Roles > central nervous system drug
Page last updated: 2024-08-05 15:24:42

central nervous system drug

A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system.

ChEBI ID: 35470

Members (8)

MemberDefinitionClass
chloroformA one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.chloroform
entacaponeA monocarboxylic acid amide that is N,N-diethylprop-2-enamide in which the hydrogen at position 2 is substituted by a cyano group and the hydrogen at the 3E position is substituted by a 3,4-dihydroxy-5-nitrophenyl group.entacapone
phenterminephentermine
phenyl biguanideA member of the class of biguanides that is biguanide in which one of the terminal nitrogen atoms is substituted by a phenyl group.phenyl biguanide
pseudoephedrineA member of the class of the class of phenylethanolamines that is (1S)-2-(methylamino)-1-phenylethan-1-ol in which the pro-S hydrogen at position 2 is replaced by a methyl group.pseudoephedrine
ropiniroleropinirole
tafamidisA member of the class of 1,3-benzoxazoles that is 1,3-benzoxazole-6-carboxylic acid in which the hydrogen at position 2 is replaced by a 3,5-dichlorophenyl group. Used (as its meglumine salt) for the amelioration of transthyretin-related hereditary amyloidosis.tafamidis
zonisamideA 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.zonisamide

Research

Studies (9,745)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19903,398 (34.87)18.7374
1990's1,230 (12.62)18.2507
2000's2,086 (21.41)29.6817
2010's2,300 (23.60)24.3611
2020's731 (7.50)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials560 (5.31%)5.53%
Reviews695 (6.59%)6.00%
Case Studies517 (4.90%)4.05%
Observational23 (0.22%)0.25%
Other8,758 (82.99%)84.16%

Protein Targets (174)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-lipoxygenase, partialHomo sapiens (human)Potency10.175412
alpha-galactosidaseHomo sapiens (human)Potency32.464822
AR proteinHomo sapiens (human)Potency15.898644
arylsulfatase AHomo sapiens (human)Potency4.715612
Ataxin-2Homo sapiens (human)Potency33.491511
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency23.605723
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency33.491511
Bloom syndrome protein isoform 1Homo sapiens (human)Potency2,238.720022
Cellular tumor antigen p53Homo sapiens (human)Potency31.397213
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency31.622811
Chain A, HADH2 proteinHomo sapiens (human)Potency1.108022
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency5.623411
Chain B, HADH2 proteinHomo sapiens (human)Potency1.108022
chromobox protein homolog 1Homo sapiens (human)Potency89.125111
cytochrome P450 2C19 precursorHomo sapiens (human)Potency22.171513
cytochrome P450 2C9 precursorHomo sapiens (human)Potency20.302512
cytochrome P450 2C9, partialHomo sapiens (human)Potency0.043611
cytochrome P450 2D6Homo sapiens (human)Potency14.795512
cytochrome P450 2D6 isoform 1Homo sapiens (human)Potency7.875812
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency10.134424
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency9.771711
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency100.000011
DNA polymerase kappa isoform 1Homo sapiens (human)Potency6.701611
estrogen nuclear receptor alphaHomo sapiens (human)Potency41.408156
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency49.774155
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency9.829713
farnesoid X nuclear receptorHomo sapiens (human)Potency15.284222
flap endonuclease 1Homo sapiens (human)Potency29.934911
GVesicular stomatitis virusPotency0.043611
GABA theta subunitRattus norvegicus (Norway rat)Potency10.134412
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency10.134412
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency10.134412
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency10.134412
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency10.134412
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency10.134412
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency10.134412
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency10.134412
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency10.134412
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency10.134412
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency10.134412
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency10.134412
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency10.134412
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency10.134412
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency10.134412
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency10.134412
gemininHomo sapiens (human)Potency4.978923
GLI family zinc finger 3Homo sapiens (human)Potency27.084022
GLS proteinHomo sapiens (human)Potency18.623122
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency7.178213
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency68.032011
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1Homo sapiens (human)Potency7.943311
heat shock protein beta-1Homo sapiens (human)Potency20.780022
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency15.384628
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency35.481311
histone deacetylase 9 isoform 3Homo sapiens (human)Potency25.156622
Histone H2A.xCricetulus griseus (Chinese hamster)Potency78.753023
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency100.000011
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency0.043611
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency28.143023
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency0.043612
Interferon betaHomo sapiens (human)Potency0.188222
interleukin 8Homo sapiens (human)Potency84.126711
lamin isoform A-delta10Homo sapiens (human)Potency14.044915
lethal factor (plasmid)Bacillus anthracis str. A2012Potency0.012611
LuciferasePhotinus pyralis (common eastern firefly)Potency40.172022
mitogen-activated protein kinase 1Homo sapiens (human)Potency39.810711
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency15.954122
NFKB1 protein, partialHomo sapiens (human)Potency19.091924
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency12.282222
Nuclear receptor ROR-gammaHomo sapiens (human)Potency74.978011
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency49.851224
Ornithine decarboxylaseRattus norvegicus (Norway rat)Potency7.943311
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency112.202011
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency1.778311
phosphopantetheinyl transferaseBacillus subtilisPotency25.118911
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency3.162311
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency0.631011
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency28.183811
pregnane X nuclear receptorHomo sapiens (human)Potency33.491511
progesterone receptorHomo sapiens (human)Potency68.032011
pyruvate kinaseLeishmania mexicana mexicanaPotency10.000022
pyruvate kinase PKM isoform bHomo sapiens (human)Potency7.943322
RAR-related orphan receptor gammaMus musculus (house mouse)Potency38.096624
regulator of G-protein signaling 4Homo sapiens (human)Potency0.015011
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency35.577036
retinoid X nuclear receptor alphaHomo sapiens (human)Potency44.535823
RGS12Homo sapiens (human)Potency7.943311
SMAD family member 2Homo sapiens (human)Potency14.839022
SMAD family member 3Homo sapiens (human)Potency14.839022
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency39.810711
thioredoxin reductaseRattus norvegicus (Norway rat)Potency19.952611
ThrombopoietinHomo sapiens (human)Potency3.162322
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency16.507422
thyroid stimulating hormone receptorHomo sapiens (human)Potency0.125911
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency54.531211
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency2.986712
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency50.118711
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency68.032011

