ascorbic-acid and Arthritis

Scurvy remains prevalent in certain populations, including addicts, people of low socioeconomic status, and the severely malnourished. It classically presents as follicular hyperkeratosis and perifollicular hemorrhage of the lower extremities, as well as bleeding in other areas such as the gingiva and joints. This case presentation and literature review highlights the common pathophysiological findings associated with scurvy and current methods of diagnosis and treatment.. The patient described in this case presented with sudden oligoarthritis and purpura of the lower extremities. Following progression of the patient's symptoms and a low vitamin C serum concentration, the patient was treated with vitamin C supplementation and dramatically improved. This was considered to be the result of an underlying vitamin C deficiency secondary to insufficient fruit and vegetable intake due to allergies.. This case highlights the importance of maintaining a high index of suspicion for scurvy in atypical presentations of purpura not better explained by another disease or in additional populations at high risk of vitamin C deficiency. Early diagnosis by either a primary care physician or dermatologist can expedite the treatment process and improve patient prognosis.

Topics: Aged; Arthritis; Ascorbic Acid; Female; Humans; Panniculitis; Purpura; Scurvy; Vitamins

This paper reviews the rheumatological manifestations of scurvy, based on articles published in English from 1965 until October 2014, with a particular focus on rheumatological manifestations. Scurvy is a rare, uncommon disease in developed countries. Due to its clinical heterogeneity, the disease can easily mimic rheumatologic conditions leading to a delay in diagnosis and treatment.

Topics: Arthritis; Ascorbic Acid; Diagnosis, Differential; Humans; Rheumatic Diseases; Scurvy

To systematically review the evidence from randomized clinical trials (RCTs) for the effectiveness of the antioxidant vitamins A, C, E or selenium or their combination in the treatment of arthritis. METHODSL: A systematic search of computerized databases from inception to September 2006 for relevant RCTs, application of pre-defined inclusion/exclusion criteria and independent data extraction by two authors. Methodological quality was assessed using the Jadad scale.. The searches identified 20 unique RCTs meeting the inclusion criteria: 11 in inflammatory arthritis and 9 in osteoarthritis (OA). The studies included are generally of poor quality. They fall into three main clusters: selenium for rheumatoid arthritis (n = 5); vitamin E for inflammatory arthritis (n = 5) and vitamin E for OA (n = 7). One RCT suggests superiority of vitamin E over placebo and three RCTs suggest equivalence between vitamin E and diclofenac in the treatment of inflammatory arthritis. In OA, four RCTs compared vitamin E with placebo. Two shorter-term studies were positive and two longer-term studies were negative. Two further RCTs suggest equivalence between vitamin E and diclofenac in the treatment of OA. Findings for selenium, vitamin A and a combination product in inflammatory arthritis and for vitamin A, and a combination product in OA were negative. An isolated positive result for vitamin C in OA is of doubtful clinical significance.. Clinical trials testing the efficacy of vitamin E in the treatment of OA and inflammatory arthritis have been methodologically weak and have produced contradictory findings. There is presently no convincing evidence that selenium, vitamin A, vitamin C or the combination product selenium ACE is effective in the treatment of any type of arthritis.

Topics: Antioxidants; Arthritis; Ascorbic Acid; Evidence-Based Medicine; Humans; Randomized Controlled Trials as Topic; Selenium; Treatment Outcome; Vitamin A; Vitamin E; Vitamins

Despite 50 years of intensive research in the field of RFs, autoimmunity and chronic inflammation, some of the serological tests used for measuring autoantibodies remain an anachronism. Clinical chemistry has the potential technology to provide the rheumatologist with automated quantitative antibody/antigen measurements. It can also widen the range of tests available for disease monitoring, which would be helpful in the management of the chronic rheumatic diseases. Traditional laboratory tests must be superseded by new developments, derived from fundamental research, if we are to improve the diagnosis and management of the rheumatic diseases.

