An EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the action of SARS coronavirus main proteinase (EC 3.4.22.69).
| Member | Definition | Class |
|---|
| (-)-gallocatechin gallate | A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of (-)-gallocatechin. A natural product found in found in green tea. | (-)-gallocatechin gallate |
| 3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide | A secondary carboxamide resulting from the formal condensation of the carboxy group of 1H-indole-2-carboxylic acid with the primary amino group of 3-fluoro-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide. It is an inhibitor of SARS coronavirus main proteinase and inhibits SARS-CoV-2 replication in cell culture (EC50 = 0.72 muM). | 3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide |
| anacardic acid | A hydroxybenzoic acid that is salicylic acid substituted by a pentadecyl group at position 6. It is a major component of cashew nut shell liquid and exhibits an extensive range of bioactivities. | anacardic acid |
| baicalein | A trihydroxyflavone with the hydroxy groups at positions C-5, -6 and -7. | baicalein |
| cinanserin | An aryl sulfide that is (2E)-3-phenyl-N-(2-sulfanylphenyl)prop-2-enamide in which the hydrogen of the thiol group is substituted by a 3-(dimethylamino)propyl group. It is a 5-hydroxytryptamine receptor antagonist and an inhibitor of SARS-CoV replication. | cinanserin |
| ebselen | A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase. | ebselen |
| herbacetin | A pentahydroxyflavone that is kaempferol substituted by a hydroxy group at position 8. It is a natural flavonoid from flaxseed which exerts antioxidant, anti-inflammatory and anticancer activities. | herbacetin |
| N-[(2S)-3-cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)propan-2-yl]-1H-indole-2-carboxamide | A secondary carboxamide resulting from the formal condensation of the carboxy group of 1H-indole-2-carboxylic acid with the primary amino group of 3-cyclohexyl-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-alaninamide. It is an inhibitor of SARS coronavirus main proteinase and inhibits SARS-CoV-2 replication in cell culture (EC50 = 0.53 muM). | N-[(2S)-3-cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)propan-2-yl]-1H-indole-2-carboxamide |
| N-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-alanyl-L-valyl-N-{(2S,3E)-5-(benzyloxy)-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl}-L-leucinamide | A tripeptide resulting from the formal condensation of the carboxy group of N-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-alanyl-L-valine with the amino group of benzyl (2E,4S)-4-(L-leucylamino)-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate. It is an inhibitor of the main protease of SARS-CoV-2. | N-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-alanyl-L-valyl-N-{(2S,3E)-5-(benzyloxy)-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl}-L-leucinamide |
| narlaprevir | An azabicyclohexane that is (1R,5S)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane substituted by [(3S)-1-(cyclopropylamino)-1,2-dioxoheptan-3-yl]aminoacyl and N-({1-[(tert-butylsulfonyl)methyl]cyclohexyl}carbamoyl)-3-methyl-L-valyl groups at positions 2S and 3, respectively. It is a hepatitis C virus (HCV) NS3/4A serine protease inhibitor (Ki = 6 nM) that is used for the treatment of chronic hepatitis C. | narlaprevir |
| nirmatrelvir | An azabicyclohexane that is (1R,5S)-3-azabicyclo[3.1.0]hexane substituted by {(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}aminoacyl, 3-methyl-N-(trifluoroacetyl)-L-valinamide, methyl and methyl groups at positions 2S, 3, 6 and 6, respectively. It is the first orally administered inhibitor of SARS-CoV-2 main protease developed by Pfizer and used in combination with ritonavir for the treatment of COVID-19. | nirmatrelvir |
| pectolinarin | A disaccharide derivative that consists of pectolinarigenin substituted by a 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. | pectolinarin |
| PF-00835231 | A primary alcohol resulting from the cleavage of the phosphate group of the prodrug PF-07304814. It is an inhibitor of SARS-CoV-1 and -2 main protease (3CLpro) and exhibits potent in vitro antiviral activity. | PF-00835231 |
| PF-07304814 | An indolecarboxamide resulting from the formal condensation of the carboxy group of 4-methoxy-1H-indole-2-carboxylic acid with the primary amino group of N-[(2S)-3-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]-4-(phosphonooxy)butan-2-yl]-L-leucinamide. It is the phosphate prodrug of PF-00835231, an anticoronaviral agent. | PF-07304814 |
