Any human metabolite produced by metabolism of a xenobiotic compound in humans.
| Member | Definition | Class |
|---|
| (-)-gallocatechin gallate | A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of (-)-gallocatechin. A natural product found in found in green tea. | (-)-gallocatechin gallate |
| (3,4-dimethoxyphenyl)acetic acid | A phenylacetic acid substituted at positions 3 and 4 by methoxy groups. | homoveratric acid |
| 1-methyl-4-phenylpyridinium | A pyridinium ion that is N-methylpyridinium having a phenyl substituent at the 4-position. | N-methyl-4-phenylpyridinium |
| 1-methyluric acid | An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trione substituted by a methyl group at N-1. It is one of the metabolites of caffeine found in human urine. | 1-methyluric acid |
| 1-naphthol | A naphthol carrying a hydroxy group at position 1. | 1-naphthol |
| 1-naphthylamine | A naphthylamine that is naphthalene substituted by an amino group at position 1. | 1-naphthylamine |
| 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid | A member of the class of beta-carbolines that is 1,2,3,4-tetrahydro-beta-carboline substituted at position 3 by a carboxy group. | 1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid |
| 1,25-dihydroxyergocalciferol | A hydroxycalciol that is vitamin D2 bearing additional hydroxy substituents at positions 1alpha and 25. | 1alpha,25-dihydroxyvitamin D2 |
| 1,3,5-trimethoxybenzene | A methoxybenzene carrying methoxy groups at positions 1, 3 and 5. It has been found to be a biomarker of flavonoid consumption in humans. | 1,3,5-trimethoxybenzene |
| 1,3,7-trimethylurate | An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8, and the nitrogens at positions 1, 3, and 7 are substituted by methyl groups. It is a metabolite of caffeine. | 1,3,7-trimethyluric acid |
| 1,3,7,9-tetramethyluric acid | An oxopurine that is uric acid in which the hydrogens at positions 1,3,7 and 9 are replaced by methyl groups. It is a purine alkaloid that is found in Chinese tea known as kucha (Camellia assamica var. kucha) and exhibits anti-inflammatory and analgesic properties. | 1,3,7,9-tetramethyluric acid |
| 1,6-diaminohexane | A C6 alkane-alpha,omega-diamine. | hexane-1,6-diamine |
| 1,7-dimethyluric acid | An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trione substituted by methyl groups at N-1 and N-7. It is a metabolite of caffeine and is often found in human urine samples. | 1,7-dimethyluric acid |
| 1,7-dimethylxanthine | A dimethylxanthine having the two methyl groups located at positions 1 and 7. It is a metabolite of caffeine and theobromine in animals. | 1,7-dimethylxanthine |
| 11-hydroxy-delta(9)-tetrahydrocannabinol | A phytocannabinoid that is Delta(9)-tetrahydrocannabinol in which the methyl group at C-11 has been hydroxylated . Major metabolite of Delta(9)-tetrahydrocannabinol. | 11-hydroxy-Delta(9)-tetrahydrocannabinol |
| 11-hydroxytestosterone | An androstanoid that is testosterone carrying an additional hydroxy substituent at the 11beta-position. | 11beta-hydroxytestosterone |
| 11,12-epoxy-5,8,14-eicosatrienoic acid | An 11,12-EET in which the epoxy moiety has 11S,12R-configuration. | (11S,12R)-EET |
| 13,14-dihydro-15-ketoprostaglandin e1 | A prostaglandin E obtained by formal oxidation of the 15-hydroxy group and hydrogenation of the 13,14-double bond of prostaglandin E1. | 13,14-dihydro-15-oxoprostaglandin E1 |
| 13(S)-HODE | An HODE (hydroxyoctadecadienoic acid) in which the double bonds are at positions 9 and 11 (E and Z geometry, respectively) and the hydroxy group is at position 13 (with S-configuration). | 13(S)-HODE |
| 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid | A HPETE that consists of (5Z,8Z,11Z,13E)-icosatetraenoic acid in which the hydroperoxy group is located at position 15. | 15-HPETE |
| 17-hydroxy-4,7,10,13,15,19-docosahexaenoic acid | A hydroxydocosahexaenoic acid that consists of 4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid bearing an additional 17-hydroxy substituent. | (4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid |
| 2-(3-pyridine)acetic acid | A monocarboxylic acid that is acetic acid substituted by a (pyridin-3-yl) group. It is a metabolite of nicotine and other tobacco alkaloids. | 3-pyridylacetic acid |
| 2-(s-glutathionyl)hydroquinone | A glutathione conjugate in which the thiol hydrogen of glutathione has been replaced by a 2,5-dihydroxyphenyl group. | 2-(glutathion-S-yl)-1,4-hydroquinone |
| 2-cresol | A cresol that is phenol substituted by a methyl group at position 2. It is a minor urinary metabolite of toluene. | o-cresol |
| 2-furoic acid | A furoic acid having the carboxylic acid group located at position 2. | 2-furoic acid |
| 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine | An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, hydoxyamino, and phenyl groups, respectively. The active metabolite of the dietary carcinogen PhIP. | N-hydroxy-PhIP |
| 2-hydroxyatrazine | A monohydroxy-1,3,5-triazine that is atrazine in which the chloro group has been replaced by a hydroxy group. | 4-ethylamino-6-isopropylamino-1,3,5-triazin-2-ol |
| 2-hydroxyisobutyric acid | A 2-hydroxy monocarboxylic acid that is isobutyric acid bearing a hydroxy substituent at position 2. It is a metabolite of methyl tertiary-butyl ether. | 2-hydroxyisobutyric acid |
| 2-naphthol | A naphthol carrying a hydroxy group at position 2. | 2-naphthol |
| 2-phenyl-2-propanol | A tertiary alcohol that is isopropanol in which the hydrogen attached to the carbon bearing the hydroxy group has been replaced by a phenyl group. | 2-phenylpropan-2-ol |
| 2-phenylbutyric acid | A monocarboxylic acid that is butyric acid substituted by a phenyl group at position 2. | 2-phenylbutyric acid |
| 2,3-dihydroxybenzoic acid | A dihydroxybenzoic acid that is benzoic acid substituted by hydroxy groups at positions 2 and 3. It occurs naturally in Phyllanthus acidus and in the aquatic fern Salvinia molesta. | 2,3-dihydroxybenzoic acid |
| 2,5-dichlorophenol | A dichlorophenol with the chloro substituents at positions 2 and 5. | 2,5-dichlorophenol |
| 2,5-hexanedione | A diketone that is hexane substituted by oxo groups at positions 2 and 5. It is a toxic metabolite of hexane and of 2-hexanone | 2,5-hexanedione |
| 25-hydroxyvitamin d 2 | A hydroxycalciol that is vitamin D2 in which the hydrogen at position 25 has been replaced by a hydroxy group. | 25-hydroxyvitamin D2 |
| 3-cresol | A cresol with the methyl substituent at position 3. It is a minor urinary metabolite of toluene. | m-cresol |
| 3-hydroxybenzeneacetic acid | A monocarboxylic acid that is phenylacetic acid in which the hydrogen at position 3 on the benzene ring is replaced by a hydroxy group. | 3-hydroxyphenylacetic acid |
| 3-hydroxyphenylacetate | A hydroxy monocarboxylic acid anion that is the conjugate base of 3-hydroxyphenylacetic acid; major species at pH 7.3. | 3-hydroxyphenylacetate |
| 3-phenoxybenzoic acid | A phenoxybenzoic acid in which the phenoxy group is meta to the carboxy group. It is a metabolite of pyrethroid insecticides. | 3-phenoxybenzoic acid |
