Alcohol Withdrawal Associated Autonomic Hyperactivity

An acute organic mental disorder induced by cessation or reduction in chronic alcohol consumption. Clinical characteristics include CONFUSION; DELUSIONS; vivid HALLUCINATIONS; TREMOR; agitation; insomnia; and signs of autonomic hyperactivity (e.g., elevated blood pressure and heart rate, dilated pupils, and diaphoresis). This condition may occasionally be fatal. It was formerly called delirium tremens. (From Adams et al., Principles of Neurology, 6th ed, p1175)

Synonym
Alcohol Withdrawal Delirium
Alcohol Withdrawal-Induced Delirium Tremens
Alcohol Withdrawal Associated Autonomic Hyperactivity
Autonomic Hyperactivity, Alcohol Withdrawal Associated
Alcohol Withdrawal Hallucinosis
Delirium Tremens, Alcohol Withdrawal Induced
Delirium Tremens

Excerpt	Reference
"Delirium tremens is linked with a chronic depression of the central nervous system by alcohol and a compensatory hyperactivity of neurotransmitters."	( Meignan, ML, 1992)
"Tachycardia in delirium tremens is often not adequately controlled by present delirium therapy but it can be treated with beta-receptor blockers."	( Holzbach, E, 1980)
"The therapy of delirium tremens is reviewed and theoretical considerations discussed, with reference to an adrenergic/cholinergic imbalance model for delirium tremens."	( Decoskey, D; Kahrilas, PJ; Powers, JS, 1981)
"Delirium tremens is a potentially fatal symptom complex which may develop when a prolonged daily drinking pattern is interrupted by illness or injury."	( Gower, WE; Kersten, H, 1980)
"Patients with delirium tremens are usually treated in an intensive care unit in which benzodiazepines form the cornerstone of therapy."	( Marik, P; McCowan, C, 2000)
"Alcohol withdrawal delirium is a complex metabolic disorder, the disturbance of the highest cerebral integrative functions, which is caused by the impairment of cerebral oxidative metabolism."	( Kalmár, S, 2003)
"Delirium Tremens is quite rare in children and it is usually caused by withdrawal or abstinence from alcohol, barbiturates and other major tranquilizers."	( Extremera, VC; García-Peñas, JJ; Gutiérrez-Solana, LG; Herguedas, JL; Marín, LL; Rodriguez, AD; Ruiz-Falcó, M, 2010)
"Delirium tremens is a potentially fatal complication of alcohol withdrawal."	( Bendtsen, AO; Lauritsen, AØ; Lorentzen, K, 2014)
"Alcohol withdrawal delirium is associated with significant morbidity and mortality."	( Chan, HY; Lee, KI, 2015)

Excerpt	Reference
"Mortality from delirium tremens has been reduced to less than 5 percent of patients, through early diagnosis, supportive nursing care, treatment of coexisting medical conditions and aggressive pharmacologic therapy."	( Yost, DA, 1996)

Excerpt	Reference
"30 patients with delirium tremens were given in a double-blind trial--beside the basic treatment with chlormethiazol (Distraneurin)--aprotinin (Trasylol) or placebo."	( Athen, D; Bender, W; Meyendorf, R, 1976)
"Thirty-four patients with severe delirium tremens were allocated randomly to treatment with paraldehyde (10 ml rectally very 30 minutes) or diazepam (10 mg then 5 mg intravenously every 5 minutes) until they were calm but awake."	( Johnson, AD; Maddrey, WL; Thompson, WL, 1975)
"Tachycardia in delirium tremens is often not adequately controlled by present delirium therapy but it can be treated with beta-receptor blockers."	( Holzbach, E, 1980)
"They are prescribed in the treatment of Delirium Tremens and other acute withdrawal syndromes, often by intramuscular injections or intraveinous infusions."	( Ades, J; Rodière, C, 1983)
"Mortality from delirium tremens has been reduced to less than 5 percent of patients, through early diagnosis, supportive nursing care, treatment of coexisting medical conditions and aggressive pharmacologic therapy."	( Yost, DA, 1996)
"Patients with delirium tremens are usually treated in an intensive care unit in which benzodiazepines form the cornerstone of therapy."	( Marik, P; McCowan, C, 2000)
"To compare outcomes of treating alcohol withdrawal delirium (AWD) with a symptom-driven benzodiazepine protocol versus nonprotocol benzodiazepine infusions in the intensive care unit (ICU)."	( Cassaro, S; DeCarolis, DD; Ho, L; Rice, KL; Willenbring, ML, 2007)
"The use of sedative to treat delirium tremens is well documented, with benzodiazepines being the agents of choice."	( Darrouj, J; Gerber, DR; Lomonaco, A; Prince, E; Puri, N; Spevetz, A, 2008)
"In patients with delirium tremens, dexmedetomidine should be considered as an option for primary treatment."	( Darrouj, J; Gerber, DR; Lomonaco, A; Prince, E; Puri, N; Spevetz, A, 2008)
"Twelve of the 15 patients treated for delirium tremens with propofol for 48 h were successfully treated."	( Bendtsen, AO; Lauritsen, AØ; Lorentzen, K, 2014)
"People treated for delirium tremens appear to have higher rates of mortality and comorbidity than people with other alcohol use disorders."	( Bramness, JG; Heiberg, IH; Høye, A; Rossow, I, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	411 (44.58)	23.3326
1990's	268 (29.07)	12.5806
2000's	127 (13.77)	18.1394
2010's	101 (10.95)	28.8240
2020's	15 (1.63)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	medium	21	4
5-hydroxytryptophan	medium	1	1
ethylene glycol	low	1	0
acetic acid	low	1	0
acetaldehyde	low	2	0
acetone	low	2	0
agmatine	low	1	0
ammonium hydroxide	low	3	0
chlorine	low	3	0
beta-lysine	low	1	0
3-hydroxybutyric acid	low	1	0
3,4-dihydroxyphenylacetic acid	low	2	0
lactic acid	low	1	0
glycine	low	3	0
hydrogen carbonate	low	2	0
methanol	low	2	0
melatonin	low	4	0
niacinamide	low	1	0
niacin	medium	4	1
nitrous oxide	medium	6	1
propylene glycol	low	3	0
pyrazole	low	3	0
pyridoxine	low	1	0
spermidine	low	1	0
succinic acid	low	1	0
taurine	medium	4	1
thiamine	low	16	0
toluene	low	1	0
tryptamine	low	1	0
uric acid	low	1	0
7-hydroxy-2-n,n-dipropylaminotetralin	low	1	0
8-hydroxy-2-(di-n-propylamino)tetralin	low	2	0
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid	low	1	0
vanilmandelic acid	low	1	0
homovanillic acid	medium	12	1
phenytoin	medium	13	1
5,7-dichlorokynurenic acid	low	1	0
hydroxyindoleacetic acid	medium	8	1
alprazolam	medium	1	1
amantadine	low	1	0
dan 2163	low	2	0
amobarbital	low	1	0
aspirin	low	1	0
atenolol	medium	2	2
baclofen	low	5	0
barbital	medium	7	3
biperiden	low	2	0