| savinin | A lignan that is dihydrofuran-2(3H)-one (gamma-butyrolactone) substituted by a 1,3-benzodioxol-5-ylmethylidene group at position 3 and a 1,3-benzodioxol-5-ylmethyl group at position 4 (the 3E,4R-isomer). It exhibits antiviral activity against SARS-CoV-2. | savinin |
| vitamin k 3 | A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia. | menadione |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 11.5420 | 1 | 7 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 0.8188 | 1 | 3 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 7.5686 | 1 | 1 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 0.7762 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 57.1324 | 2 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 6.5596 | 1 | 8 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 32.4648 | 2 | 2 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 4.4780 | 1 | 3 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 27.8744 | 7 | 12 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 18.7137 | 2 | 7 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 7.9081 | 3 | 3 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 5.5197 | 5 | 6 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 6.7456 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 26.1216 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 13.3138 | 1 | 3 |
| BRCA1 | Homo sapiens (human) | Potency | 10.8820 | 1 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 5.7062 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 76.9588 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 76.9588 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 35.7360 | 2 | 5 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 10.0439 | 2 | 6 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 4.7544 | 1 | 6 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 16.3482 | 1 | 3 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 39.9558 | 2 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 26.6514 | 2 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 12.5893 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 2.4068 | 2 | 8 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 32.5733 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 5.7617 | 2 | 7 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 13.1300 | 3 | 11 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 0.0576 | 1 | 6 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 2.4068 | 2 | 8 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 13.8154 | 2 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 2.3086 | 1 | 4 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 3.1002 | 1 | 4 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 7.9169 | 1 | 2 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 12.6415 | 1 | 4 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 25.1334 | 2 | 8 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 1.0964 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 21.3802 | 1 | 3 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Disintegrin and metalloproteinase domain-containing protein 17 | Homo sapiens (human) | Potency | 3.4703 | 1 | 2 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 35.7963 | 2 | 3 |
| DNA polymerase III, partial | Bacillus subtilis | Potency | 4.7444 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 29.3184 | 2 | 6 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 6.3455 | 1 | 4 |
| endonuclease IV | Escherichia coli | Potency | 7.9433 | 1 | 1 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Potency | 22.3872 | 1 | 1 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | Potency | 22.3872 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 33.2169 | 9 | 21 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 21.1714 | 2 | 5 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 30.5202 | 6 | 11 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 8.5216 | 1 | 7 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 25.7005 | 4 | 8 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 37.6524 | 2 | 4 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 53.0324 | 1 | 4 |
| fructose-bisphosphate aldolase A | Oryctolagus cuniculus (rabbit) | Potency | 14.3484 | 1 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 38.9018 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 25.1334 | 1 | 4 |
