ascorbic-acid has been researched along with 4-phenylphenol* in 1 studies
1 other study(ies) available for ascorbic-acid and 4-phenylphenol
| Article | Year |
|---|---|
The effect of ascorbic acid on the conjugation of 4-hydroxybiphenyl in rat isolated hepatocytes.
Ascorbic acid at high non-physiological levels inhibited the sulphation of 4-hydroxybiphenyl by rat isolated hepatocytes. Glucuronylation of 4-hydroxybiphenyl, formed from 4-methoxybiphenyl, was increased at ascorbic acid levels which inhibited sulphation. The glucuronylation of 4-hydroxybiphenyl added directly to the cells was enhanced at concentrations of ascorbic acid which did not inhibit sulphation. Ascorbic acid did not influence the cytochrome P-450-dependent O-demethylation of 4-methoxybiphenyl or the level of cellular lipid peroxidation. Topics: Animals; Ascorbic Acid; Biphenyl Compounds; Glucuronates; In Vitro Techniques; Inactivation, Metabolic; Liver; Male; Rats; Rats, Inbred Strains; Sulfates | 1983 |