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1AHomo sapiens (human)Ki1.706011
5-hydroxytryptamine receptor 3AHomo sapiens (human)Ki1.200034
5-hydroxytryptamine receptor 3BHomo sapiens (human)Ki1.200034
5-hydroxytryptamine receptor 3CHomo sapiens (human)Ki1.200034
5-hydroxytryptamine receptor 3DHomo sapiens (human)Ki1.200034
5-hydroxytryptamine receptor 3EHomo sapiens (human)Ki1.200034
Adenosine receptor A2aHomo sapiens (human)IC502.320011
Alpha-ketoglutarate-dependent dioxygenase FTOHomo sapiens (human)IC503.000011
Amine oxidase [flavin-containing]Danio rerio (zebrafish)Ki30.800011
Amine oxidase [flavin-containing] BHomo sapiens (human)Ki3.100011
Amine oxidase [flavin-containing] BRattus norvegicus (Norway rat)Ki2.900011
Arachidonate 5-lipoxygenase-activating proteinHomo sapiens (human)Ki0.117011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC5084.050012
Beta-carbonic anhydrase 1Mycobacterium tuberculosis H37RvKi114.720033
Bile salt export pumpHomo sapiens (human)IC50107.866723
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000012
Carbonic anhydraseCandida albicans SC5314Ki0.947445
Carbonic anhydraseHelicobacter pylori 26695Ki0.224522
Carbonic anhydraseSaccharomyces cerevisiae S288CKi0.106011
Carbonic anhydraseStylophora pistillataKi0.645011
Carbonic anhydrase Anopheles gambiae (African malaria mosquito)Ki0.263011
Carbonic anhydrase Astrosclera willeyanaKi0.165011
Carbonic anhydrase Cryptococcus neoformans var. grubiiKi0.970522
Carbonic anhydrase Mycobacterium tuberculosis H37RvKi0.210011
Carbonic anhydrase Nakaseomyces glabratus CBS 138Ki0.114011
Carbonic anhydrase Stylophora pistillataKi0.259022
Carbonic anhydrase Sulfurihydrogenibium sp. YO3AOP1Ki0.140011
Carbonic anhydrase 1Homo sapiens (human)IC501.860011
Carbonic anhydrase 1Homo sapiens (human)Ki30.71495378
Carbonic anhydrase 12Homo sapiens (human)IC501.860011
Carbonic anhydrase 12Homo sapiens (human)Ki120.9278719
Carbonic anhydrase 13Homo sapiens (human)IC501.860011
Carbonic anhydrase 13Homo sapiens (human)Ki160.2182214
Carbonic anhydrase 14Homo sapiens (human)IC501.860011
Carbonic anhydrase 14Homo sapiens (human)Ki126.0486618
Carbonic anhydrase 15Mus musculus (house mouse)Ki0.497834
Carbonic anhydrase 2Bos taurus (cattle)IC501.860011
Carbonic anhydrase 2Homo sapiens (human)IC501.860011
Carbonic anhydrase 2Homo sapiens (human)Ki26.14296591
Carbonic anhydrase 2Mycobacterium tuberculosis H37RvKi0.876011
Carbonic anhydrase 3Homo sapiens (human)IC501.860011
Carbonic anhydrase 3Bos taurus (cattle)Ki14.262025
Carbonic anhydrase 3Homo sapiens (human)Ki442.8417315
Carbonic anhydrase 4Homo sapiens (human)IC501.860011
Carbonic anhydrase 4Homo sapiens (human)Ki98.2498725
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)IC501.860011
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ki119.0908719
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)IC501.860011
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Ki436.8304719
Carbonic anhydrase 6Homo sapiens (human)IC501.860011
Carbonic anhydrase 6Homo sapiens (human)Ki88.6655826
Carbonic anhydrase 7Homo sapiens (human)IC501.860011
Carbonic anhydrase 7Homo sapiens (human)Ki97.54771023
Carbonic anhydrase 9Homo sapiens (human)IC501.860011
Carbonic anhydrase 9Homo sapiens (human)Ki83.09221227
Carbonic anhydrase, alpha family Hydrogenovibrio crunogenus XCL-2Ki0.411011
Catechol O-methyltransferaseHomo sapiens (human)IC500.223022
Catechol O-methyltransferaseRattus norvegicus (Norway rat)IC501.275022
D(1A) dopamine receptorHomo sapiens (human)Ki1.200011
D(2) dopamine receptorBos taurus (cattle)IC506.810012
D(2) dopamine receptorHomo sapiens (human)Ki0.349522
D(2) dopamine receptorRattus norvegicus (Norway rat)Ki3.793733
D(3) dopamine receptorHomo sapiens (human)Ki0.038833
D(3) dopamine receptorRattus norvegicus (Norway rat)Ki0.029322
Delta carbonic anhydraseConticribra weissflogiiKi0.404011
Delta-type opioid receptorMus musculus (house mouse)Ki0.045522
Delta-type opioid receptorRattus norvegicus (Norway rat)Ki0.027822
Integrin alpha-V Homo sapiens (human)IC50200.000011
Integrin beta-3Homo sapiens (human)IC50200.000011
Mu-type opioid receptorCavia porcellus (domestic guinea pig)Ki0.035011
Mu-type opioid receptorRattus norvegicus (Norway rat)Ki0.056011
Multidrug resistance-associated protein 4Homo sapiens (human)IC5069.900012
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)Ki0.117011
Prolyl endopeptidaseRattus norvegicus (Norway rat)Ki0.020011
Retinol-binding protein 4Homo sapiens (human)IC5030.000011
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)Ki0.035211
Translocator proteinRattus norvegicus (Norway rat)Ki38.450011
TransthyretinHomo sapiens (human)IC503.371378