| geminin | Homo sapiens (human) | Potency | 17.0494 | 4 | 13 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 20.3320 | 2 | 4 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 22.8741 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 5.4025 | 2 | 3 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 35.5869 | 1 | 4 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 48.9662 | 3 | 3 |
| glucokinase regulatory protein | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 0.6310 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 20.3727 | 2 | 3 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 0.6310 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 0.6310 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| glyceraldehyde-3-phosphate dehydrogenase isoform 1 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 32.3712 | 2 | 4 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 22.1060 | 2 | 2 |
| hexokinase-4 isoform 1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 3.0752 | 2 | 18 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 0.4496 | 1 | 4 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 12.8269 | 2 | 3 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 37.2198 | 2 | 4 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 15.2028 | 4 | 6 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 25.4960 | 2 | 4 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 15.9027 | 2 | 6 |
| IDH1 | Homo sapiens (human) | Potency | 21.8528 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 38.9018 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 4.5640 | 1 | 2 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 13.0333 | 1 | 3 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 13.0333 | 1 | 3 |
| Interferon beta | Homo sapiens (human) | Potency | 24.7442 | 2 | 7 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 20.5462 | 2 | 4 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 5.3547 | 1 | 5 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 17.1216 | 3 | 5 |
| luciferase | Photuris pensylvanica (Pennsylania firefly) | Potency | 18.0789 | 3 | 5 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 56.2341 | 2 | 2 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 4.0027 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 12.6434 | 2 | 16 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 13.8154 | 1 | 2 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| Neuronal acetylcholine receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 56.2341 | 1 | 1 |
| Neuronal acetylcholine receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 56.2341 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 2.1154 | 1 | 2 |
| Nrf2 | Homo sapiens (human) | Potency | 29.2953 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 14.7820 | 2 | 4 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 34.7487 | 2 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 18.7986 | 2 | 15 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 32.6561 | 3 | 6 |
| Ornithine decarboxylase | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 104.9599 | 1 | 3 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 25.7445 | 1 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 33.8078 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 18.5415 | 2 | 3 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 21.8248 | 2 | 4 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 12.5244 | 1 | 8 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 11.7262 | 1 | 3 |
| polyprotein | Zika virus | Potency | 25.1189 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 3.0741 | 1 | 3 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 3.0252 | 1 | 3 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 19.6292 | 1 | 3 |
| PPM1D protein | Homo sapiens (human) | Potency | 22.3846 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 21.8020 | 2 | 3 |
| progesterone receptor | Homo sapiens (human) | Potency | 61.1306 | 1 | 1 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 15.5513 | 5 | 5 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 8.6955 | 4 | 6 |
| pyruvate kinase PKM isoform b | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 28.3708 | 1 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 20.7814 | 2 | 4 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 15.9139 | 1 | 3 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 35.9170 | 3 | 7 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 20.8163 | 2 | 4 |