buspirone	low	1	0
carbamazepine	medium	28	8
chloral hydrate	low	2	0
chlordiazepoxide	medium	49	5
chlorpromazine	low	21	0
chlorzoxazone	low	1	0
6-hydroxychlorzoxazone	low	1	0
cimetidine	low	1	0
clomipramine	low	1	0
clonazepam	low	2	0
clonidine	medium	33	10
deferoxamine	low	1	0
nordazepam	low	1	0
amphetamine	low	2	0
eflornithine	low	1	0
diazepam	medium	71	9
disulfiram	low	7	0
valproic acid	medium	12	4
donepezil	low	2	0
doxepin	low	1	0
droperidol	low	4	0
felodipine	low	1	0
fenfluramine	low	2	0
fluphenazine	low	1	0
flumazenil	low	2	0
flunitrazepam	medium	4	1
fluoxetine	low	1	0
flurazepam	low	2	0
fomepizole	low	1	0
gabapentin	medium	6	3
gaboxadol	low	1	0
haloperidol	medium	31	4
hexamethonium	low	1	0
imipramine	low	2	0
isoniazid	low	1	0
2-propanol	low	1	0
isradipine	low	1	0
ketamine	low	5	0
ketanserin	low	2	0
kynurenic acid	low	1	0
lamotrigine	medium	1	1
lorazepam	medium	32	4
memantine	low	2	0
meperidine	low	1	0
meprobamate	medium	4	2
methadone	low	4	0
metoclopramide	low	1	0
metoprolol	low	1	0
mianserin	low	1	0
midazolam	medium	6	1
muscimol	low	1	0
apnea	low	1	0
nimesulide	low	1	0
nimodipine	medium	2	1
nitrazepam	low	2	0
nitrendipine	low	2	0
ondansetron	low	1	0
oxazepam	medium	14	6
papaverine	low	2	0
pentobarbital	low	3	0
phenobarbital	medium	27	1
pindolol	low	2	0
piracetam	medium	4	3
prazosin	low	1	0
primidone	low	1	0
promazine	low	5	0
promethazine	low	1	0
propofol	low	11	0
propranolol	medium	7	3
risperidone	low	2	0
rofecoxib	low	1	0
sulpiride	low	2	0
temazepam	low	1	0
trazodone	low	1	0
triazolam	low	1	0
trifluoperazine	low	1	0
trimeprazine	low	2	0
vigabatrin	low	1	0
corticosterone	low	3	0
prednisolone	low	1	0
lysergic acid diethylamide	low	2	0
reserpine	low	8	0
sorbitol	low	1	0
thyroxine	low	4	0
dextroamphetamine	low	1	0
aldosterone	low	4	0
androsterone	low	1	0
etiocholanolone	low	1	0
pentylenetetrazole	low	4	0
triiodothyronine	low	3	0
aspartic acid	low	2	0
lysine	low	1	0
physostigmine	low	4	0
apomorphine	low	3	0
carbostyril	medium	1	1
adenosine monophosphate	low	1	0
leucine	low	1	0
androstenedione	low	1	0
methionine	low	1	0
cycloheximide	low	1	0
mannitol	low	1	0
ornithine	low	1	0
asparagine	low	1	0
threonine	low	1	0
methaqualone	medium	1	1
tryptophan	medium	5	1
arginine	low	2	0
pantothenic acid	low	1	0
methylprednisolone	low	1	0
isosorbide dinitrate	low	1	0
xylitol	low	1	0
n-vinyl-2-pyrrolidinone	low	4	0
quinoxalines	medium	1	1
isatin	low	1	0
phenothiazine	low	2	0
pyridostigmine bromide	low	1	0
acrylonitrile	low	1	0
deanol	low	1	0
thiamine pyrophosphate	low	3	0
isoxazoles	low	1	0
thiazoles	low	5	0
ephedrine	low	1	0
pirinitramide	medium	1	1
aminophylline	low	1	0
galantamine	medium	1	1
metofenazate	low	1	0
bicuculline	low	3	0
kainic acid	low	2	0
4-hydroxybutyric acid	medium	1	1
thiamine monophosphate	low	1	0
chlormethiazole	medium	101	12
methoxyhydroxyphenylglycol	low	7	0
lithium carbonate	medium	1	1
trimetozine	low	1	0
prothipendyl	low	1	0
benperidol	medium	1	1
tetrahydropapaveroline	low	1	0
n-methylaspartate	low	3	0
manganese	low	1	0
magnesium sulfate	low	5	0
lofexidine	low	1	0
cephapirin	low	1	0
bromocriptine	low	1	0
phenyl acetate	medium	3	1
paraldehyde	medium	16	1
pregnanolone	low	3	0
transferrin	low	11	0
calcium oxalate	low	1	0
glutamic acid	low	9	0
oxcarbazepine	low	1	0
sq-11725	low	1	0
ng-nitroarginine methyl ester	low	1	0
sufentanil	low	1	0
fomesafen	low	2	0
metsulfuron methyl	low	1	0
gepirone	low	1	0
esmolol	low	1	0
aripiprazole	medium	1	1
adenosine	low	1	0
carbogen	medium	1	1
cyamemazine	medium	1	1
norharman	low	1	0
caroverine	medium	1	1
xenon radioisotopes	low	1	0
medetomidine	low	1	0
fluorodeoxyglucose f18	medium	1	1
sertraline	low	1	0
selfotel	low	1	0
acamprosate	medium	4	1
methotrimeprazine	low	1	0
coenzyme a	low	1	0
fibrinogen	low	1	0
homocysteine	low	2	0
tert-butylbicyclophosphorothionate	low	1	0
tryptoline	low	1	0
difebarbamate, febarbamate, phenobarbital drug combination	low	1	0
tert-butylbicyclo-2-benzoate	low	1	0
2-chloro-n(6)cyclopentyladenosine	low	1	0
xylose	low	1	0
cyanopindolol	low	1	0
naproxen	low	1	0
clorazepate dipotassium	medium	5	1
atropine	medium	3	1
cortisone	low	1	0
hydroxydione	low	7	0
glycogen	low	1	0
fibrin	low	1	0
glucosamine	low	1	0
oxytocin	low	1	0
strychnine	low	2	0
indican	low	1	0
tretinoin	low	1	0
retinol	low	3	0
cocaine	low	7	0
sodium bicarbonate	low	1	0
lypressin	low	1	0
arginine vasopressin	low	1	0
physostigmine salicylate	low	1	0
chlorprothixene	medium	7	2
etomidate	low	3	0
bemesetron	low	1	0
benztropine	low	1	0
methimazole	low	1	0
D-fructopyranose	low	1	0
thiopental	low	1	0
lithium	medium	5	1
bilirubin	low	3	0
calcitriol	low	1	0
vitamin k semiquinone radical	low	4	0
harmine	low	3	0
ethchlorvynol	low	1	0
harman	low	1	0
humulene	low	2	0
thromboxane b2	low	1	0
codeine	low	1	0
nalmefene	low	1	0
naloxone	low	4	0
morphine	low	2	0
dexmedetomidine	low	16	0
lysophosphatidylcholines	low	2	0
fluvoxamine	low	1	0
naltrexone	medium	3	1
zimeldine	low	2	0
cpp 199	low	1	0
cysteine	low	1	0
heroin	low	1	0
pregabalin	medium	1	1
selenium	low	1	0
dizocilpine maleate	low	5	0
pregnanediol	low	3	0
tiapamil hydrochloride	medium	10	1
clomethiazole edisylate	low	4	0
g(m1) ganglioside	low	1	0
lactulose	low	1	0
technetium tc 99m exametazime	low	3	0
calcimycin	low	1	0
scopolamine hydrobromide	low	2	0
pituitrin	low	1	0
nad	low	1	0
cholecystokinin	low	1	0
atrial natriuretic factor	low	2	0
glucagon	low	1	0
beta-endorphin	low	3	0
neuropeptide y	low	3	0
phosphatidylcholines	low	1	0
technetium tc 99m sestamibi	low	1	0
sodium oxybate	medium	9	1
picrotoxin	low	2	0
cardiovascular agents	low	2	0
triiodothyronine, reverse	low	1	0
glycolipids	low	2	0
piperidines	low	3	0
interleukin-8	low	1	0
ascorbic acid	low	2	0
chlortetracycline	low	1	0
warfarin	low	1	0
phosphatidylethanol	low	3	0
vitamin b 12	low	4	0
muramidase	low	1	0
cyclic gmp	low	1	0
deoxyguanosine	low	1	0
folic acid	low	4	0
clozapine	low	2	0
8-hydroxy-2'-deoxyguanosine	low	1	0
eye	low	2	0
concanavalin a	low	1	0

Protein Targets (1,648)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	18	0	0	18
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	5	0	0	5
thioredoxin reductase	69	0	0	69
USP1 protein, partial	42	0	0	42
TDP1 protein	84	0	0	84
vitamin D3 receptor isoform VDRA	26	0	0	26
importin subunit beta-1 isoform 1	7	0	0	7
flap endonuclease 1	20	0	0	20
serine/threonine-protein kinase PLK1	4	0	0	4
snurportin-1	7	0	0	7
