Tumor Lysis Syndrome

A syndrome resulting from cytotoxic therapy, occurring generally in aggressive, rapidly proliferating lymphoproliferative disorders. It is characterized by combinations of hyperuricemia, lactic acidosis, hyperkalemia, hyperphosphatemia and hypocalcemia.

Synonym
Tumor Lysis Syndrome

Excerpt	Reference
"Tumor lysis syndrome is a catastrophic complication of the treatment of certain neoplasms."	( Abubakar, S; Alam, F; Khan, A; Malik, IA, 1994)
"Tumor lysis syndrome is infrequently encountered following the treatment of solid tumors."	( Bilgrami, SF; Fallon, BG, 1993)
"Tumor lysis syndrome is a critical illness characterized by massive tumor cell death leading to severe hyperuricemia, hyperphosphatemia, hypocalcemia, and acute renal failure after starting chemotherapy to cancers, especially lymphoproliferative malignancies."	( Hikita, M; Hosoya, T; Ichida, K, 1996)
"Tumor lysis syndrome is a very serious and sometimes life-threatening complication of cancer treatment."	( Ezzone, SA, 1999)
"The acute tumor lysis syndrome is a rare condition that has most frequently been documented in patients with rapidly dividing myeloproliferative and lymphoproliferative malignancies."	( Grootendorst, AF; Van Der Klooster, JM; Van Der Wiel, HE; Van Saase, JL, 2000)
"Tumor lysis syndrome is a constellation of metabolic complications that occurs in the setting of treatment of hematologic malignancies."	( Beriwal, S; Garcia-Young, JA; Singh, S, 2002)
"Hyperuricemia and tumor lysis syndrome are well-known complications during induction treatment of aggressive non-Hodgkin's lymphomas (NHLs)."	( Belhadj, K; Bologna, S; Casasnovas, O; Christian, B; Coiffier, B; Fermé, C; Herbrecht, R; Jourdan, E; Mounier, N; Sonet, A; Tilly, H, 2003)
"Tumor lysis syndrome is a potentially life-threatening complication of induction chemotherapy for treatment of lymphoproliferative malignancies."	( Bakdash, S; Ellis, D; Krishnamurti, L; LaRosa, C; McMullen, L; Moritz, ML; Wu, HY, 2007)
"Tumor lysis syndrome is an oncologic emergency that is characterized by severe electrolyte abnormalities."	( Méhes, L; Rejto, L; Szász, R; Udvardy, M, 2007)
"Tumor lysis syndrome is a potentially life threatening oncologic emergency that requires immediate medical intervention."	( Aissaoui, L; Ali, ZB; Allani, B; Belakhal, R; Ben Abdennebi, Y; Ben Abid, H; Jeddi, R; Meddeb, B, 2007)
"Tumor lysis syndrome is a set of life threatening complication that can arise from treatment of high tumor burden, drug sensitive, and rapidly proliferating neoplasm particularly of hematological origin."	( Chen, HH; Cheng, YC; Lim, KH; Lin, CJ; Wu, CJ, 2007)
"Tumor lysis syndrome is a complication of malignancies caused by massive tumor cell lysis due to either spontaneous tumor cell lysis or to different therapies and it may cause hyperuricemia."	( Góth, L, 2008)
"Tumor lysis syndrome is a potentially life threatening complication of massive cellular lysis in cancers."	( Barosi, G; Lazzaro, C; Liso, V; Marchetti, M; Morra, E; Pession, A; Rosti, G; Santoro, A; Tosi, P; Tura, S; Zinzani, PL, 2008)
"Tumor lysis syndrome is a known complication of systemic chemotherapy and has also been reported as a rare complication after IT chemotherapy in patients with CNS disease."	( Kline, RM; Simangan, LR, 2015)
"Tumor lysis syndrome is rare in hepatocellular carcinoma (HCC), but it has been reported more frequently recently in response to treatments such as transcatheter arterial chemoembolization (TACE), radiofrequency thermal ablation (RFTA), and sorafenib."	( Choi, HS; Hahm, JS; Jun, DW; Kim, JO; Lee, HL; Lee, KN; Lee, OY; Tae, HJ; Yoon, BC, 2015)
"Tumor lysis syndrome is an in vivo lysis of tumor cells that leads to elevated levels of potassium, uric acid, phosphate, and lactate dehydrogenase, as well as decreased calcium concentrations."	( Benirschke, RC; Lee, HK; Theparee, T, 2017)
"Tumor lysis syndrome is most commonly observed in patients with hematologic malignancies with a high proliferation rate undergoing treatment with very effective therapies."	( Cerri, E; Cheson, BD; Desai, M; Heitner Enschede, S; Lamanna, N; Potluri, J; Tam, C, 2017)
"Tumor lysis syndrome is a serious and sometimes lethal complication of cancer treatment that is comprised of a set of metabolic disturbances along with clinical manifestations."	( Bhardwaj, S; Varma, S, 2018)
"Tumor lysis syndrome is a potentially lethal complication of chemotherapy, usually associated with aggressive hematologic malignancies."	( Imam, SZ; Maqbool, MA; Zahid, MF, 2020)
"Tumor lysis syndrome is an unusual metabolic emergency in solid tumors."	( Aziri, R; Mego, M; Pindak, D; Puskacova, J; Rejlekova, K; Rovenska, E; Tomas, M, 2019)
"BACKGROUND Tumor lysis syndrome is common in hematological malignancy, but less frequent in chronic and solid tumors."	( Armaly, Z; Artoul, S; Elias, M; Hamzeh, M; Jabbour, AR; Saffouri, A; Yasin, R, 2019)
"Tumor lysis syndrome is an oncologic emergency resulting from rapid and massive tumor cell death that may lead to serious clinical complications including acute kidney injury and cardiac arrest."	( Brener, H; Brener, ZZ; Losev, A, 2020)
"Tumor lysis syndrome is an oncological emergency but an exceedingly rare complication in non-hematological malignancies, including prostate cancer."	( Javed, S, 2021)
"Tumor lysis syndrome is an oncologic emergency characterized by hyperuricemia."	( Hossain, S; Naber, M; Yacobucci, MJ, 2022)
"Tumor lysis syndrome is an oncologic emergency that involves multiple metabolic abnormalities and clinical symptoms such as acute renal failure, cardiac arrhythmias, seizures, and multiorgan failure, and may be fatal if not promptly recognized."	( Chen, XT; Christ, AB; Hu, JS; Luminais, SN; Ma, B; Roman, D, 2022)

Excerpt	Reference
"Acute tumor lysis syndrome has not been reported in marrow transplant patients receiving conventional preparative regimens as treatment for CML in blast crisis, and it is likely that its occurrence in this patient was precipitated by high-dose Ara-C."	( Gonzales-Chambers, R; Przepiorka, D, 1990)
"The acute tumor lysis syndrome has been reported in patients with aggressive non-Hodgkin's lymphoma, acute lymphoblastic leukemia, and rarely in other malignancies in association with the administration of cytotoxic chemotherapy."	( Ramirez, M; Sparano, J; Wiernik, PH, 1990)
"Tumor lysis syndrome has rarely been observed in solid tumors."	( Akutsu, M; Imura, G; Kano, Y; Miyazawa, N; Mori, K; Tominaga, K; Yokoi, K, 1997)
"Tumor lysis syndrome has been observed during initiation and titration."	( Griffiths, CL; Olin, JL; Smith, MB, 2018)

Excerpt	Reference
"Spontaneous or treatment-induced tumor lysis syndrome (TLS) can cause significant morbidity and potential mortality."	( Jeha, S; Pui, CH, 2005)
"This is the first report on the post-treatment tumor lysis syndrome with ovarian Burkitt's lymphoma."	( Cui, T; He, H; Hu, L; Shi, G; Wang, C, 2010)
"One of the ways to treat the tumor lysis syndrome is to irrigate patients, alkalinize the urine through the supply of BIC solution or continuous hemodialysis with regional citrate anticoagulation, using a CAL solution."	( Górecka, A; Gostyńska, A; Jankowiak-Gracz, H; Kołodziej, I; Mańkowska, D; Ogrodowczyk, M; Stawny, M, 2019)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	12 (2.39)	23.3326
1990's	81 (16.10)	12.5806
2000's	156 (31.01)	18.1394
2010's	185 (36.78)	28.8240
2020's	69 (13.72)	9.53

Drug	Relationship Strength	Studies	Trials
ethylene glycol	low	1	0
adenine	low	6	0
allantoin	low	2	0
ammonium hydroxide	low	2	0
carbamates	low	1	0
citric acid, anhydrous	low	1	0
salicylic acid	low	1	0
creatine	low	1	0
lactic acid	low	2	0
glycine	low	1	0
hydrogen carbonate	low	6	0
niacinamide	low	4	0
uric acid	medium	112	9
urea	low	1	0
xanthine	low	4	0
acetazolamide	low	1	0
amlodipine	low	1	0
azathioprine	low	1	0
bicalutamide	low	1	0
bisoprolol	low	1	0
carmustine	low	1	0
chlorambucil	low	2	0
cimetidine	low	1	0
valproic acid	low	1	0
fluorouracil	low	11	0
flutamide	low	2	0
furosemide	low	1	0
hydroxyurea	low	10	0
ifosfamide	low	6	0
iohexol	low	1	0
mitoxantrone	medium	4	2
nicardipine	low	1	0
procarbazine	low	1	0
propofol	low	1	0
propranolol	low	1	0
thalidomide	medium	9	2
corticosterone	low	1	0
prednisolone	low	12	0
sorbitol	low	1	0
prednisone	medium	22	2
mannitol	low	1	0
cytarabine	medium	23	4
methylprednisolone	low	9	0
pyrroles	low	4	0
