Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations and other alterations of mood and thinking.
ChEBI ID: 35499
| Member | Definition | Class |
|---|---|---|
| 1-(1-phenylcyclohexyl)pyrrolidine | Pyrrolidine in which the hydrogen attached to the nitrogen is substituted by a 1-phenylcyclohex-1-yl group. | rolicyclidine |
| 5-methoxy-n,n-diisopropyltryptamine | 5-methoxy-N,N-diisopropyltryptamine | |
| baeocystin | A tryptamine alkaloid that is N-methyltryptamine carrying an additional phosphoryloxy substituent at position 4. | baeocystin |
| benzydamine | A member of the class of indazoles carrying benzyl and 3-(dimethylamino)propyl groups at positions 1 and 3 respectively. A locally-acting nonsteroidal anti-inflammatory drug that also exhibits local anaesthetic and analgesic properties. | benzydamine |
| bufotenin | A tertiary amine that consists of N,N-dimethyltryptamine bearing an additional hydroxy substituent at position 5. | bufotenin |
| dronabinol | A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. The principal psychoactive constituent of the cannabis plant, it is used for treatment of anorexia associated with AIDS as well as nausea and vomiting associated with cancer chemotherapy. | Delta(9)-tetrahydrocannabinol |
| lysergic acid diethylamide | An ergoline alkaloid arising from formal condensation of lysergic acid with diethylamine. | lysergic acid diethylamide |
| mescaline | A phenethylamine alkaloid that is phenethylamine substituted at positions 3, 4 and 5 by methoxy groups. | mescaline |
| methylbufotenin | A tryptamine alkaloid that is N,N-dimethyltryptamine substituted by a methoxy group at position 5. | 5-methoxy-N,N-dimethyltryptamine |
| psilocin | A tryptamine alkaloid that is N,N-dimethyltryptamine carrying an additional hydroxy substituent at position 4. A hallucinogenic alkaloid isolated in trace amounts from Psilocybe mushrooms (also known as Teonanacatl or "magic mushrooms"). | psilocin |
| psilocybin | A tryptamine alkaloid that is N,N-dimethyltryptamine carrying an additional phosphoryloxy substituent at position 4. The major hallucinogenic alkaloid isolated from Psilocybe mushrooms (also known as Teonanacatl or "magic mushrooms"). | psilocybin |
| tenocyclidine | A tertiary amino compound that consists of cyclohexane having piperidin-1-yl and thiophen-2-yl groups attached at position 1. A dissociative anaesthetic drug with halluccinogenic and stimulant effects. Its effects are similar to those of phencyclidine (PCP, an analogue with the thienyl group replaced by phenyl), but it is rather more potent. | tenocyclidine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 7,003 (47.70) | 18.7374 |
| 1990's | 1,428 (9.73) | 18.2507 |
| 2000's | 1,848 (12.59) | 29.6817 |
| 2010's | 2,500 (17.03) | 24.3611 |
| 2020's | 1,901 (12.95) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,182 (7.05%) | 5.53% |
| Reviews | 1,602 (9.55%) | 6.00% |
| Case Studies | 478 (2.85%) | 4.05% |
| Observational | 56 (0.33%) | 0.25% |
| Other | 13,454 (80.22%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 53.5481 | 3 | 5 |
| AR protein | Homo sapiens (human) | Potency | 23.0509 | 4 | 6 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 19.2553 | 2 | 7 |
| Ataxin-2 | Homo sapiens (human) | Potency | 13.1458 | 1 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 13.1458 | 1 | 3 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 30.1356 | 2 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 82.8488 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 14.5799 | 1 | 4 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 13.9480 | 1 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 28.4837 | 2 | 5 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 13.6621 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 25.3815 | 8 | 17 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 66.9885 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 86.5410 | 3 | 3 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 2.1177 | 1 | 1 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 26.6405 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 82.8488 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 31.9112 | 2 | 6 |
| GLS protein | Homo sapiens (human) | Potency | 31.1166 | 1 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 25.2980 | 3 | 4 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 58.4656 | 2 | 4 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 28.9221 | 2 | 5 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 108.3103 | 1 | 3 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 82.8488 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 40.8606 | 1 | 3 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 82.8488 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 82.8488 | 1 | 1 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 43.8251 | 1 | 2 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 57.3394 | 1 | 2 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 44.2592 | 2 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 15.5322 | 1 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 22.5978 | 1 | 2 |
| polyprotein | Zika virus | Potency | 26.6405 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 31.8326 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 27.2088 | 2 | 4 |
| progesterone receptor | Homo sapiens (human) | Potency | 60.5518 | 1 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 45.4634 | 3 | 6 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 55.9382 | 2 | 5 |
| TDP1 protein | Homo sapiens (human) | Potency | 26.6695 | 2 | 10 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 42.0437 | 2 | 8 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 63.0265 | 4 | 6 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 48.4694 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 179.1600 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 0.0150 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.0110 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.0012 | 3 | 3 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.0210 | 8 | 9 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | IC50 | 0.5500 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.3500 | 3 | 4 |
| 5-hydroxytryptamine receptor 1D | Cavia porcellus (domestic guinea pig) | IC50 | 0.0490 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | IC50 | 0.0490 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | Ki | 0.0039 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 0.0500 | 1 | 1 |