Topics: Acute-Phase Proteins; Antibodies, Antinuclear; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Biochemistry; Humans; Iron; Liver Function Tests; Rheumatoid Factor; Rheumatology; Trace Elements

Vitamin C levels are decreased in arthritis patients and reduced levels following surgery may impair adequate healing.. This study measured changes in vitamin C and inflammatory markers in patients undergoing total knee arthroplasty (TKA).. Venous blood samples were collected from 10 patients during the preoperative to postoperative period. Vitamin C, interleukin-1. No significant changes in vitamin C levels were measured. However, all participants had suboptimal preoperative vitamin C levels and 90% had suboptimal levels postoperatively. IL-6 and CRP levels significantly increased during the immediate postoerative period.. There was a rise in inflammation following TKA while vitamin C levels did not significantly change during this short study period. Of note, every patient had suboptimal vitamin C levels prior to surgery and 90% continued with suboptimal levels two days postoperatively.

Topics: Aged; Aged, 80 and over; Arthritis; Arthroplasty, Replacement, Knee; Ascorbic Acid; Biomarkers; C-Reactive Protein; Cytokines; Female; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Male; Middle Aged; Postoperative Period; Prospective Studies

Scurvy, or vitamin C deficiency, is rarely presented to a rheumatology clinic. It can mimic several rheumatologic disorders. Although uncommon, it may present as pseudovasculitis or chronic arthritis. Scurvy still exists today within certain populations, particularly in patients with neurodevelopmental disabilities, psychiatric illness or unusual dietary habits.Scurvy presentation to the rheumatologist varies from aches and mild pains to excruciating bone pain or arthritis. Musculoskeletal and mucocutaneous features of scurvy are often what prompts referrals to pediatric rheumatology clinics. Unless health care providers inquire about nutritional habits and keep in mind the risk of nutritional deficiency, it will be easy to miss the diagnosis of scurvy. Rarity of occurrence as compared to other nutritional deficiencies, combined with a lack of understanding about modern-day risk factors for nutritional deficiency, frequently leads to delayed recognition of vitamin C deficiency. We report a case of scurvy in a mentally handicapped Saudi child, who presented with new onset inability to walk with diffuse swelling and pain in the left leg. Skin examination revealed extensive ecchymoses, hyperkeratosis and follicular purpura with corkscrew hairs, in addition to gingival swelling with bleeding. Clinical diagnosis of scurvy was rendered and confirmed by low serum vitamin C level. The patient did extremely well with proper nutritional support and vitamin C supplementation. It has been noticed lately that there is increased awareness about scurvy in rheumatology literature. A high index of suspicion, together with taking a thorough history and physical examination, is required for diagnosis of scurvy in patient who presents with musculoskeletal symptoms. Nutritional deficiency should also be considered by the rheumatologist formulating differential diagnosis for musculoskeletal or mucocutaneous complaints in children, particularly those at risk.

Topics: Arthritis; Ascorbic Acid; Ascorbic Acid Deficiency; Child; Chronic Disease; Dietary Supplements; Humans; Male; Pain; Refusal to Participate; Scurvy; Treatment Outcome; Walking

Topics: Arthritis; Ascorbic Acid; Autistic Disorder; Calcinosis; Child; Gingival Hypertrophy; Humans; Knee Joint; Male; Radiography; Scurvy

To investigate whether, there is an association between consumption of fruit and vegetables and dietary antioxidants and the risk of developing inflammatory polyarthritis (IP).. In a prospective, population based, nested case-control study of residents of Norfolk, UK, men and women aged 45-74 years were recruited, between 1993 and 1997 through general practice age-sex registers to the Norfolk arm of the European Prospective Investigation of Cancer (EPIC-Norfolk). Dietary intake was assessed at baseline using 7 day diet diaries. Seventy three participants who went on to develop IP between 1993 and 2001 and were registered by the Norfolk Arthritis Register (NOAR) were identified. Incident cases of IP, assessed by general practitioners, fulfilled the criteria of two or more swollen joints, persisting for a minimum of 4 weeks. Each case of IP was matched for age and sex with two controls free of IP.. Lower intakes of fruit and vegetables, and vitamin C were associated with an increased risk of developing IP. Those in the lowest category of vitamin C intake, compared with the highest, increased their risk of developing IP more than threefold, adjusted odds ratio (OR) with 95% confidence intervals (CI) 3.3 (95% CI 1.4 to 7.9). Weak inverse associations between vitamin E and beta-carotene intake and IP risk were found.. Patients with IP (cases) consumed less fruit and vitamin C than matched controls, which appeared to increase their risk of developing IP. The mechanism for this effect is uncertain. Thus similar studies are necessary to confirm these results.