| 3-tert-butyl-4-hydroxyanisole | An aromatic ether that is 4-methoxyphenol in which one of the hydrogens ortho- to the phenolic hydroxy group is replaced by a tert-butyl group. | 3-tert-butyl-4-hydroxyanisole |
| 3-toluic acid | A methylbenzoic acid carrying a methyl substituent at position 3. | m-toluic acid |
| 3,4-didehydroretinoic acid | A retinoid obtained by 3,4-desaturation of beta-ionone ring of all-trans-retinoic acid | all-trans-3,4-didehydroretinoic acid |
| 3,4-dihydroxyphenylpropionic acid | A monocarboxylic acid that is 3-phenylpropionic acid substituted by hydroxy groups at positions 3 and 4. Also known as dihydrocaffeic acid, it is a metabolite of caffeic acid and exhibits antioxidant activity. | 3-(3,4-dihydroxyphenyl)propanoic acid |
| 3,4,5-trimethoxybenzoic acid | A benzoic acid derivative carrying 3-, 4- and 5-methoxy substituents. | 3,4,5-trimethoxybenzoic acid |
| 3,5,6-trichloro-2-pyridinol | A hydroxypyridine that is pyridin-2-ol substituted by chloro groups at positions 3,5 and 6. It is a metabolite of the agrochemical chlorpyrifos. | 3,5,6-trichloro-2-pyridinol; 3,5,6-trichloropyridine-2-one |
| 4-bromophenol | A bromophenol containing only hydroxy and bromo substituents that are para to one another. | 4-bromophenol |
| 4-heptanone | A dialkyl ketone that is heptane in which the two methylene protons at position 4 have been replaced by an oxo group. | 4-heptanone |
| 4-methylumbelliferyl sulfate | A member of the class of coumarins that is umbelliferone sulfate which carries a methyl group at position 4. It is a metabolite of 4-methylumbelliferone. | 4-methylumbelliferone sulfate |
| 4-nitrocatechol | A member of the class of catechols that is benzene-1,2-diol substituted by a nitro group at position 4.It is the by-product of the hydroxylation of p-nitrophenol. | 4-nitrocatechol |
| 4-nitrophenol | A member of the class of 4-nitrophenols that is phenol in which the hydrogen that is para to the hydroxy group has been replaced by a nitro group. | 4-nitrophenol |
| 4-oxoretinoic acid | A retinoid that consists of all-trans-retinoic acid bearing an oxo substituent at position 4 on the cyclohexenyl ring. | all-trans-4-oxoretinoic acid |
| 4-vinylphenol | A member of the class of phenols that is styrene carrying a hydroxy substituent at position 4. | 4-hydroxystyrene |
| 5-oxo-15-hydroxy-6,8,11,13-eicosatetraenoic acid | An icosanoid that is (6E,8Z,11Z,13E)-icosatetraenoic acid substituted at positions 5 and 15 by oxo and hydroxy groups respectively. | (6E,8Z,11Z,13E,15S)-15-hydroxy-5-oxoicosatetraenoic acid |
| 5,12-dihydroxy-6,8,14-eicosatrienoic acid | A leukotriene obtained by formal dehydrogenation of the 10,11-double bond in leukotriene B4. | 10,11-dihydroleukotriene B4 |
| 5,15-dihydroxy-6,8,11,13-eicosatetraenoic acid | A DiHETE that is (6E,8Z,11Z,13E)-icosatetraenoic acid in which the two hydroxy substituents are placed at the 5S- and 15S-positions. | 5(S),15(S)-DiHETE |
| 5,6-didehydrosparteine | A quinolizidine alkaloid obtained by formal dehydrogenation at the 5,6-position of sparteine. It is a metabolite of sparteine found in human urine and plasma. | 5,6-didehydrosparteine |
| 5s,12r,18r-trihydroxy-6z,8e,10e,14z,16e-eicosapentaenoic acid | A resolvin that is (6Z,8E,10E,14Z,16E)-icosa-6,8,10,14,16-pentaenoic acid which is substituted at positions 5, 12 and 18 by hydroxy groups (the 5S,12R,18R stereoisomer). | resolvin E1 |
| 6-methylthioguanine | | 6-methylthioguanine |
| 7-hydroxydehydroepiandrosterone | An androstanoid that is dehydroepiandrosterone carrying an additional hydroxy substituent at the 7alpha-position. | 7alpha-hydroxydehydroepiandrosterone |
| 7-methylxanthine | An oxopurine that is xanthine in which the hydrogen attached to the nitrogen at position 7 is replaced by a methyl group. It is an intermediate metabolite in the synthesis of caffeine. | 7-methylxanthine |
| acrolein | An enal that is prop-2-ene with an oxo group at position 1. | acrolein |
| adipic acid | An alpha,omega-dicarboxylic acid that is the 1,4-dicarboxy derivative of butane. | adipic acid |
| aflatoxin m1 | A member of the class of aflatoxins that is aflatoxin B1 in which the hydrogen at position 9a is replaced by a hydroxy group. | aflatoxin M1 |
| aflatoxin q1 | A member of the class of aflatoxins that is aflatoxin B1 in which the hydrogen at the pro-3S position is replaced by a hydroxy group. | aflatoxin Q1 |
| androsta-1,4,6-triene-3,17-dione | An androstanoid that is androsta-1,4,6-triene substituted by oxo groups at positions 3 and 17. | androsta-1,4,6-triene-3,17-dione |
| arachidonic acid 5-hydroperoxide | A HPETE that consists of (6E,8Z,11Z,14Z)-icosatetraenoic acid in which the hydroperoxy group is located at position 5. | 5-HPETE |
| aspartyl-phenylalanine | A dipeptide formed from L-alpha-aspartyl and L-phenylalanine residues. It is obtained after the hydrolysis of aspartame in intestinal lumen. | Asp-Phe |
| benzohydrol | A secondary alcohol that is diphenylmethane which carries a hydroxy group at position 1. | diphenylmethanol |
| benzoic acid | A compound comprising a benzene ring core carrying a carboxylic acid substituent. | benzoic acid |
| benzoylecgonine | A benzoate ester metabolite of cocaine formed by hydrolysis of the methyl ester group, catalysed by carboxylesterases. | ecgonine benzoate |
| cotinine | An N-alkylpyrrolidine that consists of N-methylpyrrolidinone bearing a pyridin-3-yl substituent at position C-5 (the 5S-enantiomer). It is an alkaloid commonly found in Nicotiana tabacum. | (-)-cotinine |
| cyclamic acid | A member of the class of sulfamic acids that is sulfamic acid carrying an N-cyclohexyl substituent. | cyclohexylsulfamic acid |
| cyclohexanone | A cyclic ketone that consists of cyclohexane bearing a single oxo substituent. | cyclohexanone |
| demethylmirtazapine | A benzazepine metabolite resulting from demethylation of the antidpressant, mirtazapine. | N-demethylmirtazapine |
| dichlorodiphenyl dichloroethylene | A chlorophenylethylene that is ethylene substituted by two 4-chlorophenyl groups at position 1 and two chlorine atoms at position 2. | DDE |
| diethanolamine | A member of the class of ethanolamines that is ethanolamine having a N-hydroxyethyl substituent. | diethanolamine |
| diethyl phosphate | A dialkyl phosphate having ethyl as the alkyl group. | diethyl hydrogen phosphate |
| dihydro-3-coumaric acid | A monocarboxylic acid that is propionic acid carrying a 3-hydroxyphenyl substituent at C-3. | 3-(3-hydroxyphenyl)propanoic acid |
| dihydroferulic acid | A monocarboxylic acid that is propanoic acid in which one of the hydrogens at position 3 has been replaced by a 4-hydroxy-3-methoxyphenyl group. | dihydroferulic acid |
| dimethyldiselenide | An organoselenium compound that is diselane covalently bound to two methyl groups. It has been detected in onion-family vegetables and soft-necked garlics. It induces ER stress and toxic protein aggregation in the budding yeast, S. cerevisiae and used as a reagent to identify distonic radical cations. | dimethyl diselenide |
| eseroline | A pyrroloindole that is 1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole substituted by methyl groups at positions 1, 3a and 8 and a hydroxy group at position 5. It is a metabolite of physostigmine and causes neuronal cell death by a mechanism involving loss of cell ATP. | eseroline |
