ascorbic-acid and Scalp-Dermatoses

An unclassified amicrobial pustular dermatosis particularly affecting the main cutaneous folds, external auditory canals and scalp and coexisting with systemic lupus erythematosus has been recently described.. We studied 3 young females bearing such cutaneous manifestations in association with subacute cutaneous lupus erythematosus, celiac disease and various serum autoantibodies, respectively, in order to further characterize this possibly new entity.. Various routine and immunological laboratory tests, histopathologic and direct immunofluorescence examinations and in vitro studies of neutrophil function were performed in each patient.. We reported our findings and compared our cases with the few others appearing in the literature. We documented an impaired neutrophil chemotaxis in 2 subjects, but neutrophil dysfunction does not seem to be one of the verifying criteria.. All of these cases may represent a distinctive form in the clinicopathological spectrum of neutrophilic dermatoses (ND) because of the typical distribution and the close link with different autoimmune disorders. Cimetidine in combination with ascorbic acid can be indicated as an effective and safe alternative to the classic medications of ND, although the action of both drugs remains unexplained.

Topics: Adult; Ascorbic Acid; Autoantibodies; Autoimmune Diseases; Celiac Disease; Chemotaxis, Leukocyte; Cimetidine; Ear Canal; Female; Fluorescent Antibody Technique, Direct; Histamine H2 Antagonists; Humans; Lupus Erythematosus, Cutaneous; Neutrophils; Scalp Dermatoses; Skin; Skin Diseases, Vesiculobullous