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antiamoebic agent
An antiparasitic agent which is effective against amoeba, a genus of single-celled amoeboids in the family Amoebidae.
ChEBI ID: 171664
Members (8)
| Member | Definition | Class |
|---|---|---|
| amphotericin b | A macrolide antibiotic used to treat potentially life-threatening fungal infections. | amphotericin B |
| diloxanide furoate | A carboxylic ester resulting from the formal condensation of the carboxy group of furan-2-carboxylic acid with the hydroxy group of 2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide. It is a drug used for the treatment of asymptomatic amebiasis. | diloxanide furoate |
| emetine | A pyridoisoquinoline comprising emetam having methoxy substituents at the 6'-, 7'-, 10- and 11-positions. It is an antiprotozoal agent and emetic. It inhibits SARS-CoV2, Zika and Ebola virus replication and displays antimalarial, antineoplastic and antiamoebic properties. | emetine |
| iodoquinol | A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by iodine. It is considered the drug of choice for treating asymptomatic or moderate forms of amoebiasis. | iodoquinol |
| metronidazole | A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. | metronidazole |
| ornidazole | A C-nitro compound that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by 3-chloro-2-hydroxypropyl and methyl groups, respectively. It is used in the treatment of susceptible protozoal infections and for the treatment of anaerobic bacterial infections. | ornidazole |
| rifampin | A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei). | rifampicin zwitterion; rifampicin |
| tinidazole | 1H-imidazole substituted at C-1 by a (2-ethylsulfonyl)ethyl group, at C-2 by a methyl group and at C-5 by a nitro group. It is used as an antiprotozoal, antibacterial agent. | tinidazole |
Research
Studies (50,249)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 15,987 (31.82) | 18.7374 |
| 1990's | 8,050 (16.02) | 18.2507 |
| 2000's | 10,116 (20.13) | 29.6817 |
| 2010's | 12,094 (24.07) | 24.3611 |
| 2020's | 4,002 (7.96) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 5,115 (9.24%) | 5.53% |
| Reviews | 4,515 (8.16%) | 6.00% |
| Case Studies | 10,239 (18.50%) | 4.05% |
| Observational | 210 (0.38%) | 0.25% |
| Other | 35,257 (63.71%) | 84.16% |
Protein Targets (204)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 31.6228 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 5.0119 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 1.6930 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 22.0557 | 1 | 4 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 1.7783 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 13.1040 | 10 | 15 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 15.0593 | 2 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 0.7791 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 0.3084 | 2 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 0.3349 | 2 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 14.6474 | 2 | 6 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 16.5311 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 26.9680 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 9.9150 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 16.6632 | 1 | 4 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 32.1841 | 2 | 3 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 22.3386 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 32.1841 | 2 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 85.4114 | 1 | 3 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 12.2907 | 2 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 0.2371 | 1 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 11.5433 | 10 | 22 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 10.3830 | 2 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 12.0108 | 6 | 13 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 23.5805 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 0.1049 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 27.9632 | 3 | 3 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 32.7081 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 38.9018 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 7.3393 | 2 | 6 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 9.8745 | 3 | 6 |
| GLS protein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 12.5486 | 4 | 6 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 16.8788 | 1 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 31.6228 | 1 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 81.8208 | 2 | 3 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 8.9125 | 1 | 2 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 23.3507 | 1 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 11.6067 | 1 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 1.3557 | 2 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 3.6626 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 38.9018 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 8.2283 | 3 | 5 |
