Compounds > phillygenin
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phillygenin

Description

phillygenin: cytoprotective lignan from Forsythia suspensa; structure in first source [MeSH]

Cross-References

ID SourceID
PubMed CID3083590
CHEMBL ID2260010
SCHEMBL ID10052265
MeSH IDM0537666

Synonyms (33)

Synonym
phenol, 4-(4-(3,4-dimethoxyphenyl)tetrahydro-1h,3h-furo(3,4-c)furan-1-yl)-2-methoxy-, (1s-(1alpha,3aalpha,4beta,6aalpha))-
unii-886ial08gn
phillygenol
epipinoresinol methyl ether
phillygenin
487-39-8
886ial08gn ,
ACON1_001142
sylvatesmin
MEGXP0_000876
NCGC00169636-01
BRD-K69431605-001-01-7
4-[(3s,3ar,6r,6ar)-6-(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2-methoxyphenol
S9187
(+)-monomethylpinoresinol
(+)-phillygenin
phillyrin aglycone
phenol, 4-((1s,3ar,4r,6ar)-4-(3,4-dimethoxyphenyl)tetrahydro-1h,3h-furo(3,4-c)furan-1-yl)-2-methoxy-
CHEMBL2260010
SCHEMBL10052265
AC-34423
Q-100547
DTXSID80197588
CS-5705
HY-N0483
AKOS030524964
4-((1s,3ar,4r,6ar)-4-(3,4-dimethoxyphenyl)tetrahydro-1h,3h-furo[3,4-c]furan-1-yl)-2-methoxyphenol
mfcd01075148
forsythigenol
CCG-268325
Q27269895
(+)-sylvatesmin
AS-56623

Bioassays (3)

Assay IDTitleYearJournalArticle
AID1371010Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase SOD-inhibitable ferricytochrome c reduction incubated for 5 mins before fMLP/CB stimulation for 3 mins 2017Journal of natural products, 04-28, Volume: 80, Issue:4
ISSN: 1520-6025		Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa.
AID1371011Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release pre-incubated for 5 mins before fMLP/CB stimulation using MeO-Suc-Ala-Ala-Pro-Val-pnitroanilide as substrate2017Journal of natural products, 04-28, Volume: 80, Issue:4
ISSN: 1520-6025		Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa.
AID1371012Anti-inflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation by measuring superoxide dismutase SOD-inhibitable ferricytochrome c reduction at 10 ug/ml incubated for 5 mins before fMLP/CB stimulation2017Journal of natural products, 04-28, Volume: 80, Issue:4
ISSN: 1520-6025		Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa.