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	10	0	0	10
GTP-binding nuclear protein Ran isoform 1	4	0	0	4
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	30	0	0	30
urokinase-type plasminogen activator precursor	8	0	0	8
plasminogen precursor	8	0	0	8
urokinase plasminogen activator surface receptor precursor	8	0	0	8
geminin	75	0	0	75
DNA polymerase kappa isoform 1	20	0	0	20
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	2	0	2
Beta-lactamase	0	1	0	1
Transthyretin	0	2	1	5
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	2	0	2
Cannabinoid receptor 1	0	2	1	3
Cyclin-dependent kinase 2	0	2	1	3
Choline O-acetyltransferase	0	3	0	3
Mitogen-activated protein kinase 12	0	2	0	2
Guanine nucleotide-binding protein G	9	0	0	9
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	2	0	2
Mitogen-activated protein kinase 14	0	2	0	2
interferon gamma precursor	0	0	0	2
5-hydroxytryptamine receptor 1A	0	29	13	43
Adenosine receptor A3	0	17	3	21
Adenosine receptor A1	0	6	2	10
Adenosine receptor A1	0	1	0	1
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	3	4	8
Adenosine receptor A2b	0	1	2	4
Adenosine receptor A2b	0	2	2	5
Adenosine receptor A1	0	7	4	12
Adenosine receptor A2a	0	7	3	13
Delta-type opioid receptor	0	12	2	17
Delta-type opioid receptor	0	12	4	17
Adenylate cyclase type 5	0	5	0	5
Adenosine receptor A1	0	1	0	1
Adenosine receptor A1	0	1	1	2
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A3	0	1	0	1
Cannabinoid receptor 2	0	0	1	1
hypoxia-inducible factor 1 alpha subunit	16	0	0	16
RAR-related orphan receptor gamma	54	0	0	54
GLI family zinc finger 3	72	0	0	72
AR protein	90	0	0	90
aldehyde dehydrogenase 1 family, member A1	52	0	0	52
retinoic acid nuclear receptor alpha variant 1	60	0	0	60
retinoid X nuclear receptor alpha	37	0	0	37
estrogen nuclear receptor alpha	98	0	0	98
peroxisome proliferator-activated receptor delta	27	0	0	27
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	31	0	0	31
activating transcription factor 6	26	0	0	26
v-jun sarcoma virus 17 oncogene homolog (avian)	29	0	0	29
Histone H2A.x	22	0	0	22
thyroid hormone receptor beta isoform a	17	0	0	17
heat shock protein beta-1	16	0	0	16
nuclear factor erythroid 2-related factor 2 isoform 1	51	0	0	51
lamin isoform A-delta10	78	0	0	78
Voltage-dependent calcium channel gamma-2 subunit	27	0	0	27
Glutamate receptor 2	28	9	2	41
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	48	0	0	48
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
regulator of G-protein signaling 4	49	0	0	49
nonstructural protein 1	16	0	0	16
euchromatic histone-lysine N-methyltransferase 2	102	0	0	102
M-phase phosphoprotein 8	25	0	0	25
histone acetyltransferase KAT2A isoform 1	35	0	0	35
Glutamate receptor 1	2	11	2	17
Glutamate receptor ionotropic, NMDA 1	0	26	6	38
Glutamate receptor ionotropic, kainate 3	0	9	0	11
Glutamate receptor ionotropic, NMDA 2A	0	25	5	36
Glutamate receptor ionotropic, NMDA 2B	0	25	5	36
Glutamate receptor ionotropic, NMDA 2C	0	26	5	37
Glutamate receptor ionotropic, NMDA 2D	0	25	5	36
Glutamate receptor ionotropic, NMDA 3B	0	25	5	36
Glutamate receptor ionotropic, NMDA 3A	0	25	5	36
ATP-dependent phosphofructokinase	53	0	0	53
Protein skinhead-1	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	22	0	0	22
Chain A, HADH2 protein	25	0	0	25
Chain B, HADH2 protein	25	0	0	25
Chain A, 2-oxoglutarate Oxygenase	33	0	0	33
Chain A, Protocatechuate 3,4-dioxygenase	0	0	1	1
Chain M, Protocatechuate 3,4-dioxygenase	0	0	1	1
Olfactory receptor class A-like protein 1	0	0	1	1
Luciferase	17	0	0	17
endonuclease IV	14	0	0	14
RGS12	1	0	0	1
phosphopantetheinyl transferase	34	0	0	34
NFKB1 protein, partial	19	0	0	19
GLS protein	48	0	0	48
Microtubule-associated protein tau	32	0	0	32
Thrombopoietin	13	0	0	13
alkaline phosphatase, intestinal	0	0	1	1
thioredoxin glutathione reductase	8	0	0	8
apical membrane antigen 1, AMA1	11	0	0	11
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	18	0	0	18
thyroid stimulating hormone receptor	45	0	0	45
hypothetical protein, conserved	4	0	0	4
Bloom syndrome protein isoform 1	36	0	0	36
lysosomal alpha-glucosidase preproprotein	10	0	0	10
peripheral myelin protein 22 isoform 1	18	0	0	18
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein	0	1	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	25	0	0	25
intestinal alkaline phosphatase precursor	0	1	0	1
chromobox protein homolog 1	57	0	0	57
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
DNA polymerase beta	10	0	0	10
alkaline phosphatase, germ cell type preproprotein	0	0	1	1
POsterior Segregation	0	0	1	1
muscarinic acetylcholine receptor M1	37	0	0	37
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	40	4	44
Zinc finger protein mex-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	36	31	6	73
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	36	31	6	73
Gamma-aminobutyric acid receptor subunit delta	36	31	6	73
Gamma-aminobutyric acid receptor subunit gamma-2	36	31	8	75
Gamma-aminobutyric acid receptor subunit alpha-5	36	31	6	73
Gamma-aminobutyric acid receptor subunit alpha-3	36	31	6	73
Gamma-aminobutyric acid receptor subunit gamma-1	36	31	6	73
Gamma-aminobutyric acid receptor subunit alpha-2	36	31	6	73
Gamma-aminobutyric acid receptor subunit alpha-4	36	31	6	73
Gamma-aminobutyric acid receptor subunit gamma-3	36	31	6	73
Gamma-aminobutyric acid receptor subunit alpha-6	36	31	6	73
Gamma-aminobutyric acid receptor subunit alpha-1	36	33	8	77
Gamma-aminobutyric acid receptor subunit beta-3	36	31	6	73
Gamma-aminobutyric acid receptor subunit beta-2	36	31	8	75
Tetraspanin	0	1	0	1
Proton-coupled amino acid transporter 1	0	5	0	6
GABA theta subunit	36	31	6	73
Gamma-aminobutyric acid receptor subunit epsilon	36	31	6	73
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 2C	0	36	5	41
5-hydroxytryptamine receptor 2A	0	38	6	45
5-hydroxytryptamine receptor 1A	0	61	8	72
5-hydroxytryptamine receptor 1B	0	44	3	48
5-hydroxytryptamine receptor 1D	0	19	3	23
5-hydroxytryptamine receptor 1F	0	19	3	23
5-hydroxytryptamine receptor 2B	0	33	7	40
5-hydroxytryptamine receptor 6	0	7	3	10
Sodium-dependent serotonin transporter	0	40	5	45
Sodium-dependent serotonin transporter	0	19	2	22
5-hydroxytryptamine receptor 7	0	18	3	21
5-hydroxytryptamine receptor 5A	0	7	3	10
5-hydroxytryptamine receptor 5B	0	7	3	10
5-hydroxytryptamine receptor 3A	0	15	5	20
