ARSA Deficiency

Synonym
Metachromatic Leukodystrophy, Infant-Type
Arylsulfatase A Deficiency Disease
Leukodystrophy, Metachromatic, Juvenile
Cerebroside Sulfatase Deficiency
Cerebral sclerosis, Diffuse, Metachromatic Form
Greenfield Disease
ARSA Deficiency
Sulfatide Lipidosis
Metachromatic Leukodystrophy, Infant
Greenfield's Disease
Cerebroside Sulphatase Deficiency Disease
Leukodystrophy, Metachromatic, Adult
Metachromatic Leukodystrophy, Adult-Type
Metachromatic Leukodystrophy, Adult
Metachromatic Leukodystrophy
Arylsulfatase A Deficiency
Metachromatic Leukodystrophy, Juvenile
Metachromatic Leukodystrophy, Juvenile-Type
Metachromatic Leukodystrophy, Late Infantile
Metachromatic Leukoencephalopathy

Excerpt	Reference
"Metachromatic leukodystrophy is the name given to a group of diseases in patients having a deficiency of CS sulfatase activity."	( Bitter, MA; Kudoh, T; Malmstrom, J; Sattler, M; Wenger, DA, 1981)
"Metachromatic leukodystrophy is a recessively inherited disease of children and adults."	( McKhann, GM, 1984)
"Metachromatic leukodystrophy is an inherited disorder characterized by a deficiency of the lysosomal enzyme arylsulfatase A and the subsequent accumulation of sulfatide in neural and visceral tissues."	( Johnson, DW; Meikle, PJ; Nelson, P; Sharp, PC; Whitfield, PD, 2001)
"Metachromatic leukodystrophy is a lysosomal storage disorder caused by the deficiency of arylsulphatase A."	( Dietz, F; Gieselmann, V; Habetha, M; Klein, RA; Poeppel, P; Schestag, F; Yaghootfam, A; Zlotogora, J, 2002)
"Metachromatic leukodystrophy is a lysosomal storage disorder caused by the deficiency of arylsulfatase A."	( Baumann, N; Gieselmann, V; Schwarz, A; Yaghootfam, A, 2004)
"Metachromatic leukodystrophy is a lysosomal disease caused by the deficiency of arylsulfatase A, which results in the storage of the sphingolipid 3-O-sulfogalactosylceramide (sulfatide) in, e."	( Büssow, H; Fewou, SN; Gieselmann, V; Klein, D, 2005)
"Metachromatic leukodystrophy is a lysosomal storage disorder caused by deficiency in the sulfolipid degrading enzyme arylsulfatase A (ASA)."	( Beck, H; Eckhardt, M; Fewou, SN; Gieselmann, V; Hedayati, KK; Lüllmann-Rauch, R; Pitsch, J, 2007)
"Metachromatic leukodystrophy is a lysosomal storage disease caused by the deficiency of arylsulphatase A (ASA)."	( Gieselmann, V, 2008)
"Metachromatic leukodystrophy is a neurodegenerative disease that is characterized by a deficiency of arylsulfatase A, resulting in the accumulation of sulfatide and other lipids in the lysosomal network of affected cells."	( Fuller, M; Hopwood, JJ; Meikle, PJ; Tan, MA; Zabidi-Hussin, ZA, 2010)
"Metachromatic leukodystrophy is a neurological lysosomal deposit disease that affects public health despite its low incidence in the population."	( Bautista-Niño, PK; Sanchez-Álvarez, NT; Serrano-Díaz, NC; Trejos-Suárez, J, 2022)