Topics: Aged; Arthritis; Ascorbic Acid; beta Carotene; Case-Control Studies; Diet; England; Female; Fruit; Humans; Male; Middle Aged; Odds Ratio; Prospective Studies; Risk Assessment; Vegetables; Vitamin E

Topics: Animals; Antioxidants; Arthritis; Ascorbic Acid; Dog Diseases; Dogs; Treatment Outcome

Topics: Arthritis; Ascorbic Acid; Humans

We performed animal experiments to test the hypothesis that active oxygen species (AOS) play a major role in adjuvant-induced arthritis in rats and to determine whether large-dose ascorbic acid administration would suppress the development of arthritis, reducing the level of damaging AOS in the same animal model. Arthritis was induced in male Lewis rats by adjuvant injection into the base of the tail. Ascorbic acid at doses of 0.5, 1.0, and 2.0 g/kg body weight (BW) was injected intraperitoneally twice each week for 3 weeks (9 rats per group). The BW, hind paw edema, and arthritis score of the extremities were monitored during the period. On day 21, synovial tissues obtained from the ankle joints were examined histologically and for the activity of superoxide dismutase (SOD). The SOD activity in the red blood cells (RBC) was also measured. The arthritic control rats showed significant increases in paw volume and arthritis score from day 11. These changes were dose-dependently reduced by ascorbic acid administration. The infiltration of inflammatory cells into the synovial tissues was markedly decreased by ascorbic acid. The increases in SOD activities produced by the adjuvant injection were significantly reduced in both the synovium and the RBC at ascorbic acid doses of 1.0 and 2.0 g/kg BW. In conclusion, large-dose ascorbic acid administration reduced the increases in hind paw inflammatory edema, arthritis in the extremities, and infiltration of the inflammatory cells into the synovial tissue in the adjuvant-induced arthritis rats. Since these anti-arthritic effects were associated with a decrease in SOD activities in both the synovium and RBC, the decrease in SOD activity could be one of the mechanisms underlying the suppressive effects of large-dose ascorbic acid on the development of arthritis in this animal model, inhibiting the damaging AOS.

Topics: Animals; Arthritis; Ascorbic Acid; Free Radical Scavengers; Male; Rats; Rats, Inbred Lew; Superoxide Dismutase; Synovial Membrane

We report a case of calcium oxalate arthropathy in a woman undergoing intermittent peritoneal dialysis who was not receiving pharmacologic doses of ascorbic acid. She developed acute arthritis, with calcium oxalate crystals in Heberden's and Bouchard's nodes, a phenomenon previously described in gout. Intermittent peritoneal dialysis may be less efficient than hemodialysis in clearing oxalate, and physicians should now consider calcium oxalate-associated arthritis in patients undergoing peritoneal dialysis who are not receiving large doses of ascorbic acid.

Topics: Aged; Arthritis; Ascorbic Acid; Calcium Oxalate; Crystallization; Female; Hand; Humans; Kidney Failure, Chronic; Peritoneal Dialysis; Radiography