2-chloroadenosine	low	1	0
indazoles	low	1	0
thiazoles	medium	4	1
pyrazines	medium	10	1
calcium gluconate	low	1	0
hydrazine	low	1	0
dexamethasone 21-phosphate	low	1	0
azacitidine	low	6	0
betamethasone	low	1	0
fusarium	low	1	0
deoxycytidine	low	6	0
uridine diphosphate glucuronic acid	medium	1	1
cladribine	low	2	0
vidarabine	medium	19	2
camptothecin	low	6	0
tricalcium phosphate	low	2	0
tetradecanoylphorbol acetate	medium	1	1
daunorubicin	low	6	0
fludarabine phosphate	low	3	0
gallium citrate	low	1	0
vidarabine phosphate	low	3	0
paclitaxel	low	7	0
etoposide	medium	22	1
vindesine	low	2	0
epirubicin	low	2	0
idarubicin	low	2	0
propiconazole	low	1	0
topotecan	medium	2	1
gemcitabine	low	5	0
irinotecan	low	6	0
capecitabine	low	2	0
triazoles	low	3	0
zoledronic acid	low	1	0
voriconazole	low	1	0
bendamustine hydrochloride	medium	3	1
2'-chloro-2'-deoxyadenosine	low	1	0
imatinib mesylate	low	10	0
methotrexate	medium	13	2
docetaxel anhydrous	low	4	0
conivaptan	low	1	0
sorafenib	low	5	0
lenalidomide	medium	4	2
bortezomib	medium	16	1
carboplatin	medium	11	1
n-formylmethionine leucyl-phenylalanine	medium	1	1
tacrolimus	low	1	0
decitabine	low	5	0
dactinomycin	low	1	0
melphalan	low	5	0
posaconazole	low	1	0
micafungin	low	1	0
sodium bicarbonate	low	9	0
s 1033	low	2	0
leuprolide	low	2	0
fludarabine	medium	19	2
mercaptopurine	low	4	0
tamoxifen	low	1	0
nelarabine	low	1	0
dasatinib	low	1	0
calcitriol	low	1	0
amphotericin b	low	2	0
naloxone	low	1	0
sirolimus	medium	1	1
alvocidib	medium	9	6
morphine	low	1	0
goserelin	low	1	0
su 11248	low	4	0
gallium	low	1	0
phosphorus	medium	12	1
everolimus	medium	1	1
panobinostat	low	1	0
lenvatinib	low	1	0
pazopanib	low	2	0
binimetinib	low	1	0
regorafenib	low	1	0
er-086526	low	2	0
carfilzomib	low	5	0
idelalisib	low	1	0
dactolisib	medium	1	1
pituitrin	low	1	0
pci 32765	low	6	0
incb-018424	low	2	0
ixazomib	low	1	0
piperidines	medium	15	6
abt-199	medium	38	3
encorafenib	low	1	0
ascorbic acid	low	1	0
pm 01183	low	2	0
selinexor	low	1	0
cyclosporine	low	1	0
technetium tc 99m medronate	low	1	0
nedaplatin	low	1	0
levoleucovorin	low	6	0
hypoxanthine	low	3	0
dacarbazine	low	3	0

Protein Targets (1,740)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	18	0	0	18
Chain A, Beta-lactamase	14	0	0	14
glp-1 receptor, partial	10	0	0	10
TDP1 protein	49	0	0	49
Smad3	12	0	0	12
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
NPYLR7B	0	0	3	3
67.9K protein	22	0	0	22
IDH1	18	0	0	18
cellular tumor antigen p53 isoform a	11	0	0	11
vasopressin V1b receptor	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	19	0	0	19
glycogen synthase kinase-3 beta isoform 1	0	0	3	3
mitogen-activated protein kinase 1	8	0	0	8
flap endonuclease 1	7	0	0	7
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	2	2
DNA polymerase iota isoform a (long)	13	0	0	13
urokinase-type plasminogen activator precursor	11	0	0	11
plasminogen precursor	11	0	0	11
urokinase plasminogen activator surface receptor precursor	11	0	0	11
geminin	44	0	0	44
survival motor neuron protein isoform d	20	0	0	20
relaxin receptor 1 isoform 1	3	0	0	3
high affinity choline transporter 1 isoform a	0	1	0	1
relaxin receptor 2 isoform 1	1	0	0	1
lamin isoform A-delta10	30	0	0	30
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
Renin	0	3	0	3
Integrin beta-3	10	2	0	12
Heat shock protein HSP 90-alpha	0	2	2	4
Integrin alpha-IIb	10	1	0	11
Adenosine receptor A3	0	6	2	8
Endoplasmin	0	1	1	2
Adenosine receptor A1	0	3	0	4
Adenosine receptor A1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	9	1	10
Adenosine receptor A3	0	4	0	4
Adenosine receptor A2a	0	5	4	10
Adenosine receptor A2b	0	1	1	3
Adenosine receptor A2b	0	3	0	5
Adenosine receptor A1	0	5	0	6
Adenosine receptor A2a	0	5	0	7
Adenosine receptor A2a	0	0	1	1
Adenosine receptor A1	0	1	1	2
Adenosine deaminase	0	1	0	3
Adenylate cyclase type 5	0	1	0	1
Ataxin-2	36	0	0	36
EWS/FLI fusion protein	45	0	0	45
Apoptosis regulator Bcl-2	0	3	2	5
Spike glycoprotein	30	0	3	33
Bcl-2-like protein 1	0	3	0	3
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	0	2
Aspartyl/asparaginyl beta-hydroxylase	0	1	0	1
Bcl-2-related protein A1	0	1	0	1
Bcl-2-like protein 2	0	1	0	1
Bcl2-associated agonist of cell death	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	13	0	0	13
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	2	0	2
thioredoxin reductase	19	0	0	19
GALC protein	5	0	0	5
GLI family zinc finger 3	38	0	0	38
nuclear receptor subfamily 1, group I, member 3	34	0	0	34
cytochrome P450 family 3 subfamily A polypeptide 4	35	0	0	35
glucocorticoid receptor [Homo sapiens]	40	0	0	40
retinoic acid nuclear receptor alpha variant 1	36	0	0	36
retinoid X nuclear receptor alpha	33	0	0	33
estrogen-related nuclear receptor alpha	50	0	0	50
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	13	0	0	13
Carbonic anhydrase	0	1	0	1
euchromatic histone-lysine N-methyltransferase 2	30	0	0	30
Bloom syndrome protein isoform 1	15	0	0	15
thyroid hormone receptor beta isoform a	13	0	0	13
nuclear factor erythroid 2-related factor 2 isoform 1	39	0	0	39
peripheral myelin protein 22	24	0	0	24
muscleblind-like protein 1 isoform 1	11	0	0	11
Gamma-aminobutyric acid receptor subunit pi	13	5	2	20
ATP-binding cassette sub-family C member 3	0	47	0	47
Multidrug resistance-associated protein 4	0	47	0	48
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	5	0	5
Carbonic anhydrase 12	0	8	1	12
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	57	0	57
Glycogen phosphorylase, muscle form	0	2	0	2
Carbonic anhydrase 1	0	15	1	21
Carbonic anhydrase 2	0	17	2	24
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	8	0	9
Carbonic anhydrase 3	0	6	1	9
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	23	1	27
Steryl-sulfatase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	4	0	5
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Cytochrome P450 2C8	0	3	0	5
Cytochrome P450 2D6	0	15	0	15
Cytochrome P450 2A6	0	3	0	3
Cytochrome P450 2C9	0	16	0	18
5-hydroxytryptamine receptor 2A	0	4	0	4
Androgen receptor	0	11	0	11
Gamma-aminobutyric acid receptor subunit beta-1	13	5	2	20
Translocator protein	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	13	5	2	20
Gamma-aminobutyric acid receptor subunit gamma-2	13	5	2	20
Gamma-aminobutyric acid receptor subunit alpha-5	13	5	2	20
Gamma-aminobutyric acid receptor subunit alpha-3	13	5	2	20
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	5	0	6
Carbonic anhydrase 4	0	9	1	12
Carbonic anhydrase 6	0	6	1	9
Gamma-aminobutyric acid receptor subunit gamma-1	13	5	2	20
Gamma-aminobutyric acid receptor subunit alpha-2	13	5	2	20
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Serum paraoxonase/arylesterase 1	0	6	0	6
Dipeptidyl peptidase 4	0	1	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	13	5	2	20
Gamma-aminobutyric acid receptor subunit gamma-3	13	5	2	20
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	13	5	2	20
5-hydroxytryptamine receptor 2B	0	3	0	3
Sodium-dependent serotonin transporter	0	3	0	3
Delta-type opioid receptor	0	4	2	8
Cytochrome P450 2C19	0	10	0	11
Delta-type opioid receptor	0	7	3	11
Mu-type opioid receptor	0	8	3	14
Carbonic anhydrase 5A, mitochondrial	0	10	1	14
Carbonic anhydrase	0	3	0	3
Kappa-type opioid receptor	0	5	2	7
Carbonic anhydrase 7	0	7	1	10
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	6	1	0	7
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	13	5	2	20
Gamma-aminobutyric acid receptor subunit beta-3	13	5	2	20
Gamma-aminobutyric acid receptor subunit beta-2	13	5	2	20
Cholinesterase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	6	1	7
Fatty-acid amide hydrolase 1	0	4	0	4
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	3	1	5
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Carbonic anhydrase 9	0	12	1	17
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	3	0	3
Renin	0	1	0	1
Carbonic anhydrase	0	1	0	1
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	2	0	2
Carbonic anhydrase 13	0	3	1	5
GABA theta subunit	13	5	2	20
Canalicular multispecific organic anion transporter 1	0	49	0	50
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 15	0	5	0	6
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	5	0	7
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	13	5	2	20
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 14	0	7	1	11
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	7	1	11
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	37	0	0	37
AR protein	51	0	0	51
pregnane X nuclear receptor	37	0	0	37
