Page last updated: 2024-09-27

Smith-Lemli-Opitz Syndrome

An autosomal recessive disorder of CHOLESTEROL metabolism. It is caused by a deficiency of 7-dehydrocholesterol reductase, the enzyme that converts 7-dehydrocholesterol to cholesterol, leading to an abnormally low plasma cholesterol. This syndrome is characterized by multiple CONGENITAL ABNORMALITIES, growth deficiency, and INTELLECTUAL DISABILITY.

Synonyms(1)

Synonym
Smith-Lemli-Opitz Syndrome

Research

Studies (338)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's88 (26.04)12.5806
2000's140 (41.42)18.1394
2010's99 (29.29)28.8240
2020's11 (3.25)9.53
DrugIndicatedRelationship StrengthStudiesTrials
hydrogen0low10
picolinic acid0low10
selenious acid0low10
homovanillic acid0low10
hydroxyindoleacetic acid0low10
hydroxyurea0low10
ketoconazole0low10
trazodone0low10
corticosterone0low10
estriol0medium181
aldosterone0low20
androsterone0low10
dehydroepiandrosterone0low10
serine0low10
lysine0low10
methionine0low20
1,2-dipalmitoylphosphatidylcholine0low10
17-alpha-hydroxyprogesterone0low10
threonine0low30
arginine0low10
acetonitrile0low10
triparanol0low10
taurocholic acid0medium11
2-methylpentane0low10
pyrroles0low10
pregnenolone0low10
trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride0low240
d-alpha tocopherol0low60
silver0low20
phenyl acetate0low20
pregnanolone0low10
lovastatin0low30
aripiprazole0low10
atorvastatin0low10
mevastatin0low10
lathosterol0medium101
triazoles0low10
4-phenyl-1,2,4-triazoline-3,5-dione0low10
7-ketocholesterol0low40
acetoacetyl coa0low10
pregnanetriol0medium51
ym 94290low10
27-hydroxycholesterol0low20
cholesta-5,8-dien-3 beta-ol0medium221
7,25-dihydroxycholesterol0low10
16-hydroxydehydroepiandrosterone sulfate0low10
lanosterol0low50
mevalonic acid0low80
7-dehydrocholesterol0medium1342
desmosterol0low70
cyclopamine0low10
betadex0low20
acetyl coenzyme a0low20
ergosterol0low30
3-hydroxy-3-methylglutaryl-coenzyme a0low10
retinol0low10
t09013170low10
gamma-sitosterol0low20
squalene0low30
3-methylglutaconic acid0low20
1,3-dimethylthiourea0low10
thiourea0low10
nadp0low10
cytellin0low50
bilirubin0low10
dinoprostone0low10
calcitriol0low10
stigmasterol0low20
brassicasterol0low20
coenzyme q100low20
4-hydroxy-2-nonenal0low10
sirolimus0low10
mevalonolactone0low10
dolichols0low20
bm 157660low80
g(m1) ganglioside0low10
11 beta-hydroxyandrosterone0low10
24-hydroxycholesterol0low10
phytosterols0low40
cytochrome c-t0low10
phosphatidylcholines0low20
ubiquinone0low40
glycolipids0low20
piperidines0low10
ascorbic acid0low10
cyclosporine0low10
filipin0low10

Protein Targets (905)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
hypoxia-inducible factor 1 alpha subunit6006
RAR-related orphan receptor gamma140014
GLI family zinc finger 3170017
AR protein230023
estrogen receptor 2 (ER beta)120012
nuclear receptor subfamily 1, group I, member 39009
progesterone receptor100010
retinoid X nuclear receptor alpha180018
estrogen-related nuclear receptor alpha220022
thyroid hormone receptor beta isoform 2170017
nuclear factor erythroid 2-related factor 2 isoform 1170017
acetylcholinesterase7007
pregnane X receptor6006
SMAD family member 2100010
SMAD family member 3100010
TDP1 protein180018
Microtubule-associated protein tau9009
glucocorticoid receptor [Homo sapiens]180018
retinoic acid nuclear receptor alpha variant 1200020
farnesoid X nuclear receptor110011
pregnane X nuclear receptor130013
estrogen nuclear receptor alpha220022
G6006
vitamin D (1,25- dihydroxyvitamin D3) receptor120012
arylsulfatase A2002
euchromatic histone-lysine N-methyltransferase 2120012
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a9009
activating transcription factor 66006
nuclear receptor subfamily 1, group I, member 24004
chromobox protein homolog 18008
geminin200020
survival motor neuron protein isoform d4004
histone acetyltransferase KAT2A isoform 14004
lamin isoform A-delta10110011
Voltage-dependent calcium channel gamma-2 subunit8008
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 6006
Glucocorticoid receptor0404
Sex hormone-binding globulin0077
Glycine receptor subunit alpha-10404
Corticosteroid-binding globulin0707
Adenosine receptor A30202
Replicase polyprotein 1ab0213
Androgen receptor0808
Alpha-1B adrenergic receptor0404
Glutamate receptor 28008
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Mitogen-activated protein kinase 3 0112