The metabolic disorder, alkaptonuria, is distinguished by elevated serum levels of 2,5-dihydroxyphenylacetic acid (homogentisic acid), pigmentation of cartilage and connective tissue and, ultimately, the development of inflammatory arthritis. Oxygen radical generation during homogentisic acid autoxidation was characterized in vitro to assess the likelihood that oxygen radicals act as molecular agents of alkaptonuric arthritis in vivo. For homogentisic acid autoxidized at physiological pH and above, yielding superoxide (O2-)2 and hydrogen peroxide (H2O2), the homogentisic acid autoxidation rate was oxygen dependent, proportional to homogentisic acid concentration, temperature dependent and pH dependent. Formation of the oxidized product, benzoquinoneacetic acid was inhibited by the reducing agents, NADH, reduced glutathione, and ascorbic acid and accelerated by SOD and manganese-pyrophosphate. Manganese stimulated autoxidation was suppressed by diethylenetriaminepentaacetic acid (DTPA). Homogentisic acid autoxidation stimulated a rapid cooxidation of ascorbic acid at pH 7.45. Hydrogen peroxide was among the products of cooxidation. The combination of homogentisic acid and Fe3+-EDTA stimulated hydroxyl radical (OH.) formation estimated by salicylate hydroxylation. Ferric iron was required for the reaction and Fe3+-EDTA was a better catalyst than either free Fe3+ or Fe3+-DTPA. SOD accelerated OH. production by homogentisic acid as did H2O2, and catalase reversed much of the stimulation by SOD. Catalase alone, and the hydroxyl radical scavengers, thiourea and sodium formate, suppressed salicylate hydroxylation. Homogentisic acid and Fe3+-EDTA also stimulated the degradation of hyaluronic acid, the chief viscous element of synovial fluid. Hyaluronic acid depolymerization was time dependent and proportional to the homogentisic acid concentration up to 100 microM. The level of degradation observed was comparable to that obtained with ascorbic acid at equivalent concentrations. The hydroxyl radical was an active intermediate in depolymerization. Thus, catalase and the hydroxyl radical scavengers, thiourea and dimethyl sulfoxide, almost completely suppressed the depolymerization reaction. The ability of homogentisic acid to generate O2-, H2O2 and OH. through autoxidation and the degradation of hyaluronic acid by homogentisic acid-mediated by OH. production suggests that oxygen radicals play a significant role in the etiology of alkaptonuric arthritis.

Topics: Alkaptonuria; Animals; Arthritis; Ascorbic Acid; Edetic Acid; Free Radicals; Homogentisic Acid; Hyaluronic Acid; Oxidation-Reduction; Oxygen Consumption; Polarography; Pyrogallol; Superoxide Dismutase

Topics: Administration, Topical; Aloe; Animals; Arthritis; Arthritis, Experimental; Ascorbic Acid; Disease Models, Animal; Drug Combinations; Male; Plant Extracts; Plants, Medicinal; Rats; Rats, Inbred Strains; RNA

High but well-tolerated doses of the nutritional antioxidants selenium and vitamins E and C have significant immunostimulant, anti-inflammatory, and anti-carcinogenic effects which are well documented in the existing biomedical literature. In addition, these antioxidants help to protect the structural integrity of ischemic or hypoxic tissues, and may have useful anti-thrombotic actions as well. Supplementation with high-dose nutritional antioxidants may eventually gain a broad role in the prevention, treatment, or palliation of cancer, cardiovascular disease, infection, inflammatory disorders, and certain diabetic complications.

Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Antioxidants; Arthritis; Ascorbic Acid; Cardiovascular Diseases; Diabetes Mellitus; Free Radicals; Humans; Hypoxia; Ischemia; Mice; Neoplasms; Rabbits; Rats; Selenium; Superoxides; Thrombosis; Vitamin E

Topics: Aloe; Animals; Arthritis; Arthritis, Experimental; Ascorbic Acid; DNA; Male; Plants, Medicinal; Rats; Rats, Inbred Strains; Thymus Extracts

Topics: Animals; Arthritis; Ascorbic Acid; Connective Tissue; Depression, Chemical; Drug Synergism; Glycosaminoglycans; Indomethacin; Male; Rats

Topics: Adrenal Glands; Aminopyrine; Animals; Anti-Inflammatory Agents; Arthritis; Ascorbic Acid; Aspirin; Benzoates; Capillary Permeability; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Edema; Erythema; Flufenamic Acid; Gastric Mucosa; Granuloma; Mefenamic Acid; Phenylbutazone; Phenylenediamines; Prednisolone; Rats; Thymus Gland

Topics: Animals; Anti-Inflammatory Agents; Arthritis; Ascorbic Acid; Aspirin; Carrageenan; Disease Models, Animal; Edema; Erythema; Female; Freund's Adjuvant; Glucuronidase; Guinea Pigs; In Vitro Techniques; Liver; Lysosomes; Male; Phenylbutazone; Rats; Rats, Inbred Strains; Ultraviolet Rays

Topics: Adult; Arthritis; Ascorbic Acid; Biopsy; Bloodletting; Deferoxamine; Female; Gastric Juice; Hemochromatosis; Humans; Intestinal Absorption; Iron; Liver; Male; Middle Aged

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Aspirin; Blood Chemical Analysis; Humans; Knee; Plasma; Proteins; Salicylates; Serum Albumin; Synovial Fluid

