Page last updated: 2024-08-05 13:22:20
ansamycin
A class of macrocyclic lactams that consist of an aromatic (phenyl or naphthyl) or quinonoid (benzoquinone or naphthoquinone) moiety that is bridged by an aliphatic chain.
ChEBI ID: 22565
Members (3)
| Member | Definition | Role |
|---|---|---|
| 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin | A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group. | alvespimycin |
| geldanamycin | An ansamycin consisting of a 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It shows antimicrobial activity against many Gram-positive and some Gram-negative bacteria. | geldanamycin |
| tanespimycin | A 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumour effects. | tanespimycin |
Research
Studies (1,184)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (0.76) | 18.2507 |
| 2000's | 412 (34.80) | 29.6817 |
| 2010's | 655 (55.32) | 24.3611 |
| 2020's | 108 (9.12) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 48 (3.77%) | 5.53% |
| Reviews | 75 (5.90%) | 6.00% |
| Case Studies | 1 (0.08%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,148 (90.25%) | 84.16% |