5-hydroxytryptamine receptor 4	0	8	3	12
5-hydroxytryptamine receptor 3B	0	15	5	20
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
15-lipoxygenase, partial	16	0	0	16
arylsulfatase A	38	0	0	38
cytochrome P450 2D6 isoform 1	28	0	0	28
cytochrome P450 2C19 precursor	22	0	0	22
cytochrome P450 2C9 precursor	18	0	0	18
Glutamate receptor 3	2	9	2	15
Glutamate receptor 4	2	9	2	15
Glutamate receptor ionotropic, kainate 1	0	7	2	11
Glutamate receptor ionotropic, kainate 2	0	7	3	12
Histamine H2 receptor	27	6	3	43
Inositol monophosphatase 1	18	0	0	18
Glutamate receptor ionotropic, kainate 4	0	7	0	9
Glutamate receptor ionotropic, kainate 5	0	7	0	9
Transporter	0	15	2	17
dopamine D1 receptor	8	0	0	8
D(1A) dopamine receptor	36	0	0	36
D(2) dopamine receptor	0	53	8	70
D(3) dopamine receptor	0	25	1	26
Sodium-dependent dopamine transporter	0	21	1	22
D(3) dopamine receptor	0	48	5	61
D(2) dopamine receptor	0	39	4	44
Histamine H3 receptor	0	3	1	4
Sigma non-opioid intracellular receptor 1	0	12	2	14
mu-type opioid receptor isoform MOR-1	0	0	2	2
5-hydroxytryptamine receptor 2A	0	0	2	2
Cytochrome P450 3A4	0	20	2	27
Neuronal acetylcholine receptor subunit alpha-4	2	5	0	7
Cytochrome P450 2C9	0	25	2	29
Neuronal acetylcholine receptor subunit beta-2	2	4	0	6
Alpha-1B adrenergic receptor	0	47	9	56
Translocator protein	0	6	3	10
D	0	27	0	27
Alpha-2B adrenergic receptor	0	30	5	36
D(2) dopamine receptor	0	11	0	11
Alpha-2C adrenergic receptor	0	30	5	36
Alpha-2A adrenergic receptor	0	31	5	37
Alpha-1D adrenergic receptor	0	38	9	48
Alpha-1D adrenergic receptor	0	41	4	50
5-hydroxytryptamine receptor 1D	0	7	0	10
5-hydroxytryptamine receptor 1B	0	8	2	10
5-hydroxytryptamine receptor 2C	0	53	3	57
5-hydroxytryptamine receptor 7	0	18	1	19
Alpha-1A adrenergic receptor	0	14	5	26
Alpha-1B adrenergic receptor	0	10	4	19
Alpha-1A adrenergic receptor	0	52	10	62
5-hydroxytryptamine receptor 5A	0	6	0	6
5-hydroxytryptamine receptor 6	0	38	1	42
5-hydroxytryptamine receptor 7	0	19	0	19
D	0	4	0	4
5-hydroxytryptamine receptor 2A	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	38	1	39
Lysosomal alpha-glucosidase	0	2	0	2
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
acetylcholinesterase	41	0	0	41
SMAD family member 2	9	0	0	9
SMAD family member 3	9	0	0	9
caspase 7, apoptosis-related cysteine protease	11	0	0	11
estrogen receptor 2 (ER beta)	32	0	0	32
nuclear receptor subfamily 1, group I, member 3	44	0	0	44
progesterone receptor	40	0	0	40
glucocorticoid receptor [Homo sapiens]	66	0	0	66
estrogen-related nuclear receptor alpha	78	0	0	78
farnesoid X nuclear receptor	28	0	0	28
pregnane X nuclear receptor	54	0	0	54
peroxisome proliferator activated receptor gamma	31	0	0	31
vitamin D (1,25- dihydroxyvitamin D3) receptor	34	0	0	34
caspase-3	11	0	0	11
thyroid stimulating hormone receptor	25	0	0	25
thyrotropin-releasing hormone receptor	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	18	0	0	18
Caspase-7	8	0	0	8
caspase-3	8	0	0	8
thyroid hormone receptor beta isoform 2	61	0	0	61
Cellular tumor antigen p53	47	0	0	47
ATPase family AAA domain-containing protein 5	18	0	0	18
Ataxin-2	34	0	0	34
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fyn	0	3	1	4
Fibrinogen C domain-containing protein 1	0	1	0	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	2	0	0	2
NPYLR7B	0	0	2	2
IDH1	23	0	0	23
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	27	0	0	27
nuclear receptor ROR-gamma isoform 1	29	0	0	29
peripheral myelin protein 22	46	0	0	46
survival motor neuron protein isoform d	22	0	0	22
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	8	0	0	8
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	5	0	5
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	3	0	3
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenylate kinase 2, mitochondrial	0	2	0	3
Adenylate kinase isoenzyme 1	0	2	0	3
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
Chain A, Glycogen Phosphorylase B	0	0	1	1
Chain B, Glycogen Phosphorylase B	0	0	1	1
Chain A, ADP-dependent glucokinase	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, phosphodiesterase-nucleotide pyrophosphatase	0	1	0	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain B, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	1	1
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Alcohol dehydrogenase E chain	0	3	2	5
Alcohol dehydrogenase S chain	0	3	2	5
L-lactate dehydrogenase A chain	0	1	1	2
Adenylate kinase isoenzyme 1	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	3
Fructose-1,6-bisphosphatase 1	0	2	0	2
2-dehydropantoate 2-reductase	0	1	1	2
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Amine oxidase [flavin-containing] B	0	4	0	5
5'-nucleotidase	0	0	0	1
GTP:AMP phosphotransferase AK3, mitochondrial	0	0	0	1
P2Y purinoceptor 2	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	0	1
Glycine--tRNA ligase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Adenosine deaminase-like protein	0	0	0	1
Protease	0	4	1	5
P2Y purinoceptor 11	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
5'-AMP-activated protein kinase subunit beta-1	0	0	2	2
Chain A, Cruzipain	15	0	0	15
lethal factor (plasmid)	26	0	0	26
Solute carrier family 22 member 2	0	10	0	15
Solute carrier family 22 member 1	0	30	0	35
Polyamine oxidase 1	0	1	0	1
Solute carrier family 22 member 3	0	7	0	9
Solute carrier family 22 member 3	0	2	0	3
Nischarin	0	4	0	4
Solute carrier family 22 member 1	0	11	0	12
Deoxyhypusine synthase	0	1	0	1
Solute carrier family 22 member 2	0	8	0	10
nuclear factor erythroid 2-related factor 2 isoform 2	19	0	0	19
Sex hormone-binding globulin	0	0	6	6
Corticosteroid-binding globulin	0	7	0	7
Mineralocorticoid receptor	0	3	4	7
Androgen receptor	0	10	0	10
Mineralocorticoid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	3
Bromodomain-containing protein 4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	27	12	39
Gamma-aminobutyric acid receptor subunit gamma-2	0	25	9	34
Cholecystokinin receptor type A	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-5	0	24	9	33
Gamma-aminobutyric acid receptor subunit alpha-3	0	24	6	30
Gamma-aminobutyric acid receptor subunit alpha-2	0	24	7	31
Gamma-aminobutyric acid receptor subunit beta-2	0	23	8	31
Cholecystokinin receptor type A	0	4	0	4
EWS/FLI fusion protein	38	0	0	38
putative alpha-glucosidase	1	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	6	0	6