Research

Studies (21)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (9.52)29.6817
2010's7 (33.33)24.3611
2020's12 (57.14)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.55%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other21 (95.45%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
ursolic acid
1
hydroxy monocarboxylic acid;
pentacyclic triterpenoid		geroprotector;
plant metabolite		201720177.0low000010
pinoresinol
1
pinoresinolhypoglycemic agent;
phytoestrogen;
plant metabolite		201720177.0medium000010
matairesinol
1
gamma-lactone;
lignan;
polyphenol		angiogenesis inhibitor;
anti-asthmatic agent;
phytoestrogen;
plant metabolite		201720177.0low000010
oleanolic acid 3-acetate
1
201720177.0low000010
sorafenib
1
(trifluoromethyl)benzenes;
aromatic ether;
monochlorobenzenes;
phenylureas;
pyridinecarboxamide		angiogenesis inhibitor;
anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
ferroptosis inducer;
tyrosine kinase inhibitor		201720177.0low000010
epipinoresinol
1
pinoresinolmarine metabolite;
plant metabolite		201720177.0medium000010
forsythiaside
1
hydroxycinnamic acid201720177.0low000010
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
molsidomine
1
ethyl ester;
morpholines;
oxadiazole;
zwitterion		antioxidant;
apoptosis inhibitor;
cardioprotective agent;
nitric oxide donor;
vasodilator agent		2009200915.0low000100
linsidomine
1
morpholines2009200915.0low000100
carbon tetrachloride
1
chlorocarbon;
chloromethanes		hepatotoxic agent;
refrigerant		202220222.0low000001
diquat
1
organic cationdefoliant;
herbicide		2010201014.0low000100
furaldehyde
1
aldehyde;
furans		Maillard reaction product;
metabolite		2010201014.0low000100
diethylhexyl phthalate
1
diester;
phthalate ester		androstane receptor agonist;
apoptosis inhibitor;
plasticiser		2010201014.0low000100
podophyllotoxin
1
furonaphthodioxole;
lignan;
organic heterotetracyclic compound		antimitotic;
antineoplastic agent;
keratolytic drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator		202020204.0low000010
glucose, (beta-d)-isomer
2
D-glucopyranoseepitope;
mouse metabolite		2009201711.0low000110
masoprocol
1
nordihydroguaiaretic acidantineoplastic agent;
hypoglycemic agent;
lipoxygenase inhibitor;
metabolite		202020204.0low000010
diphyllin
1
lignan202020204.0low000010
peroxynitrous acid
1
nitrogen oxoacid2009200915.0low000100
5-hydroxymethylfurfural
1
arenecarbaldehyde;
furans;
primary alcohol		indicator;
Maillard reaction product		2010201014.0low000100
lignans
17
200920226.9high000467
gamma-sitosterol
1
3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols		marine metabolite;
plant metabolite		2010201014.0low000100
terameprocol
1
lignan202020204.0low000010
glycosides
2
2009201014.5low000200
1,1-diphenyl-2-picrylhydrazyl
1
2010201014.0low000100
8-hydroxypinoresinol
1
lignan2009200915.0medium000100
cytellin
1
2010201014.0low000100
dinoprostone
1
prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic		202120213.0low000001
stigmasterol
1
3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols;
stigmastane sterol		plant metabolite2010201014.0low000100
forsythiaside
2
hydroxycinnamic acid2009201014.5low000200
suspensaside
1
201720177.0medium000010
acteoside
1
catechols;
cinnamate ester;
disaccharide derivative;
glycoside;
polyphenol		anti-inflammatory agent;
antibacterial agent;
antileishmanial agent;
neuroprotective agent;
plant metabolite		201720177.0low000010
bicyclol
1
202020204.0low000010
phillyrin
1
2009200915.0low000100
ascorbic acid
1
ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent		2010201014.0low000100
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Ache0
1
202220222.0low000001
Acute Lung Injury0
1
202120213.0low000001
Anasarca0
1
202220222.0low000001
Cancer of Esophagus0
1
201920195.0low000010
Cirrhosis, Liver0
3
202020232.3low000012
Colitis0
2
202220231.5low000002
Colitis Gravis0
1
202320231.0low000001
Colitis, Ulcerative0
1
202320231.0low000001
Coronavirus Infections0
1
202220222.0low000001
Disease Models, Animal0
1
202220222.0low000001
Edema0
1
202220222.0low000001
Esophageal Neoplasms0
1
201920195.0low000010
Fatty Liver, Nonalcoholic0
1
202220222.0low000001
Hepatitis0
1
202020204.0low000010
Infections, Coronavirus0
1
202220222.0low000001
Inflammation0
5
202120232.2medium000005
Innate Inflammatory Response0
5
202120232.2medium000005
Liver Cirrhosis0
3
202020232.3low000012
Lung Injury, Acute0
1
202120213.0low000001
Metastase0
1
202120213.0low000001
Neoplasm Metastasis0
1
202120213.0low000001
Non-alcoholic Fatty Liver Disease0
1
202220222.0low000001
Osteogenic Sarcoma0
1
202120213.0low000001
Osteosarcoma0
1
202120213.0low000001
Pain0
1
202220222.0low000001
Poultry Diseases0
1
202220222.0low000001

Pharmacokinetics (1)

ArticleYear
Determination of phillygenin in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies.
European journal of drug metabolism and pharmacokinetics, , Volume: 38, Issue:3		2013