Page last updated: 2024-08-05 15:25:51

EC 2.5.1.15 (dihydropteroate synthase) inhibitor

An EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor that interferes with the action of dihydropteroate synthase (EC 2.5.1.15), an enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate.

ChEBI ID: 50502

Members (11)

MemberDefinitionClass
asulamA carbamate ester that is methyl carbamate substituted by a (4-aminophenyl)sulfonyl group at the nitrogen atom. A dihydropteroate synthase inhibitor, it is used (normally as the corresponding sodium salt, asulam-sodium) as a herbicide, mainly for killing bracken.asulam
sulfacetamideA sulfonamide that is sulfanilamide acylated on the sulfonamide nitrogen.sulfacetamide
sulfacetamide sodiumAn organic sodium salt that is the monohydrate form of sulfacetamide sodium.sulfacetamide sodium
sulfachlorpyridazineA sulfonamide antimicrobial used for urinary tract infections and in veterinary medicine.sulfachloropyridazine
sulfadiazineA sulfonamide consisting of pyrimidine with a 4-aminobenzenesulfonamido group at the 2-position.sulfadiazine
sulfamethazineA sulfonamide consisting of pyrimidine with methyl substituents at the 4- and 6-positions and a 4-aminobenzenesulfonamido group at the 2-position.sulfamethazine
sulfamethizoleA sulfonamide consisting of a 1,3,4-thiadiazole nucleus with a methyl substituent at C-5 and a 4-aminobenzenesulfonamido group at C-2.sulfamethizole
sulfamethoxazoleAn isoxazole (1,2-oxazole) compound having a methyl substituent at the 5-position and a 4-aminobenzenesulfonamido group at the 3-position.sulfamethoxazole
sulfamethoxypyridazineA sulfonamide consisting of pyridazine having a methoxy substituent at the 6-position and a 4-aminobenzenesulfonamido group at the 3-position.sulfamethoxypyridazine
sulfathiazoleA 1,3-thiazole compound having a 4-aminobenzenesulfonamido group at the 2-position.sulfathiazole
sulfathioureaA substituted aniline that is thiourea in which one of the hydrogens has been replaced by a (p-aminophenyl)sulfonyl group.sulfathiourea

Research

Studies (11,133)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19907,232 (64.96)18.7374
1990's881 (7.91)18.2507
2000's789 (7.09)29.6817
2010's1,376 (12.36)24.3611
2020's855 (7.68)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials970 (7.54%)5.53%
Reviews439 (3.41%)6.00%
Case Studies1,232 (9.58%)4.05%
Observational8 (0.06%)0.25%
Other10,209 (79.40%)84.16%