Glutamate receptor ionotropic, NMDA 3B	0	6	0	6
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Spike glycoprotein	39	4	8	51
Glutamate receptor ionotropic, NMDA 1	0	8	0	8
Glutamate receptor ionotropic, NMDA 2A	0	8	0	8
Glutamate receptor ionotropic, NMDA 2B	0	8	0	8
Glutamate receptor ionotropic, NMDA 2C	0	6	0	6
Glutamate receptor ionotropic, NMDA 3A	0	6	0	6
Multidrug and toxin extrusion protein 1	0	11	0	11
ATP-binding cassette sub-family C member 3	0	60	0	60
Multidrug resistance-associated protein 4	0	60	0	63
Bile salt export pump	0	96	0	96
Canalicular multispecific organic anion transporter 1	0	57	0	57
Phenylethanolamine N-methyltransferase	0	3	0	3
Cytochrome P450 2A6	0	4	1	5
Substance-P receptor	0	1	0	1
Cytochrome P450 2A5	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	7	1	8
Beta-2 adrenergic receptor	0	5	5	11
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	19	0	0	19
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Carbonic anhydrase 1	0	12	0	21
Carbonic anhydrase 2	0	13	1	24
60 kDa heat shock protein, mitochondrial	0	3	0	3
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	4	0	4
Solute carrier family 15 member 1	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	3	0	3
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Thiosulfate sulfurtransferase	0	2	0	2
Metallo-beta-lactamase VIM-13	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	3	0	3
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	3	0	3
Metallo-b-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	1	0	3
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
interleukin 8	8	0	0	8
Smad3	15	0	0	15
cytochrome P450 family 3 subfamily A polypeptide 4	51	0	0	51
potassium voltage-gated channel subfamily H member 2 isoform d	42	0	0	42
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
muscleblind-like protein 1 isoform 1	11	0	0	11
neuropeptide S receptor isoform A	15	0	0	15
Beta-glucuronidase	0	1	0	1
Cholinesterase	0	9	0	9
Aromatase	0	4	0	6
Gastrin/cholecystokinin type B receptor	0	5	0	6
Testosterone 17-beta-dehydrogenase 3	0	2	0	2
Alpha-synuclein	7	6	0	13
Nuclear receptor ROR-gamma	10	1	1	12
TAR DNA-binding protein 43	16	0	0	16
Chain A, retinol dehydratase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
G-protein coupled bile acid receptor 1	0	0	2	2
ATAD5 protein, partial	33	0	0	33
Chain A, Putative fructose-1,6-bisphosphate aldolase	15	0	0	15
cytochrome P450 2D6	45	0	0	45
aryl hydrocarbon receptor	32	0	0	32
cellular tumor antigen p53 isoform a	13	0	0	13
cytochrome P450 3A4 isoform 1	36	0	0	36
Polyunsaturated fatty acid lipoxygenase ALOX15B	15	0	0	15
Integrin beta-3	7	2	1	10
Integrin alpha-IIb	7	2	1	10
Tryptophan 5-hydroxylase 1	0	3	0	3
D(1A) dopamine receptor	0	33	3	41
D(4) dopamine receptor	0	23	2	31
D(1B) dopamine receptor	0	11	0	15
D(1B) dopamine receptor	0	19	0	19
5-hydroxytryptamine receptor 2A	0	52	5	61
D(4) dopamine receptor	0	20	1	21
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
D	0	8	0	8
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
alpha-galactosidase	9	0	0	9
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Cationic amino acid transporter 3	0	2	0	2
Vasopressin V2 receptor	0	3	2	6
Oxytocin receptor	0	3	3	6
Vasopressin V1a receptor	0	1	3	4
Vasopressin V1a receptor	0	4	3	7
Vasopressin V1b receptor	0	2	2	4
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	2	1	4
Translocator protein	0	1	0	2
Oxytocin receptor	0	2	1	3
Vasopressin V2 receptor	0	2	1	3
5-hydroxytryptamine receptor 3E	0	8	3	12
Fumarate hydratase	20	0	0	20
PPM1D protein	13	0	0	13
G	27	0	0	27
polyprotein	20	0	0	20
67.9K protein	15	0	0	15
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	5	0	0	5
transcriptional regulator ERG isoform 3	5	0	0	5
5-hydroxytryptamine receptor 3A	0	2	2	4
5-hydroxytryptamine receptor 3B	0	8	3	12
Interferon beta	38	0	0	38
HLA class I histocompatibility antigen, B alpha chain	27	0	0	27
ATP-dependent translocase ABCB1	0	24	0	32
Alpha-2C adrenergic receptor	0	39	5	47
Muscarinic acetylcholine receptor M3	0	30	3	35
Histamine H1 receptor	0	6	4	11
Histamine H1 receptor	0	39	4	45
5-hydroxytryptamine receptor 2B	0	51	2	54
5-hydroxytryptamine receptor 3A	0	10	3	14
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	41	0	41
5-hydroxytryptamine receptor 3D	0	8	3	12
Multidrug and toxin extrusion protein 2	0	7	0	7
5-hydroxytryptamine receptor 3C	0	8	3	12
Inositol hexakisphosphate kinase 1	27	0	0	27
Histamine H3 receptor	0	10	2	12
cytochrome P450 2C9, partial	27	0	0	27
Chain A, Hyaluronidase, phage associated	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	4	0	0	4
Polyphenol oxidase 2	0	5	0	6
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	2	0	2
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	40	4	47
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	1	1	3
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Neutral amino acid transporter A	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	7
Amino acid transporter	0	2	0	2
Chain A, Ferritin light chain	18	0	0	18
Metabotropic glutamate receptor 6	0	1	3	5
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	2	0	2
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase 4	0	1	0	4
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
glucocerebrosidase	11	0	0	11
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Solute carrier family 22 member 6	0	5	0	5
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Fatty acid-binding protein, liver	0	6	0	6
Myeloperoxidase	0	6	0	6
Prostaglandin G/H synthase 1	0	5	0	5
Seed linoleate 13S-lipoxygenase-1	0	2	0	2
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	8	0	8
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	7	0	7
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	4	0	4
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Beta-1 adrenergic receptor	0	2	6	10
Beta-2 adrenergic receptor	0	12	8	21
Beta-1 adrenergic receptor	0	16	6	22
Beta-3 adrenergic receptor	0	7	6	13
Atrial natriuretic peptide receptor 1	0	0	1	1
Atrial natriuretic peptide receptor 1	0	0	1	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
short transient receptor potential channel 6 isoform 1	0	0	2	2
5-hydroxytryptamine receptor 4	0	42	0	42
Muscarinic acetylcholine receptor M2	0	28	3	34
Muscarinic acetylcholine receptor M4	0	30	2	34
Muscarinic acetylcholine receptor M1	0	14	1	17