| 5-hydroxytryptamine receptor 1E | Homo sapiens (human) | Ki | 0.0930 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 0.0500 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0083 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.9725 | 4 | 4 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.1353 | 9 | 9 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.8374 | 16 | 22 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.0011 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 0.9725 | 4 | 4 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.2924 | 3 | 3 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.3746 | 6 | 7 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.1289 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.8280 | 5 | 5 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.1050 | 4 | 4 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.3064 | 11 | 13 |
| 5-hydroxytryptamine receptor 5A | Homo sapiens (human) | Ki | 0.0095 | 2 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.0227 | 6 | 6 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 0.0143 | 3 | 3 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.0148 | 2 | 4 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 12.7000 | 1 | 2 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | IC50 | 0.0150 | 1 | 1 |
| Beta-1 adrenergic receptor | Homo sapiens (human) | Ki | 0.1400 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Ki | 0.7400 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | IC50 | 0.0028 | 1 | 1 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 0.2180 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 0.0295 | 18 | 18 |
| Cannabinoid receptor 1 | Mus musculus (house mouse) | Ki | 0.0405 | 2 | 2 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.0468 | 10 | 10 |
| Cannabinoid receptor 2 | Rattus norvegicus (Norway rat) | IC50 | 0.2180 | 1 | 1 |
| Cannabinoid receptor 2 | Mus musculus (house mouse) | Ki | 0.0303 | 3 | 4 |
| Cannabinoid receptor 2 | Rattus norvegicus (Norway rat) | Ki | 0.0460 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | IC50 | 0.0095 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 0.0366 | 22 | 22 |
| Catechol O-methyltransferase | Rattus norvegicus (Norway rat) | Ki | 0.0025 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| D | Mus musculus (house mouse) | Ki | 0.1800 | 1 | 1 |
| D(1B) dopamine receptor | Homo sapiens (human) | Ki | 0.3400 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.1229 | 2 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.0270 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 0.0560 | 1 | 1 |
| Fatty acid-binding protein, liver | Mus musculus (house mouse) | Ki | 1.0000 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 43.6000 | 1 | 1 |
| G-protein coupled receptor 55 | Homo sapiens (human) | IC50 | 14.2000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Ki | 33.3385 | 2 | 3 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 1.5400 | 1 | 1 |
| L-lactate dehydrogenase A chain | Homo sapiens (human) | Ki | 14.0000 | 1 | 1 |
| Lysophosphatidylserine lipase ABHD12 | Homo sapiens (human) | IC50 | 11.6000 | 1 | 1 |
| Lysosomal Pro-X carboxypeptidase | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| Melatonin receptor type 1A | Homo sapiens (human) | Ki | 0.2100 | 1 | 1 |
| Melatonin receptor type 1B | Homo sapiens (human) | Ki | 0.0160 | 1 | 1 |
| Monoacylglycerol lipase ABHD6 | Homo sapiens (human) | IC50 | 48.2000 | 1 | 1 |
| Monoglyceride lipase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 0.2400 | 1 | 1 |
| Sodium-dependent dopamine transporter | Macaca fascicularis (crab-eating macaque) | Ki | 0.3400 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 0.0130 | 2 | 2 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.3400 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 1.2000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | EC50 | 0.1970 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Kd | 0.0413 | 2 | 2 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| 5-hydroxytryptamine receptor 1B | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| 5-hydroxytryptamine receptor 1D | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| 5-hydroxytryptamine receptor 1E | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | EC50 | 0.3757 | 11 | 15 |
| 5-hydroxytryptamine receptor 2A | Mus musculus (house mouse) | EC50 | 0.0098 | 1 | 2 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | EC50 | 2.9545 | 5 | 7 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | EC50 | 0.0660 | 1 | 2 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Kd | 1.5202 | 2 | 3 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | EC50 | 0.2680 | 1 | 2 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | EC50 | 12.0389 | 2 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| 5-hydroxytryptamine receptor 5A | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Kd | 0.0794 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Kd | 2.2387 | 1 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0794 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0794 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0794 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0794 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0794 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.0794 | 1 | 1 |
| alternatively spliced Trp4 | Mus musculus (house mouse) | EC50 | 0.6700 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | EC50 | 0.0458 | 3 | 3 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | EC50 | 0.0738 | 2 | 3 |
| Cannabinoid receptor 2 | Mus musculus (house mouse) | EC50 | 0.0073 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | EC50 | 0.0086 | 3 | 3 |
| D(3) dopamine receptor | Homo sapiens (human) | EC50 | 0.0102 | 1 | 1 |
| G-protein coupled receptor 55 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | EC50 | 0.1970 | 1 | 2 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | EC50 | 0.1995 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | EC50 | 0.1995 | 1 | 1 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | EC50 | 0.1995 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | EC50 | 0.1995 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Homo sapiens (human) | EC50 | 1.3000 | 1 | 1 |
| Guanylate cyclase soluble subunit alpha-1 | Homo sapiens (human) | EC50 | 1.0200 | 1 | 1 |
| Guanylate cyclase soluble subunit alpha-2 | Homo sapiens (human) | EC50 | 1.0200 | 1 | 1 |
| Guanylate cyclase soluble subunit beta-1 | Homo sapiens (human) | EC50 | 1.0200 | 1 | 1 |
| Guanylate cyclase soluble subunit beta-2 | Homo sapiens (human) | EC50 | 1.0200 | 1 | 1 |
| Melatonin receptor type 1A | Homo sapiens (human) | EC50 | 0.2570 | 1 | 1 |
| Melatonin receptor type 1B | Homo sapiens (human) | EC50 | 0.1120 | 1 | 1 |
| N-arachidonyl glycine receptor | Homo sapiens (human) | EC50 | 4.6100 | 1 | 1 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 18.9333 | 3 | 3 |
| Transient receptor potential cation channel subfamily A member 1 | Rattus norvegicus (Norway rat) | EC50 | 0.2300 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | K0.5 | 0.0135 | 1 | 2 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Log Ki | 0.0016 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Log Ki | 0.0016 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | Activity | 10.0000 | 1 | 1 |