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Blood Protein Electrophoresis; Hemagglutination Inhibition Tests; Humans; Hyaluronic Acid; Knee; Synovial Fluid

Topics: Anticoagulants; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Aspirin; Gout; Hip Joint; Humans; Joint Diseases; Rheumatology; Spondylitis; Spondylitis, Ankylosing

Topics: Antimalarials; Arthritis; Ascorbic Acid; Child; Giant Cell Arteritis; Humans; Lupus Erythematosus, Systemic; Pyridoxine; Rheumatology; Toxicology

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid

Topics: Antimalarials; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Gout; Humans; Psoriasis; Spondylitis; Spondylitis, Ankylosing; Sunlight; Triamcinolone; Ultraviolet Rays; Vitamin A

Topics: Adrenal Glands; Arthritis; Ascorbic Acid; Blood Glucose; Body Fluids; Glycoproteins; Metabolism; Mucoproteins; Mycobacterium Infections; Physiology; Rats; Research; Urine

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Blood Proteins; Blood Sedimentation; Humans; Tyrosine; Vitamins

Topics: Adrenal Cortex; Arthritis; Ascorbic Acid; Commiphora; Gingiva; Plant Extracts; Plant Gums; Plants, Medicinal; Spleen

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Body Fluids; Humans; Joint Diseases; Thiamine; Vitamins

Topics: Arthritis; Ascorbic Acid; Ascorbic Acid Deficiency; Humans; Vitamins

Topics: 4-Aminobenzoic Acid; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Aspirin; Niacin; Nicotinic Acids; Vitamins

Topics: 4-Aminobenzoic Acid; Arthritis; Ascorbic Acid; Disease Management; Drug Synergism; Humans; Hydrocortisone; Salicylic Acid; Vitamins

Topics: Adrenal Cortex Hormones; Antacids; Arthritis; Ascorbic Acid; Aspirin; General Practice; Humans; Prednisone; Rheumatic Diseases; Salicylates; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Humans; Prednisone; Salicylamides; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Mechlorethamine; Nitrogen Mustard Compounds; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Combined Modality Therapy; Gold; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Flavones; Hesperidin; Osteoarthritis; Vitamins

Topics: Antacids; Arthritis; Arthritis, Reactive; Arthritis, Rheumatoid; Ascorbic Acid; Aspirin; Prednisone; Vitamins

Topics: Anthelmintics; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Mephenesin; Salicylates; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Vitamins

Topics: Adenosine Triphosphate; Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Humans; Hypersensitivity; Rheumatic Diseases

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Carbohydrate Metabolism; Electrolytes; Humans; Leukocyte Count; Minerals; Rheumatic Diseases; Salicylates; Sodium Salicylate; Uric Acid

Topics: Administration, Intravenous; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Eosinophils; Humans; Infrared Rays; Leukocyte Count; Quartz; Ultraviolet Rays; Ultraviolet Therapy; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Cortisone; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Cortisone; Oxytetracycline; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Blood Proteins; Capillary Permeability; Desoxycorticosterone; Desoxycorticosterone Acetate

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Desoxycorticosterone Acetate; Pregnenolone; Vitamins

Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Cortisone; Desoxycorticosterone Acetate; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Vitamins

Topics: Adrenal Glands; Animals; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Formaldehyde; Rats; Respiratory Hypersensitivity

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Desoxycorticosterone Acetate; Rheumatic Diseases; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Rheumatic Diseases; Steroids

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Desoxycorticosterone Acetate; Diabetes Mellitus; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Cortisone

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Steroids; Vitamins

Topics: Animals; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Cortisone; Desoxycorticosterone; Formaldehyde; Rats; Vitamins

Topics: Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Desoxycorticosterone Acetate; Psoriasis; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Desoxycorticosterone Acetate; Rheumatic Fever; Vitamins

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Vitamins

Topics: Acetates; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Pregnenolone; Steroids; Testosterone Propionate

Topics: Acetates; Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Vitamins

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Vitamins

Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Cortisone; Formaldehyde; Vitamins

Topics: Age Factors; Animals; Arthritis; Ascorbic Acid; Cold Temperature; Formaldehyde; Rats

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Cortisone; Desoxycorticosterone; Nitrogen; Pregnenolone; Sulfur

