ascorbic-acid and Scoliosis

It has been shown that vitamin C and B2, calcium and phosphorus daily intake strongly correlated with their urinary excretion in children 5-8 years old (Moscow) from the decreased bone mineral density risk group. Hour urinary calcium, phosphorus, creatinine excretion values for adequately supplied children has been determined. Vitamin and mineral status evaluation by means of estimation of vitamins and minerals consumption and urinary level (except vitamin B2) give relatively coincided results. Difference between these methods of nutritive status assessment attains 8-25 per cent. Thus these methods are substituted for group nutritive status evaluation.

Topics: Ascorbic Acid; Bone Density; Calcium; Child; Child, Preschool; Creatinine; Dietary Supplements; Humans; Minerals; Phosphorus; Riboflavin; Scoliosis; Thiamine; Vitamins

Channel catfish fingerlings fed purified diets devoid of vitamin C showed reduced growth rate, deformed spinal columns, external and internal hemorrhages, erosion of fins, dark skin color and reduced bone collagen content after 8 to 12 weeks, whereas fish fed a diet containing 30 mg/kg of vitamin C had none of these anomalies after 22 weeks. A dietary level of 30 mg of vitamin C per kg was insufficient to prevent distortion of gill filament cartilage, although 60 mg of vitamin C per kg was sufficient. Vertebral collagen percentages of 25 or below and liver ascorbic acid levels of 30 microgram/g or below appeared to be indicative of vitamin C deficiency in channel catfish fingerlings. Epidermis and dermis were almost completely healed and extensive collagen fiber formation had commenced in the somatic muscle, in experimentally inflicted wounds after 10 days in fish fed the vitamin C-free diet. Skin and muscle at the wound site were almost regenerated to normal after 10 days in fish fed 60 mg of vitamin C per kg of diet.

Topics: Animals; Ascorbic Acid; Collagen; Fishes; Gills; Liver; Lordosis; Scoliosis; Skin Pigmentation; Vitamin D Deficiency; Wound Healing

The treatment of osteogenesis imperfecta with magnesium is theoreticaly sound, but usually works in a few individuals. There are greater expectations with calcitonin, which reduces the overall osteolysis. The treatment of fractures should, whenever possible, be concervative. Internal fixation by plates is not indicated, because the plate should span from metaphysis to metyphysis, which leads to a softeming of the underlying cortex. Because of the weak bone, srews do not hold well. For operative treatment of the lower limb, the Küntscher nail is the fixation of choice, as well as for treatment of deformity by multiple fragmentation. Rapidly progressive scoliosis should be treated operatively from 9 years of age on.

Topics: Age Factors; Ascorbic Acid; Bone Nails; Calcitonin; Child; Fracture Fixation; Fracture Fixation, Intramedullary; Fractures, Spontaneous; Humans; Infant; Magnesium; Osteogenesis Imperfecta; Osteolysis; Scoliosis

Rats fed a vitamin E-deficient diet containing 10% "stripped" corn oil had reduced growth rate and elevated platelet count by 12 weeks of age, and a normocytic anemia with elevated reticulocytes by 16 weeks of age. After 5 months, rats became emaciated and developed kyphoscoliosis. Some rats developed skin ulcers and tremors, and mortality was high. Neuromuscular lesions included a chronic necrotizing myopathy and localized axonal dystrophy. There was also a selective activation of lysosomes in the central nervous system microcirculation. Liver ascorbic acid of deficient rats was the same as in those receiving vitamin E. Urinary excretion of p-hydroxyphenylpyruvate after a tyrosine load was also the same in deficient and control rats. It was concluded that neither vitamin C synthesis or utilization was affected the E-deficient rats.

Topics: Age Factors; Anemia; Animals; Ascorbic Acid; Female; Kyphosis; Male; Muscular Diseases; Necrosis; Nervous System Diseases; Rats; Scoliosis; Skin Ulcer; Thrombocytosis; Vitamin E Deficiency

Three feeding studies on the vitamin C requirements of channel catfish were conducted with practical and semipurified diets. In a long-duration study in which fish achieved almost a 4,000% increase in weight, 50 mg of l-ascorbic acid/kg diet was required for maximal growth and food efficiency. A diet stability study revealed that excessive losses in activity of l-ascorbic acid occurred when practical diets were stored for 16 weeks at 20 degrees. The typical scoliosis condition associated with severe vitamin C deficiency in fish occurred in the nonsupplemented groups in the study with practical diets. Severe growth reductions were obtained from fish fed nonsupplemented semi-purified diets, yet no incidences of spinal abnormalities were noted.

Topics: Animal Nutritional Physiological Phenomena; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Body Weight; Dose-Response Relationship, Drug; Drug Stability; Fishes; Hematocrit; Nutritional Requirements; Scoliosis; Spinal Diseases

Topics: Aeromonas; Animal Nutritional Physiological Phenomena; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Bacterial Infections; Body Weight; Environment; Eukaryota; Fish Diseases; Fisheries; Fishes; Gills; Kidney; Liver; Lordosis; Nutritional Requirements; Pigmentation Disorders; Scoliosis

Topics: Adaptation, Biological; Age Factors; Animals; Ascorbic Acid; Calcium; Dark Adaptation; Darkness; Fish Diseases; Fishes; Hypocalcemia; Male; Scoliosis; Seawater; Testis; Water

Topics: Alkaline Phosphatase; Animals; Ascorbic Acid; Avitaminosis; Body Weight; Brain Chemistry; Cecum; Diet; Kidney; Liver; Salmonidae; Scoliosis; Spine; Vitamin A