estrogen nuclear receptor alpha	55	0	0	55
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	33	0	0	33
heat shock protein beta-1	9	0	0	9
importin subunit beta-1 isoform 1	4	0	0	4
snurportin-1	4	0	0	4
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	25	0	0	25
Cyclin-dependent kinase 1	0	4	16	21
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	26	0	0	26
Xanthine dehydrogenase/oxidase	0	5	0	6
TAR DNA-binding protein 43	6	1	0	7
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	3	7	10
ATPase family AAA domain-containing protein 5	31	0	0	31
RGS12	1	0	0	1
estrogen receptor 2 (ER beta)	26	0	0	26
vitamin D3 receptor isoform VDRA	16	0	0	16
thyroid hormone receptor beta isoform 2	38	0	0	38
Alpha-synuclein	6	0	0	6
interleukin 8	10	0	0	10
thyroid stimulating hormone receptor	12	0	0	12
progesterone receptor	29	0	0	29
transcriptional regulator ERG isoform 3	4	0	0	4
ras-related protein Rab-9A	7	0	0	7
Polyphenol oxidase 2	0	3	0	4
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	3
Cellular tumor antigen p53	37	0	0	37
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	2	0	2
Nuclear receptor ROR-gamma	0	2	0	2
Xanthine dehydrogenase/oxidase	0	5	1	8
Purine nucleoside phosphorylase	0	0	2	2
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	2	0	2
Chain A, Protein (glycogen Phosphorylase)	0	1	0	1
Leukotriene C4 synthase	0	0	7	7
Glycogen synthase kinase-3 beta	0	1	0	1
[Tau protein] kinase	0	1	0	1
Bone morphogenetic protein receptor type-1B	0	0	16	16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	6	9	15
Serine/threonine-protein kinase PLK4	0	2	16	18
Serine/threonine-protein kinase 25	0	0	7	7
ATP-dependent RNA helicase DDX3X	0	0	16	16
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	2	7	9
Pyridoxal kinase	0	0	16	16
Citron Rho-interacting kinase	0	0	16	16
Serine/threonine-protein kinase RIO3	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 7	0	0	7	7
Serine/threonine-protein kinase Chk1	0	1	17	18
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	7	9
Peripheral plasma membrane protein CASK	0	0	7	7
Aurora kinase A	0	3	16	19
Cyclin-G-associated kinase	0	1	16	17
Serine/threonine-protein kinase DCLK1	0	0	7	7
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	1	7	8
Muscle, skeletal receptor tyrosine-protein kinase	0	0	7	7
Ephrin type-B receptor 6	0	0	16	16
Peroxisomal acyl-coenzyme A oxidase 3	0	0	16	16
Mitogen-activated protein kinase 13	0	1	7	8
3-phosphoinositide-dependent protein kinase 1	0	0	7	7
Mitogen-activated protein kinase kinase kinase 13	0	0	7	7
Death-associated protein kinase 3	0	0	7	7
Mitogen-activated protein kinase kinase kinase 7	0	0	7	7
Receptor-interacting serine/threonine-protein kinase 2	0	3	16	19
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	16	16
NUAK family SNF1-like kinase 1	0	1	7	8
Dynamin-like 120 kDa protein, mitochondrial	0	0	16	16
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	7	7
Cyclin-T1	0	2	0	2
UDP-glucuronosyltransferase 1A9	0	0	0	3
Tyrosine-protein kinase JAK2	0	4	11	15
Eukaryotic translation initiation factor 5B	0	0	13	13
Rho-associated protein kinase 2	0	0	16	16
Serine/threonine-protein kinase ULK1	0	0	16	16
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	16	16
Ribosomal protein S6 kinase alpha-5	0	0	16	16
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	16	16
Ribosomal protein S6 kinase alpha-4	0	0	16	16
Serine/threonine-protein kinase 16	0	0	16	16
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	7	7
Cyclin-K	0	1	0	1
Serine/threonine-protein kinase PAK 3	0	0	7	7
Cyclin-dependent kinase-like 5	0	0	10	10
Serine/threonine-protein kinase 17B	0	0	7	7
Serine/threonine-protein kinase 10	0	0	16	16
Serine/threonine-protein kinase D3	0	2	17	19
Cyclin-dependent kinase 14	0	0	7	7
G2/mitotic-specific cyclin-B2	0	1	0	2
Structural maintenance of chromosomes protein 2	0	0	16	16
Mitogen-activated protein kinase kinase kinase 6	0	0	16	16
Serine/threonine-protein kinase OSR1	0	0	7	7
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	16	16
Serine/threonine-protein kinase LATS1	0	0	16	16
Serine/threonine-protein kinase PAK 4	0	2	16	18
Serine/threonine-protein kinase Chk2	0	1	7	8
G1/S-specific cyclin-E2	0	1	0	1
Tyrosine-protein kinase ABL1	0	11	20	33
Epidermal growth factor receptor	0	10	17	27
RAF proto-oncogene serine/threonine-protein kinase	0	6	7	13
Vitamin K-dependent protein C	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	7	8	15
High affinity nerve growth factor receptor	0	0	14	14
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	13	13
Protein kinase C gamma type	0	3	1	4
ADP/ATP translocase 2	0	0	16	16
Protein kinase C alpha type	0	2	0	2
Protein kinase C beta type	0	3	17	20
Insulin receptor	0	3	16	19
Tyrosine-protein kinase Lck	0	10	16	26
Tyrosine-protein kinase Fyn	0	7	16	23
Glycogen phosphorylase, liver form	0	0	16	16
Tyrosine-protein kinase Fes/Fps	0	0	16	16
Macrophage colony-stimulating factor 1 receptor	0	7	7	14
Adenine phosphoribosyltransferase	0	0	13	13
Tyrosine-protein kinase Yes	0	2	16	18
Tyrosine-protein kinase Lyn	0	3	16	19
Proto-oncogene tyrosine-protein kinase receptor Ret	0	8	16	24
Insulin-like growth factor 1 receptor	0	1	16	17
Signal recognition particle receptor subunit alpha	0	0	14	14
Cytochrome c1, heme protein, mitochondrial	0	0	16	16
Hepatocyte growth factor receptor	0	2	16	18
Tyrosine-protein kinase HCK	0	6	16	22
Proto-oncogene tyrosine-protein kinase ROS	0	1	7	8
Protein kinase C delta type	0	2	0	2
Protein kinase C epsilon type	0	2	0	2
Protein kinase C zeta type	0	2	0	2
Platelet-derived growth factor receptor beta	0	12	16	28
Tyrosine-protein kinase Fgr	0	1	12	13
Wee1-like protein kinase 2	0	0	7	7
Uncharacterized serine/threonine-protein kinase SBK3	0	0	7	7
Serine/threonine-protein kinase A-Raf	0	1	16	17
Mast/stem cell growth factor receptor Kit	0	10	8	18
Glycogen phosphorylase, brain form	0	0	16	16
Breakpoint cluster region protein	0	5	19	26
Serine/threonine-protein kinase pim-1	0	0	16	16
Fibroblast growth factor receptor 1	0	6	16	22
DNA topoisomerase 2-alpha	0	4	15	26
Myosin light chain kinase, smooth muscle	0	0	5	5
Cyclin-dependent kinase 4	0	3	16	20
ADP/ATP translocase 3	0	0	16	16
Inosine-5'-monophosphate dehydrogenase 2	0	0	16	16
Proto-oncogene tyrosine-protein kinase Src	0	11	16	27
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	16	16
Insulin receptor-related protein	0	0	7	7
G2/mitotic-specific cyclin-B1	0	2	0	3
Serine/threonine-protein kinase B-raf	0	5	17	22
G2/mitotic-specific cyclin-B	0	1	0	1
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	16	16
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	16	17
Platelet-derived growth factor receptor alpha	0	10	8	18
Tyrosine-protein kinase Fer	0	0	16	16
Protein kinase C alpha type	0	4	17	21
cAMP-dependent protein kinase catalytic subunit alpha	0	1	16	17
Vascular endothelial growth factor receptor 1	0	6	7	13
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	16	16
Glycogen synthase kinase-3 beta	0	1	0	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	7	7
Casein kinase II subunit alpha'	0	1	16	17
Cyclin-A2	0	3	0	4
Ras-related protein Rab-6A	0	0	14	14
Serine/threonine-protein kinase MAK	0	0	7	7
Cyclin-dependent kinase 11B	0	0	7	7
Ephrin type-A receptor 1	0	0	16	16
Fibroblast growth factor receptor 2	0	1	7	8
Receptor tyrosine-protein kinase erbB-3	0	1	7	8
Multifunctional protein ADE2	0	0	16	16
Nucleoside diphosphate kinase B	0	0	2	2
Fibroblast growth factor receptor 4	0	0	7	7
Dual specificity protein kinase CLK1	0	1	0	1
Fibroblast growth factor receptor 3	0	0	7	7
cAMP-dependent protein kinase catalytic subunit gamma	0	1	15	16
cAMP-dependent protein kinase catalytic subunit beta	0	1	16	17
Ferrochelatase, mitochondrial	0	0	16	16
Ribosomal protein S6 kinase beta-1	0	0	14	14
Tyrosine-protein kinase JAK1	0	4	17	21
G1/S-specific cyclin-D1	0	2	0	3
Protein kinase C eta type	0	2	8	10
G1/S-specific cyclin-E1	0	2	0	2
Cyclin-dependent kinase 2	0	7	17	26
Beta-adrenergic receptor kinase 1	0	0	16	16
Probable ATP-dependent RNA helicase DDX6	0	0	16	16
Activin receptor type-2A	0	0	7	7
Mitogen-activated protein kinase 3	0	2	16	18
MAP/microtubule affinity-regulating kinase 3	0	0	16	16
Deoxycytidine kinase	0	0	16	20
Mitogen-activated protein kinase 1	0	1	16	17
Ephrin type-A receptor 2	0	3	16	19
Ephrin type-A receptor 3	0	0	7	7
Ephrin type-A receptor 8	0	0	7	7
Ephrin type-B receptor 2	0	1	16	17
Leukocyte tyrosine kinase receptor	0	0	7	7
Non-receptor tyrosine-protein kinase TYK2	0	2	17	19