| RGS12 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 20.4054 | 2 | 2 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 2.9935 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Potency | 5.7988 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 37.5564 | 2 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 37.5564 | 2 | 3 |
| Smad3 | Homo sapiens (human) | Potency | 27.6625 | 1 | 3 |
| Sodium channel protein type 1 subunit alpha | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Sodium channel protein type 2 subunit alpha | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Sodium channel protein type 3 subunit alpha | Rattus norvegicus (Norway rat) | Potency | 5.7988 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 7.0871 | 1 | 2 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 10.5051 | 1 | 3 |
| TDP1 protein | Homo sapiens (human) | Potency | 15.4407 | 2 | 25 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 32.6570 | 1 | 3 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 14.7715 | 2 | 3 |
| Thrombopoietin | Homo sapiens (human) | Potency | 3.1623 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 20.1142 | 2 | 8 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 44.6684 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 35.4814 | 3 | 4 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 3.4703 | 1 | 2 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 11.7262 | 1 | 3 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 11.7262 | 1 | 3 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 31.9064 | 2 | 5 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 17.7360 | 2 | 4 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 16.8440 | 3 | 5 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 13.8906 | 1 | 7 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 30.2436 | 1 | 2 |
| WRN | Homo sapiens (human) | Potency | 5.3233 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 5.4685 | 2 | 4 |
| 1-deoxy-D-xylulose 5-phosphate reductoisomerase | Escherichia coli K-12 | IC50 | 2.2000 | 1 | 1 |
| 10 kDa chaperonin | Escherichia coli | IC50 | 5.7500 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| 3-oxoacyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1.1000 | 1 | 1 |
| 4-aminobutyrate aminotransferase, mitochondrial | Homo sapiens (human) | IC50 | 12,800.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 3.5000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 2.2500 | 2 | 2 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 3.5000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 3.5000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.0020 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0190 | 4 | 4 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 3 | 3 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 0.0020 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 3 | 3 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.0020 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.2000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.0040 | 3 | 3 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | IC50 | 350.0000 | 1 | 1 |
| 6-phosphogluconate dehydrogenase, decarboxylating | Homo sapiens (human) | IC50 | 1.4500 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli K-12 | IC50 | 250.0000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 5.7500 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 28.0050 | 2 | 2 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| Aldehyde oxidase | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| Aldehyde oxidase 1 | Macaca fascicularis (crab-eating macaque) | IC50 | 0.1100 | 1 | 1 |
| Aldehyde oxidase 1 | Mus musculus (house mouse) | IC50 | 0.1500 | 1 | 1 |
| Aldehyde oxidase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 2.0000 | 1 | 1 |
| Aldehyde oxidase 1 | Cavia porcellus (domestic guinea pig) | Ki | 7.2300 | 1 | 1 |
| Aldehyde oxidase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.1900 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 8.9333 | 2 | 3 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 6.6100 | 1 | 2 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | Ki | 26.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 0.4000 | 1 | 1 |
| Angiotensin-converting enzyme 2 | Homo sapiens (human) | IC50 | 6.4400 | 1 | 4 |
