An EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor that interferes with the action of sphinganine kinase (EC 2.7.1.91).
ChEBI ID: 78760
| Member | Definition | Class |
|---|---|---|
| n,n-dimethylsphingenine | A sphingoid that is sphingosine in which the two amino hydrogens are replaced by methyl groups. | N,N-dimethylsphingosine |
| rome | A 2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol that has R-configuration. It is a sphingosine kinase-2 inhibitor. | (2R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 854 (31.34) | 18.7374 |
| 1990's | 391 (14.35) | 18.2507 |
| 2000's | 482 (17.69) | 29.6817 |
| 2010's | 646 (23.71) | 24.3611 |
| 2020's | 352 (12.92) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 87 (2.59%) | 5.53% |
| Reviews | 81 (2.41%) | 6.00% |
| Case Studies | 85 (2.53%) | 4.05% |
| Observational | 46 (1.37%) | 0.25% |
| Other | 3,060 (91.10%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Lethal factor | Bacillus anthracis | IC50 | 2.3000 | 1 | 1 |
| Sphingosine kinase 1 | Homo sapiens (human) | IC50 | 29.0217 | 6 | 6 |
| Sphingosine kinase 1 | Homo sapiens (human) | Ki | 9.0000 | 3 | 3 |
| Sphingosine kinase 2 | Homo sapiens (human) | IC50 | 38.3225 | 4 | 4 |
| Sphingosine kinase 2 | Homo sapiens (human) | Ki | 16.4375 | 7 | 8 |