UMP-CMP kinase	0	0	11	11
Phosphatidylethanolamine-binding protein 1	0	0	15	15
G1/S-specific cyclin-D2	0	1	0	2
G1/S-specific cyclin-D3	0	1	0	2
Wee1-like protein kinase	0	0	16	16
Heme oxygenase 2	0	0	16	16
Tyrosine-protein kinase receptor UFO	0	1	7	8
Mitogen-activated protein kinase 4	0	0	7	7
S-adenosylmethionine synthase isoform type-2	0	0	16	16
DnaJ homolog subfamily A member 1	0	0	16	16
RAC-alpha serine/threonine-protein kinase	0	3	16	19
RAC-beta serine/threonine-protein kinase	0	1	16	17
G protein-coupled receptor kinase 4	0	0	7	7
Dual specificity protein kinase TTK	0	0	13	13
DNA replication licensing factor MCM4	0	0	16	16
Prostaglandin G/H synthase 2	0	2	7	9
Myosin-10	0	0	12	12
Tyrosine-protein kinase receptor Tie-1	0	0	7	7
Vascular endothelial growth factor receptor 3	0	6	7	13
Vascular endothelial growth factor receptor 2	0	11	9	21
Dual specificity mitogen-activated protein kinase kinase 2	0	2	16	18
Receptor-type tyrosine-protein kinase FLT3	0	8	16	25
Bone morphogenetic protein receptor type-1A	0	0	16	16
Activin receptor type-1B	0	0	16	16
TGF-beta receptor type-1	0	0	16	16
Serine/threonine-protein kinase receptor R3	0	0	9	9
TGF-beta receptor type-2	0	0	16	16
Electron transfer flavoprotein subunit beta	0	0	13	13
Tyrosine-protein kinase CSK	0	2	16	18
Glycine--tRNA ligase	0	0	16	16
Protein kinase C iota type	0	2	17	19
Exosome RNA helicase MTR4	0	0	16	16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	5	8	13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	6	8	14
Serine/threonine-protein kinase mTOR	0	9	9	18
Megakaryocyte-associated tyrosine-protein kinase	0	0	7	7
Tyrosine-protein kinase Tec	0	2	16	18
Tyrosine-protein kinase TXK	0	2	8	10
Tyrosine-protein kinase ABL2	0	0	16	16
Tyrosine-protein kinase FRK	0	1	16	17
Tyrosine-protein kinase ZAP-70	0	1	7	8
Tyrosine-protein kinase SYK	0	2	16	18
26S proteasome regulatory subunit 6B	0	2	16	18
Mitogen-activated protein kinase 8	0	0	16	16
Mitogen-activated protein kinase 9	0	0	16	16
Dual specificity mitogen-activated protein kinase kinase 4	0	0	9	9
Dual specificity mitogen-activated protein kinase kinase 3	0	0	16	16
Casein kinase I isoform alpha	0	3	15	18
Casein kinase I isoform delta	0	0	16	16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	6	8	14
MAP kinase-activated protein kinase 2	0	1	16	17
Cyclin-dependent kinase 8	0	1	7	8
Elongation factor Tu, mitochondrial	0	0	16	16
Choline-phosphate cytidylyltransferase A	0	0	10	10
Cysteine--tRNA ligase, cytoplasmic	0	0	15	15
Casein kinase I isoform epsilon	0	0	16	16
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	16	16
Dual specificity protein kinase CLK1	0	0	16	16
Dual specificity protein kinase CLK2	0	0	16	16
Dual specificity protein kinase CLK3	0	0	12	12
Glycogen synthase kinase-3 alpha	0	1	16	17
Glycogen synthase kinase-3 beta	0	2	16	18
Cyclin-dependent kinase 7	0	1	16	17
Cyclin-dependent kinase 9	0	2	16	18
Ras-related protein Rab-27A	0	0	16	16
Tyrosine-protein kinase Blk	0	3	8	11
Interleukin-1 receptor-associated kinase 1	0	0	16	16
Ribosomal protein S6 kinase alpha-3	0	2	16	18
Cytoplasmic tyrosine-protein kinase BMX	0	2	8	10
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	8	8
Cyclin-H	0	1	0	1
CDK-activating kinase assembly factor MAT1	0	1	0	1
Serine/threonine-protein kinase Nek2	0	1	16	17
Serine/threonine-protein kinase Nek3	0	0	16	16
Serine/threonine-protein kinase Nek4	0	0	7	7
Tyrosine-protein kinase JAK3	0	4	8	12
Dual specificity mitogen-activated protein kinase kinase 6	0	0	16	16
Serine/threonine-protein kinase PLK1	0	3	13	16
Death-associated protein kinase 1	0	0	7	7
LIM domain kinase 1	0	1	16	17
LIM domain kinase 2	0	1	16	17
Mitogen-activated protein kinase 12	0	1	7	8
Mitogen-activated protein kinase 10	0	0	15	15
Tyrosine--tRNA ligase, cytoplasmic	0	0	16	16
5'-AMP-activated protein kinase subunit gamma-1	0	0	16	17
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	1	7	9
Ephrin type-B receptor 3	0	0	16	16
Ephrin type-A receptor 5	0	0	16	16
Ephrin type-B receptor 4	0	3	16	19
Ephrin type-B receptor 1	0	0	7	7
Ephrin type-A receptor 4	0	0	16	16
Adenylate kinase 2, mitochondrial	0	0	16	16
Adenosine kinase	0	0	16	16
Hormonally up-regulated neu tumor-associated kinase	0	0	7	7
Serine/threonine-protein kinase SIK1	0	2	7	9
Receptor-interacting serine/threonine-protein kinase 4	0	0	7	7
Ras-related protein Rab-10	0	0	16	16
Cell division control protein 2 homolog	0	0	7	7
Actin-related protein 3	0	0	16	16
Actin-related protein 2	0	0	16	16
Calcium-dependent protein kinase 1	0	0	7	7
GTP-binding nuclear protein Ran	0	0	16	16
Protein kinase C gamma type	0	2	0	2
Tubulin alpha-1A chain	0	0	5	5
Casein kinase II subunit alpha	0	1	7	8
Protein kinase C beta type	0	2	0	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	7	7
SRSF protein kinase 2	0	0	7	7
Casein kinase I isoform gamma-2	0	0	14	14
Cyclin-A1	0	3	0	4
Mitogen-activated protein kinase kinase kinase 9	0	0	7	7
Serine/threonine-protein kinase PknB	0	0	7	7
Cyclin-dependent kinase 3	0	0	14	14
Cyclin-dependent kinase-like 1	0	0	7	7
Cyclin-dependent kinase 6	0	2	16	18
Cyclin-dependent-like kinase 5	0	1	16	17
Cyclin-dependent kinase 16	0	0	16	16
Cyclin-dependent kinase 17	0	0	16	16
Cyclin homolog	0	1	0	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	16	16
Protein kinase C epsilon type	0	3	8	11
Dual specificity mitogen-activated protein kinase kinase 1	0	2	16	18
Angiopoietin-1 receptor	0	3	7	10
Mitogen-activated protein kinase kinase kinase 10	0	0	7	7
DNA topoisomerase 2-beta	0	2	17	27
Protein kinase C theta type	0	2	17	19
Activin receptor type-1	0	0	16	16
Macrophage-stimulating protein receptor	0	0	16	16
Focal adhesion kinase 1	0	2	16	18
Protein kinase C zeta type	0	3	8	11
Protein kinase C delta type	0	4	17	21
Tyrosine-protein kinase BTK	0	5	17	22
Tyrosine-protein kinase receptor TYRO3	0	0	7	7
Cyclin-dependent kinase 18	0	0	8	8
Activated CDC42 kinase 1	0	1	16	17
Epithelial discoidin domain-containing receptor 1	0	5	16	21
Tyrosine-protein kinase ITK/TSK	0	3	8	11
Myotonin-protein kinase	0	0	7	7
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	16	16
Mitogen-activated protein kinase kinase kinase 12	0	0	7	7
Tyrosine-protein kinase Mer	0	2	11	13
Serine/threonine-protein kinase 4	0	0	16	16
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	1	16	18
Serine/threonine-protein kinase PAK 1	0	0	7	7
Dual specificity mitogen-activated protein kinase kinase 5	0	0	16	16
Mitogen-activated protein kinase 7	0	0	16	16
Serine/threonine-protein kinase PAK 2	0	0	16	16
Serine/threonine-protein kinase 3	0	0	16	16
Mitogen-activated protein kinase kinase kinase 1	0	0	16	16
cGMP-dependent protein kinase 2	0	0	7	7
Integrin-linked protein kinase	0	0	16	16
Rho-associated protein kinase 1	0	0	16	16
Non-receptor tyrosine-protein kinase TNK1	0	0	16	16
Serine/threonine-protein kinase PRP4 homolog	0	0	7	7
Serine/threonine-protein kinase ATR	0	0	7	7
Receptor-interacting serine/threonine-protein kinase 1	0	2	7	9
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	7	7
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	16	16
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	16	16
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	16	16
Activin receptor type-2B	0	0	16	16
Bone morphogenetic protein receptor type-2	0	0	16	16
Protein-tyrosine kinase 6	0	2	16	18
cGMP-dependent protein kinase 1	0	0	16	16
Cyclin-dependent kinase 13	0	0	16	16
Calcium/calmodulin-dependent protein kinase type 1	0	0	7	7
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	16	16
Protein-tyrosine kinase 2-beta	0	0	16	16
Maternal embryonic leucine zipper kinase	0	0	16	16
Structural maintenance of chromosomes protein 1A	0	0	16	16
Chromodomain-helicase-DNA-binding protein 4	0	0	16	16
Peroxisomal acyl-coenzyme A oxidase 1	0	0	14	14
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Cyclin-dependent kinase 10	0	0	5	5
Serine/threonine-protein kinase D1	0	2	8	10
Serine/threonine-protein kinase 38	0	0	10	10
Receptor tyrosine-protein kinase erbB-4	0	1	8	9
Ribosomal protein S6 kinase alpha-2	0	0	7	7
Ephrin type-A receptor 7	0	0	13	13
Delta(24)-sterol reductase	0	0	16	16
Ribosomal protein S6 kinase alpha-1	0	3	16	19
Dual specificity testis-specific protein kinase 1	0	0	13	13
Myosin light chain kinase, smooth muscle	0	0	16	16
Mitogen-activated protein kinase 11	0	1	16	17
Serine/threonine-protein kinase STK11	0	0	16	16
Rhodopsin kinase GRK1	0	0	7	7
NT-3 growth factor receptor	0	0	7	7
Serine/threonine-protein kinase N1	0	0	16	16