| estetrol | A 3-hydroxy steroid that is 17beta-estradiol which has been substituted at the 15alpha and 16alpha positions by two additional hydroxy groups. It is a natural estrogen produced exclusively during pregnancy by the fetal liver. | estetrol |
| estriol | A 3-hydroxy steroid that is estra-1,3,5(10)-trien-3-ol substituted by additional hydroxy groups at positions 16 and 17 (16alpha,17beta-stereoisomer). | estriol |
| ethyl arachidonate | A long-chain fatty acid ethyl ester resulting from the formal condensation of the carboxy group of arachidonic acid with the hydroxy group of ethanol. | ethyl arachidonate |
| gallic acid | A trihydroxybenzoic acid in which the hydroxy groups are at positions 3, 4, and 5. | gallic acid |
| gamma-terpinene | One of three isomeric monoterpenes differing in the positions of their two double bonds (alpha- and beta-terpinene being the others). In gamma-terpinene the double bonds are at the 1- and 4-positions of the p-menthane skeleton. | gamma-terpinene |
| gamma-valerolactone | A butan-4-olide that is dihydrofuran-2(3H)-one substituted by a methyl group at position 5. It has been found in the urine samples of humans exposed to n-hexane. | gamma-valerolactone |
| glycyrrhetyl 3-monoglucuronide | A triterpenoid saponin that is the 3-O-beta-glucuronide of glycyrrhetic acid. It is a metabolite of glycyrrhizin contained in licorice and potentially a causative agent in the pathogenesis of pseudoaldosteronism. | glycyrrhetic acid 3-O-glucuronide |
| hydratropic acid | A 2-arylpropionic acid carrying a phenyl group at position 2. It is a metabolite of alpha-methylstyrene (AMS), a volatile hydrocarbon. | hydratropic acid |
| hydroquinone | A benzenediol comprising benzene core carrying two hydroxy substituents para to each other. | hydroquinone |
| hydroxydione | A 3-oxo-5beta-steroid formed from 11-deoxycorticosterone by reduction across the C4-C5 double bond. | 5beta-dihydrodeoxycorticosterone |
| hydroxypioglitazone | A member of the class of thiazolidenediones that is the hydroxy derivative of pioglitazone. | hydroxypioglitazone |
| indole-3-acetonitrile | A nitrile that is acetonitrile where one of the methyl hydrogens is substituted by a 1H-indol-3-yl group. | indole-3-acetonitrile |
| indole-3-carbaldehyde | A heteroarenecarbaldehyde that is indole in which the hydrogen at position 3 has been replaced by a formyl group. | indole-3-carbaldehyde |
| kaempferol | A tetrahydroxyflavone in which the four hydroxy groups are located at positions 3, 5, 7 and 4'. Acting as an antioxidant by reducing oxidative stress, it is currently under consideration as a possible cancer treatment. | kaempferol |
| leukotriene b5 | A leukotriene composed of (6Z,8E,10E,14Z,17Z)-icosapentaenoic acid carrying (5S)- and (12R)-hydroxy substituents. | leukotriene B5 |
| mandelic acid | A 2-hydroxy monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by phenyl and hydroxyl groups. | mandelic acid |
| mandelic acid, (r)-isomer | The (R)-enantiomer of mandelic acid. | (R)-mandelic acid |
| melilotic acid | A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 3 is substituted by a 2-hydroxyphenyl group. | 3-(2-hydroxyphenyl)propanoic acid |
| meso-zeaxanthin | A carotenol that is beta,beta-carotene carrying two hydroxy substituents at positions 3 and 3' (the 3R,3'S-diastereomer). It is rarely found in diet and is believed to be formed at the macula by metabolic transformations of ingested carotenoids. | meso-zeaxanthin |
| methanearsonous acid | A one-carbon compound that is arsonous acid in which the hydrogen attached to arsenic is replaced by a methyl group. | methylarsonous acid |
| methoxyacetic acid | A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by a methoxy group. | methoxyacetic acid |
| methylselenic acid | An organoselenium compound that is seleninic acid in which the hydrogen attached to selenium is replaced by a methyl group. | methylseleninic acid |
| mono-n-octyl phthalate | A phthalic acid monoester obtained by formal condensation of one of the carboxy groups of phthalic acid with the hydroxy group of octanol. | monooctyl phthalate |
| mono(2-ethyl-5-hydroxyhexyl) phthalate | A phthalic acid monoester obtained by formal condensation of one of the carboxy groups of phthalic acid with the primary hydroxy group of 2-ethylhexane-1,5-diol | mono(2-ethyl-5-hydroxyhexyl) phthalate |
| mono(2-ethyl-5-oxohexyl)phthalate | A phthalic acid monoester obtained by formal condensation of one of the carboxy groups of phthalic acid with the hydroxy group of 2-ethyl-5-oxohexan-1-ol. | mono(2-ethyl-5-oxohexyl) phthalate |
| muconic acid | The trans,trans-isomer of muconic acid. It is metabolite of benzene in humans and serves as a biomarker of occupational exposure to benzene. | trans,trans-muconic acid |
| n-hydroxy-4-aminobiphenyl | A N-substituted amine that is 4-aminobiphenyl substituted by a hydroxy group at the nitrogen atom. | N-hydroxy-4-aminobiphenyl |
| n-methylthiourea | A member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by a methyl group. | N-methylthiourea |
| n(4)-hydroxycytidine | A nucleoside analogue that is cytidine which carries a hydroxy group at the N(4)-positon. It has broad-spectrum antiviral activity against influenza, SARS-CoV , SARS-CoV-2 and MERS-CoV. | N(4)-hydroxycytidine |
| norepinephrine, (+,-)-isomer | A catecholamine in which C-1 of the aminoethyl side-chain is hydroxy-substituted. | noradrenaline |
| o,o-diethyl phosphorothionate | An organic thiophosphate that is the diethyl ester of phosphorothioic O,O,O-acid. | O,O-diethyl hydrogen thiophosphate |
| pentachlorophenol | A chlorophenol that is phenol substituted by 5 chloro groups. | pentachlorophenol |
| phenol | An organic hydroxy compound that consists of benzene bearing a single hydroxy substituent. The parent of the class of phenols. | phenol |
| phenoxyacetic acid | A monocarboxylic acid that is the O-phenyl derivative of glycolic acid. A metabolite of 2-phenoxyethanol, it is used in the manufacture of pharmaceuticals, pesticides, fungicides and dyes. | phenoxyacetic acid |
| phenylalanine | The L-enantiomer of phenylalanine. | L-phenylalanine zwitterion; L-phenylalanine |
| phenylglyoxylic acid | A 2-oxo monocarboxylic acid that is glyoxylic acid in which the aldehyde hydrogen is substituted by a phenyl group. | phenylglyoxylic acid |
| phenylsulfate | An aryl sulfate that is phenol bearing an O-sulfo substituent. | phenyl hydrogen sulfate |
| phthalic acid | A benzenedicarboxylic acid cosisting of two carboxy groups at ortho positions. | phthalic acid |
| propylene glycol | The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze. | propane-1,2-diol |
| protectin d1 | A dihydroxydocosahexaenoic acid that is (4Z,7Z,11E,13E,15Z,19Z)-docosahexaenoic acid in which the two hydroxy substituents are located at positions 10 and 17 (the 10R,17S-stereoisomer). Protectin D1 is one of the specialised proresolving mediators. When produced in neural tissues, it is called neuroprotectin D1 | protectin D1 |