Protein Targets (110)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency43.648611
activating transcription factor 6Homo sapiens (human)Potency11.985611
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency27.698614
AR proteinHomo sapiens (human)Potency29.751023
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency32.464812
Chain A, Beta-lactamaseEscherichia coli K-12Potency76.311913
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency0.303512
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency27.315313
chromobox protein homolog 1Homo sapiens (human)Potency92.139514
cytochrome P450 2C19 precursorHomo sapiens (human)Potency10.000011
cytochrome P450 2C9 precursorHomo sapiens (human)Potency10.000011
cytochrome P450 2C9, partialHomo sapiens (human)Potency18.585614
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency39.810723
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency14.141712
DNA polymerase eta isoform 1Homo sapiens (human)Potency35.481311
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency56.234111
DNA polymerase kappa isoform 1Homo sapiens (human)Potency89.125111
estrogen nuclear receptor alphaHomo sapiens (human)Potency32.9686411
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency29.849311
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency27.594613
EWS/FLI fusion proteinHomo sapiens (human)Potency13.785344
farnesoid X nuclear receptorHomo sapiens (human)Potency58.131612
Fumarate hydrataseHomo sapiens (human)Potency9.874412
GVesicular stomatitis virusPotency18.585614
GABA theta subunitRattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency39.810712
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency39.810712
gemininHomo sapiens (human)Potency16.733124
GLI family zinc finger 3Homo sapiens (human)Potency22.550423
glp-1 receptor, partialHomo sapiens (human)Potency7.943311
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency2.683211
heat shock protein beta-1Homo sapiens (human)Potency58.292922
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency10.000013
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency0.398111
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency18.585614
IDH1Homo sapiens (human)Potency6.513111
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency18.585618
Interferon betaHomo sapiens (human)Potency18.585614
interleukin 8Homo sapiens (human)Potency68.455015
lamin isoform A-delta10Homo sapiens (human)Potency8.028715
lethal factor (plasmid)Bacillus anthracis str. A2012Potency12.589311
Microtubule-associated protein tauHomo sapiens (human)Potency8.912511
neuropeptide S receptor isoform AHomo sapiens (human)Potency15.848911
nonstructural protein 1Influenza A virus (A/WSN/1933(H1N1))Potency2.818411
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency34.692422
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency8.687812
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency47.978135
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency6.911111
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency55.189811
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency18.436723
phosphopantetheinyl transferaseBacillus subtilisPotency50.118711
plasminogen precursorMus musculus (house mouse)Potency5.011911
polyproteinZika virusPotency9.874412
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency12.589311
pregnane X nuclear receptorHomo sapiens (human)Potency64.918723
RAR-related orphan receptor gammaMus musculus (house mouse)Potency14.928112
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency53.0081310
retinoid X nuclear receptor alphaHomo sapiens (human)Potency17.729723
survival motor neuron protein isoform dHomo sapiens (human)Potency0.722213
TAR DNA-binding protein 43Homo sapiens (human)Potency1.000011
thioredoxin glutathione reductaseSchistosoma mansoniPotency89.125111
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency24.982735
thyroid stimulating hormone receptorHomo sapiens (human)Potency8.240024
transcriptional regulator ERG isoform 3Homo sapiens (human)Potency11.220211
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency43.239711
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency5.011911
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency5.011911
USP1 protein, partialHomo sapiens (human)Potency55.998223
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency100.000011

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)IC503.600012
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000012
ATP-dependent 6-phosphofructokinaseTrypanosoma brucei bruceiIC5057.000011
Aurora kinase AHomo sapiens (human)IC5021.000011
Bile salt export pumpHomo sapiens (human)IC50653.6000310
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000012
Carbonic anhydrase 1Homo sapiens (human)IC5012.720313
Carbonic anhydrase 2Homo sapiens (human)IC5012.720313
Carbonic anhydrase 6Homo sapiens (human)IC5012.720313
corticotropin releasing factor-binding proteinHomo sapiens (human)IC5047.100011
corticotropin-releasing hormone receptor 2Homo sapiens (human)IC5047.100011
Cytochrome P450 3A4Homo sapiens (human)IC50835.603011
Dihydrofolate reductaseHomo sapiens (human)IC5018.000011
Dihydrofolate reductasePneumocystis cariniiIC500.100011
Dihydrofolate reductase Bos taurus (cattle)IC5022.000011
Dihydropteroate synthaseEscherichia coli K-12IC503.600012
Endothelin-1 receptorHomo sapiens (human)IC5069.000011
Endothelin-1 receptorRattus norvegicus (Norway rat)IC50184.750034
exodeoxyribonuclease V subunit RecBEscherichia coli str. K-12 substr. MG1655IC5087.879625
exodeoxyribonuclease V subunit RecCEscherichia coli str. K-12 substr. MG1655IC5087.879625
exodeoxyribonuclease V subunit RecDEscherichia coli str. K-12 substr. MG1655IC5087.879625
Multidrug and toxin extrusion protein 1Homo sapiens (human)IC50500.000011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000012
Protease Human immunodeficiency virus 1Ki0.010111
Protein arginine N-methyltransferase 6Homo sapiens (human)IC50430.000011
Protein-arginine deiminase type-4Homo sapiens (human)IC5010,000.000011
Serum paraoxonase/arylesterase 1Homo sapiens (human)Ki86.000011
Transcriptional activator protein LasRPseudomonas aeruginosa PAO1IC509.000011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
corticotropin releasing factor-binding proteinHomo sapiens (human)EC5053.000011
corticotropin-releasing hormone receptor 2Homo sapiens (human)EC5053.000011
Protease Human immunodeficiency virus 1Kd0.577011