Alpha-1A adrenergic receptor0404
Sodium-dependent dopamine transporter 0606
TAR DNA-binding protein 435005
Inositol hexakisphosphate kinase 16006
cytochrome P450 2C9, partial6006
ATP-dependent phosphofructokinase4004
Oxysterols receptor LXR-alpha0235
glp-1 receptor, partial2002
vitamin D3 receptor isoform VDRA100010
Transient receptor potential cation channel subfamily A member 10011
Chain A, Beta-lactamase7007
Chain A, Putative fructose-1,6-bisphosphate aldolase4004
bromodomain adjacent to zinc finger domain 2B3003
IDH18008
[tau protein] kinase 0101
lysosomal alpha-glucosidase preproprotein3003
transcriptional regulator ERG isoform 32002
Rap guanine nucleotide exchange factor 43003
Vitamin D3 receptor0237
serine/threonine-protein kinase PLK12002
DNA polymerase iota isoform a (long)5005
Rap guanine nucleotide exchange factor 33003
NPC1-like intracellular cholesterol transporter 10022
Chain A, 2-ENOYL-COA HYDRATASE0101
Chain B, 2-ENOYL-COA HYDRATASE0101
N-alpha-acetyltransferase 500011
thyroid hormone receptor beta isoform a4004
nuclear factor erythroid 2-related factor 2 isoform 27007
Mineralocorticoid receptor 0134
Mineralocorticoid receptor0101
Solute carrier organic anion transporter family member 1A10406
Guanine nucleotide-binding protein G2002
Chain A, retinol dehydratase0101
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Gamma-aminobutyric acid receptor subunit pi4206
Glucose-6-phosphate 1-dehydrogenase0404
Gamma-aminobutyric acid receptor subunit beta-14206
Gamma-aminobutyric acid receptor subunit delta4206
Gamma-aminobutyric acid receptor subunit gamma-24206
Gamma-aminobutyric acid receptor subunit alpha-54206
Gamma-aminobutyric acid receptor subunit alpha-34206
Gamma-aminobutyric acid receptor subunit gamma-14206
Gamma-aminobutyric acid receptor subunit alpha-24206
Gamma-aminobutyric acid receptor subunit alpha-44206
Gamma-aminobutyric acid receptor subunit gamma-34206
Gamma-aminobutyric acid receptor subunit alpha-64206
Gamma-aminobutyric acid receptor subunit alpha-14206
Gamma-aminobutyric acid receptor subunit beta-34206
Gamma-aminobutyric acid receptor subunit beta-24206
G-protein coupled bile acid receptor 10145
GABA theta subunit4206
Gamma-aminobutyric acid receptor subunit epsilon4206
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE5005
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
thioredoxin reductase7007
phosphopantetheinyl transferase8008
NFKB1 protein, partial5005
GLS protein4004
thyroid stimulating hormone receptor9009
alpha-galactosidase2002
cytochrome P450 2C19 precursor1001
flap endonuclease 12002
muscarinic acetylcholine receptor M14004
lethal factor (plasmid)3003
Cytochrome P450 3A406211
Nitric oxide synthase, endothelial0002
Nitric oxide synthase, brain0001
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0102
Nitric oxide synthase, inducible0013
Cationic amino acid transporter 30202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, JmjC domain-containing histone demethylation protein 3A3003
5-hydroxytryptamine receptor 3E0101
Fumarate hydratase5005
USP1 protein, partial110011
PPM1D protein2002
EWS/FLI fusion protein5005
cytochrome P450 2D65005
polyprotein5005
67.9K protein3003
peroxisome proliferator-activated receptor delta9009
peroxisome proliferator activated receptor gamma100010
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
thyroid stimulating hormone receptor6006
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a6006
mu-type opioid receptor isoform MOR-10011
potassium voltage-gated channel subfamily H member 2 isoform d6006
heat shock protein beta-18008
nuclear receptor ROR-gamma isoform 19009
peripheral myelin protein 226006
5-hydroxytryptamine receptor 2A0011
neuropeptide S receptor isoform A3003
Solute carrier family 22 member 20203
ATP-binding cassette sub-family C member 30808
Multidrug resistance-associated protein 409010
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 3B0101
Bile salt export pump011012
Cellular tumor antigen p53120012
ATP-dependent translocase ABCB10809
5-hydroxytryptamine receptor 1A0224
5-hydroxytryptamine receptor 2C0101
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
D(2) dopamine receptor0314
5-hydroxytryptamine receptor 2A0404
Alpha-2C adrenergic receptor0314
D0101
5-hydroxytryptamine receptor 1A0505
Muscarinic acetylcholine receptor M30101
D(1A) dopamine receptor0101
