Any agent that interferes with the activity of T-type calcium channels.
ChEBI ID: 194338
| Member | Definition | Class |
|---|---|---|
| ethosuximide | A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures. | ethosuximide |
| mibefradil | Mibefradil | |
| nnc 55-0396 | The dihydrochloride salt of NNC 55-0396. It is a stable analogue of mibefradil and a highly selective T-type calcium channel blocker. | NNC 55-0396 dihydrochloride |
| NNC 55-0396 (free base) | NNC 55-0396 (free base) | |
| paclitaxel | A trihydroxyflavanone having a structure of naringenin prenylated at C-6. | 6-prenylnaringenin |
| ulixacaltamide | ulixacaltamide | |
| zonisamide | A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position. | zonisamide |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 533 (21.00) | 18.7374 |
| 1990's | 468 (18.44) | 18.2507 |
| 2000's | 679 (26.75) | 29.6817 |
| 2010's | 680 (26.79) | 24.3611 |
| 2020's | 178 (7.01) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 229 (8.26%) | 5.53% |
| Reviews | 302 (10.90%) | 6.00% |
| Case Studies | 228 (8.23%) | 4.05% |
| Observational | 13 (0.47%) | 0.25% |
| Other | 1,999 (72.14%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 18.0636 | 2 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 43.6486 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 30.3578 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 21.1317 | 1 | 1 |
| arylsulfatase A | Homo sapiens (human) | Potency | 6.5844 | 1 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 17.3512 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 23.2809 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 23.7358 | 2 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 19.9054 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 0.3162 | 2 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| D(1A) dopamine receptor | Sus scrofa (pig) | Potency | 10.3992 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 5.3080 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 20.4946 | 2 | 2 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 18.8500 | 1 | 4 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 28.3292 | 2 | 2 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 25.3206 | 1 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 0.3162 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 1.4125 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 2.7511 | 1 | 8 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 0.9521 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 25.1189 | 2 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 0.3329 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 12.2097 | 2 | 2 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 26.6320 | 2 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 58.0479 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 26.3510 | 2 | 4 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 44.6684 | 1 | 1 |
| polyprotein | Zika virus | Potency | 35.4813 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 2.7511 | 1 | 4 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 73.0780 | 1 | 1 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 15.1191 | 4 | 4 |
| Smad3 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 4.7394 | 2 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 10.2636 | 2 | 3 |
| Thrombopoietin | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 1.3400 | 1 | 1 |
| Amine oxidase [flavin-containing] | Danio rerio (zebrafish) | Ki | 30.8000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 3.1000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | Ki | 2.9000 | 1 | 1 |
| Arachidonate 5-lipoxygenase-activating protein | Homo sapiens (human) | Ki | 0.1170 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 1.5800 | 5 | 5 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | IC50 | 8.7000 | 4 | 4 |
| Beta-carbonic anhydrase 1 | Mycobacterium tuberculosis H37Rv | Ki | 114.7200 | 3 | 3 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 285.2000 | 3 | 5 |
| Calcium release-activated calcium channel protein 1 | Homo sapiens (human) | IC50 | 76.0500 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Carbonic anhydrase | Candida albicans SC5314 | Ki | 0.9474 | 4 | 5 |
| Carbonic anhydrase | Helicobacter pylori 26695 | Ki | 0.2245 | 2 | 2 |
| Carbonic anhydrase | Saccharomyces cerevisiae S288C | Ki | 0.1060 | 1 | 1 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 0.6450 | 1 | 1 |
| Carbonic anhydrase | Anopheles gambiae (African malaria mosquito) | Ki | 0.2630 | 1 | 1 |
| Carbonic anhydrase | Astrosclera willeyana | Ki | 0.1650 | 1 | 1 |
| Carbonic anhydrase | Cryptococcus neoformans var. grubii | Ki | 0.9705 | 2 | 2 |
| Carbonic anhydrase | Mycobacterium tuberculosis H37Rv | Ki | 0.2100 | 1 | 1 |
| Carbonic anhydrase | Nakaseomyces glabratus CBS 138 | Ki | 0.1140 | 1 | 1 |
| Carbonic anhydrase | Stylophora pistillata | Ki | 0.2590 | 2 | 2 |
| Carbonic anhydrase | Sulfurihydrogenibium sp. YO3AOP1 | Ki | 0.1400 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 30.7149 | 53 | 78 |
| Carbonic anhydrase 12 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 120.9278 | 7 | 19 |
| Carbonic anhydrase 13 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 160.2182 | 2 | 14 |
| Carbonic anhydrase 14 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 126.0486 | 6 | 18 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 0.4978 | 3 | 4 |