Excerpt	Reference
"A 4-year-old child with metachromatic leukodystrophy was initially diagnosed with chronic immune demyelinating polyneuropathy and treated with immunosuppressive therapy."	( Carroll, SL; Lopate, G; Nevo, Y; Pestronk, A, 1996)
"Treatments are being developed for metachromatic leukodystrophy (MLD), suggesting the need for eventual newborn screening."	( Barcenas, M; Gelb, MH; Scott, CR; Suhr, TR; Turecek, F, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	164 (53.95)	23.3326
1990's	32 (10.53)	12.5806
2000's	52 (17.11)	18.1394
2010's	43 (14.14)	28.8240
2020's	13 (4.28)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	1	0
choline	medium	3	1
citric acid, anhydrous	low	1	0
chlorine	low	1	0
creatine	medium	4	1
cytosine	low	1	0
lactic acid	low	2	0
glycine	low	6	0
hydrogen carbonate	low	1	0
inositol	low	2	0
oxalic acid	low	1	0
uric acid	low	1	0
aspirin	low	1	0
azathioprine	low	1	0
baclofen	low	1	0
chloroquine	low	1	0
foscarnet	low	1	0
isoflurane	low	1	0
2-propanol	low	1	0
metformin	low	1	0
propofol	medium	3	1
ropinirole	low	1	0
stearic acid	low	3	0
trihexyphenidyl	low	1	0
vigabatrin	low	1	0
thymidine	low	1	0
estrone	low	3	0
dehydroepiandrosterone	low	3	0
alanine	low	2	0
serine	low	3	0
aspartic acid	medium	4	1
glutamine	low	1	0
lysine	low	1	0
galactose	low	7	0
tyrosine	low	2	0
adenosine monophosphate	low	1	0
leucine	low	3	0
lactose	low	3	0
methionine	low	1	0
phenylalanine	low	2	0
valine	low	2	0
tryptophan	low	1	0
isoleucine	low	1	0
arginine	low	1	0
taurocholic acid	low	3	0
aminacrine	low	1	0
tolonium chloride	low	1	0
pyrroles	low	1	0
pregnenolone	low	1	0
ninhydrin	low	1	0
d-alpha tocopherol	low	1	0
fucose	low	6	0
uridine diphosphate galactose	low	1	0
mannose	low	3	0
hepes	low	1	0
manganese	low	3	0
mercury	low	1	0
silver	low	1	0
gadolinium	low	2	0
acetylglucosamine	low	3	0
galactosamine	low	1	0
silver nitrate	low	2	0
galactose	low	1	0
phytanic acid	low	1	0
cresyl violet	low	1	0
cetylpyridinium chloride anhydrous	low	1	0
glutamic acid	low	3	0
acetylgalactosamine	low	2	0
paroxetine	low	1	0
atracurium	low	1	0
simvastatin	low	1	0
remifentanil	low	1	0
adenosine	low	1	0
n-acetylaspartic acid	medium	3	1
n-formylglycine	low	2	0
homocysteine	low	1	0
n-acetylglucosaminylasparagine	low	1	0
xylose	low	1	0
proline	low	3	0
4-nitrocatechol sulfate	low	5	0
atropine	low	2	0
deoxycholic acid	low	2	0
lanosterol	low	1	0
glycogen	low	4	0
mannose-6-phosphate	low	2	0
desmosterol	low	1	0
rocuronium	low	1	0
c(alpha)-formylglycine	low	1	0
retinol	low	3	0
tyrosine o-sulfate	low	1	0
glycosides	low	1	0
benztropine	low	1	0
sodium taurodeoxycholate	low	1	0
krn 7000	low	1	0
thiopental	medium	2	1
dermatan sulfate	low	2	0
cystine	low	1	0
cupric ferrocyanide	low	1	0
myelin basic protein	low	4	0
sphingosine	low	6	0
psychosine	low	12	0
hymecromone	low	5	0
su 5402	low	1	0
lysophosphatidylcholines	low	1	0
lead	low	1	0
barium	low	1	0
cysteine	low	1	0
oxalates	low	1	0
i(3)so3-galactosylceramide	medium	154	1
phosphocreatine	low	1	0
mocetinostat	low	1	0
g(m2) ganglioside	low	12	0
g(m1) ganglioside	low	7	0
n-acetylgalactosamine 4-sulfate	low	1	0
enerbol	low	1	0
acid phosphatase	low	8	0
ammonium citrate	low	1	0
oligonucleotides	low	1	0
cellulose	low	1	0
phosphatidylcholines	low	2	0
psychosine-3'-sulfate ester	low	8	0
olaparib	low	1	0
glycolipids	low	22	0
piperidines	low	1	0
galactocerebroside	low	1	0
chondroitin	low	2	0
heparitin sulfate	low	3	0
ascorbic acid	low	1	0
warfarin	low	1	0
g(m3) ganglioside	low	1	0
vitamin b 12	low	2	0
cyclosporine	low	4	0
chondroitin sulfates	low	1	0
acyclovir	low	1	0
guanosine	low	1	0
ganciclovir	low	1	0
defibrotide	low	1	0
alcian blue	low	1	0
eye	low	3	0
concanavalin a	low	2	0
metallothionein	low	1	0

