Compounds > irganox 1010
Page last updated: 2024-12-06

irganox 1010

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Occurs in Manufacturing Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Irganox 1010, also known as pentaerythritol tetrakis(3,5-di-tert-butyl-4-hydroxyhydrocinnamate), is a hindered phenolic antioxidant widely used in polymers and other materials to prevent degradation caused by oxidation. It is synthesized through a multi-step process involving the reaction of pentaerythritol with 3,5-di-tert-butyl-4-hydroxyhydrocinnamic acid. Irganox 1010 effectively scavenges free radicals, thereby inhibiting chain reactions that lead to polymer degradation. Its high effectiveness and compatibility with various polymers have made it a crucial component in numerous applications, including plastics, rubber, and fuels. Research on Irganox 1010 focuses on understanding its mechanism of action, optimizing its performance, and exploring potential environmental and health effects. The compound's impact on the environment and potential toxicity are areas of ongoing study.'
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pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate): has antioxidant activity [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID64819
CHEMBL ID3187856
SCHEMBL ID30209
MeSH IDM0132908

Synonyms (100)

Synonym
AC-15274
AKOS005444166
irganox 1010
hydrocinnamic acid, 3,5-di-tert-butyl-4-hydroxy-, tetraester with pentaerythritol
naugard 10
ra 1010
irganox 1010ff
irganox 1010fp
phenosane 23
einecs 229-722-6
fenozan 22
tetrakis(3-(4-hydroxy-3,5-di-tert-butylphenyl)propionyloxymethyl)methane
ralox 630
sumilizer bp 101
pentaerythritol, tetrakis(3,5-di-tert-butyl-4-hydroxyhydrocinnamate)
dovernox 10
neopentanetetrayl 3,5-di-tert-butyl-4-hydroxyhydrocinnamate
phenosan-23
tetrakis(methylene(3,5-di-tert-butyl-4-hydroxyhydrocinnamate)methane
irganox 1040
benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, 2,2-bis((3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-1-oxopropoxy)methyl)-1,3-propanediyl ester
anox 20
hydrocinnamic acid, 3,5-di-tert-butyl-4-hydroxy-, neopentanetetrayl ester
anox 20am
tetrakis(((beta-(3,5-di-tert-butyl-4-hydroxyphenyl)propionyl)oxy)methyl)methane
mark ao 60
tetrakis(3,5-di-tert-butyl-4-hydroxyhydrocinnamoyloxymethyl)methane
ao 60
adk stab ao 60
brn 2035465
ir 1010
tetraalkofen bpe
bp 101
fenozan 23
pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate)
STK367172
pentaerythritol tetrakis(3,5-di-tert-butyl-4-hydroxyhydrocinnamate), 98%
AO3 ,
benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, 2,2-bis[[3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-1-oxopropoxy]methyl]-1,3-propanediyl ester
3-{[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl]oxy}-2,2-bis({[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl]oxy}methyl)propyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate
6683-19-8
[3-[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxy]-2,2-bis[3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyloxymethyl]propyl] 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate
FT-0659922
tetrakis[methylene-3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]methane
P0932
pentaerythritol tetrakis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate]
dtxsid1027633 ,
tox21_301970
NCGC00255211-01
cas-6683-19-8
dtxcid007633
ec 229-722-6
pentaerithritol tetrakis(3,5-di-tert-butyl-4-hydroxyhydrocinnamate)
255pif62ms ,
benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, 1,1'-(2,2-bis((3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-1-oxopropoxy)methyl)-1,3-propanediyl) ester
unii-255pif62ms
2,2-bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)
pentaerythrityl tetrakis(3,5-di-tert-butyl-4-hydroxyhydrocinnamate)
pentaerythritol 4-hydroxy-3,5-di-tert-butylphenylpropionate
pentaerythritol 3-(4-hydroxy-3,5-di-tert-butylphenyl)propionate (1:4)
pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate
plastic additive 2
pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate [inci]
pentaerythrityl tetrakis(3,5-di-tert- butyl-4-hydroxyhydrocinnamate)
pentaerythrityl tetrakis (3,5-di-tert-butyl-4-hydroxyhydrocinnamate)
antioxidant 1010 ,
irganox-1010
pentaerythritol tetrakis ester with 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionic acid
plastic additive 2 [usp-rs]
tinogard ttdd
tinogard tt
pentaerthrityl tetra-di-t-butyl hydroxyhydrocinnamate
pentaerythritol tetrakis(3,5-di-tert-butyl-4-hydroxyhydrocinnamate)
pentaerithritol tetrakis[3,5-di-tert-butyl-4-hydroxyhydrocinnamate]
SCHEMBL30209
W-104737
3-([3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyl]oxy)-2,2-bis(([3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoyl]oxy)methyl)propyl 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate #
benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, 1,1'-[2,2-bis[[3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-1-oxopropoxy]methyl]-1,3-propanediyl] ester
tetrakis [methylene (3,5-di-t-butyl-4-hydroxyhydrocinnamate)] methane
pentaerythritol tetrakis[3-(3',5'-di-tert-butyl-4'-hydroxyphenyl)propionate]
pentaerythrityl tetrakis-3-(3',5'-di-t-butyl-4'-hydroxyphenyl)propionate
lowinox pp35
tetrakis[methylene(3,5-di-tert-butyl-4-hydroxyhydrocinnamate)methane]
CHEMBL3187856
mfcd00059345
plastic additive 2, united states pharmacopeia (usp) reference standard
plastic additive 09, european pharmacopoeia (ep) reference standard
2,2-bis((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyloxy)methyl)propane-1,3-diyl bis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)
2,2-bis[[[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl]oxy]methyl]propane-1,3-diyl bis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate]
SY052363
irganox1010
AS-13857
AMY37985
Q27253913
CS-W011369
2,2-bis(((3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoyl)oxy)methyl)propane-1,3-diylbis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate)
tetrakis-(methylene-(3,5-di-(tert)-butyl-4-hydrocinnamate)) methane
plastic additive 2 (usp-rs)
PD132638
tetrakis[3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionyloxymethyl]methane