D(4) dopamine receptor0101
D(1B) dopamine receptor0101
Alpha-1D adrenergic receptor0202
Alpha-1D adrenergic receptor0303
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 2C0404
D(4) dopamine receptor0101
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0707
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 70101
Alpha-1A adrenergic receptor0202
Histamine H1 receptor0404
Alpha-1B adrenergic receptor0101
D(3) dopamine receptor0314
5-hydroxytryptamine receptor 2B0303
5-hydroxytryptamine receptor 3A0101
5-hydroxytryptamine receptor 60101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0606
Spike glycoprotein6017
D(2) dopamine receptor0101
Inositol monophosphatase 13003
Potassium voltage-gated channel subfamily H member 20303
5-hydroxytryptamine receptor 3D0101
Multidrug and toxin extrusion protein 20101
5-hydroxytryptamine receptor 3C0101
Canalicular multispecific organic anion transporter 10707
Multidrug and toxin extrusion protein 10101
Histamine H3 receptor0101
Chain A, Hyaluronidase, phage associated0101
thioredoxin glutathione reductase3003
cytochrome P450 family 3 subfamily A polypeptide 48008
lethal(3)malignant brain tumor-like protein 1 isoform I2002
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0101
Urease0304
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0426
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, Cruzipain5005
caspase 7, apoptosis-related cysteine protease4004
caspase-34004
Caspase-72002
caspase-32002
Solute carrier organic anion transporter family member 2B1 0002
3-hydroxy-3-methylglutaryl-coenzyme A reductase0606
Insulin receptor 0404
Dipeptidyl peptidase 40101
Prostaglandin G/H synthase 20404
Histone deacetylase 10202
Histone deacetylase 20202
Solute carrier organic anion transporter family member 1B30205
Histone deacetylase 60202
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Solute carrier organic anion transporter family member 1B10609
Chain A, D-MALTODEXTRIN BINDING PROTEIN0011
Chain A, Limit Dextrinase0011
Chain A, Solute-binding protein0011
Chain A, Solute-binding protein0011
Chain B, SusD0011
Chain A, SusD0011
Chain A, SusD0011
Chain A, Alpha-hemolysin0011
Chain B, Alpha-hemolysin0011
Chain C, Alpha-hemolysin0011
Chain D, Alpha-hemolysin0011
Chain E, Alpha-hemolysin0011
Chain F, Alpha-hemolysin0011
Chain G, Alpha-hemolysin0011
aldehyde dehydrogenase 1 family, member A18008
Chain A, HADH2 protein3003
Chain B, HADH2 protein3003
Chain A, 2-oxoglutarate Oxygenase4004
DNA polymerase kappa isoform 14004
caspase-1 isoform alpha precursor1001
Caspase-71001
C-8 sterol isomerase0303
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0303
Sigma non-opioid intracellular receptor 10505
Chain A, Vitamin D Nuclear Receptor0011
Chain A, Ferritin light chain4004
Vitamin D3 receptor0011
mitogen-activated protein kinase 16006
Vitamin D-binding protein0011
Cytochrome P450 1A20001
Androgen receptor0101
Cytochrome P450 2D60101
Cytochrome P450 2C9 0203
Vitamin D3 receptor0113
Retinoic acid receptor RXR-alpha0123
Cytochrome P450 2C190202
Kappa-type opioid receptor0011
Vitamin D3 receptor0011
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0213
Vitamin D3 receptor0112
Transporter0101
Vitamin D3 receptor A0022
Chain A, serum paraoxonase0101
Carbonic anhydrase 120101
Carbonic anhydrase 10101
Carbonic anhydrase 20203
Carbonic anhydrase 30101
Neutrophil cytosol factor 10101
Carbonic anhydrase 40202
Carbonic anhydrase 60101
Carbonic anhydrase 5A, mitochondrial0202
Carbonic anhydrase 70101
Carbonic anhydrase 90203
Carbonic anhydrase 130101
Poly [ADP-ribose] polymerase tankyrase-20101
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
Ubiquitin carboxyl-terminal hydrolase 20101
Phospholipase A20011
Alpha-2A adrenergic receptor0415
Glutamate receptor ionotropic, NMDA 1 0011
Glutamate receptor ionotropic, NMDA 2A 0011
Glutamate receptor ionotropic, NMDA 2B0011
Glutamate receptor ionotropic, NMDA 2C0011
Glutamate receptor ionotropic, NMDA 2D0011
G-protein coupled bile acid receptor 10101
Glutamate receptor ionotropic, NMDA 3B0011
Bile acid receptor0123
Glutamate receptor ionotropic, NMDA 3A0011
GALC protein1001
Thrombopoietin1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
nonstructural protein 11001
serine/threonine-protein kinase mTOR isoform 12002
cytochrome P450 3A4 isoform 14004
Solute carrier family 22 member 1 0304
Solute carrier family 22 member 30101
