Page last updated: 2024-08-05 15:15:49

antiseborrheic

A drug or agent applied to the skin to control seborrhea or seborrheic dermatitis.

ChEBI ID: 59010

Members (4)

MemberDefinitionClass
chloroxineA monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 have been substituted by chlorine. A synthetic antibacterial prepared by chlorination of quinolin-8-ol, it is used for the treatment of dandruff and seborrhoeic dermatitis of the scalp.chloroxine
ciclopiroxA cyclic hydroxamic acid that is 1-hydroxypyridin-2(1H)-one in which the hydrogens at positions 4 and 6 are substituted by methyl and cyclohexyl groups, respectively. A broad spectrum antigfungal agent, it also exhibits antibacterial activity against many Gram-positive and Gram-negative bacteria, and has anti-inflammatory properties. It is used a a topical treatment of fungal skin and nail infections.ciclopirox
delgocitinibA pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted by a (3S,4R)-1-(cyanoacetyl)-3-methyl-1,6-diazaspiro[3.4]octan-6-yl group at position 4. It is a pan-Janus kinase (JAK) inhibitor and is approved for treatment of atopic dermatitis (AD) in Japan.delgocitinib
thioxoloneA 1,3-benzoxathiole having a hydroxy substituent at the 6-position.tioxolone

Research

Studies (510)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199056 (10.98)18.7374
1990's47 (9.22)18.2507
2000's139 (27.25)29.6817
2010's179 (35.10)24.3611
2020's89 (17.45)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials88 (15.12%)5.53%
Reviews59 (10.14%)6.00%
Case Studies54 (9.28%)4.05%
Observational0 (0.00%)0.25%
Other381 (65.46%)84.16%

Protein Targets (158)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency35.481311
67.9K proteinVaccinia virusPotency7.943311
acetylcholinesteraseHomo sapiens (human)Potency30.900811
activating transcription factor 6Homo sapiens (human)Potency0.952111
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency7.079511
Alpha-synucleinHomo sapiens (human)Potency4.466811
AR proteinHomo sapiens (human)Potency15.872067
aryl hydrocarbon receptorHomo sapiens (human)Potency5.973222
ATAD5 protein, partialHomo sapiens (human)Potency15.695522
Ataxin-2Homo sapiens (human)Potency13.333211
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency13.865022
Cellular tumor antigen p53Homo sapiens (human)Potency13.206823
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency5.552822
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency24.803312
Chain A, Beta-lactamaseEscherichia coli K-12Potency112.202011
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency28.183811
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency11.530112
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency3.763112
chromobox protein homolog 1Homo sapiens (human)Potency89.125111
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency15.848923
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency13.454723
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency11.883211
DNA dC->dU-editing enzyme APOBEC-3F isoform aHomo sapiens (human)Potency35.481311
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.125111
estrogen nuclear receptor alphaHomo sapiens (human)Potency14.435888
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency17.032822
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency16.976766
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency27.829812
EWS/FLI fusion proteinHomo sapiens (human)Potency11.0636412
farnesoid X nuclear receptorHomo sapiens (human)Potency13.332211
flap endonuclease 1Homo sapiens (human)Potency35.481311
Fumarate hydrataseHomo sapiens (human)Potency20.726513
GABA theta subunitRattus norvegicus (Norway rat)Potency15.848912
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency15.848912
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency15.848912
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency15.848912
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency15.848912
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency15.848912
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency15.848912
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency15.848912
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency15.848912
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency15.848912
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency15.848912
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency15.848912
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency15.848912
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency15.848912
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency15.848912
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency15.848912
gemininHomo sapiens (human)Potency10.212325
GLI family zinc finger 3Homo sapiens (human)Potency0.795522
glp-1 receptor, partialHomo sapiens (human)Potency2.238711
GLS proteinHomo sapiens (human)Potency35.481311
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency9.228723
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency18.833611
Guanine nucleotide-binding protein GHomo sapiens (human)Potency11.220211
heat shock protein beta-1Homo sapiens (human)Potency5.536122
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency25.118912
Histone H2A.xCricetulus griseus (Chinese hamster)Potency30.955022
huntingtin isoform 2Homo sapiens (human)Potency9.837923
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency0.848511
IDH1Homo sapiens (human)Potency20.596211
Integrin alpha-IIbHomo sapiens (human)Potency7.943311
Integrin beta-3Homo sapiens (human)Potency7.943311
Interferon betaHomo sapiens (human)Potency22.091416
lamin isoform A-delta10Homo sapiens (human)Potency5.145412
LuciferasePhotinus pyralis (common eastern firefly)Potency13.459111
Microtubule-associated protein tauHomo sapiens (human)Potency19.560924
Nrf2Homo sapiens (human)Potency35.481311
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency16.833422
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency12.995311
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency0.301111
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency746.360423
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency35.481311
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency31.670422
P53Homo sapiens (human)Potency70.794611
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency15.887522
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency21.130011
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency6.827222
plasminogen precursorMus musculus (house mouse)Potency15.165212
polyproteinZika virusPotency20.726513
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency1.000011
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency25.118911
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency25.118912
PPM1D proteinHomo sapiens (human)Potency22.091514
pregnane X nuclear receptorHomo sapiens (human)Potency27.393522
progesterone receptorHomo sapiens (human)Potency0.841311
RAR-related orphan receptor gammaMus musculus (house mouse)Potency12.115622
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency7.697422
retinoid X nuclear receptor alphaHomo sapiens (human)Potency1.506622
SMAD family member 2Homo sapiens (human)Potency23.914511
SMAD family member 3Homo sapiens (human)Potency23.914511
Smad3Homo sapiens (human)Potency3.548111
survival motor neuron protein isoform dHomo sapiens (human)Potency24.035312
TAR DNA-binding protein 43Homo sapiens (human)Potency2.818411
TDP1 proteinHomo sapiens (human)Potency12.192827
thioredoxin glutathione reductaseSchistosoma mansoniPotency15.848911
thioredoxin reductaseRattus norvegicus (Norway rat)Potency78.117112
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency6.319122
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency15.165212
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency15.165212
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency4.349122
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency11.172422
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency36.426112
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency18.833611
VprHuman immunodeficiency virus 1Potency4.466811