Research Excerpts

Overview

Irganox 1010 is a common commercial antioxidant (polymer additive) used in the manufacturing of polyolefin materials for container closure systems.

ExcerptReferenceRelevance
"Irganox 1010 is a common commercial antioxidant (polymer additive) used in the manufacturing of polyolefin materials for container closure systems."( Identification of leachable impurities in an ophthalmic drug product originating from a polymer additive Irganox 1010 using mass spectroscopy.
Blinder, A; Gollapalli, R; Patel, M; Singh, G, 2018)		1.42

Dosage Studied

ExcerptRelevanceReference
" A cell culture irritation test was dosed with a positive control, negative control and PTTC."( Localized delivery of a lipophilic proteasome inhibitor into human skin for treatment of psoriasis.
Arbiser, J; Banga, AK; Coulon, R; Gujjar, M, 2016)		0.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (3 Product(s))

Product Categories

Product CategoryProducts
Beauty & Personal Care3

Products

ProductBrandCategoryCompounds Matched from IngredientsDate Retrieved
Dead Sea Naturals Facial Moisturizer Broad Spectrum SPF 20 -- 1.7 fl ozDead Sea NaturalsBeauty & Personal Carebutylene glycol, aminomethyl propanol, citric acid, ascorbyl palmitate, ascorbyl glucoside, ascorbic acid, cetearyl alcohol, citric acid, tocopherol, ethylhexylglycerin, tocopherol, vitamin E, glyceryl stearate, glycerin, dimethicone, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, lactic acid, niacinamide, phenoxyethanol, propylene glycol, salicylic acid, beta-sitosterol, sodium benzoate, sodium citrate, sodium hydroxide, squalene, stearyl alcohol2024-11-29 10:47:42
Dead Sea Naturals Skincare Starter Kit -- 1 KitDead Sea NaturalsBeauty & Personal Carecaprylyl glycol, butylene glycol, aminomethyl propanol, methylpropanediol, citric acid, ascorbyl palmitate, alanine, allantoin, ascorbyl glucoside, ascorbic acid, bisabolol, cetearyl alcohol, cetyl alcohol, cetyl palmitate, chlorphenesin, citric acid, cocamidopropyl betaine, tocopherol, panthenol, pro vitamin B5, ethylhexylglycerin, farnesol, tocopherol, vitamin E, glyceryl stearate, glycerin, glycine, dimethicone, hexyl cinnamal, hydroxyethylcellulose, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, isopropyl myristate, kaolin, lactic acid, linalool, niacinamide, phenoxyethanol, peg-40 stearate, propylene glycol, salicylic acid, beta-sitosterol, sodium benzoate, sodium citrate, sodium hydroxide, sodium lactate, squalene, stearyl alcohol, trehalose, urea, zinc oxide2024-11-29 10:47:42
Mineral Fusion Concealer Refillable Palette - Indulgence -- 0.21 ozMineral FusionBeauty & Personal Caretocopherol, tocopherol, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, glyceryl caprylate, CI 778912024-11-29 10:47:42