Solute carrier family 22 member 30101
Nuclear receptor ROR-gamma4228
Solute carrier family 22 member 10202
Solute carrier family 22 member 20202
Integrin beta-10101
Integrin alpha-40101
Smoothened homolog0101
Sonic hedgehog protein0101
Sonic hedgehog protein0112
Smoothened homolog0213
importin subunit beta-1 isoform 11001
snurportin-11001
GTP-binding nuclear protein Ran isoform 11001
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
aryl hydrocarbon receptor3003
Beta-glucuronidase0101
Beta-glucuronidase0101
Alpha-synuclein3205
Glucose-6-phosphate 1-dehydrogenase 0101
regulator of G-protein signaling 44004
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
prostaglandin E2 receptor EP2 subtype1001
Solute carrier organic anion transporter family member 1A50002
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP4 subtype0101
Prostaglandin E2 receptor EP1 subtype0213
Prostaglandin E2 receptor EP1 subtype0101
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin F2-alpha receptor0011
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP3 subtype0213
Prostaglandin E2 receptor EP2 subtype0213
Prostacyclin receptor0213
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 60001
Solute carrier family 22 member 70001
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 200101
Solute carrier family 22 member 80001
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1B20002
Solute carrier family 22 member 70001
Estrogen receptor0202
Polyunsaturated fatty acid lipoxygenase ALOX150202
UDP-glucuronosyltransferase 2B70001
Lanosterol 14-alpha demethylase0011
Olfactory receptor 51E20011
UDP-glucuronosyltransferase 1A100001
ClpP1001
ATAD5 protein, partial2002
M-phase phosphoprotein 82002
Solute carrier family 22 member 80102
endonuclease IV1001
Smad36006
hypothetical protein, conserved1001
peripheral myelin protein 22 isoform 12002
cytochrome P450 2C9 precursor2002
urokinase-type plasminogen activator precursor5005
plasminogen precursor5005
urokinase plasminogen activator surface receptor precursor5005
Histamine H2 receptor2002
Uracil nucleotide/cysteinyl leukotriene receptor0101
Histone H2A.x3003
Bloom syndrome protein isoform 11001
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Stromelysin-10011
Gamma-aminobutyric acid receptor subunit alpha-10101
Urease subunit alpha0202
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit gamma-20101
Ribonucleoside-diphosphate reductase large subunit0101
Gamma-aminobutyric acid receptor subunit beta-30101
Gamma-aminobutyric acid receptor subunit alpha-50101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit beta-20101
Gamma-aminobutyric acid receptor subunit alpha-40101
Urease subunit beta0202
Gamma-aminobutyric acid receptor subunit epsilon0101
Gamma-aminobutyric acid receptor subunit alpha-60101
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit theta0101
Estrogen receptor beta0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0101
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial0202
Cytochrome P450 26A10101
Prostaglandin G/H synthase 1 0101
Prostaglandin G/H synthase 2 0101
Bile salt export pump0102
3',5'-cyclic-AMP phosphodiesterase 0101
Camphor 5-monooxygenase0001
Phospholipase A2, major isoenzyme0101
Chymotrypsinogen A0101
Beta-lactamase0101
Steroid 17-alpha-hydroxylase/17,20 lyase0202
ATP-dependent translocase ABCB10202
Epoxide hydrolase 10001
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20202
Cytochrome P450 2C11 0101
Steroid 21-hydroxylase0101
Cytochrome P450 2C80101
Aromatase0202
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cholesterol side-chain cleavage enzyme, mitochondrial 0101
Indoleamine 2,3-dioxygenase 10101
Cytochrome P450 2A20101
Cytochrome P450 11B1, mitochondrial 0101
Cytochrome P450 11B1, mitochondrial0101
Translocator protein0101
Cytochrome P450 7A1 0101
Cytochrome P450 11B2, mitochondrial0101
Estrogen receptor0101
ATP-dependent translocase ABCB10202
Substance-K receptor0404
UDP-glucuronosyltransferase 1A1 0101
Sodium-dependent noradrenaline transporter 0404
Thromboxane-A synthase 0101
Histamine H2 receptor0202
Gonadotropin-releasing hormone receptor0112
Type-1 angiotensin II receptor0101
Malate dehydrogenase, cytoplasmic0101
Delta-type opioid receptor0202
Cytochrome P450 4F20101
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial0101
Sodium/bile acid cotransporter0203