Protein Targets (956)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
RAR-related orphan receptor gamma	17	0	0	17
GLI family zinc finger 3	23	0	0	23
AR protein	24	0	0	24
aldehyde dehydrogenase 1 family, member A1	10	0	0	10
retinoic acid nuclear receptor alpha variant 1	19	0	0	19
retinoid X nuclear receptor alpha	11	0	0	11
estrogen nuclear receptor alpha	27	0	0	27
peroxisome proliferator-activated receptor delta	12	0	0	12
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	11	0	0	11
activating transcription factor 6	11	0	0	11
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
Histone H2A.x	9	0	0	9
thyroid hormone receptor beta isoform a	6	0	0	6
heat shock protein beta-1	11	0	0	11
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
lamin isoform A-delta10	18	0	0	18
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Glutamate receptor 2	6	2	1	9
Chain A, Protein-tyrosine phosphatase yopH	0	1	0	1
Fibrinogen C domain-containing protein 1	0	1	0	1
Putative glycosyltransferase WbgO	0	0	0	1
Cytochrome P450 3A4	0	3	0	4
Cannabinoid receptor 1	0	1	0	1
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
Chain A, Ferritin light chain	11	0	0	11
Thymidine kinase	0	3	0	4
thioredoxin reductase	14	0	0	14
phosphopantetheinyl transferase	10	0	0	10
GLS protein	11	0	0	11
TDP1 protein	19	0	0	19
Smad3	2	0	0	2
thyroid stimulating hormone receptor	8	0	0	8
EWS/FLI fusion protein	10	0	0	10
arylsulfatase A	11	0	0	11
euchromatic histone-lysine N-methyltransferase 2	18	0	0	18
Bloom syndrome protein isoform 1	12	0	0	12
hemoglobin subunit beta	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Solute carrier family 22 member 1	0	2	0	5
ATP-binding cassette sub-family C member 3	0	10	0	10
Multidrug resistance-associated protein 4	0	12	0	12
Solute carrier family 22 member 6	0	2	0	3
Bile salt export pump	0	2	0	3
Bile salt export pump	0	13	0	14
Purine nucleoside phosphorylase	0	2	0	3
Thymidine kinase, cytosolic	0	2	0	5
POU domain, class 2, transcription factor 2	0	0	0	2
Cytochrome P450 2C9	0	3	0	3
Cytochrome P450 2J2	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	2	2
Solute carrier family 22 member 6	0	0	0	3
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Canalicular multispecific organic anion transporter 1	0	10	0	10
Thymidine kinase	0	1	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	11	0	0	11
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Membrane lipoprotein tmpC	0	0	2	2
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	6	0	0	6
glucocorticoid receptor [Homo sapiens]	23	0	0	23
NPYLR7B	0	0	2	2
IDH1	8	0	0	8
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	6	0	0	6
flap endonuclease 1	6	0	0	6
nuclear receptor ROR-gamma isoform 1	4	0	0	4
peripheral myelin protein 22	6	0	0	6
survival motor neuron protein isoform d	5	0	0	5
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
Epidermal growth factor receptor	0	3	0	3
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	1	0	2
Adenosine receptor A3	0	2	2	5
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	1	0	2
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	1	0	3
Adenosine receptor A1	0	2	1	5
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	1	2	4
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	2	0	3
Adenosine receptor A1	0	2	3	6
Adenosine receptor A2a	0	2	1	5
Adenylate kinase isoenzyme 1	0	2	0	3
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, Glycogen Phosphorylase B	0	0	1	1
Chain B, Glycogen Phosphorylase B	0	0	1	1
Chain A, ADP-dependent glucokinase	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, phosphodiesterase-nucleotide pyrophosphatase	0	1	0	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain B, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
estrogen-related nuclear receptor alpha	19	0	0	19
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	1	1
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
L-lactate dehydrogenase A chain	0	1	1	2
Adenylate kinase isoenzyme 1	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	4
Fructose-1,6-bisphosphatase 1	0	1	0	1