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
90-kda heat shock protein beta HSP90 beta, partialHomo sapiens (human)IC5050.000012
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproproteinHomo sapiens (human)IC50100.000011
Amine oxidase [flavin-containing] AHomo sapiens (human)IC509.770011
Amine oxidase [flavin-containing] BHomo sapiens (human)IC509.570011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
Bile salt export pumpHomo sapiens (human)IC50133.000011
Botulinum neurotoxin type A Clostridium botulinumIC5011.500011
Carbonic anhydrase 2Homo sapiens (human)IC501.770011
delta-type opioid receptorHomo sapiens (human)IC5032.000011
Deoxyhypusine hydroxylaseHomo sapiens (human)IC505.000011
heat shock protein HSP 90-alpha isoform 2Homo sapiens (human)IC5050.000012
Hypoxia-inducible factor 1-alphaHomo sapiens (human)IC504.500011
Integrase Human immunodeficiency virus 1IC5020.000022
intestinal alkaline phosphatase precursorMus musculus (house mouse)IC502.590011
Isocitrate dehydrogenase [NADP] cytoplasmicHomo sapiens (human)Ki50.000011
kappa-type opioid receptor isoform 1Homo sapiens (human)IC5018.280022
large T antigenBetapolyomavirus macacaeIC5019.020011
Lysine-specific demethylase 4BHomo sapiens (human)IC503.800011
Multidrug and toxin extrusion protein 1Homo sapiens (human)IC50500.000011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000011
Non-receptor tyrosine-protein kinase TYK2Homo sapiens (human)IC500.053333
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)IC503.600011
Polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)IC501.900011
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)IC502.400011
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)IC5028.000011
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2IC507.240011
Tyrosine-protein kinase JAK1Homo sapiens (human)IC500.020366
Tyrosine-protein kinase JAK2Homo sapiens (human)IC500.074566
Tyrosine-protein kinase JAK3Homo sapiens (human)IC500.022033
Tyrosine-protein kinase LckHomo sapiens (human)IC505.800011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
alkaline phosphatase, germ cell type preproproteinHomo sapiens (human)EC5012.000011
alkaline phosphatase, intestinalHomo sapiens (human)EC508.330011
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)EC5031.500011
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)EC5031.500011
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)EC5031.500011
Beta-galactosidaseEscherichia coliEC5031.500011
citrate synthase 2, partialSaccharomyces cerevisiae (brewer's yeast)EC5019,750.000011
delta-type opioid receptorHomo sapiens (human)EC5032.000011
large T antigenBetapolyomavirus macacaeEC5031.180011
MEP2Saccharomyces cerevisiae (brewer's yeast)EC5036,100.000011
mu opioid receptor, partialHomo sapiens (human)EC5032.000011
Nuclear receptor subfamily 1 group I member 2Homo sapiens (human)EC5039.800011
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 2Kd4.600011
streptokinase A precursorStreptococcus pyogenes M1 GASEC500.148011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Carbonic anhydrase 1Homo sapiens (human)Kinact0.091011
Carbonic anhydrase 12Homo sapiens (human)Kinact7.790011
Carbonic anhydrase 13Mus musculus (house mouse)Kinact8.230011
Carbonic anhydrase 14Homo sapiens (human)Kinact8.590011
Carbonic anhydrase 15Mus musculus (house mouse)Kinact7.870011
Carbonic anhydrase 2Homo sapiens (human)Kinact160.410022
Carbonic anhydrase 3Homo sapiens (human)Kinact6.560011
Carbonic anhydrase 4Homo sapiens (human)Kinact8.410011
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Kinact7.060011
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Kinact9.040011
Carbonic anhydrase 6Homo sapiens (human)Kinact4.930011
Carbonic anhydrase 7Homo sapiens (human)Kinact5.730011
Carbonic anhydrase 9Homo sapiens (human)Kinact6.670011
heat shock protein 90, putativePlasmodium falciparum 3D7AC500.511011
heat shock protein HSP 90-alpha isoform 2Homo sapiens (human)AC501.045011