A reagent used to improve selectivity in chromatographic analyses or separations, e.g. by formation of a derivative or by modification of the mobile phase.
ChEBI ID: 59745
| Member | Definition | Class |
|---|---|---|
| 1-(trimethylsilyl)-1h-imidazole | A member of the class of imidazoles in which the hydrogen at position 1 is replaced by a trimethylsilyl group. N-trimethylsilylimidazole is a derivatisation agent used in gas chromatography/mass spectrometry applications. | N-trimethylsilylimidazole |
| dimethylformamide-dimethylacetal | An acetal obtained by formal condensation of N,N-dimethylformamide with methanol. N,N-dimethylformamide dimethyl acetal is a derivatisation agent used in gas-chromatography applications | N,N-dimethylformamide dimethyl acetal |
| dinitrofluorobenzene | The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions. | 1-fluoro-2,4-dinitrobenzene |
| heptafluorobutyric anhydride | An acyclic carboxylic anhydride that is perfluorinated butyric anhydride. It is used as a derivatising reagent for gas chromatographic analyses. | heptafluorobutyric anhydride |
| hexamethylsilazane | An N-silyl compound obtained from ammonia by replacement of two of the hydrogens with trimethylsilyl groups. Hexamethyldisilazane is a derivatisation agent used in gas chromatography mass spectrometry applications. | hexamethyldisilazane |
| n-methyl-n-(tert-butyldimethylsilyl)trifluoroacetamide | An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a tert-butyldimethylsilyl group. | N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide |
| n-methyl-n-(trimethylsilyl)trifluoroacetamide | An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a trimethylsilyl group. N-methyl-N-(trimethylsilyl)trifluoroacetamide is a derivatisation agent used in gas chromatography/mass spectrometry applications. | N-methyl-N-(trimethylsilyl)trifluoroacetamide |
| pentafluorobenzoyl chloride | The acid chloride of pentafluorobenzoic acid. It is a sensitive derivatising reagent for the analysis of amines, amides and phenols by electron capture gas chromatography. | pentafluorobenzoyl chloride |
| perfluorobutyric acid | A monocarboxylic acid that is perfluorinated butyric acid. | perfluorobutyric acid |
| tert-butyldimethylsilyl chloride | A silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry applications. | tert-butyldimethylsilyl chloride |
| trimethylchlorosilane | A silyl chloride consisting of a central silicon atom covalently bound to one chloro and three methyl groups. Chlorotrimethylsilane is a derivatisation agent used in gas chromatography/mass spectrometry applications. | chlorotrimethylsilane |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 657 (32.77) | 18.7374 |
| 1990's | 347 (17.31) | 18.2507 |
| 2000's | 430 (21.45) | 29.6817 |
| 2010's | 444 (22.14) | 24.3611 |
| 2020's | 127 (6.33) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 6 (0.29%) | 5.53% |
| Reviews | 24 (1.14%) | 6.00% |
| Case Studies | 8 (0.38%) | 4.05% |
| Observational | 1 (0.05%) | 0.25% |
| Other | 2,060 (98.14%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 29.1993 | 4 | 6 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 44.0633 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 21.1699 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 31.5060 | 10 | 14 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 16.2282 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 26.0251 | 1 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 26.0251 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 12.3089 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 12.3089 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 41.7993 | 1 | 3 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 10.0000 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 22.3872 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 26.4256 | 8 | 15 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 42.3384 | 6 | 6 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 19.4741 | 2 | 2 |
| geminin | Homo sapiens (human) | Potency | 0.1852 | 2 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 41.5144 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 23.6014 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 27.5561 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 55.4725 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 17.9718 | 2 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 13.8144 | 2 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 66.8242 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 25.1189 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 31.2003 | 3 | 5 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 0.0474 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 22.3872 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 60.6336 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 35.0356 | 2 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 60.6336 | 1 | 1 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 56.2341 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 38.2793 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 49.4399 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 49.4399 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 33.4983 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 100.0000 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 44.0174 | 2 | 4 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 27.5561 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Glutaminyl-peptide cyclotransferase | Homo sapiens (human) | Ki | 167.0000 | 1 | 1 |