Page last updated: 2024-08-05 11:08:46
thioester
A compound of general formula RC(=O)SR'. Compare with thionoester, RC(=S)OR'.
ChEBI ID: 51277
Members (12)
| Member | Definition | Role |
|---|---|---|
| 2-(3,4-dimethylphenoxy)ethanethioic acid S-(4-methylphenyl) ester | 2-(3,4-dimethylphenoxy)ethanethioic acid S-(4-methylphenyl) ester | |
| benphothiamine | A thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation. | benfotiamine |
| dithiopyr | Dithiopyr | |
| fluticasone | A trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis. | fluticasone |
| fluticasone furoate | A trifluorinated corticosteroid that consists of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a 2-furoyl substituent at position 17. Used in combination with vilanterol trifenate for treatment of bronchospasm associated with chronic obstructive pulmonary disease. | fluticasone furoate |
| fluticasone propionate | A trifluorinated corticosteroid that consists of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a propionyl substituent at position 17; has anti-inflammatory, anti-asthmatic and anti-allergic activity. | fluticasone propionate |
| S-[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioate | S-[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioate | |
| s-methyl benzo(1,2,3)thiadiazole-7-carbothioate | A benzothiadiazole that is the S-methyl thioester derivative of acibenzolar. A profungicide (by hydrolysis of the thioester group to give the corresponding carboxylic acid), it is used as a fungicide and plant activator on a variety of crops, including cotton, chili peppers, lettuce, onions, spinach, tobacco, and tomatoes. | acibenzolar-S-methyl |
| sid 26681509 | A carbohydrazide that is L-tryptophan in which the amino and carboxy groups are substituted by tert-butoxycarbonyl and 2-({[2-(2-ethylanilino)-2-oxoethyl]sulfanyl}carbonyl)hydrazinyl groups, respectively. It is a potent and reversible inhibitor of human cathepsin L (IC50 = 56 nM). | SID 26681509 |
| spironolactone | A steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7. | spironolactone |
| tixocortol pivalate | The pivalate thioester of tixocortol. | tixocortol pivalate |
| zofenopril | A proline derivative that is 4-(phenylsulfanyl)-L-proline in which the amine proton is replaced by a (2S)-3-(benzoylsulfanyl)-2-methylpropanoyl group. A prodrug for zofenoprilat. | zofenopril |
Research
Studies (10,391)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,759 (26.55) | 18.7374 |
| 1990's | 1,077 (10.36) | 18.2507 |
| 2000's | 2,989 (28.77) | 29.6817 |
| 2010's | 2,830 (27.24) | 24.3611 |
| 2020's | 736 (7.08) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 2,404 (21.70%) | 5.53% |
| Reviews | 1,165 (10.52%) | 6.00% |
| Case Studies | 786 (7.09%) | 4.05% |
| Observational | 41 (0.37%) | 0.25% |
| Other | 6,683 (60.32%) | 84.16% |