Compounds > n,n-dimethylepinephrine

Page last updated: 2024-12-10

n,n-dimethylepinephrine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N,N-dimethylepinephrine: quaternary analog of epinephrine; RN given refers to iodidestructure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	3082487
MeSH ID	M0114431

Synonyms (8)

Synonym
nsc62513
38522-73-5
nsc-62513
nsc 62513
benzeneethanaminium, beta,3,4-trihydroxy-n,n,n-trimethyl-, iodide
n,n-dimethylepinephrine
catecholine
[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-trimethylazanium;iodide

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (5)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	IC50 (µMol)	949.0000	0.0007	0.9774	9.7000	AID169083
Sodium-dependent dopamine transporter	Rattus norvegicus (Norway rat)	Ki	530.0000	0.0003	0.3708	8.1600	AID65655
Sodium- and chloride-dependent creatine transporter 1	Rattus norvegicus (Norway rat)	IC50 (µMol)	221.0000	1.6000	1.6000	1.6000	AID219566
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	IC50 (µMol)	3,600.0000	0.0003	0.8197	8.4900	AID3172
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	Ki	390.0000	0.0000	0.7056	10.0000	AID3173
Choline O-acetyltransferase	Rattus norvegicus (Norway rat)	Ki	25,000.0000	0.0002	0.0013	0.0030	AID52114
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	Km	150.0000	0.2000	0.2000	0.2000	AID3174
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay ID	Title	Year	Journal	Article
AID169083	Inhibition of high affinity dopamine uptake at concentration of 1 uM	1993	Journal of medicinal chemistry, Jun-25, Volume: 36, Issue:13	Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.
AID218791	Maximum rate was determined for high affinity transport of dopamine	1993	Journal of medicinal chemistry, Jun-25, Volume: 36, Issue:13	Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.
AID65655	Inhibition constant of high-affinity dopamine uptake	1993	Journal of medicinal chemistry, Jun-25, Volume: 36, Issue:13	Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.
AID219697	Maximum rate was determined for high affinity transport of choline	1993	Journal of medicinal chemistry, Jun-25, Volume: 36, Issue:13	Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.
AID3174	Michaelis-Menten constant was reported for high affinity transport of 5-HT	1993	Journal of medicinal chemistry, Jun-25, Volume: 36, Issue:13	Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.
AID3175	Maximum rate was determined for high affinity transport of 5-HT	1993	Journal of medicinal chemistry, Jun-25, Volume: 36, Issue:13	Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.
AID52114	Enzyme inhibition dissociation constant for choline acetyl transferase (ChAcT) was determined	1993	Journal of medicinal chemistry, Jun-25, Volume: 36, Issue:13	Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.
AID169084	Michaelis-Menten constant was reported for high affinity transport of dopamine	1993	Journal of medicinal chemistry, Jun-25, Volume: 36, Issue:13	Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.
AID3173	Inhibition constant of high-affinity 5-HT uptake	1993	Journal of medicinal chemistry, Jun-25, Volume: 36, Issue:13	Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.
AID219696	Michaelis-Menten constant was reported for high affinity transport of choline	1993	Journal of medicinal chemistry, Jun-25, Volume: 36, Issue:13	Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.
AID3172	Inhibition of high affinity 5-HT uptake at concentration of 1 uM	1993	Journal of medicinal chemistry, Jun-25, Volume: 36, Issue:13	Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.
AID219566	Inhibition of high affinity choline uptake at concentration of 1 uM	1993	Journal of medicinal chemistry, Jun-25, Volume: 36, Issue:13	Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.
AID219695	Inhibition constant of high-affinity choline uptake	1993	Journal of medicinal chemistry, Jun-25, Volume: 36, Issue:13	Inhibition and inactivation of presynaptic cholinergic markers using redox-reactive choline analogs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (25.00)	18.7374
1990's	3 (37.50)	18.2507
2000's	3 (37.50)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.15 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	4.45 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.15)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (12.50%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (87.50%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
choline [no description available]	2.4	2	0	cholines	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; neurotransmitter; nutrient; plant metabolite; Saccharomyces cerevisiae metabolite
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.02	1	0	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
deferoxamine Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.	2.02	1	0	acyclic desferrioxamine	bacterial metabolite; ferroptosis inhibitor; iron chelator; siderophore
isoproterenol Isoproterenol: Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.. isoprenaline : A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.	1.96	1	0	catechols; secondary alcohol; secondary amino compound	beta-adrenergic agonist; bronchodilator agent; cardiotonic drug; sympathomimetic agent
ferric chloride ferric chloride: RN given refers to cpd with MF of Fe-Cl3; used to induce experimental arterial thrombosis to evaluate antithrombotic agents	2.02	1	0	iron coordination entity	astringent; Lewis acid
3-trimethylaminomethylcatechol 3-trimethylaminomethylcatechol: structure given in first source	2.38	2	0
rhizoferrin rhizoferrin: a ferric polycarboxylate; a complexone-type siderophore; synthesized and secreted by Rhizopus microsporus	2.02	1	0
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	1.96	1	0	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
agar Agar: A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.. agar : A complex mixture of polysaccharides extracted from species of red algae. Its two main components are agarose and agaropectin. Agarose is the component responsible for the high-strength gelling properties of agar, while agaropectin provides the viscous properties.	2.03	1	0
digitonin Digitonin: A glycoside obtained from Digitalis purpurea; the aglycone is digitogenin which is bound to five sugars. Digitonin solubilizes lipids, especially in membranes and is used as a tool in cellular biochemistry, and reagent for precipitating cholesterol. It has no cardiac effects.. digitonin : A spirostanyl glycoside that is digitogenin in which the 3-hydroxy group is substituted by a beta-D-glucopyranosyl-(1->3)-beta-D-galactopyranosyl-(1->2)-[beta-D-xylopyranosyl-(1->3)]-beta-D-glucopyranosyl-(1->4)-beta-D-galactopyranosyl group. It is a steroidal saponin isolated from the foxglove plant, Digitalis purpurea. It is used extensively as a mild non-ionic detergent for extracting proteins from membranes for structure and function studies.	1.96	1	0

Condition	Indicated	Relationship Strength	Studies	Trials
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	0	2.02	1	0
Anoxemia [description not available]	0	3.37	1	1
Hypoxia Sub-optimal OXYGEN levels in the ambient air of living organisms.	0	3.37	1	1