Serine/threonine-protein kinase N2	0	0	16	16
Mitogen-activated protein kinase 14	0	3	18	21
Calcium/calmodulin-dependent protein kinase type IV	0	0	16	16
Mitogen-activated protein kinase kinase kinase 11	0	0	16	16
BDNF/NT-3 growth factors receptor	0	0	7	7
Mitogen-activated protein kinase 6	0	0	7	7
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	7	7
Discoidin domain-containing receptor 2	0	7	16	23
AP2-associated protein kinase 1	0	2	16	18
Myosin light chain kinase 3	0	0	16	16
La-related protein 7	0	1	0	1
Serine/threonine-protein kinase SBK1	0	0	7	7
Mitogen-activated protein kinase kinase kinase 19	0	0	7	7
Putative heat shock protein HSP 90-beta 2	0	0	15	15
Serine/threonine-protein kinase TNNI3K	0	1	7	8
Rab-like protein 3	0	0	12	12
Serine/threonine-protein kinase MRCK alpha	0	0	16	16
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Protein kinase C eta type	0	2	0	2
Serine/threonine-protein kinase MRCK gamma	0	0	16	16
Acyl-CoA dehydrogenase family member 10	0	0	15	15
Serine/threonine-protein kinase Nek5	0	0	7	7
Serine/threonine-protein kinase N3	0	0	15	15
Serine/threonine-protein kinase ULK3	0	0	16	16
Dual serine/threonine and tyrosine protein kinase	0	0	7	7
Mitogen-activated protein kinase kinase kinase 15	0	0	7	7
Uncharacterized protein FLJ45252	0	0	16	16
Acyl-CoA dehydrogenase family member 11	0	0	16	16
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	15	15
Serine/threonine-protein kinase MARK2	0	0	16	16
ATP-dependent RNA helicase DHX30	0	0	12	12
Serine/threonine-protein kinase TAO1	0	0	16	16
STE20-related kinase adapter protein alpha	0	0	16	16
Myosin-14	0	0	15	15
AarF domain-containing protein kinase 1	0	0	16	16
Serine/threonine-protein kinase tousled-like 2	0	0	7	7
Serine/threonine-protein kinase 32C	0	0	7	7
Serine/threonine-protein kinase pim-3	0	0	7	7
ATP-dependent RNA helicase DDX42	0	0	12	12
Serine/threonine-protein kinase VRK2	0	0	7	7
Myosin light chain kinase family member 4	0	0	7	7
Homeodomain-interacting protein kinase 1	0	1	7	8
Calcium/calmodulin-dependent protein kinase type 1D	0	0	7	7
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	16	16
Cyclin-dependent kinase-like 3	0	0	7	7
MAP kinase-activated protein kinase 5	0	0	15	15
Serine/threonine-protein kinase BRSK2	0	0	7	7
Serine/threonine-protein kinase NIM1	0	0	7	7
Serine/threonine-protein kinase ULK2	0	0	7	7
Misshapen-like kinase 1	0	0	13	13
Serine/threonine-protein kinase DCLK2	0	0	7	7
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	7	7
Casein kinase I isoform alpha-like	0	0	7	7
Homeodomain-interacting protein kinase 4	0	1	7	8
Myosin-IIIa	0	0	7	7
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	7	7
Serine/threonine-protein kinase Nek11	0	0	7	7
Atypical kinase COQ8A, mitochondrial	0	0	16	16
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	16	16
Mitogen-activated protein kinase 15	0	0	16	16
Serine/threonine-protein kinase Nek9	0	0	16	16
Serine/threonine-protein kinase BRSK1	0	0	7	7
Serine/threonine-protein kinase 35	0	0	7	7
Serine/threonine-protein kinase Nek7	0	0	11	11
Rhodopsin kinase GRK7	0	0	7	7
Serine/threonine-protein kinase 32A	0	0	7	7
G2/mitotic-specific cyclin-B3	0	1	0	2
Myosin-IIIb	0	0	7	7
ATP-dependent RNA helicase DDX1	0	0	16	16
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	7	7
Cyclin-dependent kinase-like 2	0	0	7	7
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	16	16
Serine/threonine-protein kinase Sgk3	0	0	7	7
Atypical kinase COQ8B, mitochondrial	0	0	7	7
Aurora kinase B	0	3	16	19
MAP/microtubule affinity-regulating kinase 4	0	0	16	16
Calcium/calmodulin-dependent protein kinase type 1G	0	0	10	10
Serine/threonine-protein kinase Nek1	0	0	16	16
Cyclin-dependent kinase 15	0	0	7	7
PAS domain-containing serine/threonine-protein kinase	0	0	14	14
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	16	16
EKC/KEOPS complex subunit TP53RK	0	0	16	16
Dual specificity testis-specific protein kinase 2	0	0	9	9
SRSF protein kinase 1	0	0	7	7
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	2	16	18
Mitogen-activated protein kinase kinase kinase 5	0	0	16	16
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	7	7
Mitogen-activated protein kinase kinase kinase 3	0	0	16	16
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	16	16
Serine/threonine-protein kinase RIO1	0	0	7	7
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	7	7
Serine/threonine-protein kinase RIO2	0	0	7	7
Cyclin-dependent kinase 19	0	1	7	8
Transient receptor potential cation channel subfamily M member 6	0	0	7	7
Testis-specific serine/threonine-protein kinase 1	0	0	7	7
Serine/threonine-protein kinase 33	0	0	7	7
Nucleolar GTP-binding protein 1	0	0	16	16
Serine/threonine-protein kinase D2	0	0	16	16
Serine/threonine-protein kinase DCLK3	0	0	7	7
Cyclin-dependent kinase 1	0	1	0	1
NUAK family SNF1-like kinase 2	0	0	15	15
RNA cytidine acetyltransferase	0	0	16	16
Serine/threonine-protein kinase SIK2	0	1	16	17
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	7	7
STE20-like serine/threonine-protein kinase	0	0	16	16
Serine/threonine-protein kinase TAO3	0	0	16	16
Homeodomain-interacting protein kinase 2	0	1	7	8
Tyrosine-protein kinase Srms	0	0	7	7
Homeodomain-interacting protein kinase 3	0	1	7	8
Serine/threonine-protein kinase PLK3	0	2	7	9
dCTP pyrophosphatase 1	0	0	16	16
Dual specificity protein kinase CLK4	0	0	16	16
MAP kinase-interacting serine/threonine-protein kinase 2	0	1	7	8
Serine/threonine-protein kinase Nek6	0	0	7	7
Casein kinase I isoform gamma-1	0	0	16	16
Serine/threonine-protein kinase PAK 6	0	1	10	11
SNF-related serine/threonine-protein kinase	0	0	7	7
Serine/threonine-protein kinase LATS2	0	0	7	7
Serine/threonine-protein kinase 36	0	0	7	7
Phenylalanine--tRNA ligase beta subunit	0	0	16	16
Isoleucine--tRNA ligase, mitochondrial	0	0	12	12
BMP-2-inducible protein kinase	0	0	16	16
Obg-like ATPase 1	0	0	14	14
Midasin	0	0	16	16
Interleukin-1 receptor-associated kinase 4	0	0	16	16
Serine/threonine-protein kinase 32B	0	0	7	7
Mitogen-activated protein kinase kinase kinase 20	0	0	16	16
Cyclin-dependent kinase 12	0	1	16	17
Serine/threonine-protein kinase PLK2	0	2	7	9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	15	15
Serine/threonine-protein kinase MARK1	0	0	7	7
Serine/threonine-protein kinase pim-2	0	0	9	9
Serine/threonine-protein kinase PAK 5	0	1	7	8
Serine/threonine-protein kinase 26	0	0	16	16
eIF-2-alpha kinase GCN2	0	0	7	7
Serine/threonine-protein kinase NLK	0	0	16	16
Phosphatidylinositol 4-kinase beta	0	1	7	8
Serine/threonine-protein kinase 17A	0	0	7	7
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	7	7
Ephrin type-A receptor 6	0	0	7	7
5'-AMP-activated protein kinase subunit gamma-2	0	0	16	17
Serine/threonine-protein kinase TBK1	0	1	16	17
Septin-9	0	0	16	16
Death-associated protein kinase 2	0	0	7	7
Ribosomal protein S6 kinase alpha-6	0	0	16	16
TRAF2 and NCK-interacting protein kinase	0	0	16	16
Serine/threonine-protein kinase tousled-like 1	0	0	7	7
Serine/threonine-protein kinase TAO2	0	0	16	16
Long-chain-fatty-acid--CoA ligase 5	0	0	11	11
ALK tyrosine kinase receptor	0	2	7	9
SRSF protein kinase 3	0	0	7	7
Serine/threonine-protein kinase ICK	0	0	15	15
Cyclin-dependent kinase 11A	0	0	7	7
Aurora kinase C	0	0	7	7
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	7	7
Protein kinase C theta type	0	2	0	2
RAC-gamma serine/threonine-protein kinase	0	1	16	17
Serine/threonine-protein kinase 38-like	0	0	11	11
Microtubule-associated serine/threonine-protein kinase 1	0	0	7	7
Serine/threonine-protein kinase SIK3	0	1	16	17
Mitogen-activated protein kinase kinase kinase 2	0	0	16	16
Thyroid hormone receptor-associated protein 3	0	0	14	14
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	11	11
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	16	16
Receptor-interacting serine/threonine-protein kinase 3	0	1	16	17
Serine/threonine-protein kinase MRCK beta	0	0	16	16
Interleukin-1 receptor-associated kinase 3	0	0	16	16
Serine/threonine-protein kinase 24	0	0	15	15
Casein kinase I isoform gamma-3	0	0	16	16
Mitogen-activated protein kinase kinase kinase 4	0	0	16	16
Chain A, Ferritin light chain	14	0	0	14
acid sphingomyelinase	2	0	0	2
G	21	0	0	21
cytochrome P450 2D6	19	0	0	19
chromobox protein homolog 1	24	0	0	24
NEDD8-activating enzyme E1 regulatory subunit isoform a	0	1	0	1
NEDD8-conjugating enzyme Ubc12	0	1	0	1
nuclear receptor ROR-gamma isoform 1	18	0	0	18
histone acetyltransferase KAT2A isoform 1	12	0	0	12
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Potassium channel subfamily K member 2	0	1	1	2
