Page last updated: 2024-08-05 15:36:47

EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor

An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of 4-nitrophenylphosphatase (EC 3.1.3.41).

ChEBI ID: 77024

Members (2)

MemberDefinitionClass
ouabainA steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.ouabain
vanadatesA vanadium oxoanion that is a trianion with formula VO4 in which the vanadium is in the +5 oxidation state and is attached to four oxygen atoms.vanadate(3-)

Research

Studies (20,556)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199011,242 (54.69)18.7374
1990's4,799 (23.35)18.2507
2000's2,776 (13.50)29.6817
2010's1,483 (7.21)24.3611
2020's256 (1.25)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials79 (0.37%)5.53%
Reviews521 (2.42%)6.00%
Case Studies23 (0.11%)4.05%
Observational2 (0.01%)0.25%
Other20,932 (97.10%)84.16%

Protein Targets (74)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
activating transcription factor 6Homo sapiens (human)Potency0.115712
AR proteinHomo sapiens (human)Potency0.2970920
ATAD5 protein, partialHomo sapiens (human)Potency0.106933
Ataxin-2Homo sapiens (human)Potency0.042513
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency1.741526
Cellular tumor antigen p53Homo sapiens (human)Potency0.093612
Chain A, Beta-lactamaseEscherichia coli K-12Potency25.118911
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency0.958313
estrogen nuclear receptor alphaHomo sapiens (human)Potency0.2459821
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency1.017124
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency0.12401016
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency22.387211
farnesoid X nuclear receptorHomo sapiens (human)Potency3.285924
gemininHomo sapiens (human)Potency0.175622
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency0.211824
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency0.049712
Interferon betaHomo sapiens (human)Potency0.041024
lamin isoform A-delta10Homo sapiens (human)Potency0.794311
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency77.266813
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency1.425323
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency0.029012
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency0.149335
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency84.921411
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency0.409037
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency1.102235
PPM1D proteinHomo sapiens (human)Potency0.037012
pregnane X nuclear receptorHomo sapiens (human)Potency0.570512
progesterone receptorHomo sapiens (human)Potency0.317823
RAR-related orphan receptor gammaMus musculus (house mouse)Potency40.927412
ras-related protein Rab-9AHomo sapiens (human)Potency14.609412
retinoid X nuclear receptor alphaHomo sapiens (human)Potency0.290724
SMAD family member 2Homo sapiens (human)Potency0.093624
SMAD family member 3Homo sapiens (human)Potency0.093624
survival motor neuron protein isoform dHomo sapiens (human)Potency0.223911
TDP1 proteinHomo sapiens (human)Potency0.781624
thioredoxin reductaseRattus norvegicus (Norway rat)Potency37.685811
thyroid stimulating hormone receptorHomo sapiens (human)Potency1.607034
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency0.329111
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency0.579534
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency0.049712

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Bile salt export pumpHomo sapiens (human)IC501,000.000011
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)Mus musculus (house mouse)Ki0.002811
Chain L, Igg2b-kappa 40-50 Fab (light Chain)Mus musculus (house mouse)Ki0.002811
Kruppel-like factor 5Homo sapiens (human)IC500.083233
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)IC500.164611
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC505.800011
Receptor-type tyrosine-protein phosphatase FHomo sapiens (human)IC5022.563313
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC500.097011
signal transducer and activator of transcription 1-alpha/beta isoform alphaHomo sapiens (human)IC5055.700011
Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)IC506.000011
Sodium/potassium-transporting ATPase subunit alpha-1 Rattus norvegicus (Norway rat)IC504.300011
Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)Ki0.093512
Sodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)IC506.000011
Sodium/potassium-transporting ATPase subunit alpha-2Rattus norvegicus (Norway rat)IC500.170011
Sodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)Ki0.093512
Sodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)IC506.000011
Sodium/potassium-transporting ATPase subunit alpha-3 Rattus norvegicus (Norway rat)IC500.031011
Sodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)IC506.000011
Sodium/potassium-transporting ATPase subunit alpha-4Rattus norvegicus (Norway rat)IC500.003022
Sodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)IC506.000011
Sodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)Ki0.093512
Sodium/potassium-transporting ATPase subunit beta-1 Rattus norvegicus (Norway rat)IC501.126344
Sodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)IC506.000011
Sodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)IC506.000011
Sodium/potassium-transporting ATPase subunit beta-3Rattus norvegicus (Norway rat)IC500.001811
Sodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)IC506.000011
STAT3, partialHomo sapiens (human)IC501.154011
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC5016.928824
Tyrosine-protein phosphatase non-receptor type 11Homo sapiens (human)IC5022.563313
Tyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)IC5022.563313
Tyrosine-protein phosphatase non-receptor type 6Homo sapiens (human)IC5022.563313

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, Na, K-ATPase alpha subunitSqualus acanthias (spiny dogfish)Kd0.000711

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Sodium/potassium-transporting ATPase subunit alpha-1 Homo sapiens (human)LC509.400011
Sodium/potassium-transporting ATPase subunit alpha-2Homo sapiens (human)LC509.400011
Sodium/potassium-transporting ATPase subunit alpha-3Homo sapiens (human)LC509.400011
Sodium/potassium-transporting ATPase subunit alpha-4Homo sapiens (human)LC509.400011
Sodium/potassium-transporting ATPase subunit beta-1Homo sapiens (human)LC509.400011
Sodium/potassium-transporting ATPase subunit beta-2Homo sapiens (human)LC509.400011
Sodium/potassium-transporting ATPase subunit beta-3Homo sapiens (human)LC509.400011
Sodium/potassium-transporting ATPase subunit gammaHomo sapiens (human)LC509.400011
Solute carrier organic anion transporter family member 1A1Rattus norvegicus (Norway rat)Km2,350.000022
Solute carrier organic anion transporter family member 1A2Homo sapiens (human)Km5,500.000011
Solute carrier organic anion transporter family member 1A4Rattus norvegicus (Norway rat)Km470.000011
Solute carrier organic anion transporter family member 1A5Rattus norvegicus (Norway rat)Km1,571.000011
Solute carrier organic anion transporter family member 4C1Homo sapiens (human)Km0.380011