2-dehydropantoate 2-reductase	0	1	1	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	4	0	4
Amine oxidase [flavin-containing] B	0	1	0	1
5'-nucleotidase	0	0	0	1
Choline O-acetyltransferase	0	1	0	1
GTP:AMP phosphotransferase AK3, mitochondrial	0	0	0	1
P2Y purinoceptor 2	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	0	1
Glycine--tRNA ligase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Adenosine deaminase-like protein	0	0	0	1
Protease	0	2	1	3
P2Y purinoceptor 11	0	0	1	1
Histamine H3 receptor	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
5'-AMP-activated protein kinase subunit beta-1	0	0	2	2
ATP-dependent phosphofructokinase	11	0	0	11
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Carbonic anhydrase 1	0	7	0	16
Carbonic anhydrase 2	0	8	0	16
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	7	2	12
Proton-coupled amino acid transporter 1	0	7	0	8
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
67.9K protein	4	0	0	4
alpha-galactosidase	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
DNA polymerase kappa isoform 1	6	0	0	6
caspase-1 isoform alpha precursor	3	0	0	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Trypanothione reductase	0	1	0	1
Caspase-7	2	0	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
NFKB1 protein, partial	4	0	0	4
cytochrome P450 2C19 precursor	3	0	0	3
chromobox protein homolog 1	10	0	0	10
DNA polymerase iota isoform a (long)	10	0	0	10
muscarinic acetylcholine receptor M1	7	0	0	7
lethal factor (plasmid)	6	0	0	6
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	8	0	0	8
thioredoxin glutathione reductase	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
thyroid hormone receptor beta isoform 2	13	0	0	13
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
geminin	13	0	0	13
Polyphenol oxidase 2	0	1	0	2
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	3	1	4
Spike glycoprotein	6	1	2	9
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Neutral amino acid transporter A	0	4	0	4
Neutral amino acid transporter B(0)	0	4	0	4
Carbonic anhydrase-like protein, putative	0	0	0	7
Amino acid transporter	0	4	0	4
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	5	2	10
Glutamate receptor ionotropic, NMDA 2B	0	5	2	10
Glutamate receptor ionotropic, NMDA 2C	0	5	2	10
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Glutamate receptor ionotropic, NMDA 2D	0	5	2	10
Glutamate receptor ionotropic, NMDA 3B	0	5	2	10
Glutamate receptor ionotropic, NMDA 3A	0	5	2	10
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	3	0	0	3
hypothetical protein, conserved	1	0	0	1
cytochrome P450 2D6	8	0	0	8
glucocerebrosidase	3	0	0	3
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	1	1	1	3
Myeloperoxidase	0	3	0	3
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	1	1	1	3
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	3
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Nuclear receptor ROR-gamma	4	0	1	5
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	7	3	2	12
Prostaglandin G/H synthase 2	0	2	0	2
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	7	1	8
Sigma non-opioid intracellular receptor 1	0	0	1	1
Amine oxidase [flavin-containing] A	0	0	1	1
Small conductance calcium-activated potassium channel protein 3	0	2	1	3
nuclear receptor subfamily 1, group I, member 3	11	0	0	11
pregnane X nuclear receptor	10	0	0	10
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	2	0	0	2
short transient receptor potential channel 6 isoform 1	0	0	1	1
5-hydroxytryptamine receptor 4	0	6	0	6
Muscarinic acetylcholine receptor M2	0	9	1	13
Muscarinic acetylcholine receptor M4	0	9	1	12
Muscarinic acetylcholine receptor M1	0	3	1	6
Muscarinic acetylcholine receptor M3	0	2	1	5
Muscarinic acetylcholine receptor M4	0	2	1	5
Muscarinic acetylcholine receptor M5	0	2	1	5
Muscarinic acetylcholine receptor M5	0	9	1	12
Muscarinic acetylcholine receptor M2	0	3	1	7
Muscarinic acetylcholine receptor M1	0	9	1	13
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M3	0	9	1	12
Alpha-1D adrenergic receptor	0	4	0	4
5-hydroxytryptamine receptor 2C	0	6	0	6
