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trichothecene

Any one of a large family of chemically related mycotoxins with a structure based on a sesquiterpene skeleton. The most important structural features causing the biological activities of trichothecenes are a 12,13-epoxy ring, the presence of hydroxy or acetyl groups at appropriate positions on the trichothecene nucleus and the structure and position of the side-chain.

ChEBI ID: 55517

Members (13)

MemberDefinitionRole
15-acetoxyscirpen-3,4-diolMonoacetoxyscirpenol
15-acetyldeoxynivalenolA trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-15. A skin and eye irritant, along with its 3-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants.15-acetyldeoxynivalenol
3-acetyldeoxynivalenolA trichothecene mycotoxin that is deoxynivalenol acetylated on the oxygen at C-3. A skin and eye irritant, along with its 15-acetyl regioisomer and its parent deoxynivalenol it is considered among the most commonly and widely distributed cereal contaminants.3-acetyldeoxynivalenol
acetyldeoxynivalenolAcetyldeoxynivalenol
deoxynivalenolA trichothecene mycotoxin produced by Fusarium to which wheat, barley, maize (corn) and their products are susceptible to contamination.deoxynivalenol
deoxynivalenol-3-glucosideDeoxynivalenol 3-glucoside
HT-2 toxinA trichothecene mycotoxin that is T-2 toxin in which the acetyloxy group at position 4S has been hydrolysed to the corresponding hydroxy group. It is the major metabolite of T-2 toxin.HT-2 toxin
muconomycin aA trichothecene antibiotic which incorporates a triester macrocyclic structure and an exocyclic methylene epoxide group.verrucarin A
nivalenolNivalenol
nsc 141537Anguidine
satratoxin hSatratoxin H
t-2 toxinA trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.T-2 toxin
verrucarin jVerrucarin j

Research

Studies (2,689)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-1990244 (9.07)18.7374
1990's220 (8.18)18.2507
2000's516 (19.19)29.6817
2010's1,187 (44.14)24.3611
2020's522 (19.41)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials48 (1.44%)5.53%
Reviews133 (4.00%)6.00%
Case Studies6 (0.18%)4.05%
Observational0 (0.00%)0.25%
Other3,137 (94.37%)84.16%