ascorbic-acid and Asthenia

To assess objectively a dynamics of brain functional state, EEG spectral power and peak latency of the P300 component of cognitive auditory evoked potentials have been analyzed in adolescents during the course of nootropic therapy of residual asthenic consequences of traumatic brain injury (ICD-10 F07.2). The study included 76 adolescents, aged 12-18 years, who have undergone severe closed head trauma with brain commotion 1/2--5 years ago. Patients have been divided into 3 groups treated during one month with cerebrolysin, piracetam or magne-B6, respectively. After the end of the nootropic therapy, 77% of patients treated with cerebrolysin as well as 50% of patients treated with piracetam and magne-B6 have demonstrated the positive dynamics of their brain functional state that manifested itself in the appearance of occipital EEG alpha rhythm or in the increase of its spectral power; in the normalization of alpha rhythm frequency; in the decrease in the spectral power of slow wave (theta and delta) EEG activity, in the amount (up to the disappearance) of paroxysmal EEG activity, in the EEG response to hyperventilation and in the shortening of the P300 peak latency. Such positive changes of neurophysiological parameters have been associated with the improvement of clinical conditions of patients and correlated significantly with the dynamics of psychometric scores of attention and memory.

Topics: Adolescent; Alpha Rhythm; Amino Acids; Ascorbic Acid; Asthenia; Attention; Brain; Brain Injuries, Traumatic; Child; Electroencephalography; Event-Related Potentials, P300; Evoked Potentials; Humans; Magnesium; Memory; Nootropic Agents; Piracetam; Vitamin B 6

Since ancient times, scurvy has been considered one of the most fearsome nutritional deficiency diseases. In modern developed countries, this condition has become very rare and is only occasionally encountered, especially in the pediatric population. Underlying medical conditions, such as neuropsychiatric disorders, anorexia nervosa, celiac disease, Crohn disease, hemodialysis, and severe allergies to food products may enhance the risk of developing scurvy.. We report the case of an otherwise healthy 3-year-old white boy who developed scurvy due to a selective restrictive diet derived from his refusal to try new food. He presented to our clinic with asthenia and refusal to walk. During hospitalization he developed severe anemia and hematochezia. A diagnosis of scurvy was assessed on the basis of nutritional history, clinical features, radiographic findings, and laboratory findings. Supplementation of ascorbic acid enabled a prompt resolution of symptoms.. Scurvy is caused by vitamin C deficiency. Cutaneous bleeding, mucosal bleeding, and anemia represent typical manifestations of the disease. These symptoms are directly connected to ascorbic acid involvement in collagen biosynthesis. Some radiographic findings can be useful for the diagnosis. Treatment aims to normalize serum levels of vitamin C in order to counteract the deprivation symptoms. The present case report demonstrates that scurvy may sporadically occur in pediatric patients, even in individuals with no predisposing medical conditions and/or potential risk factors.

Topics: Anemia; Ascorbic Acid; Asthenia; Child Nutritional Physiological Phenomena; Child, Preschool; Diet; Gastrointestinal Hemorrhage; Humans; Male; Nutritional Status; Risk Factors; Scurvy; Vitamins

We present the case of a 17-year-old male who was diagnosed at birth with hereditary fructose intolerance (HFI). The patient complained of morning-time asthenia and post-prandial drowsiness despite a correct sleep pattern. The physical examination and biological check-up only showed severe vitamin C deficiency (<10 mol/l; normal range: 26-84). The patient's tiredness was attributed to this vitamin C deficiency, which is a frequent side-affect of the fructose-free diet. A change in diet associated with a supplementation in vitamin C was advised, with an increase in vegetable intake, principally avoiding carrots, onions, leaks and tinned sweet-corn. This case offers the opportunity for a review of this rare disease. Two kinds of fructose metabolism disorders (both autosomal recessive) are recognized: 1) essential fructosuria caused by a deficiency of fructokinase, which has no clinical consequence and requires no dietary treatment; 2) HFI, linked to three main mutations identified in aldolase B gene that may be confirmed by fructose breath test, intravenous fructose tolerance test, and genetic testing. In HFI, fructose ingestion generally induces gastro-intestinal (nausea and vomiting, abdominal pain, meteorism) and hypoglycemic symptoms. Fasting is well tolerated. If the condition remains undiagnosed, it leads to liver disease with hepatomegaly, proximal tubular dysfunction, and slow growth and weight gain. In conclusion, endocrinologists should be aware of this rare metabolic disease in order to provide careful follow-up, particularly important when the patient reaches adulthood. Moreover, hypoglycemia induced by fructose absorption, unexplained liver disease, irritable bowel syndrome or familial gout in an adult is suggestive of the diagnosis.

Topics: Adolescent; Ascorbic Acid; Asthenia; Diagnosis, Differential; Diet; Fructose; Fructose Intolerance; Fructose-Bisphosphate Aldolase; Glycogen; Humans; Male

Clinical psychopathological, follow-up and neuropsychological evaluation was made for 125 HIV-infected patients in stage 2B of the disease (general lymphadenopathy by V. I. Pokrovskiĭ's classification). It is shown that seropositive subjects had asthenic syndrome for the initial 6 months of the disease. According to the manifestations, asthenia was defined as psychogenic-reactive and organic. In the former variant the treatment involved psychotherapy and occasionally drugs, the latter was treated with chemotherapy and psychopharmacological modalities as the first-line and psychotherapy as adjuvant means. The authors expect that a differential approach to HIV-infection-related asthenia at the disease onset may contribute to better life quality and prognosis in AIDS patients.

Topics: Adult; AIDS-Related Complex; Ascorbic Acid; Asthenia; Drug Therapy, Combination; Female; Glutamates; Glutamic Acid; HIV-1; Humans; Male; Vitamin B Complex

Topics: Adrenal Cortex Hormones; Aged; Ascorbic Acid; Ascorbic Acid Deficiency; Asthenia; Drug Combinations; Humans; Injections, Intravenous

Topics: Adaptation, Physiological; Adaptation, Psychological; Ascorbic Acid; Asthenia; Calcium; Cold Climate; Electroencephalography; Glucose; Glutamates; Glycerophosphates; Humans; Male; Psychophysiology; Sensory Deprivation; Stress, Psychological; Time Factors

Topics: Ascorbic Acid; Asthenia; Child; Child, Preschool; Hexosephosphates; Humans; Pediatrics

Topics: Adult; Aged; Anorexia Nervosa; Ascorbic Acid; Asthenia; Dyspepsia; Feeding and Eating Disorders; Female; Humans; Male; Middle Aged; Phosphatidylcholines

Topics: Aged; Anorexia Nervosa; Ascorbic Acid; Asthenia; Betaine; Cinnamates; Dyspepsia; Female; Humans; Male; Middle Aged; Phosphatidylcholines

Topics: Adenine Nucleotides; Ascorbic Acid; Asthenia; Feeding and Eating Disorders; Geriatrics; Humans; Influenza, Human; Liver Extracts; Metabolism

Topics: Amino Acids; Ascorbic Acid; Asthenia; Corrinoids; Glycine; Hematinics; Humans; Vitamin A; Vitamin B 12; Vitamin K; Vitamins

Topics: Aged; Ascorbic Acid; Asthenia; Disease; Humans; Inositol; Magnesium; Vitamins

Topics: Ascorbic Acid; Asthenia; Humans; Neurasthenia; Plasma; Vitamins