| interleukin 8 | Homo sapiens (human) | Potency | 57.0660 | 1 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 4.6780 | 1 | 4 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 38.9018 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 21.5240 | 2 | 3 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 40.7782 | 1 | 3 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 5.7122 | 1 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 58.0479 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 33.2739 | 3 | 7 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 8.7045 | 2 | 5 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 5.6601 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 19.9779 | 3 | 6 |
| Parkin | Homo sapiens (human) | Potency | 9.2000 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 4.7628 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 20.5572 | 3 | 4 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 37.8795 | 2 | 3 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 40.8708 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 12.0647 | 1 | 3 |
| PPM1D protein | Homo sapiens (human) | Potency | 0.6584 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 21.1971 | 2 | 5 |
| progesterone receptor | Homo sapiens (human) | Potency | 9.6905 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 14.9635 | 2 | 5 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 13.5084 | 3 | 5 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 3.0715 | 3 | 4 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 3.5306 | 2 | 2 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 23.7781 | 1 | 1 |
| signal transducer and activator of transcription 6, interleukin-4 induced | Homo sapiens (human) | Potency | 25.2783 | 3 | 3 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 14.5500 | 1 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 18.6298 | 1 | 2 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 17.2450 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 15.6329 | 2 | 7 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 63.0957 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 3.5481 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 4.0273 | 2 | 5 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 20.4839 | 2 | 4 |
| tumor necrosis factor | Homo sapiens (human) | Potency | 42.1632 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 4.0748 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 17.1272 | 2 | 4 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 49.5652 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 16.8788 | 1 | 2 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 10 kDa chaperonin | Escherichia coli | IC50 | 100.0000 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 100.0000 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 0.9330 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 0.5270 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9330 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.5270 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9330 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.5270 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 0.0380 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.0140 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.1820 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.0260 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 26.6500 | 2 | 2 |
| Arylacetamide deacetylase | Homo sapiens (human) | Ki | 300.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 120.2000 | 1 | 5 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 72.7571 | 7 | 7 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 174.7600 | 5 | 10 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 34.7000 | 1 | 1 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | Ki | 11.9000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 91.5000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 117.0000 | 1 | 5 |
| Caspase-1 | Homo sapiens (human) | IC50 | 8.3190 | 1 | 1 |
| Catechol O-methyltransferase | Rattus norvegicus (Norway rat) | IC50 | 5.6234 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 96.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Dihydroorotate dehydrogenase | Leishmania major | IC50 | 1,037.0000 | 1 | 2 |
| DNA gyrase subunit A | Mycobacterium tuberculosis H37Rv | IC50 | 50.0000 | 1 | 1 |
| DNA gyrase subunit B | Mycobacterium tuberculosis H37Rv | IC50 | 50.0000 | 1 | 1 |
| DNA-directed RNA polymerase subunit beta | Escherichia coli O127:H6 str. E2348/69 | IC50 | 511.3333 | 3 | 3 |
| DNA-directed RNA polymerase subunit beta | Mycobacterium tuberculosis H37Rv | IC50 | 0.0100 | 1 | 1 |