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency25.95320.000657.913322,387.1992AID1259377; AID1259394
estrogen nuclear receptor alphaHomo sapiens (human)Potency8.56690.000229.305416,493.5996AID743075; AID743077; AID743079
aryl hydrocarbon receptorHomo sapiens (human)Potency27.49100.000723.06741,258.9301AID743122
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency29.375219.739145.978464.9432AID1159509
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (24)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (16.67)18.7374
1990's0 (0.00)18.2507
2000's5 (20.83)29.6817
2010's12 (50.00)24.3611
2020's3 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 54.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index54.31 (24.57)
Research Supply Index3.33 (2.92)
Research Growth Index4.65 (4.65)
Search Engine Demand Index84.57 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (54.31)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other27 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1-anilino-8-naphthalenesulfonate
1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.		2.1710aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
1,2-dipalmitoylphosphatidylcholine
1,2-Dipalmitoylphosphatidylcholine: Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.		2.0310
bisphenol a
4,4'-isopropylidene diphenol: stimulates proliferative responses and cytokine productions of murine spleen cells and thymus cells in vitro. bisphenol : By usage, the methylenediphenols, HOC6H4CH2C6H4OH, commonly p,p-methylenediphenol, and their substitution products (generally derived from condensation of two equivalent amounts of a phenol with an aldehyde or ketone). The term also includes analogues in the the methylene (or substituted methylene) group has been replaced by a heteroatom.. bisphenol A : A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.		2.2510bisphenolendocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen
benzotriazole
benzotriazole: inhibitor of atmospheric metal corrosion; also component of motion picture film & Neva brake fluid. benzotriazole : The simplest member of the class of benzotriazoles that consists of a benzene nucleus fused to a 1H-1,2,3-triazole ring.		2.1510benzotriazolesenvironmental contaminant;
xenobiotic
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		2.1110mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
copper phthalocyanine
copper phthalocyanine: structure. copper(II) phthalocyanine : A metallophthalocyanine that is copper(2+) forming a coordination complex with phthalocyanine. It is a synthetic blue pigment which is used as a colorant in paints and dyes.		2.0110
fluorobenzenes
Fluorobenzenes: Derivatives of BENZENE that contain FLUORINE.. monofluorobenzene : The simplest member of the class of monofluorobenzenes that is benzene carrying a single fluoro substituent.. fluorobenzenes : Any fluoroarene that is a benzene or a substituted benzene carrying at least one fluoro group.		2.1110monofluorobenzenesNMR chemical shift reference compound
(2-hydroxy-4-(octyloxy)phenyl)phenylmethanone
2-hydroxy-4-octyloxybenzophenone: exhibits pseudo-positive initiation activity in carcinogenesis; structure in first source		2.0810benzophenones
irganox 1076
[no description available]		2.7930
cyanophos
[no description available]		2.0810organic thiophosphate;
organothiophosphate insecticide		agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
silver
Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.		2.4220copper group element atom;
elemental silver		Escherichia coli metabolite
argon
Argon: A noble gas with the atomic symbol Ar, atomic number 18, and atomic weight 39.948. It is used in fluorescent tubes and wherever an inert atmosphere is desired and nitrogen cannot be used.		2.4820monoatomic argon;
noble gas atom;
p-block element atom		food packaging gas;
neuroprotective agent
gold
Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.		2.0110copper group element atom;
elemental gold
triazoles
Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.		2.15101,2,3-triazole
tris-(2,4-di-tert-butylphenyl) phosphite
tris-(2,4-di-tert-butylphenyl) phosphite: structure given in first source		2.7930alkylbenzene
irganox 3114
Irganox 3114: structure in first source		2.4620
phosphites
Phosphites: Inorganic salts or organic esters of phosphorous acid that contain the (3-)PO3 radical. (From Grant & Hackh's Chemical Dictionary, 5th ed). phosphite(3-) : A trivalent inorganic anion obtained by removal of all three protons from phosphorous acid.		2.7930phosphite ion;
trivalent inorganic anion
fullerene c60
Fullerenes: A polyhedral CARBON structure composed of around 60-80 carbon atoms in pentagon and hexagon configuration. They are named after Buckminster Fuller because of structural resemblance to geodesic domes. Fullerenes can be made in high temperature such as arc discharge in an inert atmosphere.. fullerene : A compound composed solely of an even number of carbon atoms, which form a cage-like fused-ring polycyclic system with twelve five-membered rings and the rest six-membered rings. The term has been broadened to include any closed cage structure consisting entirely of three-coordinate carbon atoms.		2.0310fullerenegeroprotector
lignin
Lignin: The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed). lignin : A polyphenylpropanoid derived from three monolignol monomers: trans-p-coumaryl alcohol, coniferol and trans-sinapyl alcohol. There is extensive cross-linking and no defined primary structure.		2.1710
maleic acid
maleic acid: RN given refers to parent cpd(Z)-isomer which is maleic acid; all RR's given refer to (Z)-isomer; (E)-isomer is fumaric acid. maleic acid : A butenedioic acid in which the double bond has cis- (Z)-configuration.		1.9610butenedioic acidalgal metabolite;
mouse metabolite;
plant metabolite
ferulic acid
ferulate : A monocarboxylic acid anion obtained by the deprotonation of the carboxy group of ferulic acid.		2.1710ferulic acidsanti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite
silicon
Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].		2.0610carbon group element atom;
metalloid atom;
nonmetal atom
gramicidin a
Gramicidin: A group of peptide antibiotics from BACILLUS brevis. Gramicidin C or S is a cyclic, ten-amino acid polypeptide and gramicidins A, B, D are linear. Gramicidin is one of the two principal components of TYROTHRICIN.		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0310
Osteolysis
Dissolution of bone that particularly involves the removal or loss of calcium.		02.1310
Palmoplantaris Pustulosis
[description not available]		02.1310
Psoriasis
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.		02.1310