Muscarinic acetylcholine receptor M3	0	11	1	14
Muscarinic acetylcholine receptor M4	0	10	1	13
Muscarinic acetylcholine receptor M5	0	12	1	15
Muscarinic acetylcholine receptor M5	0	29	1	32
Muscarinic acetylcholine receptor M2	0	14	2	19
Muscarinic acetylcholine receptor M1	0	32	3	38
Muscarinic acetylcholine receptor M1	0	0	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	1	1	2
Gamma-aminobutyric acid type B receptor subunit 2	0	3	2	5
Gamma-aminobutyric acid type B receptor subunit 2	0	4	0	4
Gamma-aminobutyric acid type B receptor subunit 1	0	3	2	5
Gamma-aminobutyric acid type B receptor subunit 1	0	3	0	3
GALC protein	7	0	0	7
glp-1 receptor, partial	23	0	0	23
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	8	0	0	8
Spike glycoprotein	0	4	8	12
Replicase polyprotein 1ab	0	4	8	12
Transmembrane protease serine 2	0	4	8	12
Procathepsin L	0	5	8	13
Aldo-keto reductase family 1 member B1	0	31	0	31
Alpha-2A adrenergic receptor	0	46	6	55
Replicase polyprotein 1a	0	4	8	12
Replicase polyprotein 1ab	0	4	8	12
Replicase polyprotein 1ab	0	5	8	13
Replicase polyprotein 1ab	0	5	8	13
Histamine H2 receptor	0	25	2	27
Sodium-dependent dopamine transporter	0	26	3	29
Angiotensin-converting enzyme 2	0	4	8	12
Gamma-aminobutyric acid receptor subunit pi	0	19	0	19
Gamma-aminobutyric acid receptor subunit delta	0	19	0	19
Gamma-aminobutyric acid receptor subunit beta-1	0	20	3	23
Gamma-aminobutyric acid receptor subunit beta-3	0	25	5	30
Gamma-aminobutyric acid receptor subunit alpha-4	0	20	3	23
Gamma-aminobutyric acid receptor subunit epsilon	0	19	0	19
Gamma-aminobutyric acid receptor subunit alpha-6	0	22	3	25
Gamma-aminobutyric acid receptor subunit gamma-1	0	19	0	19
Gamma-aminobutyric acid receptor subunit gamma-3	0	19	0	19
Gamma-aminobutyric acid receptor subunit theta	0	19	0	19
caspase-1 isoform alpha precursor	2	0	0	2
Caspase-7	3	0	0	3
Solute carrier organic anion transporter family member 1B3	0	2	0	4
Solute carrier organic anion transporter family member 1B1	0	2	0	5
Genome polyprotein	0	1	1	2
serine/threonine-protein kinase mTOR isoform 1	20	0	0	20
ATP-dependent translocase ABCB1	0	5	0	5
ATP-dependent translocase ABCB1	0	5	0	5
Bile salt export pump	0	14	0	14
Beta-2 adrenergic receptor	0	11	1	14
Angiotensin-converting enzyme	0	1	0	1
Beta-1 adrenergic receptor	0	12	3	18
Beta-3 adrenergic receptor	0	8	1	9
Alpha-2A adrenergic receptor	0	4	0	4
ClpP	4	0	0	4
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
TSHR protein	1	0	0	1
Parkin	7	0	0	7
LacZ protein (plasmid)	0	0	2	2
XBP1	0	1	0	1
serine-protein kinase ATM isoform a	1	0	0	1
hexokinase-4 isoform 1	4	0	0	4
NPC intracellular cholesterol transporter 1 precursor	6	0	0	6
type-1 angiotensin II receptor	0	2	0	2
glucokinase regulatory protein	4	0	0	4
huntingtin isoform 2	6	0	0	6
ras-related protein Rab-9A	11	0	0	11
apelin receptor	0	2	0	2
heat shock protein HSP 90-alpha isoform 2	0	0	0	3
DNA damage-inducible transcript 3 protein	0	1	0	1
Vpr	3	0	0	3
streptokinase A precursor	0	0	1	1
Amyloid-beta precursor protein	2	5	0	7
D(1A) dopamine receptor	13	1	0	14
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
heat shock protein 90, putative	0	0	0	3
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	5	2	9
Androgen receptor	0	4	0	4
Cytochrome P450 2D6	0	19	2	23
Vitamin D3 receptor	0	1	2	4
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	2	5	7
Cytochrome P450 2C19	0	8	1	11
Kappa-type opioid receptor	0	10	2	13
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	5	0	5
Vitamin D3 receptor A	0	0	2	2
Albumin	0	0	11	11
Major prion protein	0	0	6	6
Sodium channel protein type 1 subunit alpha	0	4	0	4
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sodium channel protein type 3 subunit alpha	0	3	0	3
UDP-glucuronosyltransferase 2B7	0	5	0	9
Cytochrome P450 2B6	0	1	1	2
Sodium channel protein type 4 subunit alpha	0	8	0	11
Cytochrome P450 2J2	0	16	0	17
Sodium channel protein type 9 subunit alpha	0	8	0	8
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
Chain A, serum paraoxonase	0	1	0	1
Carbonic anhydrase 12	0	3	0	6
Carbonic anhydrase 3	0	3	0	6
Neutrophil cytosol factor 1	0	1	0	1
Carbonic anhydrase 4	0	5	0	8
Carbonic anhydrase 6	0	4	0	7
Carbonic anhydrase 5A, mitochondrial	0	4	0	7
Carbonic anhydrase 7	0	3	0	6
Carbonic anhydrase 9	0	5	1	10
Carbonic anhydrase 13	0	1	0	3
Poly [ADP-ribose] polymerase tankyrase-2	0	1	0	1
Carbonic anhydrase 14	0	2	0	5
Carbonic anhydrase 5B, mitochondrial	0	4	0	7
Solute carrier family 22 member 6	0	3	0	4
Solute carrier family 22 member 8	0	4	0	5
Solute carrier family 22 member 11	0	2	0	2
Solute carrier family 22 member 8	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	7	0	10
Gamma-aminobutyric acid receptor subunit beta-1	0	7	0	10
Gamma-aminobutyric acid receptor subunit alpha-2	0	7	0	10
Gamma-aminobutyric acid receptor subunit alpha-3	0	7	0	10
Gamma-aminobutyric acid receptor subunit alpha-4	0	7	0	10
Gamma-aminobutyric acid receptor subunit gamma-2	0	7	0	10
Carbonic anhydrase	0	3	0	6
Carbonic anhydrase 15	0	4	0	7
UDP-glucuronosyltransferase 1-6	0	3	0	4
UDP-glucuronosyltransferase 1A1	0	4	0	5
UDP-glucuronosyltransferase 1A4	0	3	0	7
UDP-glucuronosyltransferase 2B10	0	3	0	3
Proteasome subunit beta type-11	0	0	0	1
NADPH oxidase 1	0	4	0	4
Snq2p	0	0	0	9
Adenylate cyclase type 1	0	4	0	4
histone deacetylase 9 isoform 3	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	10	0	0	10
Proteasome subunit alpha type-7	0	0	0	1
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	13	0	13
Potassium channel subfamily K member 2	0	4	1	5
Albumin	0	1	5	8
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	3	0	3
Major prion protein	0	0	1	1
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	4	2	6
Polyunsaturated fatty acid lipoxygenase ALOX15	0	5	0	5
Angiotensin-converting enzyme	0	19	0	19
Sphingomyelin phosphodiesterase	0	2	0	2
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	4	0	4
Adenylate cyclase type 3	0	4	0	4
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	4	0	4
Adenylate cyclase type 4	0	4	0	4
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Trypanothione reductase	0	14	0	14
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	6	0	6
Pleiotropic ABC efflux transporter of multiple drugs	0	9	0	18
Mu-type opioid receptor	0	23	10	38
Sodium channel protein type 1 subunit alpha	0	6	0	6
Adenylate cyclase type 8	0	4	0	4
