ascorbic-acid and Keratitis

We report a patient with risk factors for both microbial keratitis and endophthalmitis, which were initially challenging to distinguish. Cultures of corneal scrapings yielded several organisms, including an uncultivable Gram-negative rod, eventually identified as

Topics: Administration, Ophthalmic; Adult; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Ceftazidime; Cocaine; Cocaine-Related Disorders; Coinfection; Dopamine Uptake Inhibitors; Doxycycline; Endophthalmitis; Female; Gram-Positive Bacterial Infections; Humans; Keratitis; Kingella; Linezolid; Moxifloxacin; Neisseriaceae Infections; Ophthalmic Solutions; Prednisone; Propionibacterium acnes; Streptococcal Infections; Streptococcus; Substance Abuse, Intravenous; Tobramycin; Vancomycin; Voriconazole

A 40-years-old female patient was referred to the cornea clinic as a probable case of bilateral keratitis. The patient had a history of headache followed by acute onset of redness, pain and discharge from both eyes for 15 days. The patient was diagnosed as bilateral keratitis by the first contact physician and was started on topical antibiotics, cycloplegics and lubricating eye-drops. At presentation, both eyes had visual acuity of perception of light, conjunctival congestion, limbal blanching, diffuse corneal oedema and epithelial defect. A detailed history revealed application of Vicks VapoRub [topical ayurvedic analgesic which contains (per 100 g of product) menthol (2.82 g), camphor (5.25 g) and eucalyptol (1.49 mL) and excipients include thymol (0.1 g), turpentine oil (5.57 mL), nutmeg oil (0.54 mL), cedar wood oil and petrolatum)] on the forehead and eyelids for headache several times over 2-3 days before the onset. The patient further confirmed the accidental application of the ointment in the eyes. A provisional diagnosis of acute chemical injury with Vicks VapoRub was made and treatment with topical antibiotic, cycloplegic, steroid, lubricant and vitamin C was started. On follow-up, both eyes showed gradual resolution of corneal oedema and epithelial defect. Visual acuity improved in the left eye to 6/60 with no change in right eye due to corneal haze.

Topics: Acute Disease; Administration, Topical; Adult; Anti-Bacterial Agents; Ascorbic Acid; Burns, Chemical; Corneal Edema; Diagnosis, Differential; Female; Headache; Humans; Keratitis; Lubricant Eye Drops; Medicine, Ayurvedic; Mydriatics; Steroids; Treatment Outcome; Visual Acuity

The objective of this study was to determine the effect of vitamin C supplementation on reducing the size of corneal opacity resulting from infectious keratitis.The study included 82 patients (82 affected eyes), admitted for infectious keratitis from January 2009 to August 2013, who were followed for more than 3 months. Patients were divided into control, oral vitamin C (3 g/d), and intravenous vitamin C (20 g/d) groups during hospitalization. Corneal opacity sizes were measured using anterior segment photographs and Image J program (version 1.27; National Institutes of Health, Jinju, South Korea) at admission, discharge, and final follow-up. The corneal opacity size used for analysis was the measured opacity size divided by the size of the whole cornea.The corneal opacity size decreased by 0.03 ± 0.10 in the oral vitamin C group, 0.07 ± 0.22 in the intravenous vitamin C group, and 0.02 ± 0.15 in the control group. Intravenous vitamin C reduced the corneal opacity size more than oral vitamin C (P = 0.043). Intravenous vitamin C produced greater reduction in corneal opacity size in younger patients (P = 0.015) and those with a hypopyon (P = 0.036).Systemic vitamin C supplementation reduced the size of corneal opacity resulting from infectious keratitis. Intravenous vitamin C was more beneficial than oral supplementation, especially in younger patients and those with hypopyon.

Topics: Antioxidants; Ascorbic Acid; Corneal Opacity; Dietary Supplements; Female; Humans; Keratitis; Male; Middle Aged; Retrospective Studies; Treatment Outcome

To report the long-term sequelae of a case of bilateral chemical keratitis caused by airbag deployment.. Case report and review of the literature.. A 21-year-old woman presented with bilateral reduced vision, photophobia, and tearing after a car accident. Examination revealed some facial burns and severe chemical injury to the cornea and conjunctiva. Immediate irrigation with physiologic saline solution and subsequent treatment with topical antibiotics, corticosteroids, and vitamin C resulted in full restoration of vision but could not prevent permanent corneal damage.. Severe alkali injury of the cornea generally has a good prognosis but can lead to permanent damage and persistent complaints of dry eye.

Topics: Accidents, Traffic; Adult; Air Bags; Anti-Bacterial Agents; Ascorbic Acid; Burns, Chemical; Corneal Injuries; Drug Therapy, Combination; Eye Burns; Female; Follow-Up Studies; Glucocorticoids; Humans; Keratitis; Photophobia; Therapeutic Irrigation; Vision Disorders; Wounds, Nonpenetrating

Topics: Adult; Ascorbic Acid; Contact Lenses; Female; Humans; Idoxuridine; Keratitis; Sulfisoxazole; Time Factors

Topics: Administration, Topical; Anti-Inflammatory Agents; Ascorbic Acid; Chloramphenicol; Cortisone; Dexamethasone; Humans; Keratitis; Keratitis, Dendritic; Ophthalmic Solutions; Prednisolone; Streptomycin; Uveitis

Topics: Animals; Anti-Infective Agents; Ascorbic Acid; Keratitis; Pseudomonas Infections; Rabbits

Topics: Ascorbic Acid; Herpes Zoster; Humans; Keratitis; Keratitis, Herpetic; Vitamins