Lanosterol 14-alpha demethylase0416
Cytochrome P450 7A10101
Lanosterol 14-alpha demethylase 0202
Alpha-crystallin B chain0011
Lanosterol 14-alpha demethylase0001
Peroxisome proliferator-activated receptor alpha1001
14-alpha sterol demethylase 0001
Chain A, Antigen Cd11a (p180)0101
15-lipoxygenase, partial2002
PINK14004
isocitrate dehydrogenase 1, partial2002
Parkin4004
thyrotropin-releasing hormone receptor1001
bcl-2-related protein A10101
Integrin beta-20101
Intercellular adhesion molecule 10101
Neutrophil elastase0101
Integrin alpha-L0112
Adenosine receptor A10202
Acyl-CoA:cholesterol acyltransferase 0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Glutathione reductase, mitochondrial0202
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
Large neutral amino acids transporter small subunit 10101
D(1A) dopamine receptor2002
huntingtin isoform 21001
D(1A) dopamine receptor1001
Potassium channel subfamily K member 90101
Neuraminidase 0202
Neuraminidase 0202
Neuraminidase 0202
Neuraminidase0202
Neuraminidase0101
Neuraminidase0202
Sialidase0101
Acyl-CoA desaturase 10101
Liver carboxylesterase 10001
Neuraminidase 0202
Neuraminidase 0202
Neuraminidase0101
Neuraminidase0101
Sialidase-40101
Sialidase-10101
Sialidase-30101
Sialidase-20101
Beta-lactamase 0101
Beta-lactamase 0112
Nicotinate phosphoribosyltransferase0101
Proton-coupled amino acid transporter 10202
Transmembrane prolyl 4-hydroxylase0101
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit alpha-10001
Gamma-aminobutyric acid receptor subunit beta-10001
Gamma-aminobutyric acid receptor subunit alpha-20001
Gamma-aminobutyric acid receptor subunit alpha-30001
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit alpha-40001
Gamma-aminobutyric acid receptor subunit gamma-20001
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent betaine transporter0101
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit pi0011
Gamma-aminobutyric acid receptor subunit alpha-40011
Gamma-aminobutyric acid receptor subunit theta0011
Gamma-aminobutyric acid receptor subunit gamma-10011
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
interleukin 81001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
Retinol-binding protein 40011
Beta-lactoglobulin0011
Amyloid-beta precursor protein0101
Disintegrin and metalloproteinase domain-containing protein 171001
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Acetylcholinesterase0101
Pyruvate kinase PKM0011
Neutral amino acid transporter A0101
Cholinesterase0101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
photoreceptor-specific nuclear receptor0101
transactivating tegument protein VP16 [Human herpesvirus 1]0101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Nuclear receptor subfamily 4 group A member 20011
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Sigma non-opioid intracellular receptor 10101
Bone morphogenetic protein receptor type-1B0011
Cell division cycle 7-related protein kinase0011
Serine/threonine-protein kinase PLK40011
ATP-dependent RNA helicase DDX3X0011
Pyridoxal kinase0011
Citron Rho-interacting kinase0011
Serine/threonine-protein kinase Chk10011
Aurora kinase A0011
Cyclin-G-associated kinase0011
Ephrin type-B receptor 60011
Peroxisomal acyl-coenzyme A oxidase 30011
Receptor-interacting serine/threonine-protein kinase 20011
Mitotic checkpoint serine/threonine-protein kinase BUB10011
Dynamin-like 120 kDa protein, mitochondrial0011
Tyrosine-protein kinase JAK20011
Eukaryotic translation initiation factor 5B0011
Rho-associated protein kinase 20011
Serine/threonine-protein kinase ULK10011
Serine/threonine-protein kinase/endoribonuclease IRE10011
Nuclear receptor subfamily 1 group I member 20123
Ribosomal protein S6 kinase alpha-50011
U5 small nuclear ribonucleoprotein 200 kDa helicase0011
Ribosomal protein S6 kinase alpha-40011
Serine/threonine-protein kinase 160011
Cyclin-dependent kinase-like 50011
Serine/threonine-protein kinase 100011
Serine/threonine-protein kinase D30011
Structural maintenance of chromosomes protein 20011
Mitogen-activated protein kinase kinase kinase 60011
Mitogen-activated protein kinase kinase kinase kinase 40011
Serine/threonine-protein kinase LATS10011
Serine/threonine-protein kinase PAK 40011
Tyrosine-protein kinase ABL10011
Epidermal growth factor receptor0011
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
