Page last updated: 2024-08-05 15:45:58

EC 2.7.1.91 (sphingosine kinase) inhibitor

An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of sphinganine kinase (EC 2.7.1.91).

ChEBI ID: 78760

Members (2)

MemberDefinitionClass
n,n-dimethylsphingenineA sphingoid that is sphingosine in which the two amino hydrogens are replaced by methyl groups.N,N-dimethylsphingosine
romeA 2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol that has R-configuration. It is a sphingosine kinase-2 inhibitor.(2R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol

Research

Studies (2,725)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990854 (31.34)18.7374
1990's391 (14.35)18.2507
2000's482 (17.69)29.6817
2010's646 (23.71)24.3611
2020's352 (12.92)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials87 (2.59%)5.53%
Reviews81 (2.41%)6.00%
Case Studies85 (2.53%)4.05%
Observational46 (1.37%)0.25%
Other3,060 (91.10%)84.16%

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Lethal factorBacillus anthracisIC502.300011
Sphingosine kinase 1Homo sapiens (human)IC5029.021766
Sphingosine kinase 1Homo sapiens (human)Ki9.000033
Sphingosine kinase 2Homo sapiens (human)IC5038.322544
Sphingosine kinase 2Homo sapiens (human)Ki16.437578
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