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	16	6	27
Kappa-type opioid receptor	0	18	5	29
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
Gastrin/cholecystokinin type B receptor	0	3	0	3
Proteasome subunit alpha type-6	0	0	2	3
Calmodulin	0	1	4	5
Aldehyde oxidase 1	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1D	0	13	0	13
Adenylate cyclase type 6	0	4	0	4
Aldehyde oxidase	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	13	0	13
Voltage-dependent L-type calcium channel subunit alpha-1C	0	17	0	17
Sodium channel protein type 5 subunit alpha	0	9	0	9
Nuclear receptor subfamily 3 group C member 3	0	18	0	18
Adenylyl cyclase 7	0	4	0	4
Proteasome subunit alpha-type 8	0	0	0	1
Sodium channel protein type 2 subunit alpha	0	7	0	7
Proteasome subunit beta type-7	0	0	0	1
Sodium channel protein type 3 subunit alpha	0	7	0	7
Sodium channel protein type 11 subunit alpha	0	4	0	4
Sodium channel protein type 8 subunit alpha	0	4	0	4
Sodium channel protein type 10 subunit alpha	0	5	0	5
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	6	0	7
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
P2Y purinoceptor 12	0	1	0	1
Protein-arginine deiminase type-4	0	2	0	2
bromodomain adjacent to zinc finger domain 2B	14	0	0	14
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	3	0	3
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Histamine H4 receptor	0	4	3	7
Solute carrier family 22 member 4	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	9	0	0	9
Histamine H1 receptor	0	11	1	12
Trypanothione reductase	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	4	0	4
Envelope glycoprotein	0	0	3	3
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	2	0	0	2
Translocator protein	0	2	0	2
Translocator protein	0	8	0	8
Alpha-1B adrenergic receptor	0	0	2	2
Membrane primary amine oxidase	0	1	0	1
Alpha-1A adrenergic receptor	0	2	2	4
Amine oxidase [flavin-containing] A	0	10	0	10
Amine oxidase [flavin-containing] B	0	7	0	7
Alpha-2B adrenergic receptor	0	2	0	3
Mu-type opioid receptor	0	10	2	14
Alpha-2C adrenergic receptor	0	2	0	3
Alpha-2A adrenergic receptor	0	2	0	3
Nischarin	0	4	0	4
transient receptor potential cation channel subfamily V member 1	2	0	0	2
Endothelin receptor type B	0	2	0	2
5-hydroxytryptamine receptor 3A	0	6	0	6
Endothelin receptor type B	0	2	0	2
5-hydroxytryptamine receptor 2C	0	4	0	4
5-hydroxytryptamine receptor 2A	0	3	0	3
D(2) dopamine receptor	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	3	0	3
5-hydroxytryptamine receptor 2B	0	3	0	3
5-hydroxytryptamine receptor 4	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Liver carboxylesterase 1	0	3	0	6
Lysosomal Pro-X carboxypeptidase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	5	0	5
Leukotriene B4 receptor 1	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Leukotriene B4 receptor 2	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Kappa-type opioid receptor	0	7	2	11
Mu-type opioid receptor	0	7	2	13
Cytochrome P450 2D4	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	3	3
Histone acetyltransferase p300	0	1	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
N-alpha-acetyltransferase 50	0	0	1	1
pregnane X receptor	8	0	0	8
C-8 sterol isomerase	0	3	0	3
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	3	0	3
Glucocorticoid receptor	0	6	1	12
Glycine receptor subunit alpha-1	0	7	0	7
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	3	0	3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
P53	1	0	0	1
RPL19A	0	0	1	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
COUP transcription factor 2 isoform a	0	1	0	1
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	3	1	4
Hypoxia-inducible factor 1-alpha	0	1	1	2
Endothelial PAS domain-containing protein 1	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
Choline O-acetyltransferase	0	2	0	2
Lysine-specific demethylase 4A	0	1	0	1
Methylcytosine dioxygenase TET2	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	2
Deoxycytidine kinase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	2	2
Trace amine-associated receptor 1	0	0	2	2
Gamma-aminobutyric acid	0	4	3	7
Alpha-1-acid glycoprotein 1	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	3	7
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	3	7
Gamma-aminobutyric acid receptor subunit delta	0	4	3	7
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	3	7
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	3	7
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	3	7
Gamma-aminobutyric acid receptor subunit beta-1	0	4	3	7
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	3	8
Gamma-aminobutyric acid receptor subunit beta-3	0	4	3	7
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	3	7
Gamma-aminobutyric acid receptor subunit pi	0	4	3	7
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	3	7
Gamma-aminobutyric acid receptor subunit theta	0	4	3	7
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	3	7
polyunsaturated fatty acid lipoxygenase ALOX12	5	0	0	5
runt-related transcription factor 1 isoform AML1b	2	0	0	2
core-binding factor subunit beta isoform 2	2	0	0	2
pyruvate kinase	1	0	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
beta-2 adrenergic receptor	3	0	0	3
perilipin-5	0	1	0	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
perilipin-1	0	1	0	1
polypyrimidine tract-binding protein 1 isoform a	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	8	0	0	8
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
pyruvate kinase PKM isoform b	1	0	0	1
Fatty-acid amide hydrolase 1	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Carbamate kinase	0	1	0	1
Retinal dehydrogenase 1	0	1	0	1
Aldehyde dehydrogenase, mitochondrial	0	1	0	1
Ornithine decarboxylase	1	1	0	3
C-X-C chemokine receptor type 2	0	2	0	2
Mitogen-activated protein kinase 3	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Lysine-specific demethylase 5A	0	1	0	1
Caspase-1	0	2	0	2
C-C chemokine receptor type 2	0	2	0	2
C-C chemokine receptor type 4	0	2	0	2
C-C chemokine receptor type 5	0	2	0	2
Gasdermin-D	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Lysyl oxidase homolog 4	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Monoglyceride lipase	0	1	0	1
Gasdermin-D	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
large T antigen	0	1	0	1
Acetylcholinesterase	0	16	0	17
Acetylcholinesterase	0	5	0	5