| Arrestin, beta 1 | Homo sapiens (human) | IC50 | 1.5240 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 41.0000 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 4.0600 | 1 | 1 |
| Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein) | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.6000 | 1 | 1 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 0.7575 | 4 | 4 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Calpain-1 catalytic subunit | Homo sapiens (human) | IC50 | 0.2918 | 1 | 5 |
| Casein kinase II subunit alpha | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Casein kinase II subunit alpha 3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Casein kinase II subunit beta | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Caspase-1 | Homo sapiens (human) | IC50 | 4.0400 | 1 | 1 |
| Caspase-2 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Cathepsin B | Homo sapiens (human) | IC50 | 0.5799 | 3 | 7 |
| Cathepsin D | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Cathepsin K | Homo sapiens (human) | IC50 | 0.2918 | 1 | 5 |
| Chain A, RNA-directed RNA polymerase NS5 | Dengue virus 2 16681-PDK53 | IC50 | 35.0600 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 10.4740 | 2 | 2 |
| Cyclin-dependent kinase 1 | Homo sapiens (human) | IC50 | 6.5300 | 1 | 1 |
| Cytochrome P450 11B1, mitochondrial | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 1A1 | Homo sapiens (human) | Ki | 1.2200 | 1 | 1 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.2600 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 18.8500 | 1 | 2 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 9.2000 | 1 | 1 |
| Death-associated protein kinase 1 | Homo sapiens (human) | IC50 | 120.0000 | 1 | 1 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| DNA gyrase subunit A | Mycobacterium tuberculosis H37Rv | IC50 | 200.0000 | 2 | 2 |
| DNA gyrase subunit B | Mycobacterium tuberculosis H37Rv | IC50 | 200.0000 | 1 | 1 |
| Dual specificity protein phosphatase 1 | Mus musculus (house mouse) | IC50 | 24.0000 | 1 | 1 |
| Dual specificity protein phosphatase 6 | Rattus norvegicus (Norway rat) | IC50 | 20.5000 | 1 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Homo sapiens (human) | IC50 | 0.1210 | 1 | 1 |
| Enoyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.5000 | 1 | 1 |
| eukaryotic translation initiation factor 4 gamma 1 isoform 4 | Homo sapiens (human) | IC50 | 1.1500 | 1 | 1 |
| eukaryotic translation initiation factor 4E isoform 1 | Mus musculus (house mouse) | IC50 | 1.1500 | 1 | 1 |
| Fructose-1,6-bisphosphatase 1 | Homo sapiens (human) | IC50 | 18.8500 | 1 | 2 |
| G protein-coupled receptor kinase 6 | Homo sapiens (human) | IC50 | 8.7000 | 1 | 1 |
| G-protein coupled receptor 35 | Homo sapiens (human) | IC50 | 28.2000 | 1 | 1 |
| G2/mitotic-specific cyclin-B1 | Homo sapiens (human) | IC50 | 6.5300 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | Ki | 5.6234 | 1 | 1 |
| Gamma-butyrobetaine dioxygenase | Homo sapiens (human) | IC50 | 0.7420 | 5 | 5 |
| Genome polyprotein | Zika virus | IC50 | 99.0000 | 1 | 1 |
| Genome polyprotein | | Ki | 0.0060 | 1 | 1 |
| Glucocorticoid receptor | Homo sapiens (human) | IC50 | 19.0000 | 1 | 1 |
| Glucose-6-phosphate 1-dehydrogenase | Saccharomyces cerevisiae S288C | IC50 | 0.2300 | 1 | 1 |
| glucose-6-phosphate 1-dehydrogenase isoform b | Homo sapiens (human) | IC50 | 13.2000 | 1 | 1 |
| glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | Plasmodium berghei | IC50 | 15.0867 | 3 | 3 |
| Glutathione reductase, mitochondrial | Homo sapiens (human) | Ki | 14.1000 | 2 | 2 |
| Heat shock protein HSP 90-beta | Homo sapiens (human) | IC50 | 34.0000 | 1 | 1 |
| Hepatocyte growth factor receptor | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| hexokinase | Trypanosoma brucei brucei TREU927 | IC50 | 0.9009 | 1 | 1 |
| Histone acetyltransferase KAT2B | Homo sapiens (human) | IC50 | 19.4500 | 4 | 4 |
| Histone acetyltransferase KAT5 | Homo sapiens (human) | IC50 | 64.0000 | 1 | 1 |
| Histone acetyltransferase KAT8 | Homo sapiens (human) | IC50 | 43.0000 | 1 | 1 |
| Histone acetyltransferase KAT8 | Homo sapiens (human) | Ki | 64.0000 | 1 | 1 |
| Histone acetyltransferase p300 | Homo sapiens (human) | IC50 | 7.4125 | 4 | 4 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 3.4000 | 1 | 1 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 6.5333 | 3 | 3 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| Histone-lysine N-methyltransferase EHMT1 | Homo sapiens (human) | IC50 | 0.7300 | 1 | 1 |
