Page last updated: 2024-08-05 11:10:58
polyether
Any ether that contains more than one ether linkage.
ChEBI ID: 46774
Members (19)
| Member | Definition | Role |
|---|---|---|
| bay94 9172 | A member of the class of stilbenoids in which the para-hydrogens of stilbene are replaced by methylamino and 2-{2-[2-((18)F)fluoroethoxy]ethoxy}ethoxy) groups. A positron emission tomography imaging ligand for the detection of amyloid aggregation associated with Alzheimer disease. | florbetaben ((18)F) |
| benzoylaconine | A diterpene alkaloid with formula C32H45NO10 that is isolated from several Aconitum species. | benzoylaconine |
| benzoylmesaconine | A diterpene alkaloid with formula C31H43NO10 that is isolated from several Aconitum species. | benzoylmesaconine |
| deoxyaconitine | A diterpene alkaloid with formula C34H47NO10 that is isolated from several Aconitum species. | deoxyaconitine |
| diglyme | A polyether that is the dimethyl ether derivative of diethylene glycol. | diglyme |
| er-086526 | A fully synthetic macrocyclic ketone analogue of marine sponge natural products. Inhibits growth phase of microtubules via tubulin-based antimitotic mechanism, which leads to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage | eribulin |
| glaucine | An aporphine alkaloid that is (S)-1,2,9,10-tetrahydroxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline in which the four phenolic hydrogens have been replaced by methyl groups. | (S)-glaucine |
| hexamidine | A polyether that is the bis(4-guanidinophenyl) ether of hexane-1,6-diol. | hexamidine |
| naloxegol | An organic heteropentacyclic compound that is naloxone in which the keto group is replaced by a PEG moiety. Used for treatment of opioid-induced constipation. | naloxegol |
| norverapamil | A secondary amino compound that is 3,4-dimethoxyphenylethylamine in which one of the hydrogens attached to the nitrogen has been replaced by a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group. | 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]amino}-2-(propan-2-yl)pentanenitrile |
| propamidine | A polyether that is the bis(4-guanidinophenyl) ether of propane-1,3-diol. Used (as its isethionate salt) for the treatment of minor eye or eyelid infections, such as conjunctivitis and blepharitis. | propamidine |
| Src Inhibitor-1 | A member of the class of quinazolines that is quinazoline which is substituted at position 4 by a p-phenoxyanilino group and at positions 6 and 7 by methoxy groups. It is a potent, competitive dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the 'gold standards' for Src kinase inhibition that has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. | Src Inhibitor-1 |
| syringaresinol | A lignan that is 7,9':7',9-diepoxylignane substituted by hydroxy groups at positions 4 and 4' and methoxy groups at positions 3, 3', 5 and 5' respectively. | syringaresinol |
| tetraglyme | tetraglyme | |
| tetrahydropapaverine | A benzylisoquinoline alkaloid that is norlaudanosoline in which the four phenolic hydrogens have been replaced by methyl groups. | 1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline |
| triglyme | A polyether that consists of dodecane in which the carbon atoms at positions 2, 5, 8 and 11 are replaced by oxygen atoms. | triglyme |
| verapamil | A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group. | 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile |
| yunaconitine | A diterpene alkaloid with formula C35H49NO11 that is isolated from several Aconitum species. | yunaconitine |
| zm 447439 | A member of the class of quinazolines that is quinazoline which is substituted at positions 4, 6 and 7 by a (4-benzamidophenyl)nitrilo group, methoxy group and a 3-(morpholin-4-yl)propoxy group, respectively. It is an ATP-competitive inhibitor of Aurora A and Aurora B kinases with IC50 of 110 nM and 130 nM, respectively. | ZM447439 |
Research
Studies (17,611)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 6,691 (37.99) | 18.7374 |
| 1990's | 5,032 (28.57) | 18.2507 |
| 2000's | 2,742 (15.57) | 29.6817 |
| 2010's | 2,505 (14.22) | 24.3611 |
| 2020's | 641 (3.64) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,702 (8.96%) | 5.53% |
| Reviews | 946 (4.98%) | 6.00% |
| Case Studies | 1,175 (6.18%) | 4.05% |
| Observational | 26 (0.14%) | 0.25% |
| Other | 15,154 (79.75%) | 84.16% |