Page last updated: 2024-08-05 11:16:39

1,4-naphthoquinones

A naphthoquinone in which the oxo groups of the quinone moiety are at positions 1 and 4 of the parent naphthalene ring.

ChEBI ID: 132142

Members (18)

MemberDefinitionRole
1,4-naphthoquinoneThe parent structure of the family of 1,4-naphthoquinones, in which the oxo groups of the quinone moiety are at positions 1 and 4 of the naphthalene ring. Derivatives have pharmacological properties.1,4-naphthoquinone
2-(2-hydroxyethylamino)-3-(4-methoxyanilino)naphthalene-1,4-dione2-(2-hydroxyethylamino)-3-(4-methoxyanilino)naphthalene-1,4-dione
2-(4-ethoxyanilino)-3-methoxynaphthalene-1,4-dione2-(4-ethoxyanilino)-3-methoxynaphthalene-1,4-dione
2-amino-3-chloro-1,4-naphthoquinoneQuinoclamin
2-chloro-1,4-naphthoquinone2-chloro-1,4-naphthoquinone
2-chloro-3-(4-methylanilino)naphthalene-1,4-dione2-chloro-3-(4-methylanilino)naphthalene-1,4-dione
2-chloro-3-(prop-2-enylamino)naphthalene-1,4-dione2-chloro-3-(prop-2-enylamino)naphthalene-1,4-dione
2-methoxy-1,4-naphthoquinoneA naphthoquinone that is naphthalene-1,4-dione substituted by a methoxy group at position 2. It has been isolated from the roots of Rubia yunnanensis.2-methoxy-1,4-naphthoquinone
2,3-dimethoxy-1,4-naphthoquinoneA naphthoquinone that is 1,4-naphthoquinone bearing two methoxy substituents at positions 2 and 3. Redox-cycling agent that induces intracellular superoxide anion formation and, depending on the concentration, induces cell proliferation, apoptosis or necrosis. Used to study the role of ROS in cell toxicity, apoptosis, and necrosis.2,3-dimethoxynaphthalene-1,4-dione
3-[[3-(4-morpholinyl)-1,4-dioxo-2-naphthalenyl]amino]benzoic acid3-[[3-(4-morpholinyl)-1,4-dioxo-2-naphthalenyl]amino]benzoic acid
4-[(1,4-dioxo-2-naphthalenyl)amino]benzenesulfonamide4-[(1,4-dioxo-2-naphthalenyl)amino]benzenesulfonamide
4-chloro-N-[3-(3-methyl-1-piperidinyl)-1,4-dioxo-2-naphthalenyl]benzenesulfonamide4-chloro-N-[3-(3-methyl-1-piperidinyl)-1,4-dioxo-2-naphthalenyl]benzenesulfonamide
4-chloro-N-[3-(N-methylanilino)-1,4-dioxo-2-naphthalenyl]benzamide4-chloro-N-[3-(N-methylanilino)-1,4-dioxo-2-naphthalenyl]benzamide
acequinocylAn acetate ester consisting of 1,4-naphthoquinone bearing acetoxy and dodecyl substituents at positions 2 and 3 respectively.acequinocyl
chimaphilinChimaphylin
N-[3-(4-methyl-1-piperazinyl)-1,4-dioxo-2-naphthalenyl]benzenesulfonamideN-[3-(4-methyl-1-piperazinyl)-1,4-dioxo-2-naphthalenyl]benzenesulfonamide
nsc 953972,3-bis(2-hydroxyethylthio)naphthalene-1,4-dione
vitamin k 3A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.menadione

Research

Studies (1,683)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-1990173 (10.28)18.7374
1990's76 (4.52)18.2507
2000's628 (37.31)29.6817
2010's653 (38.80)24.3611
2020's153 (9.09)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials12 (0.63%)5.53%
Reviews37 (1.93%)6.00%
Case Studies8 (0.42%)4.05%
Observational0 (0.00%)0.25%
Other1,862 (97.03%)84.16%