| protocatechuic acid | A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4. | 3,4-dihydroxybenzoic acid |
| psilocin | A tryptamine alkaloid that is N,N-dimethyltryptamine carrying an additional hydroxy substituent at position 4. A hallucinogenic alkaloid isolated in trace amounts from Psilocybe mushrooms (also known as Teonanacatl or "magic mushrooms"). | psilocin |
| quinone | The simplest member of the class of 1,4-benzoquinones, obtained by the formal oxidation of hydroquinone to the corresponding diketone. It is a metabolite of benzene. | 1,4-benzoquinone |
| resolvin d2 | A member of the class of resolvins that is (4Z,8E,10Z,12E,14E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 7, 16 and 17 (the 7S,16R,17S-stereoisomer). | resolvin D2 |
| resolvin d3 | A member of the class of resolvins that is (5Z,7E,9E,13Z,15E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 4, 11 and 17 (the 4S,11R,17S-stereoisomer). | resolvin D3 |
| resolvin D4 | A member of the class of resolvins that is (6E,8E,10Z,13Z,15E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 4, 5 and 17 (the 4S,5R,17S-stereoisomer). | resolvin D4 |
| resolvin e2 | A member of the class of resolvins that is (6E,8Z,11Z,14Z,16E)-icosapentaenoic acid carrying two hydroxy substituents at positions 5 and 18 (the 5S,18R stereoisomer). | resolvin E2 |
| retinol palmitate | An all-trans-retinyl ester obtained by formal condensation of the carboxy group of palmitic (hexadecanoic acid) with the hydroxy group of all-trans-retinol. It is used in cosmetic products to treat various skin disorders such as acne, skin aging, wrinkles, dark spots, and also protect against psoriasis. | all-trans-retinyl palmitate |
| riddelliine n-oxide | A pyrrolizine alkaloid that is 13,19-didehydrosenecionane bearing two additional hydroxy substituents at positions 12 and 18, two additional oxo groups at positions 11 and 16 and an N-oxido substituent. | riddelliine N-oxide |
| salicylurate | An N-acylglycine in which the acyl group is specified as 2-hydroxybenzoyl. | salicyluric acid |
| sodium benzoate | An organic sodium salt resulting from the replacement of the proton from the carboxy group of benzoic acid by a sodium ion. | sodium benzoate |
| styrene oxide | An epoxide that is oxirane in which one of the hydrogens has been replaced by a phenyl group. | styrene oxide |
| tert-butyl alcohol | A tertiary alcohol alcohol that is isobutane substituted by a hydroxy group at position 2. | tert-butanol |
| trandolaprilat | A heterobicyclic compound that is trandolapril in which the ethyl ester group has been hydrolysed to the corresponding acid group. It is the active metabolite of the prodrug trandolapril. | trandolaprilat |
| trifluoroacetic acid | A monocarboxylic acid that is the trifluoro derivative of acetic acid. | trifluoroacetic acid |
| trimethylamine | A tertiary amine that is ammonia in which each hydrogen atom is substituted by an methyl group. | trimethylamine |
| trimethylselenonium | An organic cation consisting of three methyl groups covalently bound to a central selenium atom. | trimethylselenonium |
| tropic acid | A 3-hydroxy monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a phenyl group, and one of the methyl hydrogens is substituted by a hydroxy group. | tropic acid |
| tyramine o-sulfate | An aryl sulfate that is tyramine in which the phenolic hydrogen at position 4 has been replaced by a sulfo group. | sulfuric acid [4-(2-aminoethyl)phenyl] ester; tyramine sulfate zwitterion; tyramine sulfate |
| tyramine o-sulfate | A zwitterion obtained by transfer of a proton from the sulfate to the amino group of tyramine sulfate; major species at pH 7.3. | sulfuric acid [4-(2-aminoethyl)phenyl] ester; tyramine sulfate zwitterion; tyramine sulfate |
| vitamin a2 | A retinoid derived from 3,4-desaturation of the beta-ionone ring of all-trans-retinol. | all-trans-3,4-didehydroretinol |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 10.8129 | 1 | 8 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 18.5518 | 1 | 6 |
| 67.9K protein | Vaccinia virus | Potency | 14.2513 | 2 | 4 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 54.8051 | 4 | 9 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 37.5704 | 2 | 12 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 25.6430 | 1 | 19 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 25.1189 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 31.4804 | 11 | 94 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 33.6024 | 3 | 38 |
| arylsulfatase A | Homo sapiens (human) | Potency | 15.1412 | 1 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 11.4677 | 1 | 3 |
| Ataxin-2 | Homo sapiens (human) | Potency | 29.7150 | 2 | 5 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 27.2024 | 2 | 4 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 27.1911 | 1 | 4 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.2118 | 2 | 6 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 58.0141 | 1 | 5 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 13.5186 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 27.1395 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 13.5186 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 27.1395 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 25.6242 | 3 | 28 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 14.0964 | 2 | 8 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 18.6551 | 1 | 6 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 37.6460 | 1 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 22.4113 | 1 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 12.5893 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 20.9961 | 1 | 4 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 18.2594 | 2 | 15 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 67.4022 | 1 | 6 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 13.5981 | 3 | 13 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 7.3738 | 2 | 3 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 21.7388 | 2 | 9 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 18.2594 | 2 | 15 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 75.0299 | 2 | 11 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 8.1548 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 7.9251 | 1 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 13.4504 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 32.4301 | 1 | 4 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 12.9244 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 19.3988 | 2 | 14 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 10.5774 | 1 | 5 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 53.6716 | 1 | 14 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 9.3680 | 2 | 2 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 28.3708 | 1 | 2 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 32.4648 | 1 | 2 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 5.3233 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 82.9265 | 1 | 7 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 25.2717 | 1 | 6 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 1.1582 | 1 | 1 |