High affinity nerve growth factor receptor0011
ADP/ATP translocase 20011
Protein kinase C beta type0011
Insulin receptor0011
Tyrosine-protein kinase Lck0011
Tyrosine-protein kinase Fyn0011
Cyclin-dependent kinase 10011
Eukaryotic translation initiation factor 4E0011
Glycogen phosphorylase, liver form0011
Tyrosine-protein kinase Fes/Fps0011
Adenine phosphoribosyltransferase0011
Tyrosine-protein kinase Yes0011
Tyrosine-protein kinase Lyn0011
Proto-oncogene tyrosine-protein kinase receptor Ret0011
Insulin-like growth factor 1 receptor0011
Signal recognition particle receptor subunit alpha0011
Cytochrome c1, heme protein, mitochondrial0011
Hepatocyte growth factor receptor0011
Tyrosine-protein kinase HCK0011
Platelet-derived growth factor receptor beta0011
Tyrosine-protein kinase Fgr0011
Serine/threonine-protein kinase A-Raf0011
Glycogen phosphorylase, brain form0011
Breakpoint cluster region protein0011
Serine/threonine-protein kinase pim-10011
Fibroblast growth factor receptor 10011
DNA topoisomerase 2-alpha0011
Cyclin-dependent kinase 40011
ADP/ATP translocase 30011
Inosine-5'-monophosphate dehydrogenase 20011
Proto-oncogene tyrosine-protein kinase Src0011
cAMP-dependent protein kinase type II-alpha regulatory subunit0011
Serine/threonine-protein kinase B-raf0011
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform0011
Ribosyldihydronicotinamide dehydrogenase [quinone]0011
Tyrosine-protein kinase Fer0011
Protein kinase C alpha type0011
cAMP-dependent protein kinase catalytic subunit alpha0011
General transcription and DNA repair factor IIH helicase subunit XPD0011
Casein kinase II subunit alpha'0011
Ras-related protein Rab-6A0011
Ephrin type-A receptor 10011
Multifunctional protein ADE20011
cAMP-dependent protein kinase catalytic subunit beta0011
Ferrochelatase, mitochondrial0011
Ribosomal protein S6 kinase beta-10011
Tyrosine-protein kinase JAK10011
Cyclin-dependent kinase 20011
Beta-adrenergic receptor kinase 10011
Probable ATP-dependent RNA helicase DDX60011
Peptidyl-prolyl cis-trans isomerase FKBP1A0101
MAP/microtubule affinity-regulating kinase 30011
Deoxycytidine kinase0011
Mitogen-activated protein kinase 10011
Ephrin type-A receptor 20011
Ephrin type-B receptor 20011
Non-receptor tyrosine-protein kinase TYK20011
UMP-CMP kinase 0011
Phosphatidylethanolamine-binding protein 10011
Wee1-like protein kinase0011
Heme oxygenase 20011
S-adenosylmethionine synthase isoform type-20011
DnaJ homolog subfamily A member 10011
RAC-alpha serine/threonine-protein kinase0011
RAC-beta serine/threonine-protein kinase0011
Dual specificity protein kinase TTK0011
DNA replication licensing factor MCM40011
Myosin-100011
Dual specificity mitogen-activated protein kinase kinase 20011
Receptor-type tyrosine-protein kinase FLT30011
Bone morphogenetic protein receptor type-1A0011
Activin receptor type-1B0011
TGF-beta receptor type-10011
Serine/threonine-protein kinase receptor R30011
TGF-beta receptor type-20011
Electron transfer flavoprotein subunit beta0011
Tyrosine-protein kinase CSK0011
Glycine--tRNA ligase0011
Protein kinase C iota type0011
Exosome RNA helicase MTR40011
Serine/threonine-protein kinase mTOR0112
Tyrosine-protein kinase Tec0011
Tyrosine-protein kinase ABL20011
Tyrosine-protein kinase FRK0011
G protein-coupled receptor kinase 60011
Tyrosine-protein kinase SYK0011
26S proteasome regulatory subunit 6B0011
Mitogen-activated protein kinase 80011
Mitogen-activated protein kinase 90011
Dual specificity mitogen-activated protein kinase kinase 30011
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha0011
Casein kinase I isoform alpha0011
Casein kinase I isoform delta0011
MAP kinase-activated protein kinase 20011
Elongation factor Tu, mitochondrial0011
Choline-phosphate cytidylyltransferase A0011
Cysteine--tRNA ligase, cytoplasmic0011
Casein kinase I isoform epsilon0011
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial0011
Dual specificity protein kinase CLK10011
Dual specificity protein kinase CLK20011
Dual specificity protein kinase CLK30011
Glycogen synthase kinase-3 alpha0011
Glycogen synthase kinase-3 beta0011
Cyclin-dependent kinase 70011
Cyclin-dependent kinase 90011
Ras-related protein Rab-27A0011
Interleukin-1 receptor-associated kinase 10011
Ribosomal protein S6 kinase alpha-30011
Serine/threonine-protein kinase Nek20011
Serine/threonine-protein kinase Nek30011
Dual specificity mitogen-activated protein kinase kinase 60011