| Histone-lysine N-methyltransferase EHMT2 | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) | IC50 | 0.8925 | 4 | 4 |
| Indoleamine 2,3-dioxygenase 1 | Homo sapiens (human) | Ki | 0.0940 | 3 | 3 |
| Insulin-degrading enzyme | Homo sapiens (human) | IC50 | 33.3520 | 3 | 3 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 3.2960 | 5 | 5 |
| Lactoylglutathione lyase | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| large T antigen | Betapolyomavirus macacae | IC50 | 13.9100 | 1 | 1 |
| Linoleate 9S-lipoxygenase-4 | Glycine max (soybean) | IC50 | 22.0000 | 1 | 1 |
| Lysine-specific demethylase 4E | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Lysine-specific demethylase 4E | Homo sapiens (human) | Ki | 4.3300 | 1 | 1 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 12.5000 | 1 | 1 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| M-phase inducer phosphatase 1 | Homo sapiens (human) | IC50 | 4.5500 | 2 | 2 |
| M-phase inducer phosphatase 2 | Homo sapiens (human) | IC50 | 3.1600 | 3 | 3 |
| M-phase inducer phosphatase 3 | Homo sapiens (human) | IC50 | 18.9000 | 2 | 2 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | IC50 | 2.4000 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | Ki | 0.5700 | 2 | 2 |
| Methionine aminopeptidase 2 | Homo sapiens (human) | IC50 | 2.4300 | 1 | 1 |
| MPI protein | Homo sapiens (human) | IC50 | 0.2905 | 2 | 2 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 8.9000 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | Ki | 13.7000 | 1 | 1 |
| neutrophil cytosol factor 1 | Homo sapiens (human) | IC50 | 0.3900 | 1 | 1 |
| Neutrophil cytosol factor 1 | Homo sapiens (human) | Ki | 125.0000 | 3 | 3 |
| Neutrophil elastase | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Non-structural protein 4A | | Ki | 0.0060 | 1 | 1 |
| perilipin-1 | Homo sapiens (human) | IC50 | 5.6525 | 1 | 2 |
| perilipin-5 | Homo sapiens (human) | IC50 | 5.2845 | 1 | 2 |
| phosphoethanolamine/phosphocholine phosphatase isoform 1 | Homo sapiens (human) | IC50 | 0.1110 | 1 | 1 |
| phosphomannomutase 2 | Homo sapiens (human) | IC50 | 0.6720 | 1 | 1 |
| Platelet glycoprotein VI | Homo sapiens (human) | IC50 | 37.5000 | 2 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 50.4250 | 1 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 2 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | IC50 | 31.5320 | 2 | 5 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Ki | 1.6000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | IC50 | 33.1800 | 2 | 5 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | Ki | 0.6000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | IC50 | 51.0929 | 3 | 7 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Rattus norvegicus (Norway rat) | IC50 | 0.2600 | 1 | 1 |
| Probable linoleate 9S-lipoxygenase 5 | Solanum tuberosum (potato) | IC50 | 43.0000 | 1 | 1 |
| Procathepsin L | Homo sapiens (human) | IC50 | 2.7365 | 3 | 10 |
| Progesterone receptor | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| Prolyl endopeptidase | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 150.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | IC50 | 2.1000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Protease | Human immunodeficiency virus 1 | IC50 | 10.0000 | 1 | 1 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 0.1870 | 1 | 1 |
| Protein kinase C alpha type | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| Protein-glutamine gamma-glutamyltransferase 2 | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| Prothrombin | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Pyruvate kinase PKM | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| Receptor protein-tyrosine kinase | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Receptor-type tyrosine-protein phosphatase eta | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| Receptor-type tyrosine-protein phosphatase S | Homo sapiens (human) | IC50 | 10.3000 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | IC50 | 6.4400 | 1 | 4 |
| Replicase polyprotein 1ab | Betacoronavirus England 1 | IC50 | 6.8455 | 3 | 8 |
| Replicase polyprotein 1ab | Human coronavirus 229E | IC50 | 5.1810 | 2 | 5 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 7.0445 | 43 | 78 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 2.5060 | 5 | 20 |
| Replicase polyprotein 1ab | Avian infectious bronchitis virus (strain Beaudette CK) | Ki | 0.0009 | 1 | 12 |