Muscarinic acetylcholine receptor M4	0	1	0	1
Histamine H2 receptor	4	0	0	5
5-hydroxytryptamine receptor 7	0	1	0	1
Reverse transcriptase/RNaseH	0	1	1	3
Muscarinic acetylcholine receptor	0	1	1	2
SMAD family member 2	7	0	0	7
ATAD5 protein, partial	5	0	0	5
Fumarate hydratase	3	0	0	3
SMAD family member 3	7	0	0	7
Microtubule-associated protein tau	6	0	0	6
farnesoid X nuclear receptor	9	0	0	9
G	8	0	0	8
polyprotein	3	0	0	3
P53	1	0	0	1
peroxisome proliferator activated receptor gamma	11	0	0	11
aryl hydrocarbon receptor	5	0	0	5
thyroid stimulating hormone receptor	8	0	0	8
peripheral myelin protein 22 isoform 1	4	0	0	4
cellular tumor antigen p53 isoform a	2	0	0	2
cytochrome P450 3A4 isoform 1	7	0	0	7
M-phase phosphoprotein 8	3	0	0	3
muscleblind-like protein 1 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	7	2	1	10
Interferon beta	12	0	0	12
HLA class I histocompatibility antigen, B alpha chain	8	0	0	8
Cellular tumor antigen p53	15	0	0	15
Gamma-aminobutyric acid receptor subunit beta-1	7	2	1	10
Gamma-aminobutyric acid receptor subunit delta	7	2	1	10
Gamma-aminobutyric acid receptor subunit gamma-2	7	2	2	11
Gamma-aminobutyric acid receptor subunit alpha-5	7	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-3	7	2	1	10
Gamma-aminobutyric acid receptor subunit gamma-1	7	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-2	7	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-4	7	2	1	10
Gamma-aminobutyric acid receptor subunit gamma-3	7	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-6	7	2	1	10
Gamma-aminobutyric acid receptor subunit beta-3	7	2	1	10
Gamma-aminobutyric acid receptor subunit beta-2	7	2	2	11
GABA theta subunit	7	2	1	10
Inositol hexakisphosphate kinase 1	8	0	0	8
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit epsilon	7	2	1	10
Protein-arginine deiminase type-4	0	1	0	1
cytochrome P450 2C9, partial	8	0	0	8
D(1A) dopamine receptor	4	0	0	4
histone acetyltransferase KAT2A isoform 1	5	0	0	5
Gamma-aminobutyric acid type B receptor subunit 2	0	3	1	4
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	3	1	4
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
potassium voltage-gated channel subfamily H member 2 isoform d	5	0	0	5
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Transmembrane protease serine 2	0	1	2	3
Procathepsin L	0	1	2	3
Aldo-keto reductase family 1 member B1	0	7	0	7
Alpha-2A adrenergic receptor	0	3	0	3
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Alpha-2C adrenergic receptor	0	3	0	3
Sodium-dependent noradrenaline transporter	0	6	1	7
Sodium-dependent dopamine transporter	0	4	0	4
Histamine H2 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	1	3
Sodium-dependent serotonin transporter	0	5	1	6
Sodium-dependent serotonin transporter	0	3	1	4
Histamine H1 receptor	0	2	0	2
D(3) dopamine receptor	0	3	1	4
5-hydroxytryptamine receptor 2B	0	6	0	6
5-hydroxytryptamine receptor 6	0	2	0	2
Sodium-dependent dopamine transporter	0	4	1	5
Angiotensin-converting enzyme 2	0	1	2	3
USP1 protein, partial	8	0	0	8
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	13	0	0	13
progesterone receptor	9	0	0	9
caspase-3	3	0	0	3
thyrotropin-releasing hormone receptor	1	0	0	1
vitamin D3 receptor isoform VDRA	4	0	0	4
Caspase-2	0	0	1	1
Inositol monophosphatase 1	2	0	0	2
Carbonic anhydrase 4	0	4	0	7
Carbonic anhydrase	0	2	0	5
Carbonic anhydrase 15	0	2	0	5
PPM1D protein	5	0	0	5
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Dihydrofolate reductase	0	1	0	1
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Amyloid-beta precursor protein	0	3	0	3
Histidine-rich protein PFHRP-II	0	1	0	2
Spike glycoprotein	0	1	0	1
DNA ligase 1	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Beta-secretase 1	0	2	0	2
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	1	0	3
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	1	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	2	0	2
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	1	0	2
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Deoxycytidine kinase	0	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	8	0	0	8