Serine/threonine-protein kinase PLK10011
LIM domain kinase 10011
LIM domain kinase 20011
Mitogen-activated protein kinase 100011
Tyrosine--tRNA ligase, cytoplasmic0011
5'-AMP-activated protein kinase subunit gamma-10011
Ephrin type-B receptor 30011
Ephrin type-A receptor 50011
Ephrin type-B receptor 40011
Ephrin type-A receptor 40011
Adenylate kinase 2, mitochondrial0011
Adenosine kinase0011
Ras-related protein Rab-100011
Actin-related protein 30011
Actin-related protein 20011
GTP-binding nuclear protein Ran0011
Peptidyl-prolyl cis-trans isomerase FKBP1A0213
Peptidyl-prolyl cis-trans isomerase FKBP1B0011
Casein kinase I isoform gamma-20011
Cyclin-dependent kinase 60011
Cyclin-dependent-like kinase 5 0011
Cyclin-dependent kinase 160011
Cyclin-dependent kinase 170011
ATP-dependent 6-phosphofructokinase, platelet type0011
Dual specificity mitogen-activated protein kinase kinase 10011
DNA topoisomerase 2-beta0011
Protein kinase C theta type0011
Activin receptor type-10011
Macrophage-stimulating protein receptor0011
Focal adhesion kinase 10011
Protein kinase C zeta type0011
Protein kinase C delta type0011
Tyrosine-protein kinase BTK0011
Cyclin-dependent kinase 180011
Activated CDC42 kinase 10011
Epithelial discoidin domain-containing receptor 10011
Mitogen-activated protein kinase kinase kinase kinase 20011
Tyrosine-protein kinase Mer0011
Serine/threonine-protein kinase 40011
5'-AMP-activated protein kinase catalytic subunit alpha-10011
Dual specificity mitogen-activated protein kinase kinase 50011
Mitogen-activated protein kinase 70011
Serine/threonine-protein kinase PAK 20011
Serine/threonine-protein kinase 30011
Mitogen-activated protein kinase kinase kinase 10011
Integrin-linked protein kinase0011
Peptidyl-prolyl cis-trans isomerase FKBP50101
Rho-associated protein kinase 10011
Non-receptor tyrosine-protein kinase TNK10011
Calcium/calmodulin-dependent protein kinase type II subunit gamma0011
Calcium/calmodulin-dependent protein kinase type II subunit delta0011
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0011
Activin receptor type-2B0011
Bone morphogenetic protein receptor type-20011
Protein-tyrosine kinase 60011
cGMP-dependent protein kinase 1 0011
Cyclin-dependent kinase 130011
Inhibitor of nuclear factor kappa-B kinase subunit epsilon0011
Protein-tyrosine kinase 2-beta0011
Maternal embryonic leucine zipper kinase0011
Structural maintenance of chromosomes protein 1A0011
Chromodomain-helicase-DNA-binding protein 40011
Peroxisomal acyl-coenzyme A oxidase 10011
Delta(24)-sterol reductase0011
Ribosomal protein S6 kinase alpha-10011
Dual specificity testis-specific protein kinase 10011
Myosin light chain kinase, smooth muscle0011
Mitogen-activated protein kinase 110011
Serine/threonine-protein kinase STK110011
Serine/threonine-protein kinase N10011
Serine/threonine-protein kinase N20011
Mitogen-activated protein kinase 140011
Calcium/calmodulin-dependent protein kinase type IV0011
Mitogen-activated protein kinase kinase kinase 110011
Discoidin domain-containing receptor 20011
AP2-associated protein kinase 10011
Myosin light chain kinase 30011
Uncharacterized aarF domain-containing protein kinase 50011
Programmed cell death protein 40011
Putative heat shock protein HSP 90-beta 20011
Serine/threonine-protein kinase MRCK alpha0011
Serine/threonine-protein kinase MRCK gamma0011
Acyl-CoA dehydrogenase family member 100011
Serine/threonine-protein kinase N30011
Serine/threonine-protein kinase ULK30011
Uncharacterized protein FLJ452520011
Acyl-CoA dehydrogenase family member 110011
Serine/threonine-protein kinase/endoribonuclease IRE20011
Serine/threonine-protein kinase MARK20011
ATP-dependent RNA helicase DHX300011
Serine/threonine-protein kinase TAO10011
STE20-related kinase adapter protein alpha0011
Myosin-140011
AarF domain-containing protein kinase 10011
Mitogen-activated protein kinase kinase kinase kinase 30011
MAP kinase-activated protein kinase 50011
Regulatory-associated protein of mTOR0101
Misshapen-like kinase 10011
Atypical kinase COQ8A, mitochondrial0011
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma0011
Mitogen-activated protein kinase 150011
Serine/threonine-protein kinase Nek90011
ATP-dependent RNA helicase DDX10011
Mitogen-activated protein kinase kinase kinase kinase 10011
Aurora kinase B0011
MAP/microtubule affinity-regulating kinase 40011
