Page last updated: 2024-08-05 11:24:33
azacycloalkane
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ChEBI ID: 37949
Members (11)
Member | Definition | Role |
---|---|---|
1,4,7-triazacyclononane | 1,4,7-triazonane | |
azetidine | azetidine | |
aziridine | aziridine | |
cyclam | 1,4,8,11-tetraazacyclotetradecane | |
cyclen | An azacycloalkane that is cyclododecane in which the carbon atoms at positions 1, 4, 7 and 10 are replaced by nitrogen atoms. | 1,4,7,10-tetraazacyclododecane |
hexahydroazepine | An azacycloalkane that is cycloheptane in which one of the carbon atoms is replaced by a nitrogen atom. | azepane |
imidazolidines | imidazolidine | |
piperazine | An azacycloalkane that consists of a six-membered ring containing two nitrogen atoms at opposite positions. | piperazine |
piperidine | An azacycloalkane that is cyclohexane in which one of the carbons is replaced by a nitrogen. It is a metabolite of cadaverine, a polyamine found in the human intestine. | piperidine |
plerixafor | An azamacrocycle consisting of two cyclam rings connected by a 1,4-phenylenebis(methylene) linker. It is a CXCR4 chemokine receptor antagonist and a hematopoietic stem cell mobilizer. It is used in combination with grulocyte-colony stimulating factor (G-CSF) to mobilize hematopoietic stem cells to the perpheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin's lymphoma and multiple myeloma. | plerixafor |
pyrrolidine | A cyclic amine whose five-membered ring contains four carbon atoms and one nitrogen atom; the parent compound of the pyrrolidine family. | pyrrolidine |
Research
Studies (6,167)
Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
---|---|---|
pre-1990 | 933 (15.13) | 18.7374 |
1990's | 603 (9.78) | 18.2507 |
2000's | 1,516 (24.58) | 29.6817 |
2010's | 2,548 (41.32) | 24.3611 |
2020's | 567 (9.19) | 2.80 |
Study Types
Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
---|---|---|
Trials | 309 (4.74%) | 5.53% |
Reviews | 332 (5.09%) | 6.00% |
Case Studies | 112 (1.72%) | 4.05% |
Observational | 9 (0.14%) | 0.25% |
Other | 5,762 (88.32%) | 84.16% |