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Sex hormone-binding globulin	0	0	3	3
Beta-glucuronidase	0	1	0	1
Corticosteroid-binding globulin	0	3	0	3
Beta-glucuronidase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	4	0	4
Alpha-synuclein	1	2	0	3
TAR DNA-binding protein 43	5	0	0	5
G-protein coupled bile acid receptor 1	0	0	4	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
NPC1-like intracellular cholesterol transporter 1	0	0	1	1
Chain A, STEROID DELTA-ISOMERASE	0	0	1	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Steroid Delta-isomerase	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Ileal sodium/bile acid cotransporter	0	3	0	4
Bile acid receptor	0	0	1	1
endonuclease IV	4	0	0	4
GALC protein	2	0	0	2
nonstructural protein 1	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
glucokinase regulatory protein	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Estrogen receptor	0	2	1	4
Steryl-sulfatase	0	1	0	1
Aromatase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
17-beta-hydroxysteroid dehydrogenase type 1	0	2	0	3
Androgen receptor	0	2	0	2
Mu-type opioid receptor	0	1	1	2
Solute carrier organic anion transporter family member 1A1	0	2	0	4
Mu-type opioid receptor	0	1	1	2
Cytochrome P450 1B1	0	1	0	1
Estrogen receptor beta	0	1	1	3
Ghrelin O-acyltransferase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Chain A, probable fosfomycin resistance protein	0	0	1	1
Chain B, probable fosfomycin resistance protein	0	0	1	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
DNA polymerase delta catalytic subunit	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	4
Carbonic anhydrase 9	0	3	0	6
Fucose-binding lectin PA-IIL	0	2	0	2
CD209 antigen	0	3	0	3
P-selectin	0	1	0	1
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
ClpP	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
Transitional endoplasmic reticulum ATPase	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
glp-1 receptor, partial	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	3	0	3
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Asc-type amino acid transporter 1	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	8	0	9
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, TYROSINE PHOSPHATASE	0	1	0	1
Chain A, Tyrosine Phosphatase	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
cytochrome P450 2C9 precursor	2	0	0	2
Acetylcholinesterase	0	4	0	4
Carbonic anhydrase 12	0	1	0	4
Aldo-keto reductase family 1 member B1	0	1	0	2
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Genome polyprotein	0	1	0	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Cholinesterase	0	2	0	2
Sorbitol dehydrogenase	0	1	0	1
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Oleandomycin glycosyltransferase	0	0	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
Alpha-crystallin B chain	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	0	1
Peroxisome proliferator-activated receptor alpha	1	0	1	2
Lanosterol 14-alpha demethylase	0	1	0	2
14-alpha sterol demethylase	0	0	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Intestinal-type alkaline phosphatase	0	3	0	3
Phospholipase A-2-activating protein	0	3	0	3
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
Alpha-mannosidase 2C1	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Dipeptidyl peptidase 4	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Cytochrome P450 2D6	0	5	0	5
Integrin alpha-4	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Carbonic anhydrase 7	0	1	0	4
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cholinesterase	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	2	2	4
Protein mono-ADP-ribosyltransferase PARP6	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP10	0	1	1	2
Protein mono-ADP-ribosyltransferase PARP8	0	0	1	1
Protein mono-ADP-ribosyltransferase PARP16	0	1	1	2
Protein mono-ADP-ribosyltransferase PARP12	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Histamine H3 receptor	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	2	3