| Endothelial PAS domain-containing protein 1 | Homo sapiens (human) | IC50 | 0.0965 | 2 | 2 |
| Enoyl-[acyl-carrier-protein] reductase [NADH] | Mycobacterium tuberculosis H37Rv | IC50 | 0.0300 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 1.8890 | 1 | 1 |
| Glucose transporter | Leishmania mexicana | IC50 | 0.0810 | 1 | 1 |
| Glutathione S-transferase omega-1 | Homo sapiens (human) | IC50 | 75.0000 | 1 | 1 |
| Hexose transporter 1 | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.0900 | 1 | 1 |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | IC50 | 0.0965 | 2 | 2 |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | IC50 | 115.0000 | 1 | 2 |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | IC50 | 0.2940 | 1 | 1 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 0.3640 | 1 | 1 |
| Mitogen-activated protein kinase 3 | Homo sapiens (human) | IC50 | 5.2640 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 114.7800 | 1 | 5 |
| NH(3)-dependent NAD(+) synthetase | Bacillus subtilis subsp. subtilis str. 168 | IC50 | 1.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 2.9490 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (human) | IC50 | 8.5770 | 1 | 1 |
| Serine hydrolase RBBP9 | Homo sapiens (human) | IC50 | 7.8000 | 1 | 1 |
| Solute carrier family 2, facilitated glucose transporter member 1 | Homo sapiens (human) | IC50 | 0.1080 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A1 | Rattus norvegicus (Norway rat) | Ki | 18.2000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A2 | Homo sapiens (human) | Ki | 51.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1A4 | Rattus norvegicus (Norway rat) | Ki | 1.4300 | 2 | 2 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 1.5000 | 4 | 4 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Ki | 9.0500 | 2 | 2 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 3.2000 | 2 | 2 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | IC50 | 65.0000 | 1 | 1 |
| Solute carrier organic anion transporter family member 2B1 | Homo sapiens (human) | Ki | 63.0000 | 1 | 1 |
| Thioredoxin reductase | Entamoeba histolytica | Ki | 3.3000 | 1 | 1 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 1.5710 | 1 | 1 |
| Tyrosine-protein kinase Lck | Homo sapiens (human) | IC50 | 2.4610 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 177.9000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 177.9000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 177.9000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 177.9000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Albumin | Homo sapiens (human) | Kd | 12.0000 | 1 | 1 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | EC50 | 0.0325 | 1 | 2 |
| citrate synthase 2, partial | Saccharomyces cerevisiae (brewer's yeast) | EC50 | 166.3000 | 1 | 1 |
| Cytochrome P450 2B6 | Homo sapiens (human) | EC50 | 1.3000 | 1 | 1 |
| LAP4 | Saccharomyces cerevisiae (brewer's yeast) | EC50 | 77.4500 | 2 | 2 |
| MEP2 | Saccharomyces cerevisiae (brewer's yeast) | EC50 | 27,710.0000 | 1 | 1 |
| NS5 | Zika virus | EC50 | 0.0308 | 2 | 2 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 2.1656 | 9 | 9 |
| Procathepsin L | Homo sapiens (human) | EC50 | 0.0325 | 1 | 2 |
| recombinase A | Mycobacterium tuberculosis H37Rv | EC50 | 195.1500 | 2 | 2 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.0325 | 1 | 2 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | EC50 | 0.0325 | 1 | 2 |
| Replicase polyprotein 1ab | Human coronavirus 229E | EC50 | 0.0325 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 0.0325 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.0325 | 1 | 2 |
| Spike glycoprotein | Betacoronavirus England 1 | EC50 | 0.0325 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | EC50 | 0.0325 | 1 | 2 |
| Transmembrane protease serine 2 | Homo sapiens (human) | EC50 | 0.0325 | 1 | 2 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aryl hydrocarbon receptor nuclear translocator | Homo sapiens (human) | AC50 | 7.4600 | 1 | 1 |
| Arylacetamide deacetylase | Homo sapiens (human) | Km | 200.0000 | 1 | 2 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Km | 6.0000 | 1 | 1 |
| Endothelial PAS domain-containing protein 1 | Homo sapiens (human) | MIC | 0.3000 | 1 | 1 |
| Flavodoxin | Helicobacter pylori 26695 | MIC | 67.3000 | 3 | 3 |
| heat shock protein 90, putative | Plasmodium falciparum 3D7 | AC50 | 0.3140 | 1 | 1 |
| heat shock protein HSP 90-alpha isoform 2 | Homo sapiens (human) | AC50 | 0.3910 | 1 | 1 |
| Hypoxia-inducible factor 1-alpha | Homo sapiens (human) | MIC | 0.3000 | 1 | 1 |
| PAX8 | Homo sapiens (human) | AC50 | 4.8700 | 1 | 1 |
| replicative DNA helicase | Mycobacterium tuberculosis H37Rv | AC50 | 196.9400 | 2 | 2 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | Km | 7.2500 | 2 | 2 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Km | 2.3000 | 1 | 1 |
| transforming acidic coiled-coil-containing protein 3 | Homo sapiens (human) | AC50 | 7.4600 | 1 | 1 |