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polyether

Any ether that contains more than one ether linkage.

ChEBI ID: 46774

Members (19)

MemberDefinitionRole
bay94 9172A member of the class of stilbenoids in which the para-hydrogens of stilbene are replaced by methylamino and 2-{2-[2-((18)F)fluoroethoxy]ethoxy}ethoxy) groups. A positron emission tomography imaging ligand for the detection of amyloid aggregation associated with Alzheimer disease.florbetaben ((18)F)
benzoylaconineA diterpene alkaloid with formula C32H45NO10 that is isolated from several Aconitum species.benzoylaconine
benzoylmesaconineA diterpene alkaloid with formula C31H43NO10 that is isolated from several Aconitum species.benzoylmesaconine
deoxyaconitineA diterpene alkaloid with formula C34H47NO10 that is isolated from several Aconitum species.deoxyaconitine
diglymeA polyether that is the dimethyl ether derivative of diethylene glycol.diglyme
er-086526A fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mechanism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockageeribulin
glaucineAn aporphine alkaloid that is (S)-1,2,9,10-tetrahydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline in which the four phenolic hydrogens have been replaced by methyl groups.(S)-glaucine
hexamidineA polyether that is the bis(4-guanidinophenyl) ether of hexane-1,6-diol.hexamidine
naloxegolAn organic heteropentacyclic compound that is naloxone in which the keto group is replaced by a PEG moiety. Used for treatment of opioid-induced constipation.naloxegol
norverapamilA secondary amino compound that is 3,4-dimethoxyphenylethylamine in which one of the hydrogens attached to the nitrogen has been replaced by a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-(propan-2-yl)pentanenitrile
propamidineA polyether that is the bis(4-guanidinophenyl) ether of propane-1,3-diol. Used (as its isethionate salt) for the treatment of minor eye or eyelid infections, such as conjunctivitis and blepharitis.propamidine
Src Inhibitor-1A member of the class of quinazolines that is quinazoline which is substituted at position 4 by a p-phenoxyanilino group and at positions 6 and 7 by methoxy groups. It is a potent, competitive dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the 'gold standards' for Src kinase inhibition that has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases.Src Inhibitor-1
syringaresinolA lignan that is 7,9':7',9-diepoxylignane substituted by hydroxy groups at positions 4 and 4' and methoxy groups at positions 3, 3', 5 and 5' respectively.syringaresinol
tetraglymetetraglyme
tetrahydropapaverineA benzylisoquinoline alkaloid that is norlaudanosoline in which the four phenolic hydrogens have been replaced by methyl groups.1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
triglymeA polyether that consists of dodecane in which the carbon atoms at positions 2, 5, 8 and 11 are replaced by oxygen atoms.triglyme
verapamilA tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
yunaconitineA diterpene alkaloid with formula C35H49NO11 that is isolated from several Aconitum species.yunaconitine
zm 447439A member of the class of quinazolines that is quinazoline which is substituted at positions 4, 6 and 7 by a (4-benzamidophenyl)nitrilo group, methoxy group and a 3-(morpholin-4-yl)propoxy group, respectively. It is an ATP-competitive inhibitor of Aurora A and Aurora B kinases with IC50 of 110 nM and 130 nM, respectively.ZM447439

Research

Studies (17,611)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-19906,691 (37.99)18.7374
1990's5,032 (28.57)18.2507
2000's2,742 (15.57)29.6817
2010's2,505 (14.22)24.3611
2020's641 (3.64)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials1,702 (8.96%)5.53%
Reviews946 (4.98%)6.00%
Case Studies1,175 (6.18%)4.05%
Observational26 (0.14%)0.25%
Other15,154 (79.75%)84.16%