Interferon beta	45	0	0	45
HLA class I histocompatibility antigen, B alpha chain	21	0	0	21
ATP-dependent translocase ABCB1	0	14	1	20
Alpha-2A adrenergic receptor	0	7	3	11
Alpha-2C adrenergic receptor	0	5	2	8
Alpha-2B adrenergic receptor	0	2	1	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Alpha-2C adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	3	1	4
Alpha-1D adrenergic receptor	0	3	1	5
Alpha-1A adrenergic receptor	0	2	2	5
Alpha-1B adrenergic receptor	0	1	1	3
5-hydroxytryptamine receptor 6	0	9	1	11
Sodium-dependent dopamine transporter	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	8	0	8
Potassium channel subfamily K member 2	0	1	0	1
Inositol hexakisphosphate kinase 1	21	0	0	21
cytochrome P450 2C9, partial	21	0	0	21
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, Cruzipain	3	0	0	3
phosphopantetheinyl transferase	13	0	0	13
GLS protein	11	0	0	11
farnesoid X nuclear receptor	30	0	0	30
peroxisome proliferator-activated receptor delta	25	0	0	25
vitamin D (1,25- dihydroxyvitamin D3) receptor	23	0	0	23
tumor necrosis factor	1	0	0	1
Nuclear receptor ROR-gamma	11	0	0	11
Potassium voltage-gated channel subfamily H member 2	0	16	0	16
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	15	0	18
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	18	0	0	18
thioredoxin glutathione reductase	8	0	0	8
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
lethal factor (plasmid)	5	0	0	5
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	2	2	5
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
pregnane X receptor	9	0	0	9
ATAD5 protein, partial	14	0	0	14
Fumarate hydratase	26	0	0	26
NFKB1 protein, partial	6	0	0	6
PPM1D protein	26	0	0	26
Thrombopoietin	6	0	0	6
aldehyde dehydrogenase 1 family, member A1	23	0	0	23
polyprotein	26	0	0	26
Parkin	4	0	0	4
peroxisome proliferator activated receptor gamma	27	0	0	27
aryl hydrocarbon receptor	19	0	0	19
thyroid stimulating hormone receptor	18	0	0	18
activating transcription factor 6	14	0	0	14
peripheral myelin protein 22 isoform 1	9	0	0	9
hemoglobin subunit beta	5	0	0	5
huntingtin isoform 2	12	0	0	12
serine/threonine-protein kinase mTOR isoform 1	11	0	0	11
muscarinic acetylcholine receptor M1	9	0	0	9
DNA (cytosine-5)-methyltransferase 1	0	2	0	2
Multidrug and toxin extrusion protein 1	0	7	0	7
Histone-lysine N-methyltransferase EHMT2	0	2	0	2
ATP-dependent phosphofructokinase	14	0	0	14
SMAD family member 2	7	0	0	7
SMAD family member 3	7	0	0	7
Microtubule-associated protein tau	10	0	0	10
P53	1	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	12	0	0	12
Histone H2A.x	18	0	0	18
cytochrome P450 3A4 isoform 1	13	0	0	13
M-phase phosphoprotein 8	9	0	0	9
Bile salt export pump	0	8	0	8
Protein-arginine deiminase type-4	0	2	0	2
nuclear receptor subfamily 1, group I, member 2	9	0	0	9
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	9	2	16
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
ORF73	0	0	1	1
tyrosine-protein kinase Yes	12	0	0	12
Estrogen receptor	0	6	1	8
Progesterone receptor	0	1	0	1
Progesterone receptor	0	4	0	5
Glucocorticoid receptor	0	2	1	3
Androgen receptor	0	7	1	10
Androgen receptor	0	1	0	1
Mineralocorticoid receptor	0	1	0	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Progesterone receptor	0	2	0	2
Membrane-associated progesterone receptor component 1	0	0	11	11
Cell division cycle 7-related protein kinase	0	0	9	9
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	14	14
MAP kinase-activated protein kinase 3	0	0	6	6
Uncharacterized aarF domain-containing protein kinase 5	0	0	8	8
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	15	15
DNA polymerase kappa isoform 1	11	0	0	11
Beta-2 adrenergic receptor	0	3	2	5
Beta-1 adrenergic receptor	0	4	2	6
Beta-3 adrenergic receptor	0	4	2	6
Beta-1 adrenergic receptor	0	2	0	2
Chain H, Proteasome component PUP1	0	1	0	1
Chain I, Proteasome component PUP3	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Proteasome subunit beta type-11	0	3	0	3
caspase 7, apoptosis-related cysteine protease	13	0	0	13
caspase-3	13	0	0	13
Caspase-7	7	0	0	7
caspase-3	7	0	0	7
26S proteasome non-ATPase regulatory subunit 11	0	2	0	2
26S proteasome non-ATPase regulatory subunit 12	0	2	0	2
26S proteasome non-ATPase regulatory subunit 14	0	2	0	2
Proteasome subunit alpha type-7	0	3	0	3
Histone deacetylase 3	0	6	1	7
26S proteasome non-ATPase regulatory subunit 3	0	2	0	2
Prothrombin	0	1	0	3
Chymotrypsinogen A	0	2	0	2
Cathepsin B	0	2	0	2
Neutrophil elastase	0	1	0	1
Cathepsin G	0	3	0	3
Lysosomal protective protein	0	2	0	2
Chymotrypsinogen B	0	1	0	1
26S proteasome regulatory subunit 6A	0	2	0	2
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Proteasome subunit beta type-1	0	3	0	4
Chymase	0	1	0	1
Proteasome subunit alpha type-1	0	3	0	3
Proteasome subunit alpha type-2	0	3	0	3
Proteasome subunit alpha type-3	0	3	0	3
Proteasome subunit alpha type-4	0	3	0	3
Proteasome subunit beta type-8	0	3	0	3
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	3	0	3
Proteasome subunit alpha type-5	0	3	0	3
Proteasome subunit beta type-4	0	3	0	3
Proteasome subunit beta type-6	0	3	0	3
Proteasome subunit beta type-5	0	4	0	5
26S proteasome regulatory subunit 7	0	2	0	2
Lon protease homolog, mitochondrial	0	1	0	1
Proteasome subunit beta type-10	0	3	0	3
26S proteasome non-ATPase regulatory subunit 8	0	2	0	2
Proteasome subunit beta type-3	0	3	0	3
Proteasome subunit beta type-2	0	3	0	4
26S proteasome non-ATPase regulatory subunit 7	0	2	0	2
26S proteasome non-ATPase regulatory subunit 4	0	2	0	2
26S proteasome complex subunit SEM1	0	2	0	2
Proteasome subunit alpha type-6	0	3	0	3
26S proteasome regulatory subunit 4	0	2	0	2
26S proteasome regulatory subunit 8	0	2	0	2
26S proteasome regulatory subunit 10B	0	2	0	2
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
26S proteasome non-ATPase regulatory subunit 2	0	2	0	2
Histone deacetylase 1	0	7	1	8
26S proteasome non-ATPase regulatory subunit 6	0	2	0	2
Proteasomal ubiquitin receptor ADRM1	0	2	0	2
ATP-dependent Clp protease proteolytic subunit	0	2	2	4
NACHT, LRR and PYD domains-containing protein 3	0	2	0	2
Proteasome subunit alpha-type 8	0	3	0	3
Histone deacetylase 2	0	6	1	7
Proteasome subunit beta type-7	0	3	0	3
26S proteasome non-ATPase regulatory subunit 1	0	2	0	2
Histone deacetylase 8	0	7	0	7
Histone deacetylase 6	0	9	1	10
26S proteasome non-ATPase regulatory subunit 13	0	2	0	2
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
USP1 protein, partial	21	0	0	21
Vitamin D-binding protein	0	0	1	1
Vitamin D3 receptor	0	1	2	4
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
DNA topoisomerase	0	1	0	1
15-lipoxygenase, partial	7	0	0	7
regulator of G-protein signaling 4	4	0	0	4
glucocerebrosidase	4	0	0	4
putative alpha-glucosidase	1	0	0	1
alpha-galactosidase	4	0	0	4
lysosomal alpha-glucosidase preproprotein	1	0	0	1
cytochrome P450 2C19 precursor	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
Telomerase reverse transcriptase	0	1	0	1
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
DNA ligase	0	1	0	1
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	3	3	13
Type-2 restriction enzyme BamHI	0	1	0	1
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
5-hydroxytryptamine receptor 2B	0	13	1	14
Type-2 restriction enzyme HindIII	0	1	0	1
Histone deacetylase 4	0	5	0	5
Ribonuclease pancreatic	0	1	0	1
Inositol monophosphatase 1	7	0	0	7
DNA topoisomerase 1	0	2	0	3
DNA topoisomerase 1	0	1	0	1
Integrase	0	3	0	3
Histone deacetylase 7	0	5	0	5
DNA topoisomerase type IB small subunit	0	0	1	1
Polyamine deacetylase HDAC10	0	5	0	5
Histone deacetylase 11	0	5	0	5
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Histone deacetylase 9	0	5	0	5
Histone deacetylase 5	0	5	0	5
Liver carboxylesterase 1	0	1	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	6	0	0	6
Proteasome subunit beta type-2	0	1	0	1
Proteasome subunit beta type-1	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
endonuclease IV	5	0	0	5
Glutathione reductase, mitochondrial	0	1	0	1
Glutathione reductase	0	1	0	1
Luciferase	8	0	0	8
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	8	0	9
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	7	0	8
Solute carrier family 22 member 1	0	11	0	11
Solute carrier family 22 member 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
ATP-dependent translocase ABCB1	0	4	0	4
Potassium-transporting ATPase alpha chain 1	0	1	0	1
ATP-dependent translocase ABCB1	0	5	0	5
Histamine H2 receptor	0	4	0	4