| endonuclease IV | Escherichia coli | Potency | 10.0000 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 30.3546 | 12 | 135 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 23.4602 | 3 | 32 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 31.8988 | 10 | 71 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 13.4551 | 1 | 8 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 17.6341 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 30.0610 | 4 | 17 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 15.2825 | 2 | 6 |
| fructose-bisphosphate aldolase A | Oryctolagus cuniculus (rabbit) | Potency | 19.9526 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 13.4504 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| GALC protein | Homo sapiens (human) | Potency | 0.5623 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 19.3988 | 1 | 7 |
| geminin | Homo sapiens (human) | Potency | 10.4189 | 3 | 14 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 14.6474 | 2 | 50 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 24.3900 | 2 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 14.4992 | 2 | 7 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 19.3072 | 1 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 28.4292 | 4 | 31 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 7.0795 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 33.5685 | 2 | 12 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 7.0795 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 7.0795 | 1 | 1 |
| glyceraldehyde-3-phosphate dehydrogenase isoform 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 26.9537 | 1 | 3 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 48.5123 | 2 | 10 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 26.2000 | 2 | 2 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 12.2236 | 2 | 8 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 27.9150 | 1 | 7 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 28.7791 | 2 | 7 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 73.1882 | 2 | 24 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 13.4504 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 12.5893 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 56.3908 | 2 | 7 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 1.7901 | 2 | 4 |
| IDH1 | Homo sapiens (human) | Potency | 21.0441 | 1 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 55.0000 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 13.4504 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 23.6756 | 2 | 3 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 14.0341 | 1 | 4 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 14.0341 | 1 | 4 |
| Interferon beta | Homo sapiens (human) | Potency | 13.4504 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 66.0220 | 1 | 4 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 5.9878 | 2 | 9 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 10.1006 | 1 | 9 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 29.8816 | 1 | 2 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 50.9745 | 2 | 12 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 12.4822 | 1 | 2 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 69.6219 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 8.8549 | 2 | 9 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 20.8646 | 2 | 5 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 91.9997 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 50.0758 | 4 | 65 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 23.1093 | 1 | 1 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 48.9814 | 2 | 9 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 20.2435 | 1 | 13 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 18.7575 | 2 | 13 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 38.4018 | 3 | 53 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 85.2802 | 1 | 2 |
| Parkin | Homo sapiens (human) | Potency | 31.1123 | 2 | 3 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 8.4921 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 9.5129 | 2 | 3 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 53.1264 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 80.9849 | 4 | 20 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 28.0063 | 5 | 13 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 4.7755 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 28.4012 | 1 | 3 |
| PINK1 | Homo sapiens (human) | Potency | 32.1220 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 21.4806 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 104.2984 | 2 | 27 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 35.4813 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 35.5860 | 2 | 21 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 25.1189 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 104.3717 | 1 | 4 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 44.7164 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 29.6645 | 2 | 43 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 58.0479 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 20.7431 | 1 | 5 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 37.9025 | 3 | 61 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 56.8352 | 4 | 35 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 17.5531 | 3 | 3 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 16.3262 | 1 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 28.4511 | 2 | 8 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 28.4511 | 2 | 8 |
| Smad3 | Homo sapiens (human) | Potency | 24.3193 | 1 | 3 |
| snurportin-1 | Homo sapiens (human) | Potency | 55.0000 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 32.6672 | 1 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 2.5146 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.3955 | 2 | 26 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 33.9508 | 1 | 2 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 42.0559 | 2 | 11 |
| Thrombopoietin | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 35.6894 | 3 | 38 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 10.3756 | 2 | 9 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 32.7894 | 6 | 36 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 33.1575 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 34.7858 | 2 | 5 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 45.8689 | 2 | 19 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 30.5413 | 3 | 12 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 59.6596 | 1 | 5 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 35.9766 | 1 | 11 |
| Vpr | Human immunodeficiency virus 1 | Potency | 4.4668 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 17-beta-hydroxysteroid dehydrogenase type 1 | Homo sapiens (human) | IC50 | 1.0500 | 1 | 1 |
| 17-beta-hydroxysteroid dehydrogenase type 2 | Homo sapiens (human) | IC50 | 0.3600 | 2 | 2 |
| 3-dehydroquinate synthase | Escherichia coli K-12 | Ki | 54.5000 | 2 | 2 |
| 3-oxoacyl- | Pseudomonas aeruginosa | IC50 | 27.0000 | 1 | 1 |
| 3-oxoacyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 2.5500 | 1 | 2 |
| 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 | Homo sapiens (human) | IC50 | 99.2060 | 1 | 10 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0083 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.2820 | 3 | 4 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.0011 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.0078 | 1 | 1 |
| 5'-nucleotidase | Rattus norvegicus (Norway rat) | IC50 | 80.2000 | 1 | 1 |
| 6-phosphogluconate dehydrogenase, decarboxylating | Homo sapiens (human) | IC50 | 1.4500 | 1 | 1 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 99.2060 | 1 | 10 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 2.4729 | 2 | 2 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | Ki | 0.0012 | 1 | 1 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 62.0950 | 3 | 8 |
| Acetylcholinesterase | Drosophila melanogaster (fruit fly) | IC50 | 40,000.0000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 98.0800 | 3 | 6 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 183.6500 | 2 | 4 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 1.3300 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | Ki | 361.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | IC50 | 0.6800 | 1 | 1 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Homo sapiens (human) | IC50 | 101.7000 | 3 | 3 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Bos taurus (cattle) | IC50 | 80.2033 | 3 | 3 |
| Alpha-(1,3)-fucosyltransferase 7 | Homo sapiens (human) | IC50 | 99.2060 | 1 | 10 |
| Alpha-glucosidase MAL12 | Saccharomyces cerevisiae S288C | IC50 | 228.3667 | 2 | 3 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 9.3767 | 3 | 3 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 4.8200 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 10.2000 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 75.1000 | 3 | 3 |
| Androgen receptor | Homo sapiens (human) | IC50 | 9.7000 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 226.0021 | 1 | 2 |
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 | 7,700.0000 | 1 | 1 |
| Anthrax toxin receptor 2 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 3 |
| Arginase | Leishmania amazonensis | IC50 | 55.0000 | 1 | 1 |
| Aromatase | Homo sapiens (human) | Ki | 0.0912 | 2 | 2 |
| Aryl hydrocarbon receptor | Homo sapiens (human) | IC50 | 0.0280 | 1 | 1 |
| ATP phosphoribosyltransferase | Mycobacterium tuberculosis H37Rv | Ki | 50.0000 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 4.0300 | 1 | 1 |
| Autoinducer 2-binding periplasmic protein LuxP | Vibrio harveyi | IC50 | 50.0000 | 1 | 1 |
| Beta-carbonic anhydrase 1 | Mycobacterium tuberculosis H37Rv | Ki | 64.0000 | 1 | 1 |
| Beta-glucuronidase | Homo sapiens (human) | IC50 | 36.4700 | 1 | 1 |
| Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein) | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.6000 | 1 | 1 |
| Beta-lactamase | Klebsiella pneumoniae | IC50 | 2,000.0000 | 1 | 1 |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Leishmania major | IC50 | 2,000.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 5.4500 | 2 | 2 |
| C-terminal-binding protein 2 | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| Calcium release-activated calcium channel protein 1 | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| Calcium/calmodulin-dependent protein kinase type II subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 0.0001 | 1 | 1 |
| Calcium/calmodulin-dependent protein kinase type II subunit alpha | Rattus norvegicus (Norway rat) | Ki | 0.1259 | 1 | 1 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | Ki | 250.3450 | 1 | 2 |
| Carbonic anhydrase | Candida albicans SC5314 | Ki | 20.8500 | 2 | 2 |
| Carbonic anhydrase | Dicentrarchus labrax (European seabass) | Ki | 6.7425 | 1 | 4 |
| Carbonic anhydrase | Cryptococcus neoformans var. grubii | Ki | 25.9000 | 1 | 1 |
| Carbonic anhydrase | Mycobacterium tuberculosis H37Rv | Ki | 79.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | IC50 | 4.6300 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 130.8143 | 20 | 58 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 112.0939 | 10 | 37 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 697.0000 | 2 | 2 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 178.1580 | 4 | 30 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 126.0379 | 7 | 33 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | Ki | 8.5520 | 3 | 5 |
| Carbonic anhydrase 2 | Homo sapiens (human) | IC50 | 4.6300 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 116.1614 | 22 | 60 |
| Carbonic anhydrase 3 | Bos taurus (cattle) | IC50 | 4.6300 | 1 | 1 |
| Carbonic anhydrase 3 | Bos taurus (cattle) | Ki | 9.6460 | 2 | 5 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 127.8119 | 6 | 32 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 104.9700 | 12 | 48 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 362.5358 | 7 | 33 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 194.2169 | 6 | 32 |
| Carbonic anhydrase 6 | Homo sapiens (human) | IC50 | 4.6300 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 144.6058 | 10 | 43 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 223.2440 | 8 | 34 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 3,953.2964 | 12 | 39 |
| carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 | Homo sapiens (human) | IC50 | 9.9330 | 1 | 1 |
| Carboxylic ester hydrolase | Musca domestica (house fly) | IC50 | 25,000.0000 | 1 | 1 |
| Casein kinase II subunit alpha | Homo sapiens (human) | IC50 | 0.7000 | 2 | 2 |
| Casein kinase II subunit alpha 3 | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | IC50 | 0.7000 | 2 | 2 |
| Casein kinase II subunit beta | Homo sapiens (human) | IC50 | 0.7000 | 2 | 2 |
| Caspase-1 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| cathepsin L1 | Homo sapiens (human) | IC50 | 59.6420 | 1 | 1 |
| Cationic trypsin | Bos taurus (cattle) | IC50 | 105.9000 | 1 | 1 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | IC50 | 3.1000 | 1 | 1 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | Ki | 0.1320 | 1 | 1 |
| Chain A, AMINOPEPTIDASE | Streptomyces griseus | Ki | 12,700.0000 | 1 | 2 |
| Chain A, Benzoylformate Decarboxylase | Pseudomonas putida | Ki | 1,000.0000 | 1 | 1 |
| Chain A, Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 0.0900 | 1 | 3 |
| Chain A, Oxygen-insensitive Nad(p)h Nitroreductase | Enterobacter cloacae | Ki | 100.0000 | 1 | 1 |
| Chain A, Penicillin Amidohydrolase | Escherichia coli | Ki | 82.0000 | 1 | 7 |
| Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE | Pseudomonas putida | Ki | 10,000.0000 | 1 | 6 |
| Chain A, Protocatechuate 3,4-dioxygenase Alpha Chain | Acinetobacter baylyi ADP1 | Ki | 0.9000 | 1 | 1 |
| Chain A, Sulfotransferase 1A1 | Homo sapiens (human) | Ki | 283.0000 | 1 | 2 |
| Chain B, Benzoylformate Decarboxylase | Pseudomonas putida | Ki | 1,000.0000 | 1 | 1 |
| Chain B, Oxygen-insensitive Nad(p)h Nitroreductase | Enterobacter cloacae | Ki | 100.0000 | 1 | 1 |
| Chain B, Penicillin Amidohydrolase | Escherichia coli | Ki | 82.0000 | 1 | 7 |
| Chain B, Protocatechuate 3,4-dioxygenase Beta Chain | Acinetobacter baylyi ADP1 | Ki | 0.9000 | 1 | 1 |
| Chain C, Respiratory nitrate reductase 1 gamma chain | Escherichia coli | Ki | 0.0570 | 1 | 1 |
| Chain M, Protocatechuate 3,4-dioxygenase | Pseudomonas putida | Ki | 10,000.0000 | 1 | 6 |
| Cholinesterase | Homo sapiens (human) | Ki | 57.8650 | 2 | 7 |
| CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | Homo sapiens (human) | IC50 | 99.2060 | 1 | 10 |
| Coagulation factor XII | Homo sapiens (human) | Ki | 67.1675 | 1 | 6 |
| Cocaine esterase | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| Corticosteroid-binding globulin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Cyclin homolog | Herpesvirus saimiri (strain 11) | IC50 | 29.3750 | 1 | 4 |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| Cyclin-dependent kinase 1 | Oryzias latipes (Japanese medaka) | IC50 | 29.3750 | 1 | 4 |
| Cyclin-dependent kinase 5 activator 1 | Homo sapiens (human) | IC50 | 33.7000 | 2 | 5 |
| Cyclin-dependent kinase 6 | Homo sapiens (human) | IC50 | 27.9000 | 2 | 5 |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | IC50 | 33.7000 | 2 | 5 |
| Cytochrome P450 1A1 | Homo sapiens (human) | IC50 | 0.6320 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 0.7500 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 4,084.1832 | 2 | 5 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 0.0470 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.0430 | 1 | 1 |
| Cytochrome P450 2A5 | Mus musculus (house mouse) | IC50 | 387.1884 | 2 | 5 |
| Cytochrome P450 2A6 | Homo sapiens (human) | IC50 | 4,552.3720 | 4 | 8 |
| Cytochrome P450 2A6 | Homo sapiens (human) | Ki | 11.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 6.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
| D-amino-acid oxidase | Homo sapiens (human) | IC50 | 62.1723 | 4 | 4 |
| D-amino-acid oxidase | Homo sapiens (human) | Ki | 22.2800 | 5 | 5 |
| D-aspartate oxidase | Homo sapiens (human) | IC50 | 10,000.0000 | 2 | 2 |
| Death-associated protein kinase 1 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Dihydroorotate dehydrogenase | Leishmania major | IC50 | 677.2518 | 1 | 4 |
| Dihydroorotate dehydrogenase | Schistosoma mansoni | IC50 | 8.8000 | 1 | 1 |
| Dihydroorotate dehydrogenase (quinone), mitochondrial | Homo sapiens (human) | IC50 | 34.0000 | 1 | 1 |
| Dipeptidyl peptidase 3 | Homo sapiens (human) | IC50 | 32.9000 | 1 | 1 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 45.7133 | 2 | 3 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | IC50 | 36.1000 | 1 | 1 |
| Dopamine beta-hydroxylase | Bos taurus (cattle) | Ki | 700.0000 | 1 | 1 |
| Dual specificity protein phosphatase 1 | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| dual specificity protein phosphatase 6 | Rattus norvegicus (Norway rat) | IC50 | 93.7500 | 4 | 8 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Homo sapiens (human) | IC50 | 0.1210 | 1 | 1 |
| E-selectin | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| E3 ubiquitin-protein ligase Mdm2 | Homo sapiens (human) | IC50 | 13.9000 | 1 | 1 |
| E3 ubiquitin-protein ligase XIAP | Homo sapiens (human) | IC50 | 90.1000 | 2 | 2 |
| Enoyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 10.2500 | 1 | 2 |
| Estrogen receptor | Homo sapiens (human) | IC50 | 0.0017 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | Ki | 0.0005 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 1,230.2700 | 1 | 1 |
| G2/mitotic-specific cyclin-B | Marthasterias glacialis (spiny starfish) | IC50 | 29.3750 | 1 | 4 |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| G2/mitotic-specific cyclin-B2 | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| G2/mitotic-specific cyclin-B3 | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Bos taurus (cattle) | IC50 | 22.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Bos taurus (cattle) | IC50 | 22.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Bos taurus (cattle) | IC50 | 22.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Bos taurus (cattle) | IC50 | 22.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Bos taurus (cattle) | IC50 | 22.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Bos taurus (cattle) | IC50 | 22.0000 | 1 | 1 |
| Genome polyprotein | Zika virus | IC50 | 99.0000 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 39.3450 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | Ki | 17.8840 | 1 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | Saccharomyces cerevisiae S288C | IC50 | 0.2300 | 1 | 1 |
| Glutathione S-transferase Mu 1 | Mus musculus (house mouse) | IC50 | 100.0000 | 1 | 1 |
| glyceraldehyde-3-phosphate dehydrogenase isoform 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 2 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 39.3450 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 17.8840 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 39.3450 | 1 | 1 |
| Glycine receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 17.8840 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 39.3450 | 1 | 1 |
| Glycine receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 17.8840 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | IC50 | 39.3450 | 1 | 1 |
| Glycine receptor subunit beta | Rattus norvegicus (Norway rat) | Ki | 17.8840 | 1 | 1 |
| Glycogen synthase kinase-3 alpha | Homo sapiens (human) | IC50 | 3.5000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 3.5000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Rattus norvegicus (Norway rat) | IC50 | 29.3750 | 1 | 4 |
| Guanine deaminase | Homo sapiens (human) | Ki | 5.5500 | 1 | 1 |
| heat shock 70kDa protein 1A | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| heat shock cognate 71 kDa protein isoform 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| heat shock cognate 71 kDa protein isoform 2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Heat shock protein HSP 90-beta | Homo sapiens (human) | IC50 | 34.0000 | 1 | 1 |
| Hepatocyte growth factor receptor | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Histone acetyltransferase KAT8 | Homo sapiens (human) | IC50 | 181.0000 | 1 | 1 |
| Histone-lysine N-methyltransferase SETD7 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Inosine-5'-monophosphate dehydrogenase 2 | Homo sapiens (human) | IC50 | 22.7000 | 1 | 1 |
| Inositol hexakisphosphate kinase 2 | Homo sapiens (human) | IC50 | 2.5000 | 1 | 1 |
| Inositol polyphosphate multikinase | Homo sapiens (human) | IC50 | 4.4000 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 81.2500 | 2 | 2 |
| Interstitial collagenase | Homo sapiens (human) | IC50 | 2.6350 | 1 | 2 |
| Intestinal-type alkaline phosphatase | Bos taurus (cattle) | IC50 | 80.2060 | 5 | 5 |
| Intestinal-type alkaline phosphatase | Homo sapiens (human) | IC50 | 61.7333 | 3 | 3 |
| L-selectin | Homo sapiens (human) | IC50 | 27.6000 | 1 | 1 |
| Lactoylglutathione lyase | Homo sapiens (human) | IC50 | 20.6000 | 1 | 1 |
| Large neutral amino acids transporter small subunit 1 | Homo sapiens (human) | IC50 | 69.0000 | 2 | 2 |
| Large neutral amino acids transporter small subunit 1 | Rattus norvegicus (Norway rat) | Ki | 55.0000 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | IC50 | 7.7600 | 1 | 1 |
| Liver carboxylesterase 1 | Homo sapiens (human) | Ki | 71.8579 | 2 | 7 |
| Liver carboxylesterase 1 | Oryctolagus cuniculus (rabbit) | Ki | 71.8579 | 2 | 7 |
| M-phase inducer phosphatase 2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| M18 aspartyl aminopeptidase | Plasmodium falciparum 3D7 | IC50 | 0.4794 | 1 | 1 |
| Mandelate racemase | Pseudomonas putida | Ki | 700.0000 | 2 | 2 |
| MAP kinase-activated protein kinase 2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Matrilysin | Homo sapiens (human) | IC50 | 99.2060 | 1 | 10 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 18.7500 | 1 | 2 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 18.7500 | 1 | 2 |
| Mitogen-activated protein kinase kinase kinase 5 | Homo sapiens (human) | IC50 | 13.3000 | 1 | 1 |
| mothers against decapentaplegic homolog 3 isoform 1 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Multidrug resistance-associated protein 1 | Homo sapiens (human) | Ki | 2.4000 | 2 | 2 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 2.2400 | 1 | 1 |
| NADPH oxidase 4 | Homo sapiens (human) | IC50 | 1.2000 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/USSR/90/1977(H1N1)) | IC50 | 63.7000 | 2 | 2 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 38.5750 | 4 | 4 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | Ki | 21.1000 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 28.5000 | 2 | 2 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 28.5000 | 2 | 2 |
| Nicotinate phosphoribosyltransferase | Homo sapiens (human) | Ki | 0.0016 | 1 | 2 |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| nuclear receptor subfamily 0 group B member 1 | Homo sapiens (human) | IC50 | 67.5410 | 1 | 1 |
| P-selectin | Homo sapiens (human) | IC50 | 19.1000 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | IC50 | 390.0000 | 3 | 3 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | Ki | 1.2000 | 1 | 1 |
| Phenylethanolamine N-methyltransferase | Bos taurus (cattle) | IC50 | 1,000.0000 | 1 | 1 |
| Phospholipase A-2-activating protein | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Plasminogen activator inhibitor 1 | Homo sapiens (human) | IC50 | 6.6000 | 1 | 1 |
| Polypeptide N-acetylgalactosaminyltransferase 2 | Homo sapiens (human) | IC50 | 1.3700 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 1,033.8862 | 19 | 21 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 2.7000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 42.8000 | 2 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | IC50 | 55.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Oryctolagus cuniculus (rabbit) | IC50 | 5.4175 | 2 | 2 |
| Prolyl 4-hydroxylase subunit alpha-1 | Gallus gallus (chicken) | Ki | 6,768.5000 | 1 | 8 |
| Prolyl endopeptidase | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Prolyl hydroxylase EGLN2 | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | IC50 | 2.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | IC50 | 2.0000 | 1 | 1 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 1,780.4218 | 3 | 4 |
| Protein E6 | Human papillomavirus 16 | IC50 | 20.0000 | 1 | 1 |
| Protein orai-2 | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| Protein orai-3 | Homo sapiens (human) | IC50 | 500.0000 | 2 | 2 |
| Pteridine reductase 1 | Leishmania major | IC50 | 1,100.0000 | 1 | 1 |
| rac GTPase-activating protein 1 isoform a | Homo sapiens (human) | IC50 | 44.4900 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 2.3200 | 1 | 1 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 145.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 0.1567 | 2 | 3 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | IC50 | 100.0000 | 1 | 1 |
| Secreted chorismate mutase | Mycobacterium tuberculosis H37Rv | IC50 | 23.1000 | 1 | 1 |
| Serine racemase | Homo sapiens (human) | IC50 | 10,000.0000 | 1 | 1 |
| Serine/threonine-protein kinase pim-1 | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| Short transient receptor potential channel 5 | Homo sapiens (human) | IC50 | 3.9000 | 1 | 1 |
| Sialidase | Clostridium perfringens | IC50 | 8.0000 | 1 | 1 |
| Sialidase-2 | Homo sapiens (human) | IC50 | 230.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | IC50 | 10.0000 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 10.3360 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 26.7455 | 2 | 2 |
| Solute carrier family 2, facilitated glucose transporter member 1 | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | Ki | 6.9000 | 2 | 2 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | Ki | 12.3000 | 1 | 1 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | Ki | 2.4000 | 1 | 1 |
| Solute carrier family 22 member 2 | Rattus norvegicus (Norway rat) | Ki | 1.8000 | 1 | 1 |
| Solute carrier family 22 member 20 | Mus musculus (house mouse) | Ki | 798.1235 | 1 | 4 |
| Solute carrier family 22 member 3 | Homo sapiens (human) | Ki | 54.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | IC50 | 27.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Mus musculus (house mouse) | Ki | 126.2516 | 1 | 4 |
| Solute carrier family 22 member 6 | Rattus norvegicus (Norway rat) | Ki | 11.0000 | 2 | 2 |
| Solute carrier organic anion transporter family member 1A1 | Rattus norvegicus (Norway rat) | Ki | 9.8000 | 1 | 1 |
| Squalene monooxygenase | Rattus norvegicus (Norway rat) | IC50 | 73.0000 | 1 | 1 |
| Steroid hormone receptor ERR1 | Homo sapiens (human) | IC50 | 9.6400 | 1 | 1 |
| Substance-K receptor | Cavia porcellus (domestic guinea pig) | IC50 | 58.6000 | 1 | 1 |
| Substance-P receptor | Cavia porcellus (domestic guinea pig) | IC50 | 58.6000 | 1 | 1 |
| Tetraspanin | Rattus norvegicus (Norway rat) | IC50 | 12.0000 | 1 | 1 |
| Thiopurine S-methyltransferase | Homo sapiens (human) | IC50 | 173.7800 | 1 | 1 |
| Tissue-type plasminogen activator | Homo sapiens (human) | IC50 | 6.6000 | 1 | 1 |
| Toll-like receptor 2 | Mus musculus (house mouse) | IC50 | 61.5250 | 1 | 2 |
| Tryptophan 2,3-dioxygenase | Mus musculus (house mouse) | IC50 | 80.0000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 2,216.5275 | 4 | 4 |
| Tyrosinase | Mus musculus (house mouse) | IC50 | 137.8850 | 1 | 2 |
| Tyrosinase | Homo sapiens (human) | Ki | 520.0000 | 1 | 1 |
| Tyrosine-protein kinase Yes | Homo sapiens (human) | Ki | 6.7700 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 4,100.0000 | 1 | 2 |
| tyrosine-protein phosphatase non-receptor type 7 isoform 2 | Homo sapiens (human) | IC50 | 100.0000 | 2 | 4 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 260.0000 | 2 | 2 |
| Urokinase-type plasminogen activator | Homo sapiens (human) | IC50 | 6.6000 | 1 | 1 |
| Urokinase-type plasminogen activator | Mus musculus (house mouse) | IC50 | 6.6000 | 1 | 1 |
| Voltage-dependent calcium channel subunit alpha-2/delta-1 | Mus musculus (house mouse) | Ki | 0.9786 | 1 | 2 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 5.8000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 1.0600 | 1 | 1 |