citrulline malate: an anti-fatigue cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 162762 |
| CHEMBL ID | 4297667 |
| SCHEMBL ID | 319676 |
| MeSH ID | M0193424 |
| Synonym |
|---|
| stimol (tn) |
| citrulline malate |
| 54940-97-5 |
| D07707 |
| (2s)-2-amino-5-(carbamoylamino)pentanoic acid; 2-hydroxybutanedioic acid |
| A830416 |
| (2s)-2-amino-5-ureido-pentanoic acid; 2-hydroxybutanedioic acid |
| AKOS015919504 |
| l-citrulline dl-malate (1:1) |
| 70796-17-7 |
| unii-pab4036kho |
| stimol |
| pab4036kho , |
| l-ornithine, n5-(aminocarbonyl)-, 2-hydroxybutanedioate (1:1) |
| l-citrulline dl-malate |
| l-ornithine, n5-(aminocarbonyl)-, hydroxybutanedioate (1:1) |
| citrulline malate [who-dd] |
| SCHEMBL319676 |
| l-citrulline-dl-malate |
| mfcd09839004 |
| GS-3899 |
| l-citrulline dl-malate(1:1) |
| (2s)-2-amino-5-(carbamoylamino)pentanoic acid;2-hydroxybutanedioic acid |
| citrulline malate (salt) [mi] |
| (s)-2-amino-5-ureidopentanoic acid 2-hydroxysuccinic acid salt |
| BCP11994 |
| l-citrulline dl-malate 2:1 |
| 2-hydroxybutanedioic acid--n~5~-[hydroxy(imino)methyl]ornithine (1/1) |
| DTXSID60970275 |
| Q27286437 |
| di-tert-butyl1-(tert-butylthio)-1,2-hydrazinedicarboxylate |
| CHEMBL4297667 |
| citrulline malate (salt) |
| l-citrulline malate |
| (s)-2-amino-5-ureidopentanoic acid compound with 2-hydroxysuccinic acid (1:1) |
| A914153 |
| l-citrulline,dl-malate |
| CS-0083737 |
| HY-N0391A |
Citrulline malate (CitMal) is a dietary supplement that is suggested to enhance strength training performance. It is a nonessential amino acid that increases exercise performance in males.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Citrulline malate (CitMal) is a dietary supplement that is suggested to enhance strength training performance. " | ( Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis. Bjørnsen, T; Gonzalez, AM; Vårvik, FT, 2021) | 2.41 |
| "Citrulline malate (CM) is a nonessential amino acid that increases exercise performance in males. " | ( Acute citrulline malate supplementation improves upper- and lower-body submaximal weightlifting exercise performance in resistance-trained females. Glenn, JM; Gray, M; Moyen, NE; Stewart, RW; Stone, MS; Wethington, LN, 2017) | 2.38 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Citrulline malate (CM) has been shown to improve muscle performance in healthy participants during a single exercise session. " | ( Effect of citrulline malate supplementation on muscle function and bioenergetics during short-term repeated bouts of fatiguing exercise. Bendahan, D; Giannesini, B; Meimoun, L; Pecchi, É; Vilmen, C, 2022) | 2.57 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Oral treatment by citrulline malate was found to increase resistance to fatigue in infected rats, whereas twitch tension was not modified." | ( Citrulline malate limits increase in muscle fatigue induced by bacterial endotoxins. Allaf, O; Gillardin, JM; Goubel, F; Vanhoutte, C; Verleye, M, 1997) | 2.06 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Further exploration of the optimal dose is therefore required including quantification of the bioavailability of NO, citrulline, and malate following ingestion of a range of CM doses." | ( A critical review of citrulline malate supplementation and exercise performance. Bridge, CA; Faghy, MA; Gough, LA; Higgins, MF; McNaughton, LR; Newbury, JW; Sparks, SA; Trexler, E, 2021) | 0.94 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " The most frequent dosage used in the studies was 8 g of citrulline malate." | ( Effect of citrulline on post-exercise rating of perceived exertion, muscle soreness, and blood lactate levels: A systematic review and meta-analysis. Jang, KM; Kim, SJ; Park, J; Rhim, HC, 2020) | 0.8 |
| " Reasons for the disparity in conclusions seem to be due to methodological discrepancies such as the testing protocols and the associated test-retest reliability, dosing strategy (i." | ( A critical review of citrulline malate supplementation and exercise performance. Bridge, CA; Faghy, MA; Gough, LA; Higgins, MF; McNaughton, LR; Newbury, JW; Sparks, SA; Trexler, E, 2021) | 0.94 |
| " Eighteen recreationally trained males consumed both a placebo (PL) and CM treatment for two separate dosing periods." | ( Acute and Chronic Citrulline Malate Supplementation on Muscle Contractile Properties and Fatigue Rate of the Quadriceps. Farney, TM; Fick, AN; Hearon, CM; Kowalsky, RJ; Stone, MS, 2021) | 0.96 |
| Item | Process | Frequency |
|---|---|---|
| Energy drinks | core-ingredient | 5 |
| Beverages | core-ingredient | 4 |
| Artificially sweetened beverages | core-ingredient | 2 |
| Dietary supplements | core-ingredient | 1 |
| pre workout | core-ingredient | 1 |
| creatine | core-ingredient | 1 |
| Non-alcoholic beverages | core-ingredient | 1 |
| Energy drink without sugar and with artificial sweeteners | core-ingredient | 1 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (10.26) | 18.2507 |
| 2000's | 3 (7.69) | 29.6817 |
| 2010's | 18 (46.15) | 24.3611 |
| 2020's | 14 (35.90) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (59.09) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 23 (58.97%) | 5.53% |
| Reviews | 6 (15.38%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (25.64%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||