Topics: Aged; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Humans; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Gonadal Steroid Hormones

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Joint Diseases

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Vitamins

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Corticosterone; Rheumatic Diseases

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Vitamins

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Diabetes Mellitus; Humans; Vitamins

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Vitamins

Topics: Adrenal Cortex Hormones; Arthritis; Ascorbic Acid; Desoxycorticosterone; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Vitamins

Topics: Adrenal Cortex Hormones; Arthritis; Ascorbic Acid; Progesterone; Vitamins

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Vitamins

Topics: Animals; Arthritis; Ascorbic Acid; Chorionic Gonadotropin; Gonadotropins; Rats; Vitamins

Topics: Adrenal Cortex; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Vitamins

Topics: Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Cortisone; Steroids; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Corticosterone; Desoxycorticosterone; Psychotherapy, Multiple; Vitamins

Topics: Arthritis; Ascorbic Acid; Desoxycorticosterone; Desoxycorticosterone Acetate; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Hormones; Steroids; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Cortisone; Formaldehyde; Potassium; Potassium Chloride; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Cortisone; Desoxycorticosterone; Humans; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Desoxycorticosterone Acetate; Eosinophils; Joints; Leukocyte Count; Leukocytes

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Vitamins

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Vitamins

Topics: Adrenal Cortex Hormones; Animals; Arthritis; Arthritis, Experimental; Ascorbic Acid; Desoxycorticosterone Acetate

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Vitamins

Topics: Adrenal Cortex Hormones; Animals; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Leukocytes; Rats

Topics: Adrenal Cortex Hormones; Arthritis; Ascorbic Acid; Chronic Disease; Desoxycorticosterone Acetate; Joints

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Vitamins

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Vitamins

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Vitamins

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Muscles; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone

Topics: Adrenal Cortex Hormones; Animals; Arthritis; Ascorbic Acid; Desoxycorticosterone Acetate; Formaldehyde; Rats; Vitamins

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Rheumatic Diseases

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Joint Diseases; Water-Electrolyte Balance

Topics: Adrenal Cortex Hormones; Animals; Arthritis; Ascorbic Acid; Desoxycorticosterone Acetate; Formaldehyde; Rats; Vitamins

Topics: Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Rheumatic Diseases

Topics: Adrenal Cortex; Adrenal Glands; Animals; Arthritis; Ascorbic Acid; Formaldehyde; Rats; Tissue Extracts; Vitamins

Topics: Adrenal Glands; Arthritis; Ascorbic Acid; Humans; Tissue Extracts

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Steroids; Vitamins

Topics: Adrenal Cortex; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Tissue Extracts; Vitamins

Topics: Adrenal Cortex; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Tissue Extracts

Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Tissue Extracts; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Rheumatic Diseases; Vitamins

Topics: Adrenal Cortex; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Tissue Extracts

Topics: Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Epinephrine; Injections, Intramuscular; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Humans; Joint Diseases; Niacin; Niacinamide

Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Arthritis; Ascorbic Acid; Cortisone; Desoxycorticosterone Acetate; Joints; Tissue Extracts

Topics: Adrenal Cortex; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Tissue Extracts

Topics: Adrenal Cortex; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Joint Diseases; Tissue Extracts

Topics: Adrenal Cortex; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone Acetate; Tissue Extracts

Topics: Adrenal Cortex; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Desoxycorticosterone; Joint Diseases; Tissue Extracts

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Gold; Organogold Compounds; Vitamins

Topics: Acetates; Adrenal Glands; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Injections; Tissue Extracts; Vitamins

Topics: Acetates; Adrenal Glands; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Tissue Extracts; Vitamins

Topics: Adrenocorticotropic Hormone; Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Cortisone

Topics: Arthritis; Ascorbic Acid

Topics: Arthritis; Ascorbic Acid; Female; Humans; Pre-Eclampsia; Pregnancy; Toxemia; Vitamins

Topics: Arthritis; Ascorbic Acid; Calcium; Calcium, Dietary; Humans; Milk; Vitamin D; Vitamins

Topics: Arthritis; Arthritis, Rheumatoid; Ascorbic Acid; Blood Vessels; Capillaries; Capillary Fragility; Cardiovascular System; Hesperidin; Humans