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trichothecene
Any one of a large family of chemically related mycotoxins with a structure based on a sesquiterpene skeleton. The most important structural features causing the biological activities of trichothecenes are a 12,13-epoxy ring, the presence of hydroxy or acetyl groups at appropriate positions on the trichothecene nucleus and the structure and position of the side-chain.
ChEBI ID: 55517
Members (13)
| Member | Definition | Role |
|---|---|---|
| 15-acetoxyscirpen-3,4-diol | Monoacetoxyscirpenol | |
| 15-acetyldeoxynivalenol | A trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-15. A skin and eye irritant, along with its 3-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants. | 15-acetyldeoxynivalenol |
| 3-acetyldeoxynivalenol | A trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-3. A skin and eye irritant, along with its 15-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants. | 3-acetyldeoxynivalenol |
| acetyldeoxynivalenol | Acetyldeoxynivalenol | |
| deoxynivalenol | A trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination. | deoxynivalenol |
| deoxynivalenol-3-glucoside | Deoxynivalenol 3-glucoside | |
| HT-2 toxin | A trichothecene mycotoxin that is T-2 toxin in which the acetyloxy group at position 4S has been hydrolysed to the corresponding hydroxy group. It is the major metabolite of T-2 toxin. | HT-2 toxin |
| muconomycin a | A trichothecene antibiotic which incorporates a triester macrocyclic structure and an exocyclic methylene epoxide group. | verrucarin A |
| nivalenol | Nivalenol | |
| nsc 141537 | Anguidine | |
| satratoxin h | Satratoxin H | |
| t-2 toxin | A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals. | T-2 toxin |
| verrucarin j | Verrucarin j |
Research
Studies (2,689)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 244 (9.07) | 18.7374 |
| 1990's | 220 (8.18) | 18.2507 |
| 2000's | 516 (19.19) | 29.6817 |
| 2010's | 1,187 (44.14) | 24.3611 |
| 2020's | 522 (19.41) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 48 (1.44%) | 5.53% |
| Reviews | 133 (4.00%) | 6.00% |
| Case Studies | 6 (0.18%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 3,137 (94.37%) | 84.16% |