Page last updated: 2024-08-05 12:13:26

1,3-dihydroimidazole-2-thiones

A member of the class of imidazoles that is 1,3-dihydroimidazole-2-thione and its derivatives by substitution.

ChEBI ID: 139340

Members (14)

MemberDefinitionRole
3-(2-methoxyphenyl)-4-phenyl-1H-imidazole-2-thione3-(2-methoxyphenyl)-4-phenyl-1H-imidazole-2-thione
3,5-bis(4-methoxyphenyl)-1H-imidazole-2-thione3,5-bis(4-methoxyphenyl)-1H-imidazole-2-thione
4-(4-chlorophenyl)-3-(phenylmethyl)-1H-imidazole-2-thione4-(4-chlorophenyl)-3-(phenylmethyl)-1H-imidazole-2-thione
4-(4-chlorophenyl)-3-phenyl-1H-imidazole-2-thione4-(4-chlorophenyl)-3-phenyl-1H-imidazole-2-thione
4-(4-methylphenyl)-3-phenyl-1H-imidazole-2-thione4-(4-methylphenyl)-3-phenyl-1H-imidazole-2-thione
4,5-dimethyl-3-(2-oxolanylmethyl)-1H-imidazole-2-thione4,5-dimethyl-3-(2-oxolanylmethyl)-1H-imidazole-2-thione
5-(3-nitrophenyl)-3-phenyl-1H-imidazole-2-thione5-(3-nitrophenyl)-3-phenyl-1H-imidazole-2-thione
5-(3,4-dimethoxyphenyl)-3-(4-ethoxyphenyl)-1H-imidazole-2-thione5-(3,4-dimethoxyphenyl)-3-(4-ethoxyphenyl)-1H-imidazole-2-thione
5-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-1H-imidazole-2-thione5-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-1H-imidazole-2-thione
5-(4-nitrophenyl)-3-phenyl-1H-imidazole-2-thione5-(4-nitrophenyl)-3-phenyl-1H-imidazole-2-thione
carbimazoleA member of the class of imidazoles that is methimazole in which the nitrogen bearing a hydrogen is converted into its ethoxycarbonyl derivative. A prodrug for methimazol, carbimazole is used for the treatment of hyperthyroidism.carbimazole
ergothioneineA L-histidine derivative that is N(alpha),N(alpha),N(alpha)-trimethyl-L-histidine in which the hydrogen at position 2 on the imdazole ring is replaced by a thioxo group.ergothioneine thione form; ergothioneine
methimazoleA member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen.methimazole
nepicastatA member of the class of 1,3-dihydroimidazole-2-thiones that is 1,3-dihydro-2H-imidazole-2-thione in which one of the nitrogens is substituted by a 5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl group while the carbon adjacent to it is substituted by an aminomethyl group (the S enantiomer). It is a potent and selective inhibitor of both bovine and human dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.nepicastat

Research

Studies (4,690)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19901,688 (35.99)18.7374
1990's862 (18.38)18.2507
2000's857 (18.27)29.6817
2010's942 (20.09)24.3611
2020's341 (7.27)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials288 (5.49%)5.53%
Reviews303 (5.77%)6.00%
Case Studies1,077 (20.53%)4.05%
Observational3 (0.06%)0.25%
Other3,576 (68.15%)84.16%