Calcium/calmodulin-dependent protein kinase type 1G0011
Serine/threonine-protein kinase Nek10011
PAS domain-containing serine/threonine-protein kinase0011
Calcium/calmodulin-dependent protein kinase kinase 20011
EKC/KEOPS complex subunit TP53RK0011
Dual specificity testis-specific protein kinase 20011
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase0011
Mitogen-activated protein kinase kinase kinase 50011
Mitogen-activated protein kinase kinase kinase 30011
Eukaryotic translation initiation factor 2-alpha kinase 10011
Target of rapamycin complex subunit LST80101
Nucleolar GTP-binding protein 10011
Serine/threonine-protein kinase D20011
RNA cytidine acetyltransferase0011
Serine/threonine-protein kinase SIK20011
STE20-like serine/threonine-protein kinase 0011
Serine/threonine-protein kinase TAO30011
dCTP pyrophosphatase 10011
Dual specificity protein kinase CLK40011
Casein kinase I isoform gamma-10011
Serine/threonine-protein kinase mTOR 0101
Phenylalanine--tRNA ligase beta subunit0011
Isoleucine--tRNA ligase, mitochondrial0011
BMP-2-inducible protein kinase0011
Obg-like ATPase 10011
Midasin0011
Interleukin-1 receptor-associated kinase 40011
Mitogen-activated protein kinase kinase kinase 200011
Cyclin-dependent kinase 120011
Serine/threonine-protein kinase 260011
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial0011
Serine/threonine-protein kinase NLK0011
5'-AMP-activated protein kinase subunit gamma-20011
Serine/threonine-protein kinase TBK10011
Septin-90011
Ribosomal protein S6 kinase alpha-60011
TRAF2 and NCK-interacting protein kinase0011
Serine/threonine-protein kinase TAO20011
Serine/threonine-protein kinase ICK0011
RAC-gamma serine/threonine-protein kinase0011
Serine/threonine-protein kinase SIK30011
Mitogen-activated protein kinase kinase kinase 20011
Thyroid hormone receptor-associated protein 30011
Dual specificity tyrosine-phosphorylation-regulated kinase 1B0011
Mitogen-activated protein kinase kinase kinase kinase 50011
Receptor-interacting serine/threonine-protein kinase 30011
Serine/threonine-protein kinase MRCK beta0011
Interleukin-1 receptor-associated kinase 30011
Serine/threonine-protein kinase 240011
Casein kinase I isoform gamma-30011
Mitogen-activated protein kinase kinase kinase 40011
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Squalene monooxygenase 0001
DNA polymerase beta0101
Chain A, Oxysterols receptor LXR-beta0101
Chain A, Oxysterols receptor LXR-beta0101
interferon gamma precursor0001
nuclear factor NF-kappa-B p105 subunit isoform 11001
Plasma kallikrein0011
Nuclear receptor ROR-alpha0213
Alpha-glucosidase MAL320101
Presenilin-10112
Presenilin-20112
Oxysterols receptor LXR-beta0224
Oxysterols receptor LXR-beta0011
Oxysterols receptor LXR-beta0011
Gamma-secretase subunit APH-1B0112
Nicastrin0112
Nuclear receptor ROR-beta0112
Gamma-secretase subunit APH-1A0112
Gamma-secretase subunit PEN-20112
Sodium/bile acid cotransporter0001
Solute carrier organic anion transporter family member 1A40203
Solute carrier family 22 member 60101
ATP-binding cassette sub-family C member 30001
Sodium-dependent dopamine transporter0101
Sodium/bile acid cotransporter0102
Solute carrier organic anion transporter family member 1A20001
Ileal sodium/bile acid cotransporter0001
Solute carrier organic anion transporter family member 1A30102
Ileal sodium/bile acid cotransporter0102
Ileal sodium/bile acid cotransporter0001
Solute carrier organic anion transporter family member0001
Solute carrier organic anion transporter family member 4A10001
Multidrug resistance associated protein0102
Solute carrier organic anion transporter family member 1C10101
Solute carrier organic anion transporter family member 2B10001
Solute carrier organic anion transporter family member 1A10001
Bile salt export pump0001
serine-protein kinase ATM isoform a1001
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
D(3) dopamine receptor0101
Urease subunit alpha0101
Urease subunit beta 0101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
cytochrome P450 2D6 isoform 11001
5-hydroxytryptamine receptor 40202
Albumin0011
5-hydroxytryptamine receptor 1B0202
Spike glycoprotein0011
Replicase polyprotein 1ab0011
Transmembrane protease serine 20011
Procathepsin L0011
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Angiotensin-converting enzyme 2 0011
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]