ascorbic-acid and salicylamide
ascorbic-acid has been researched along with salicylamide* in 5 studies
Other Studies
5 other study(ies) available for ascorbic-acid and salicylamide
Article | Year |
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[Use of a densitometric method for analysis of active substances in the drugs. XVI. Multicomponent drugs containing ascorbic acid].
A densitometric method for the determination of active substances in Ascofer, Fenquil, Rutinoscorbin and Scorbolamid after separation of their components by means of TLC-has been elaborated. Usefulness of the method was checked by comparison of the obtained results with those afforded by means of reference methods. Topics: Ascorbic Acid; Densitometry; Drug Combinations; Drug Compounding; Ethanol; Methanol; Poland; Salicylamides; Tablets | 1989 |
Modulation of genotoxic and cytotoxic effects of aromatic amines in monolayers of rat hepatocytes.
Cultured rat hepatocytes exposed to 2-acetylaminofluorene (AAF), 2-aminofluorene (AF) or N-hydroxy-2-acetylaminofluorene (N-OH-AFF) for 3 hrs resulted in an increase in DNA repair measured as unscheduled DNA synthesis, with N-OH-AAF greater than AAF greater than AF. Cytotoxic effects were only seen with N-OH-AAF above 10(-6) M. alpha-Naphthoflavone increased the unscheduled DNA synthesis and cytotoxic effects of N-OH-AAF, whereas it decreased DNA repair and the covalent binding of AAF to cellular proteins. In contrast, very little effects of paraoxon were seen on the repair synthesis elicited by AAF, AF or N-OH-AAF. The addition of ascorbate reduced the covalent binding of AAF, the DNA repair synthesis caused by AAF and N-OH-AAF, and the cytotoxic effects of N-OH-AAF. The addition of pentachlorophenol or salicylamide all resulted in similar effects as ascorbate, through reduction of sulfation. Galactosamine, an inhibitor of glucuronidation, and the nucleophile GSH caused no or only minor effects of the activation of AAF, AF or N-OH-AAF as judged from the endpoints tested. These results are consistent with an arylnitrenium ion, a sulfate ester or a free radical as the arylamine metabolite causing cellular DNA damage, whereas the sulfate ester or a radical intermediate may be responsible for the cytotoxic effects of N-OH-AAF. Topics: 2-Acetylaminofluorene; Animals; Ascorbic Acid; Benzoflavones; Carcinogens; Cells, Cultured; DNA; DNA Repair; Fluorenes; Galactosamine; Glutathione; Harmine; Hydroxyacetylaminofluorene; Liver; Male; Mutagens; Paraoxon; Pentachlorophenol; Pyridines; Rats; Rats, Inbred Strains; Salicylamides | 1984 |
[Therapeutic effect of prednisone-salicylamide-ascorbic acid combination (prednicyl) in rheumatic polyarthritis].
Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Humans; Prednisone; Salicylamides; Vitamins | 1957 |
Adrenal response of rats to salicylamide and sodium salicylate with and without para-aminobenzoic acid.
Topics: 4-Aminobenzoic Acid; Adrenal Glands; Animals; Ascorbic Acid; Cholesterol; Rats; Salicylamides; Salicylates; Sodium Salicylate | 1954 |
Salicylamide II. A note on the effect of salicylamide on the circulating eosinophils and ascorbic acid of the rat.
Topics: Adrenal Cortex; Animals; Ascorbic Acid; Eosinophils; Leukocyte Count; Rats; Salicylamides; Salicylates | 1954 |