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 2AHomo sapiens (human)EC500.141211
AlbuminHomo sapiens (human)Kd2.400022
Carbonic anhydrase 2Homo sapiens (human)Kd0.047611
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Kd0.020611
D(1A) dopamine receptorHomo sapiens (human)EC500.100012
D(1B) dopamine receptorHomo sapiens (human)EC500.100012
D(2) dopamine receptorHomo sapiens (human)EC500.19111214
D(3) dopamine receptorHomo sapiens (human)EC500.040656
D(4) dopamine receptorHomo sapiens (human)EC500.100012
Trace amine-associated receptor 1Homo sapiens (human)EC505.470011
Trace amine-associated receptor 5Mus musculus (house mouse)EC5010.000011
TransthyretinHomo sapiens (human)Kd0.42661213

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AlbuminHomo sapiens (human)PB21.450022
Carbonic anhydrase Brucella suis 1330Kinact1.850011
Carbonic anhydrase 1Homo sapiens (human)Kinact0.051855
Carbonic anhydrase 12Homo sapiens (human)Kinact11.000011
Carbonic anhydrase 13Mus musculus (house mouse)Kinact0.430022
Carbonic anhydrase 14Homo sapiens (human)Kinact3.502333
Carbonic anhydrase 2Homo sapiens (human)Kinact0.029055
Carbonic anhydrase 4Homo sapiens (human)Kinact8.590022
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Kinact0.020022
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Kinact6.033033
Carbonic anhydrase 6Homo sapiens (human)Kinact0.089022
Carbonic anhydrase 7Homo sapiens (human)Kinact0.117022
Carbonic anhydrase 9Homo sapiens (human)Kinact1.753433
UDP-glucuronosyltransferase 1A9Homo sapiens (human)Km10.000011
UDP-glucuronosyltransferase 2B15Homo sapiens (human)Km322.000011