Protein mono-ADP-ribosyltransferase PARP4	0	1	1	2
Protein mono-ADP-ribosyltransferase PARP3	0	1	2	3
Chain A, Pyruvate kinase, M2 isozyme	0	1	0	1
Chain A, Phosphonopyruvate hydrolase	0	1	0	1
Chain A, Phosphoenolpyruvate-protein phosphotransferase	0	1	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	1	2
Quinolone resistance protein NorA	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	1	2
Substance-P receptor	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
P2X purinoceptor 4	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Envelope glycoprotein	0	0	1	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Rhodopsin kinase GRK1	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
P2X purinoceptor 4	0	1	0	1
Beta-adrenergic receptor kinase 1	0	0	0	1
Transporter	0	2	0	2
Luciferase	3	0	0	3
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Plasma kallikrein	0	0	0	3
Carbonic anhydrase 3	0	0	0	3
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Carbonic anhydrase 6	0	0	0	3
Carbonic anhydrase	0	0	0	3
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase	0	0	0	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
Carbonic anhydrase	0	0	0	3
Carbonic anhydrase 13	0	0	0	1
Monocarboxylate transporter 10	0	0	0	3
Carbonic anhydrase 13	0	0	0	2
Carbonic anhydrase 14	0	0	0	3
Carbonic anhydrase 5B, mitochondrial	0	0	0	3
Fatty acid-binding protein, liver	0	1	0	1
Chain A, Beta-lactamase	3	0	0	3
Guanine nucleotide-binding protein G	1	0	0	1
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Chain A, Cruzipain	2	0	0	2
pregnane X receptor	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
cytochrome P450 2D6 isoform 1	1	0	0	1
D(2) dopamine receptor	0	1	1	2
D(3) dopamine receptor	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(1A) dopamine receptor	0	0	1	1
D(4) dopamine receptor	0	0	1	1
D(1B) dopamine receptor	0	0	1	1
D(2) dopamine receptor	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
PINK1	1	0	0	1
Parkin	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
photoreceptor-specific nuclear receptor	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Sodium/bile acid cotransporter	0	1	0	3
acid sphingomyelinase	1	0	0	1
apical membrane antigen 1, AMA1	1	0	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
DNA polymerase eta isoform 1	1	0	0	1
bcl-2-related protein A1	0	1	0	1
streptokinase A precursor	0	0	1	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor beta	0	0	1	1
Protein kinase C eta type	0	1	0	1
Sphingosine kinase 2	0	1	0	1
Sphingosine kinase 1	0	1	0	1
Protein kinase C theta type	0	1	0	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
Fatty acid-binding protein, adipocyte	0	0	1	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Insulin-like growth factor 1 receptor	0	1	0	1
Fibroblast growth factor receptor 1	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
ATP-binding cassette sub-family C member 3	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Ileal sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Sodium/bile acid cotransporter	0	1	0	2
Ileal sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Bile salt export pump	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidylate synthase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
histone deacetylase 9 isoform 3	1	0	0	1
Microtubule-associated protein tau	0	2	0	2
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Stromelysin-1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Beta-1,4-galactosyltransferase 1	0	0	0	1
N-acetyllactosaminide alpha-1,3-galactosyltransferase	0	0	0	1
P2Y purinoceptor 14	0	0	1	1
Chain A, Arginase 1	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Albumin	0	0	1	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
Hsf1 protein	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(20)

Research Excerpts

Overview

Treatment

Research

Studies (304)

Protein Targets (956)

ARSA Deficiency

Synonyms(20)

Research Excerpts

Overview

Treatment

Research

Studies (304)

Drugs Studied (166)

Protein Targets (956)