Histamine H1 receptor	0	0	3	3
Histamine H2 receptor	5	2	1	8
Potassium-transporting ATPase subunit beta	0	1	0	1
Cytochrome P450 2J2	0	6	0	6
Aldehyde oxidase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	4
Solute carrier family 22 member 1	0	4	0	4
Multidrug and toxin extrusion protein 2	0	5	0	5
Solute carrier family 22 member 8	0	4	0	6
Histamine H4 receptor	0	1	0	1
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 2	0	4	0	4
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Vasopressin V2 receptor	0	2	0	2
Vasopressin V1a receptor	0	3	1	4
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	1	0	1
nonstructural protein 1	6	0	0	6
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
Solute carrier family 22 member 3	0	6	0	6
Solute carrier family 22 member 3	0	1	0	1
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	2	2	4
C-8 sterol isomerase	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	3	1	4
Sigma non-opioid intracellular receptor 1	0	7	0	7
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	2	0	2
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	2
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	3	0	4
Thymidine kinase	0	1	0	1
Probable deoxycytidylate deaminase	0	0	0	2
Cytidine deaminase	0	1	0	4
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	9	0	0	9
Matrix metalloproteinase-9	0	2	0	2
Isocitrate lyase	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
RAD51	0	1	0	1
caspase-1 isoform alpha precursor	2	0	0	2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Caspase-7	2	0	0	2
Growth factor receptor-bound protein 2	0	1	0	1
Pantothenate synthetase	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	2	1	3
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	0	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	0	2	0	2
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	3	1	4
Serine-protein kinase ATM	0	1	0	1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	5	5
Regulatory-associated protein of mTOR	0	3	0	3
Phosphatidylinositol 3-kinase catalytic subunit type 3	0	2	0	2
Phosphoinositide 3-kinase regulatory subunit 5	0	1	0	1
Target of rapamycin complex subunit LST8	0	3	0	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	0	1
Spike glycoprotein	0	0	3	3
Replicase polyprotein 1ab	0	0	3	3
Transmembrane protease serine 2	0	0	3	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Tyrosine-protein kinase ABL1	0	2	0	2
Proto-oncogene tyrosine-protein kinase Src	0	2	2	4
Transthyretin	0	1	1	2
Neuronal proto-oncogene tyrosine-protein kinase Src	0	0	0	1
Proto-oncogene tyrosine-protein kinase LCK	0	2	0	2
Procathepsin L	0	0	3	3
Quinolone resistance protein NorA	0	2	0	2
Replicase polyprotein 1a	0	0	3	3
Replicase polyprotein 1ab	0	0	3	3
Replicase polyprotein 1ab	0	0	3	3
Replicase polyprotein 1ab	0	0	3	3
Angiotensin-converting enzyme	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	4	0	4
Tyrosine-protein kinase Blk	0	1	0	1
G protein-coupled receptor kinase 6	0	0	12	12
Potassium voltage-gated channel subfamily KQT member 1	0	4	0	4
DNA-dependent protein kinase catalytic subunit	0	4	0	4
Myelin transcription factor 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Sodium channel protein type 5 subunit alpha	0	5	0	5
Breakpoint cluster region protein	0	1	0	1
Protein cereblon	0	4	3	11
Angiotensin-converting enzyme 2	0	0	3	3
Potassium voltage-gated channel subfamily D member 3	0	4	0	4
NF-kappa-B essential modulator	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
runt-related transcription factor 1 isoform AML1b	2	0	0	2
core-binding factor subunit beta isoform 2	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
72 kDa type IV collagenase	0	2	0	2
Carbonyl reductase [NADPH] 1	0	0	0	1
Glutamate receptor 1	2	0	0	2
Glutamate receptor 3	2	0	0	2
Glutamate receptor 4	2	0	0	2
Platelet-activating factor receptor	1	0	0	1
Multidrug resistance-associated protein 1	0	3	0	5
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Thymidine kinase 2	0	1	0	1
AAA family ATPase	0	0	0	2
Kinesin-like protein KIF11	0	1	0	1
Nucleotide-binding oligomerization domain-containing protein 2	0	2	0	2
Genome polyprotein	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	2	0	5
Regulatory protein E2	0	0	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
DNA topoisomerase 2	0	0	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	1	4
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	4
Glutamate receptor ionotropic, NMDA 2C	0	3	1	5
DNA topoisomerase 2-alpha	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	1	4
Tubulin beta-2B chain	0	1	1	4
Similar to alpha-tubulin isoform 1	0	1	1	4
Similar to alpha-tubulin isoform 1	0	1	0	3
Glutamate receptor ionotropic, NMDA 3B	0	2	1	4
Glutamate receptor ionotropic, NMDA 3A	0	2	1	4
histone deacetylase 9 isoform 3	1	0	0	1
Albumin	0	3	1	4
Flavin reductase (NADPH)	0	0	1	1
corticotropin-releasing hormone receptor 2	0	1	1	2
corticotropin releasing factor-binding protein	0	1	1	2
5'-nucleotidase	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Vpr	2	0	0	2
Solute carrier family 22 member 8	0	0	0	2
Amyloid-beta precursor protein	3	0	0	3
Aromatase	0	6	0	6
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
cytochrome P450 2C9 precursor	1	0	0	1
D(1A) dopamine receptor	7	0	0	7
Cocaine esterase	0	2	0	3
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
Arylacetamide deacetylase	0	0	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	3	0	3
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Chain A, DEOXYNUCLEOSIDE KINASE	0	1	0	1
Equilibrative nucleoside transporter 1	0	1	0	1
Glycine receptor subunit alpha-1	0	0	2	2
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Stromelysin-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Urease subunit alpha	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Urease subunit beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain A, Purine-nucleoside Phosphorylase	0	1	0	1
Chain C, Xanthine dehydrogenase/oxidase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
DNA polymerase III, partial	3	0	0	3
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	5	0	0	5
glucokinase regulatory protein	1	0	0	1
DNA polymerase beta	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	3	0	0	3
Single-stranded DNA cytosine deaminase	2	0	0	2
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	2
Cytochrome P450 3A5	0	3	0	4
Oxysterols receptor LXR-beta	0	1	0	1
Tyrosine-protein kinase JAK2	0	0	1	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
DNA repair and recombination protein RadA	0	0	1	1
Indoleamine 2,3-dioxygenase 1	0	0	1	1
Nitric oxide synthase, brain	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
interferon gamma precursor	0	0	0	3
Interstitial collagenase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M4	0	6	0	6
Acetylcholinesterase	0	7	0	7
Cereblon isoform 4	0	3	0	3
Bromodomain-containing protein 4	0	2	0	2
DNA-binding protein Ikaros	0	0	1	4
DNA damage-binding protein 1	0	2	1	3
Zinc finger protein Aiolos	0	0	1	1
Kinesin-1 heavy chain	0	1	0	1
Nuclear receptor coactivator 4	0	1	0	1
Coiled-coil domain-containing protein 6	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Gonadotropin-releasing hormone receptor	0	1	0	1
Gonadotropin-releasing hormone receptor	0	2	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
apical membrane antigen 1, AMA1	3	0	0	3
UDP-glucose 6-dehydrogenase	0	1	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
UDP-glucuronosyltransferase 1A1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	2	0	0	2
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	2	3
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Kappa-type opioid receptor	0	5	3	9
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
5-hydroxytryptamine receptor 3E	0	1	2	4
cytochrome P450 2D6 isoform 1	3	0	0	3
5-hydroxytryptamine receptor 4	0	10	0	10
5-hydroxytryptamine receptor 3B	0	1	2	4
Albumin	0	0	1	1
Myeloperoxidase	0	1	0	1
D(2) dopamine receptor	0	6	1	7
Alpha-1B adrenergic receptor	0	5	1	6
D	0	2	0	2
D(3) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 1A	0	7	1	9
D(2) dopamine receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	3	1	4
5-hydroxytryptamine receptor 3A	0	2	0	2
D(1B) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	11	1	12
5-hydroxytryptamine receptor 1B	0	6	0	6
5-hydroxytryptamine receptor 1D	0	2	0	2
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1F	0	2	0	2
D(3) dopamine receptor	0	4	0	4
