An agonist that binds to and activates sphingosine 1-phosphate receptors.
ChEBI ID: 63114
| Member | Definition | Class |
|---|---|---|
| fingolimod | An aminodiol that consists of propane-1,3-diol having amino and 2-(4-octylphenyl)ethyl substituents at the 2-position. It is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis. A prodrug, fingolimod is phosphorylated by sphingosine kinase to active metabolite fingolimod-phosphate, a structural analogue of sphingosine 1-phosphate. | fingolimod |
| fingolimod hydrochloride | The hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod). | fingolimod hydrochloride |
| fty 720p | A primary amino compound that is fingolimod in which one on the hydroxy groups has been converted into its dihydrogen phosphate derivative. It is the active metabolite of fingolimod. | fingolimod phosphate |
| sphingosine 1-phosphate | A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1 | sphingosine 1-phosphate |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (0.02) | 18.7374 |
| 1990's | 236 (3.80) | 18.2507 |
| 2000's | 1,642 (26.45) | 29.6817 |
| 2010's | 3,199 (51.54) | 24.3611 |
| 2020's | 1,129 (18.19) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 180 (2.70%) | 5.53% |
| Reviews | 1,130 (16.97%) | 6.00% |
| Case Studies | 229 (3.44%) | 4.05% |
| Observational | 108 (1.62%) | 0.25% |
| Other | 5,010 (75.26%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 21.0004 | 4 | 4 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 9.3495 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 23.3617 | 1 | 3 |
| polyprotein | Zika virus | Potency | 9.3495 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 23.3617 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.0190 | 1 | 2 |
| Sphingosine 1-phosphate receptor 1 | Homo sapiens (human) | IC50 | 0.1208 | 9 | 12 |
| Sphingosine 1-phosphate receptor 1 | Homo sapiens (human) | Ki | 0.2117 | 1 | 5 |
| Sphingosine 1-phosphate receptor 2 | Homo sapiens (human) | IC50 | 1.5869 | 4 | 7 |
| Sphingosine 1-phosphate receptor 2 | Homo sapiens (human) | Ki | 0.2117 | 1 | 5 |
| Sphingosine 1-phosphate receptor 3 | Homo sapiens (human) | IC50 | 1.1128 | 6 | 9 |
| Sphingosine 1-phosphate receptor 3 | Homo sapiens (human) | Ki | 0.2117 | 1 | 5 |
| Sphingosine 1-phosphate receptor 4 | Homo sapiens (human) | IC50 | 1.0395 | 7 | 10 |
| Sphingosine 1-phosphate receptor 4 | Homo sapiens (human) | Ki | 0.2117 | 1 | 5 |
| Sphingosine 1-phosphate receptor 5 | Homo sapiens (human) | IC50 | 0.3015 | 5 | 7 |
| Sphingosine 1-phosphate receptor 5 | Homo sapiens (human) | Ki | 0.2117 | 1 | 5 |
| Sphingosine-1-phosphate lyase 1 | Homo sapiens (human) | IC50 | 34.5000 | 2 | 2 |
| Sphingosine-1-phosphate lyase 1 | Mus musculus (house mouse) | IC50 | 52.4000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cytochrome P450 3A4 | Homo sapiens (human) | EC50 | 0.0001 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | EC50 | 0.0011 | 1 | 1 |
| Sphingosine 1-phosphate receptor 1 | Homo sapiens (human) | EC50 | 0.6252 | 33 | 37 |
| Sphingosine 1-phosphate receptor 2 | Homo sapiens (human) | EC50 | 2.2297 | 8 | 9 |
| Sphingosine 1-phosphate receptor 3 | Homo sapiens (human) | EC50 | 0.8768 | 23 | 26 |
| Sphingosine 1-phosphate receptor 4 | Homo sapiens (human) | EC50 | 0.8316 | 11 | 13 |
| Sphingosine 1-phosphate receptor 5 | Homo sapiens (human) | EC50 | 0.7453 | 16 | 18 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| RCG53912, isoform CRA_a | Rattus norvegicus (Norway rat) | Km | 64.6000 | 1 | 1 |
| Sphingosine 1-phosphate receptor 1 | Homo sapiens (human) | Activity | 0.0072 | 2 | 2 |
| Sphingosine kinase 1 | Homo sapiens (human) | Km | 23.7000 | 1 | 1 |
| Sphingosine kinase 1 | Rattus norvegicus (Norway rat) | Km | 64.6000 | 1 | 1 |
| Sphingosine kinase 2 | Homo sapiens (human) | Km | 23.7000 | 1 | 1 |