	6
Histamine H2 receptor	2	0	0	2
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Fatty-acid amide hydrolase 1	1	0	0	1
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Leukotriene B4 receptor 1	1	0	0	1
Glutamate receptor ionotropic, kainate 5	1	0	0	1
Leukotriene B4 receptor 2	1	0	0	1
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	1	2
NFKB1 protein, partial	1	0	0	1
GLS protein	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Urease subunit alpha	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Urease subunit beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
Dopamine beta-hydroxylase	0	1	0	1
Corticotropin-releasing factor receptor 1	0	1	0	1
Cystathionine beta-synthase	0	1	0	1
Glutathione reductase	0	1	0	1
5-lipoxygenase	0	1	0	1
Cysteine protease ATG4B	0	1	0	1
Thioredoxin reductase 2, mitochondrial	0	1	0	1
DNA polymerase beta	2	0	0	2
7,8-dihydro-8-oxoguanine triphosphatase	0	1	0	1
Toll-like receptor 8	0	0	1	1
regulator of G-protein signaling 4	3	0	0	3
Parkin	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
Ornithine decarboxylase	0	0	0	2
Mitogen-activated protein kinase 1	0	2	0	2
5-hydroxytryptamine receptor 2B	0	4	0	4
Mitogen-activated protein kinase 14	0	1	0	1
Olfactory receptor 51E2	0	1	1	2
cytochrome P450 2C19 precursor	1	0	0	1
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1B1	0	1	0	1
Chain A, Antigen Cd11a (p180)	0	1	0	1
Smad3	2	0	0	2
PINK1	2	0	0	2
isocitrate dehydrogenase 1, partial	1	0	0	1
bcl-2-related protein A1	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	3	0	3
Integrin beta-2	0	1	0	1
Intercellular adhesion molecule 1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Neutrophil elastase	0	1	0	1
Insulin receptor	0	2	0	2
Integrin alpha-L	0	1	1	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Adenosine receptor A1	0	2	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Histone deacetylase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Histone deacetylase 2	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Histone deacetylase 6	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	5	0	5
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	1	0	0	1
dopamine D1 receptor	1	0	0	1
Thymidylate synthase	0	1	0	1
alpha-galactosidase	1	0	0	1
Thymidylate synthase	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	2	1	3
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
TAR DNA-binding protein 43	2	0	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Poly [ADP-ribose] polymerase tankyrase-1	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	2	2	4
Protein mono-ADP-ribosyltransferase PARP6	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP10	0	1	1	2
Protein mono-ADP-ribosyltransferase PARP8	0	0	1	1
Protein mono-ADP-ribosyltransferase PARP16	0	1	1	2
Protein mono-ADP-ribosyltransferase PARP12	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Histamine H3 receptor	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	2	3
Protein mono-ADP-ribosyltransferase PARP4	0	1	1	2
Protein mono-ADP-ribosyltransferase PARP3	0	1	2	3
Genome polyprotein	0	1	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
Tubulin alpha-3C chain	0	1	1	3
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
Fibroblast growth factor receptor 1	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Cholecystokinin receptor type A	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Bcl-2-like protein 1	0	1	0	1
Tyrosine-protein kinase Mer	0	1	0	1
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
Serine/threonine-protein kinase D3	0	0	1	1
Protein kinase C gamma type	0	0	1	1
Protein kinase C beta type	0	0	1	1
Protein kinase C alpha type	0	0	1	1
Protein kinase C eta type	0	0	1	1
Protein kinase C iota type	0	0	1	1
Protein kinase C epsilon type	0	0	1	1
Protein kinase C theta type	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	0	1	1
Serine/threonine-protein kinase D1	0	0	1	1
beta-2 adrenergic receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
photoreceptor-specific nuclear receptor	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
polyadenylate-binding protein 1	0	1	0	1
Tyrosine-protein kinase ABL2	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Disseminated Superficial Actinic Porokeratosis

Synonyms(15)

Research Excerpts

Overview

Treatment

Research

Studies (176)

Protein Targets (721)

Disseminated Superficial Actinic Porokeratosis

Synonyms(15)

Research Excerpts

Overview

Treatment

Research

Studies (176)

Drugs Studied (83)

Protein Targets (721)