An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of dihydropteroate synthase (EC 2.5.1.15), an enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate.
| Member | Definition | Class |
|---|
| asulam | A carbamate ester that is methyl carbamate substituted by a (4-aminophenyl)sulfonyl group at the nitrogen atom. A dihydropteroate synthase inhibitor, it is used (normally as the corresponding sodium salt, asulam-sodium) as a herbicide, mainly for killing bracken. | asulam |
| sulfacetamide | A sulfonamide that is sulfanilamide acylated on the sulfonamide nitrogen. | sulfacetamide |
| sulfacetamide sodium | An organic sodium salt that is the monohydrate form of sulfacetamide sodium. | sulfacetamide sodium |
| sulfachlorpyridazine | A sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine. | sulfachloropyridazine |
| sulfadiazine | A sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position. | sulfadiazine |
| sulfamethazine | A sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position. | sulfamethazine |
| sulfamethizole | A sulfonamide consisting of a 1,3,4-thiadiazole nucleus with a methyl substituent at C-5 and a 4-aminobenzenesulfonamido group at C-2. | sulfamethizole |
| sulfamethoxazole | An isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position. | sulfamethoxazole |
| sulfamethoxypyridazine | A sulfonamide consisting of pyridazine having a methoxy substituent at the 6-position and a 4-aminobenzenesulfonamido group at the 3-position. | sulfamethoxypyridazine |
| sulfathiazole | A 1,3-thiazole compound having a 4-aminobenzenesulfonamido group at the 2-position. | sulfathiazole |
| sulfathiourea | A substituted aniline that is thiourea in which one of the hydrogens has been replaced by a (p-aminophenyl)sulfonyl group. | sulfathiourea |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 43.6486 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 11.9856 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 27.6986 | 1 | 4 |
| AR protein | Homo sapiens (human) | Potency | 29.7510 | 2 | 3 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 32.4648 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 76.3119 | 1 | 3 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.3035 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 27.3153 | 1 | 3 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 92.1395 | 1 | 4 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 18.5856 | 1 | 4 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 2 | 3 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 14.1417 | 1 | 2 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 32.9686 | 4 | 11 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 27.5946 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 13.7853 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 58.1316 | 1 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 9.8744 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 18.5856 | 1 | 4 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 16.7331 | 2 | 4 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 22.5504 | 2 | 3 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 2.6832 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 58.2929 | 2 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 10.0000 | 1 | 3 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 0.3981 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 18.5856 | 1 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 18.5856 | 1 | 8 |
| Interferon beta | Homo sapiens (human) | Potency | 18.5856 | 1 | 4 |
| interleukin 8 | Homo sapiens (human) | Potency | 68.4550 | 1 | 5 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 8.0287 | 1 | 5 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 12.5893 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 2.8184 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 34.6924 | 2 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 8.6878 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 47.9781 | 3 | 5 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 6.9111 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 55.1898 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 18.4367 | 2 | 3 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 50.1187 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 5.0119 | 1 | 1 |
| polyprotein | Zika virus | Potency | 9.8744 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 64.9187 | 2 | 3 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 14.9281 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 53.0081 | 3 | 10 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 17.7297 | 2 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 0.7222 | 1 | 3 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 1.0000 | 1 | 1 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 89.1251 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 24.9827 | 3 | 5 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 8.2400 | 2 | 4 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 43.2397 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 5.0119 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 5.0119 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 55.9982 | 2 | 3 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 100.0000 | 1 | 1 |