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thioester

A compound of general formula RC(=O)SR'. Compare with thionoester, RC(=S)OR'.

ChEBI ID: 51277

Members (12)

MemberDefinitionRole
2-(3,4-dimethylphenoxy)ethanethioic acid S-(4-methylphenyl) ester2-(3,4-dimethylphenoxy)ethanethioic acid S-(4-methylphenyl) ester
benphothiamineA thioester that is a synthetic analogue of thiamine obtained by acylative cleavage of the thiazole ring and O-phospohorylation.benfotiamine
dithiopyrDithiopyr
fluticasoneA trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis.fluticasone
fluticasone furoateA trifluorinated corticosteroid that consists of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a 2-furoyl substituent at position 17. Used in combination with vilanterol trifenate for treatment of bronchospasm associated with chronic obstructive pulmonary disease.fluticasone furoate
fluticasone propionateA trifluorinated corticosteroid that consists of 6alpha,9-difluoro-11beta,17alpha-dihydroxy-17beta-{[(fluoromethyl)sulfanyl]carbonyl}-16-methyl-3-oxoandrosta-1,4-diene bearing a propionyl substituent at position 17; has anti-inflammatory, anti-asthmatic and anti-allergic activity.fluticasone propionate
S-[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioateS-[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioate
s-methyl benzo(1,2,3)thiadiazole-7-carbothioateA benzothiadiazole that is the S-methyl thioester derivative of acibenzolar. A profungicide (by hydrolysis of the thioester group to give the corresponding carboxylic acid), it is used as a fungicide and plant activator on a variety of crops, including cotton, chili peppers, lettuce, onions, spinach, tobacco, and tomatoes.acibenzolar-S-methyl
sid 26681509A carbohydrazide that is L-tryptophan in which the amino and carboxy groups are substituted by tert-butoxycarbonyl and 2-({[2-(2-ethylanilino)-2-oxoethyl]sulfanyl}carbonyl)hydrazinyl groups, respectively. It is a potent and reversible inhibitor of human cathepsin L (IC50 = 56 nM).SID 26681509
spironolactoneA steroid lactone that is 17alpha-pregn-4-ene-21,17-carbolactone substituted by an oxo group at position 3 and an alpha-acetylsulfanyl group at position 7.spironolactone
tixocortol pivalateThe pivalate thioester of tixocortol.tixocortol pivalate
zofenoprilA proline derivative that is 4-(phenylsulfanyl)-L-proline in which the amine proton is replaced by a (2S)-3-(benzoylsulfanyl)-2-methylpropanoyl group. A prodrug for zofenoprilat.zofenopril

Research

Studies (10,391)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19902,759 (26.55)18.7374
1990's1,077 (10.36)18.2507
2000's2,989 (28.77)29.6817
2010's2,830 (27.24)24.3611
2020's736 (7.08)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials2,404 (21.70%)5.53%
Reviews1,165 (10.52%)6.00%
Case Studies786 (7.09%)4.05%
Observational41 (0.37%)0.25%
Other6,683 (60.32%)84.16%