| Replicase polyprotein 1ab | Feline infectious peritonitis virus (strain 79-1146) | Ki | 0.0009 | 1 | 12 |
| Replicase polyprotein 1ab | Human coronavirus 229E | Ki | 0.0009 | 1 | 12 |
| Replicase polyprotein 1ab | Human coronavirus HKU1 (isolate N5) | Ki | 0.0009 | 1 | 12 |
| Replicase polyprotein 1ab | Human coronavirus NL63 | Ki | 0.0009 | 1 | 12 |
| Replicase polyprotein 1ab | Human coronavirus OC43 | Ki | 0.0009 | 1 | 12 |
| Replicase polyprotein 1ab | Murine hepatitis virus strain A59 | Ki | 0.0009 | 1 | 12 |
| Replicase polyprotein 1ab | Pipistrellus bat coronavirus HKU5 | Ki | 0.0009 | 1 | 12 |
| Replicase polyprotein 1ab | Porcine epidemic diarrhea virus CV777 | Ki | 0.0009 | 1 | 12 |
| Replicase polyprotein 1ab | Rousettus bat coronavirus HKU9 | Ki | 0.0009 | 1 | 12 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Ki | 0.9503 | 9 | 21 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | Ki | 5.4500 | 1 | 2 |
| Replicase polyprotein 1ab | Tylonycteris bat coronavirus HKU4 | Ki | 0.0009 | 1 | 12 |
| RNA polymerase beta subunit (EC 2.7.7.6), partial | Escherichia coli | IC50 | 11.6872 | 1 | 1 |
| Seed linoleate 13S-lipoxygenase-1 | Glycine max (soybean) | IC50 | 37.2500 | 2 | 2 |
| Serine/threonine-protein kinase PLK1 | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| Serine/threonine-protein kinase PLK2 | Homo sapiens (human) | IC50 | 314.0000 | 1 | 1 |
| Serine/threonine-protein kinase PLK3 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Sialidase | Clostridium perfringens | IC50 | 1.4000 | 1 | 1 |
| Sialidase-2 | Homo sapiens (human) | IC50 | 130.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | IC50 | 10.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 0.1820 | 1 | 1 |
| Sodium- and chloride-dependent betaine transporter | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 2 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Sodium- and chloride-dependent GABA transporter 3 | Rattus norvegicus (Norway rat) | IC50 | 50.0000 | 1 | 1 |
| Spike glycoprotein | Betacoronavirus England 1 | IC50 | 6.4400 | 1 | 4 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | IC50 | 6.4400 | 1 | 4 |
| Structural capsid protein | Human immunodeficiency virus 1 | IC50 | 0.0467 | 1 | 1 |
| Sucrase-isomaltase, intestinal | Homo sapiens (human) | IC50 | 43.5000 | 2 | 2 |
| Sucrase-isomaltase, intestinal | Rattus norvegicus (Norway rat) | IC50 | 156.0000 | 2 | 2 |
| Sulfhydryl oxidase 1 | Homo sapiens (human) | IC50 | 5.4000 | 1 | 1 |
| SUMO-activating enzyme subunit 1 | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| Testosterone 17-beta-dehydrogenase 3 | Homo sapiens (human) | IC50 | 97.6100 | 2 | 2 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| Toxin B | Clostridioides difficile | IC50 | 0.0172 | 1 | 1 |
| TPA: protein transporter TIM10 | Saccharomyces cerevisiae S288C | IC50 | 5.2900 | 2 | 2 |
| TPA: protein transporter TIM23 | Saccharomyces cerevisiae S288C | IC50 | 0.8800 | 1 | 1 |
| Transmembrane protease serine 2 | Homo sapiens (human) | IC50 | 6.4400 | 1 | 4 |
| Trypanothione reductase | Trypanosoma cruzi | IC50 | 55.0000 | 2 | 2 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| Trypsin-2 | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| Trypsin-3 | Homo sapiens (human) | IC50 | 3.7000 | 1 | 1 |
| Tyrosine-protein kinase JAK3 | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| Tyrosine-protein kinase Yes | Homo sapiens (human) | IC50 | 3.3000 | 1 | 1 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Homo sapiens (human) | IC50 | 290.0000 | 1 | 1 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L1 | Mus musculus (house mouse) | IC50 | 180.5000 | 1 | 2 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L3 | Homo sapiens (human) | IC50 | 71.0000 | 2 | 2 |
| Ubiquitin carboxyl-terminal hydrolase isozyme L3 | Mus musculus (house mouse) | IC50 | 180.5000 | 1 | 2 |
| UDP-glucose 4-epimerase | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| UDP-glucuronosyltransferase 1A1 | Homo sapiens (human) | IC50 | 5.7000 | 2 | 2 |
| Urease subunit alpha | Helicobacter pylori 26695 | IC50 | 82.5780 | 5 | 5 |
| Urease subunit alpha | Helicobacter pylori 26695 | Ki | 0.2260 | 1 | 1 |
| Urease subunit beta | Helicobacter pylori 26695 | IC50 | 82.5780 | 5 | 5 |
| Urease subunit beta | Helicobacter pylori 26695 | Ki | 0.2260 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 37.4000 | 2 | 2 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 2.7900 | 1 | 1 |