Compounds > 3,7-dihydroxy-2,4-dimethoxyphenanthrene
Page last updated: 2024-11-12

3,7-dihydroxy-2,4-dimethoxyphenanthrene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3,7-dihydroxy-2,4-dimethoxyphenanthrene: from the orchid Scaphyglottis livida; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10445823
CHEMBL ID1083093
MeSH IDM0499081

Synonyms (5)

Synonym
CHEMBL1083093
72966-94-0
2,6-phenanthrenediol, 5,7-dimethoxy-
DTXSID40440087
3,7-dihydroxy-2,4-dimethoxyphenanthrene
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (17)

Assay IDTitleYearJournalArticle
AID668094Antibacterial activity against Bacillus subtilis NBRC 3134 after overnight incubation by microdilution method2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Phenanthrene derivatives from Cymbidium Great Flower Marie Laurencin and their biological activities.
AID767442Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-stimulated TNF-alpha release at 1 uM incubated for 1 hr prior to LPS challenge measured after 24 hrs by sandwich ELISA relative to untreated control2013European journal of medicinal chemistry, Sep, Volume: 67Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential.
AID767437Cytotoxicity against human THP1 cells assessed as cell viability at 1 uM after 24 hrs by CCK-8 assay relative to untreated control2013European journal of medicinal chemistry, Sep, Volume: 67Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential.
AID767441Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-stimulated TNF-alpha release incubated for 1 hr prior to LPS challenge measured after 24 hrs by sandwich ELISA2013European journal of medicinal chemistry, Sep, Volume: 67Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential.
AID767444Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-stimulated TNF-alpha release at 50 uM incubated for 1 hr prior to LPS challenge measured after 24 hrs by sandwich ELISA relative to untreated control2013European journal of medicinal chemistry, Sep, Volume: 67Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential.
AID767446Antioxidant activity assessed as ABTS free radical scavenging activity after 1 min2013European journal of medicinal chemistry, Sep, Volume: 67Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential.
AID767438Cytotoxicity against human THP1 cells assessed as cell viability at 10 uM after 24 hrs by CCK-8 assay relative to untreated control2013European journal of medicinal chemistry, Sep, Volume: 67Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential.
AID767439Cytotoxicity against human THP1 cells assessed as cell viability at 50 uM after 24 hrs by CCK-8 assay relative to untreated control2013European journal of medicinal chemistry, Sep, Volume: 67Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential.
AID767440Cytotoxicity against human THP1 cells assessed as cell viability at 100 uM after 24 hrs by CCK-8 assay relative to untreated control2013European journal of medicinal chemistry, Sep, Volume: 67Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential.
AID767443Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-stimulated TNF-alpha release at 10 uM incubated for 1 hr prior to LPS challenge measured after 24 hrs by sandwich ELISA relative to untreated control2013European journal of medicinal chemistry, Sep, Volume: 67Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential.
AID1327613Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction2016Journal of natural products, 08-26, Volume: 79, Issue:8
Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity.
AID767448Antioxidant activity assessed as galvinoxyl free radical scavenging activity after 20 mins2013European journal of medicinal chemistry, Sep, Volume: 67Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential.
AID767447Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins2013European journal of medicinal chemistry, Sep, Volume: 67Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential.
AID1327612Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/cytochalasin B-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by FMLP/cytochal2016Journal of natural products, 08-26, Volume: 79, Issue:8
Chemical Constituents of the Rhizomes of Bletilla formosana and Their Potential Anti-inflammatory Activity.
AID668096Cytotoxicity against human HL60 cells after 72 hrs by WST8 assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Phenanthrene derivatives from Cymbidium Great Flower Marie Laurencin and their biological activities.
AID484514Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Phenanthrenes from Dendrobium nobile and their inhibition of the LPS-induced production of nitric oxide in macrophage RAW 264.7 cells.
AID767445Antiinflammatory activity in human THP1 cells assessed as inhibition of LPS-stimulated TNF-alpha release at 100 uM incubated for 1 hr prior to LPS challenge measured after 24 hrs by sandwich ELISA relative to untreated control2013European journal of medicinal chemistry, Sep, Volume: 67Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.84 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.84)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-hydroxybenzaldehyde
[no description available]		2.1310hydroxybenzaldehydeEC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite
guaiacol
Guaiacol: An agent thought to have disinfectant properties and used as an expectorant. (From Martindale, The Extra Pharmacopoeia, 30th ed, p747). methylcatechol : Any member of the class of catechols carrying one or more methyl substituents.. guaiacol : A monomethoxybenzene that consists of phenol with a methoxy substituent at the ortho position.		2.0310guaiacolsdisinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite
phenanthrene
phenanthrene : A polycyclic aromatic hydrocarbon composed of three fused benzene rings which takes its name from the two terms 'phenyl' and 'anthracene.'		2.0810ortho-fused polycyclic arene;
ortho-fused tricyclic hydrocarbon;
phenanthrenes		environmental contaminant;
mouse metabolite
catechin
[no description available]		2.0810hydroxyflavan
pimagedine
pimagedine: diamine oxidase & nitric oxide synthase inhibitor; an advanced glycosylation end product inhibitor; used in the treatment of diabetic complications; structure. aminoguanidine : A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide.		2.0510guanidines;
one-carbon compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
EC 1.4.3.4 (monoamine oxidase) inhibitor
mitomycin
Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.		2.0710mitomycinalkylating agent;
antineoplastic agent
ampicillin
Ampicillin: Semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.. ampicillin : A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group.		2.0710beta-lactam antibiotic;
penicillin allergen;
penicillin		antibacterial drug
butylated hydroxytoluene
2,6-di-tert-butyl-4-methylphenol : A member of the class of phenols that is 4-methylphenol substituted by tert-butyl groups at positions 2 and 6.		2.0810phenolsantioxidant;
ferroptosis inhibitor;
food additive;
geroprotector
bis(4-(glucopyranosyloxy)benzyl) 2-sec-butylmalate
militarine: isolated from Rhizoma Bletillae; structure in first source		2.1310
dendrophenol
dendrophenol: isolated from Dendrobium loddigesii		2.0510
lusianthridin
lusianthridin: from rhizome of Arundina graminifolia		2.0510dihydrophenanthrene
Hircinol
[no description available]		2.0510phenanthrenes
7-hydroxy-2-methoxy-1,4-phenanthrenedione
7-hydroxy-2-methoxy-1,4-phenanthrenedione: structure in first source; from Dendrobium densiflorum		2.1310
stilbenes
Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.		2.0310stilbene
gigantol
gigantol: structure in first source		2.0310
blestriarene c
blestriarene C: structure in first source		2.1310
erianthridin
erianthridin: isolated from an extract of the orchid Maxillaria densa; structure in first source		2.7730
batatasin-iii
[no description available]		2.1310stilbenoid
idelalisib
idelalisib: an antineoplastic agent and p110delta inhibitor; structure in first source. idelalisib : A member of the class of quinazolines that is 5-fluoro-3-phenylquinazolin-4-one in which the hydrogen at position 2 is replaced by a (1S)-1-(3H-purin-6-ylamino)propyl group. used for for the treatment of refractory indolent non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukemia.		2.1310aromatic amine;
organofluorine compound;
purines;
quinazolines;
secondary amino compound		antineoplastic agent;
apoptosis inducer;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		2.0810ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
phenanthrenes
Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials