calcium channel agonist

Agents that increase calcium influx into calcium channels of excitable tissues.

ChEBI ID: 38807

Members (4)

Member	Definition	Class
calcitriol	A hydroxycalciol that is calcidiol in which the pro-S hydrogen of calcidiol is replaced by a hydroxy group. It is the active form of vitamin D3, produced fom calciol via hydoxylation in the liver to form calcidiol, which is subsequently oxidised in the kidney to give calcitriol.	calcitriol
decamethrin	A cyclopropanecarboxylate ester obtained by formal condensation between 3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylic acid and cyano(3-phenoxyphenyl)methanol. It is the active insecticide of the proinsecticide tralomethrin.	deltamethrin
fpl 64176	1H-Pyrrole substituted at C-2 and -5 by methyl groups, at C-3 by methoxycarbonyl and at C-4 by a 2-benzylbenzoyl group.	FPL 64176
naadp	A nicotinic acid dinucleotide that is NADP(+) in which the carboxamide group on the pyridine ring is replaced by a carboxy group.	nicotinic acid-adenine dinucleotide phosphate

Research

Studies (18,018)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	3,149 (17.48)	18.7374
1990's	5,014 (27.83)	18.2507
2000's	4,313 (23.94)	29.6817
2010's	4,474 (24.83)	24.3611
2020's	1,068 (5.93)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	1,277 (6.80%)	5.53%
Reviews	1,923 (10.24%)	6.00%
Case Studies	1,008 (5.37%)	4.05%
Observational	41 (0.22%)	0.25%
Other	14,536 (77.38%)	84.16%

Protein Targets (103)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
activating transcription factor 6	Homo sapiens (human)	Potency	51.0665	1	2
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	44.6684	1	1
AR protein	Homo sapiens (human)	Potency	27.3060	2	2
arylsulfatase A	Homo sapiens (human)	Potency	0.6746	1	1
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	33.8078	1	1
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	19.9526	2	2
Cellular tumor antigen p53	Homo sapiens (human)	Potency	64.9647	2	3
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	19.9526	1	1
Chain A, Cruzipain	Trypanosoma cruzi	Potency	39.8107	1	1
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	17.5594	2	2
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	50.1187	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	0.3162	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	28.1838	1	1
chromobox protein homolog 1	Homo sapiens (human)	Potency	44.6684	1	1
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	0.1000	1	1
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	2.5119	1	1
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	39.8107	1	1
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	0.5012	2	2
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	100.0000	1	1
endonuclease IV	Escherichia coli	Potency	12.5893	1	1
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	37.8790	2	3
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	41.9192	7	11
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	17.4974	1	4
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	30.4517	2	3
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	0.5012	1	1
geminin	Homo sapiens (human)	Potency	21.1360	1	1
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	39.3581	5	7
heat shock protein beta-1	Homo sapiens (human)	Potency	58.9041	2	4
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	2.5119	1	3
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	56.0640	1	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	2.5119	2	2
Interferon beta	Homo sapiens (human)	Potency	32.9993	1	3
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	25.1189	1	1
M-phase phosphoprotein 8	Homo sapiens (human)	Potency	39.8107	1	1
Microtubule-associated protein tau	Homo sapiens (human)	Potency	14.0053	2	2
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	25.1189	1	1
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	0.0100	1	1
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	5.0119	1	1
NFKB1 protein, partial	Homo sapiens (human)	Potency	28.1838	2	2
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	15.8489	1	1
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	68.5896	1	1
nuclear factor NF-kappa-B p105 subunit isoform 1	Homo sapiens (human)	Potency	39.8107	1	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	45.5130	1	2
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	13.4574	2	3
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	29.5292	1	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	30.1313	1	1
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	0.0057	1	1
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	84.9214	1	1
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	52.2353	3	4
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	35.4813	1	1
PPM1D protein	Homo sapiens (human)	Potency	32.9993	1	2
pregnane X nuclear receptor	Homo sapiens (human)	Potency	8.3545	2	3
pregnane X receptor	Rattus norvegicus (Norway rat)	Potency	25.1189	1	1
progesterone receptor	Homo sapiens (human)	Potency	21.2794	1	2
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	58.2546	2	3
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	14.2440	1	1
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	42.6153	2	2
TDP1 protein	Homo sapiens (human)	Potency	20.9508	2	10
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	39.8107	1	1
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	18.8876	1	1
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	69.9313	2	2
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	0.0100	1	1
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	32.2834	3	3
USP1 protein, partial	Homo sapiens (human)	Potency	50.4512	1	2
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	31.6316	1	2

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Androgen receptor	Homo sapiens (human)	IC50	10.0000	1	1
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	133.0000	1	1
Bile salt export pump	Homo sapiens (human)	IC50	39.7000	1	1
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	133.0000	1	1
Cytochrome P450 2C19	Homo sapiens (human)	Ki	0.0001	1	1
Cytochrome P450 2C9	Homo sapiens (human)	IC50	0.0093	1	1
Cytochrome P450 2D6	Homo sapiens (human)	Ki	0.0001	1	1
Cytochrome P450 3A4	Homo sapiens (human)	IC50	0.0093	1	1
Cytochrome P450 3A4	Homo sapiens (human)	Ki	0.0001	1	1
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	133.0000	1	1
Transporter	Rattus norvegicus (Norway rat)	Ki	0.0001	1	1
Vitamin D3 receptor	Bos taurus (cattle)	IC50	0.0000	1	1
Vitamin D3 receptor	Homo sapiens (human)	IC50	0.3401	19	19
Vitamin D3 receptor	Rattus norvegicus (Norway rat)	Ki	0.0001	11	11

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	Homo sapiens (human)	EC50	0.0030	1	1
Chain A, Vitamin D Nuclear Receptor	Homo sapiens (human)	Kd	0.0006	1	1
Kappa-type opioid receptor	Cavia porcellus (domestic guinea pig)	EC50	0.0000	1	1
Retinoic acid receptor RXR-alpha	Homo sapiens (human)	EC50	0.0016	1	1
Vitamin D-binding protein	Homo sapiens (human)	Kd	0.0240	1	1
Vitamin D3 receptor	Bos taurus (cattle)	EC50	0.0001	2	2
Vitamin D3 receptor	Homo sapiens (human)	EC50	0.0394	36	36
Vitamin D3 receptor	Mus musculus (house mouse)	EC50	0.1000	1	1
Vitamin D3 receptor	Rattus norvegicus (Norway rat)	EC50	0.0002	7	7
Vitamin D3 receptor	Homo sapiens (human)	Kd	0.0001	1	1
Vitamin D3 receptor	Sus scrofa (pig)	Kd	0.0001	1	1
Vitamin D3 receptor A	Danio rerio (zebrafish)	EC50	0.0055	1	1
Vitamin D3 receptor A	Danio rerio (zebrafish)	Kd	1.2000	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Cytochrome P450 1A2	Homo sapiens (human)	ED50	0.0002	1	1
Cytochrome P450 2C9	Homo sapiens (human)	ED50	0.0002	1	2
Cytochrome P450 3A4	Homo sapiens (human)	ED50	0.0002	1	1
Vitamin D3 receptor	Homo sapiens (human)	ED50	0.1007	4	4
Vitamin D3 receptor	Rattus norvegicus (Norway rat)	ED50	500,000.0002	6	6