5-hydroxytryptamine receptor 3A	0	4	1	5
Alpha-1A adrenergic receptor	0	5	1	6
5-hydroxytryptamine receptor 3A	0	2	2	5
5-hydroxytryptamine receptor 7	0	4	0	4
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	3
5-hydroxytryptamine receptor 3D	0	1	2	4
5-hydroxytryptamine receptor 3C	0	1	2	4
5-hydroxytryptamine receptor 3B	0	2	0	2
5-hydroxytryptamine receptor 3B	0	4	1	5
Chain A, Probable serine/threonine-protein kinase pknB	0	1	0	1
WRN	1	0	0	1
hypothetical protein, conserved	1	0	0	1
nonstructural protein 1	0	1	0	1
LANA	0	0	0	1
pyruvate kinase	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
phospholipase A2, group III	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
histone-lysine N-methyltransferase NSD2 isoform 1	0	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
protein AF-9 isoform a	0	0	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
rac GTPase-activating protein 1 isoform a	0	1	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Aldo-keto reductase family 1 member B1	0	7	0	7
Muscarinic acetylcholine receptor M2	0	5	1	6
Ornithine decarboxylase	1	0	0	1
Muscarinic acetylcholine receptor M1	0	5	1	6
Angiotensin-converting enzyme	0	4	0	4
Sodium-dependent noradrenaline transporter	0	6	0	6
Guanine nucleotide-binding protein G	2	0	0	2
Casein kinase II subunit beta	0	1	0	1
NEDD8-activating enzyme E1 regulatory subunit	0	0	1	1
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Casein kinase II subunit alpha 3	0	1	0	1
NEDD8-activating enzyme E1 catalytic subunit	0	0	1	1
P2Y purinoceptor 12	0	1	0	1
phosphoglycerate kinase	1	0	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Muscarinic acetylcholine receptor M1	0	3	0	3
Muscarinic acetylcholine receptor M3	0	3	0	3
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M2	0	3	0	3
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	3	1	6
Mu-type opioid receptor	0	7	3	12
UDP-glucuronosyltransferase 1A3	0	0	0	1
Delta-type opioid receptor	0	9	3	14
Kappa-type opioid receptor	0	7	4	13
Mu-type opioid receptor	0	3	1	7
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-2 adrenergic receptor	0	3	1	5
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Formyl peptide receptor-related sequence 1	0	0	1	1
fMet-Leu-Phe receptor	0	2	2	4
N-formyl peptide receptor 2	0	0	2	2
FML2_HUMAN	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	2	0	2
NAD-dependent protein deacetylase HST2	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	4	0	4
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	3	0	3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	3	0	3
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
NAD-dependent protein deacetylase	0	1	0	1
Equilibrative nucleoside transporter 1	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Beta-lactamase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Malate dehydrogenase, cytoplasmic	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 1A	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Beta-2 adrenergic receptor	0	3	0	4
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Beta-1 adrenergic receptor	0	4	1	6
Interleukin-6 receptor subunit alpha	0	1	0	1
Beta-3 adrenergic receptor	0	3	0	3
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
5-hydroxytryptamine receptor 6	0	1	0	1
Histamine H1 receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 7	0	3	1	4
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Thyrotropin-releasing hormone receptor	0	1	0	1
Glycine receptor subunit alpha-4	0	1	0	1
Histamine H3 receptor	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Nischarin	0	1	0	1
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin alpha-3C chain	0	1	1	3
Botulinum neurotoxin type A	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	1	0	2
Substance-K receptor	0	4	0	4
UDP-glucuronosyltransferase 1A4	0	1	0	3
Cholecystokinin receptor type A	0	3	1	4
Melanocortin receptor 5	0	4	0	4
UDP-glucuronosyltransferase 2B10	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Thiosulfate sulfurtransferase	0	1	0	1
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
60 kDa chaperonin	0	1	0	1
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
10 kDa chaperonin	0	1	0	1
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
Solute carrier organic anion transporter family member 1B1	0	4	0	4
Histone deacetylase 8	0	1	0	1
Protein Tat	0	0	1	1
Leukotriene A-4 hydrolase	0	1	0	1
NAD-dependent protein deacetylase sirtuin-7	0	1	0	1
Histone deacetylase	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Receptor protein-tyrosine kinase	0	1	0	1
Testosterone 17-beta-dehydrogenase 3	0	1	0	1
Putative nucleoside diphosphate kinase	0	0	1	1
Nuclear receptor subfamily 4 group A member 3	0	1	0	1
Peroxiredoxin-like 2A	0	1	0	1
Platelet glycoprotein VI	0	1	0	1
Sterol 14-alpha-demethylase	0	0	2	2
14-alpha sterol demethylase	0	0	2	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Lanosterol 14-alpha demethylase	0	0	2	2
Sterol 14-alpha demethylase	0	0	2	2
Sterol 14-alpha demethylase	0	1	1	2
14-alpha sterol demethylase	0	0	2	2
14-alpha sterol demethylase	0	0	2	2
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	4	1	5
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Beta-1 adrenergic receptor	0	1	1	3
Muscarinic acetylcholine receptor M3	0	3	1	4
D(1A) dopamine receptor	0	3	1	4
Endothelin-1 receptor	0	1	1	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Sodium-dependent serotonin transporter	0	4	0	4
Beta-2 adrenergic receptor	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Bifunctional epoxide hydrolase 2	0	3	0	3
Vascular endothelial growth factor receptor 3	0	2	0	2
Vascular endothelial growth factor receptor 2	0	2	0	2
Low-density lipoprotein receptor	0	1	0	1
Fibronectin	0	1	0	1
Macrophage colony-stimulating factor 1 receptor	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	0	1	1
Proprotein convertase subtilisin/kexin type 9	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Exportin-1	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Programmed cell death protein 4	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	0	1	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	0	1	0	1
melanocortin receptor 4	0	1	1	2
Platelet-derived growth factor receptor beta	0	2	0	2
Cyclin-C	0	1	1	2
Serine/threonine-protein kinase B-raf	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
Protein delta homolog 1	0	1	2	3
Vascular endothelial growth factor receptor 2	0	1	0	1
Poly [ADP-ribose] polymerase tankyrase-2	0	0	2	2
RuvB-like 2	0	1	1	2
RuvB-like 1	0	1	0	1
Mast/stem cell growth factor receptor Kit	0	1	0	1
Beta-adrenergic receptor kinase 1	0	1	0	1
Platelet-derived growth factor receptor alpha	0	1	0	1
G protein-coupled receptor kinase 5	0	1	0	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Bromodomain-containing protein 9	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Bromodomain-containing protein 7	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	2	0	2
Splicing factor 3B subunit 3	0	1	0	1
Chain A, CES1 protein	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
streptokinase A precursor	0	0	1	1
Lysosomal acid glucosylceramidase	0	0	1	1
Estrogen receptor	0	0	1	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
D(4) dopamine receptor	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Phospholipase D1	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Luciferin 4-monooxygenase	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
Prostaglandin G/H synthase 1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	1	2
Endothelial PAS domain-containing protein 1	0	0	1	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	2	0	2
P2Y purinoceptor 14	0	0	1	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Adenosylhomocysteinase	0	1	0	1
RNA-directed RNA polymerase	0	1	1	2
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
Ricin	0	1	0	1
Cholinesterase	0	1	0	1
Butyrophilin subfamily 3 member A1	0	0	1	2
Geranylgeranyl pyrophosphate synthase	0	2	0	3
Farnesyl pyrophosphate synthase	0	2	0	2
Neutrophil collagenase	0	1	0	1
Farnesyl diphosphate synthase	0	1	0	1
Matrix metalloproteinase-14	0	1	0	1
Farnesyl pyrophosphate synthase	0	2	0	2
Geranylgeranyl pyrophosphate synthase	0	2	0	2
Farnesyl pyrophosphate synthase	0	1	0	1
H	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (503)

Protein Targets (1,740)

Tumor Lysis Syndrome

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (503)

Drugs Studied (164)

Protein Targets (1,740)