| Carbonic anhydrase 2 | Bos taurus (cattle) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 26.1429 | 65 | 91 |
| Carbonic anhydrase 2 | Mycobacterium tuberculosis H37Rv | Ki | 0.8760 | 1 | 1 |
| Carbonic anhydrase 3 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 3 | Bos taurus (cattle) | Ki | 14.2620 | 2 | 5 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 442.8417 | 3 | 15 |
| Carbonic anhydrase 4 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 98.2498 | 7 | 25 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 119.0908 | 7 | 19 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 436.8304 | 7 | 19 |
| Carbonic anhydrase 6 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 88.6655 | 8 | 26 |
| Carbonic anhydrase 7 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 97.5477 | 10 | 23 |
| Carbonic anhydrase 9 | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 83.0922 | 12 | 27 |
| Carbonic anhydrase, alpha family | Hydrogenovibrio crunogenus XCL-2 | Ki | 0.4110 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 2.1400 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 0.0630 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 2.1400 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.2575 | 2 | 4 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 1.7950 | 2 | 4 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 6.0330 | 1 | 1 |
| Delta carbonic anhydrase | Conticribra weissflogii | Ki | 0.4040 | 1 | 1 |
| Delta-type opioid receptor | Mus musculus (house mouse) | Ki | 0.0455 | 2 | 2 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.0278 | 2 | 2 |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0350 | 1 | 1 |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | Ki | 0.0560 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | Ki | 0.1170 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 1.4543 | 17 | 17 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 0.2715 | 2 | 2 |
| Prolyl endopeptidase | Rattus norvegicus (Norway rat) | Ki | 0.0200 | 1 | 1 |
| Sodium channel protein type 1 subunit alpha | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| Sodium channel protein type 10 subunit alpha | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| Sodium channel protein type 11 subunit alpha | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| Sodium channel protein type 2 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 1 |
| Sodium channel protein type 3 subunit alpha | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| Sodium channel protein type 4 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 1 | 1 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 0.7400 | 2 | 2 |
| Sodium channel protein type 7 subunit alpha | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| Sodium channel protein type 8 subunit alpha | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | IC50 | 0.7400 | 2 | 2 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 0.0352 | 1 | 1 |
| Translocator protein | Rattus norvegicus (Norway rat) | Ki | 38.4500 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Cavia porcellus (domestic guinea pig) | IC50 | 0.1560 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 66.1863 | 6 | 6 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 0.3330 | 2 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 0.3330 | 2 | 2 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 0.3330 | 2 | 2 |
| Voltage-dependent L-type calcium channel subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens (human) | IC50 | 3.9390 | 4 | 4 |
| Voltage-dependent N-type calcium channel subunit alpha-1B | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Voltage-dependent T-type calcium channel subunit alpha-1G | Homo sapiens (human) | IC50 | 0.9667 | 25 | 25 |
| Voltage-dependent T-type calcium channel subunit alpha-1H | Homo sapiens (human) | IC50 | 0.6619 | 10 | 10 |
| Voltage-dependent T-type calcium channel subunit alpha-1I | Homo sapiens (human) | IC50 | 833.5713 | 5 | 6 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Carbonic anhydrase 2 | Homo sapiens (human) | Kd | 0.0476 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Kd | 0.0206 | 1 | 1 |
| Potassium channel subfamily K member 2 | Homo sapiens (human) | EC50 | 0.5000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Carbonic anhydrase | Brucella suis 1330 | Kinact | 1.8500 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Kinact | 0.0518 | 5 | 5 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Kinact | 11.0000 | 1 | 1 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Kinact | 0.4300 | 2 | 2 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Kinact | 3.5023 | 3 | 3 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Kinact | 0.0290 | 5 | 5 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Kinact | 8.5900 | 2 | 2 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Kinact | 0.0200 | 2 | 2 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Kinact | 6.0330 | 3 | 3 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Kinact | 0.0890 | 2 | 2 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Kinact | 0.1170 | 2 | 2 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Kinact | 1.7534 | 3 | 3 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ks | 0.6900 | 1 | 1 |