Amine oxidase [flavin-containing] A	0	1	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	4	0	4
Acetylcholinesterase	0	14	3	19
Acetylcholinesterase	0	5	0	5
Acetylcholinesterase	0	3	0	3
Glycogen synthase kinase-3 beta	0	2	0	2
Beta-secretase 1	0	1	0	1
Cholinesterase	0	10	0	11
Cholinesterase	0	2	0	2
Acetylcholine receptor subunit epsilon	0	1	0	1
Cytochrome P450 1B1	0	3	0	3
Acyl-CoA:cholesterol acyltransferase	0	2	0	2
Carboxylic ester hydrolase	0	2	0	3
Carboxylic ester hydrolase	0	6	0	6
N-acetyltransferase Eis	0	3	0	3
Mitochondrial 2-oxodicarboxylate carrier	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
Chain H, IGG1-KAPPA DB3 FAB (HEAVY CHAIN)	0	1	0	1
Chain L, IGG1-KAPPA DB3 FAB (LIGHT CHAIN)	0	1	0	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Acetylcholine receptor subunit delta	0	1	0	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Cathepsin B	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
fructose-bisphosphate aldolase	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Rap guanine nucleotide exchange factor 4	3	0	0	3
Aurora kinase B	0	0	1	1
Bile acid receptor	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Cytochrome P450 2C8	0	3	0	3
Dipeptidyl peptidase 4	0	1	0	1
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Sigma intracellular receptor 2	0	5	0	5
Sodium-dependent serotonin transporter	0	2	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Cytochrome P450 1A2	0	2	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	1	3
Aldo-keto reductase family 1 member B1	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	3
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	3
Gamma-aminobutyric acid receptor subunit rho-1	0	0	4	6
Gamma-aminobutyric acid receptor subunit rho-2	0	0	2	4
Sterol O-acyltransferase 1	0	0	2	2
Chain A, ACETYLCHOLINESTERASE	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
Vascular endothelial growth factor receptor 1	0	2	0	2
Vascular endothelial growth factor receptor 3	0	2	0	2
Vascular endothelial growth factor receptor 2	0	2	0	2
Prolyl endopeptidase	0	1	0	1
Small conductance calcium-activated potassium channel protein 3	0	1	0	1
Hsf1 protein	0	0	3	4
Histone deacetylase 3	0	4	0	4
Sodium- and chloride-dependent GABA transporter 1	0	5	0	5
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	5	0	5
Sodium- and chloride-dependent GABA transporter 3	0	5	0	5
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	5	0	5
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	4	0	4
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	4	0	4
Histone deacetylase 11	0	4	0	4
Histone deacetylase 8	0	4	0	4
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	4	0	4
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Glutathione reductase, mitochondrial	0	4	0	4
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	2	2
ATP-citrate synthase	0	1	0	1
Metabotropic glutamate receptor 1	0	3	1	4
Metabotropic glutamate receptor 2	0	1	1	2
Metabotropic glutamate receptor 3	0	1	1	2
Metabotropic glutamate receptor 4	0	2	1	3
Metabotropic glutamate receptor 5	0	2	2	4
Metabotropic glutamate receptor 6	0	1	1	2
Metabotropic glutamate receptor 7	0	1	1	2
Glutamate receptor ionotropic, kainate 1	0	3	2	5
Metabotropic glutamate receptor 5	0	1	2	4
Glutamate receptor 1	0	4	2	6
Glutamate receptor 2	0	4	2	6
Glutamate receptor 3	0	2	2	4
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	4	1	5
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	2	1	3
Fatty-acid amide hydrolase 1	0	4	0	4
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	3	2	5
Glutamate receptor ionotropic, kainate 3	0	3	0	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	3	0	3
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Asc-type amino acid transporter 1	0	1	0	1
Glycine receptor subunit alpha-1	0	2	2	4
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	5	0	5
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Cocaine esterase	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
UDP-glucuronosyltransferase 1A9	0	1	0	4
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Mu-type opioid receptor	0	13	4	20
Kappa-type opioid receptor	0	8	4	13
5-hydroxytryptamine receptor 2A	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
DNA repair and recombination protein RAD54-like isoform 1	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Tryptophan 2,3-dioxygenase	0	3	0	4
Chain A, Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
CDC-like kinase 1, isoform CRA_c	0	0	0	1
[Tau protein] kinase	0	1	0	1
dual specificity protein kinase CLK4	1	0	0	1
Dual specificity protein kinase CLK2	0	1	0	1
Dual specificity protein kinase CLK3	0	1	0	1
Dual specificity protein kinase CLK4	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 3	0	1	0	1
Cyclin-T1	0	1	0	1
Serine/threonine-protein kinase D3	0	2	0	2
G2/mitotic-specific cyclin-B2	0	1	0	1
Protein kinase C gamma type	0	2	0	2
Protein kinase C beta type	0	2	0	2
Cyclin-dependent kinase 1	0	1	0	1
Tyrosine-protein kinase Lyn	0	1	0	1
Serine/threonine-protein kinase pim-1	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Protein kinase C alpha type	0	2	0	2
Dual specificity protein kinase CLK1	0	1	0	1
Protein kinase C eta type	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
Neuromedin-B receptor	0	1	0	1
Protein kinase C iota type	0	2	0	2
Casein kinase I isoform delta	0	1	0	1
Casein kinase I isoform epsilon	0	1	0	1
Dual specificity protein kinase CLK1	0	1	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Cyclin-dependent kinase 7	0	1	0	1
Cyclin-dependent kinase 9	0	1	0	1
Cyclin-H	0	1	0	1
Mitogen-activated protein kinase 1	0	1	0	1
Cyclin-A1	0	1	0	1
Cyclin-dependent-like kinase 5	0	1	0	1
Protein kinase C epsilon type	0	2	0	2
Protein kinase C theta type	0	2	0	2
Protein kinase C zeta type	0	2	0	2
Protein kinase C delta type	0	2	0	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	2	0	2
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Serine/threonine-protein kinase D1	0	2	0	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Serine/threonine-protein kinase pim-3	0	1	0	1
Serine/threonine-protein kinase haspin	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 4	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	2	0	2
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Plasma kallikrein	0	0	0	3
Macrophage migration inhibitory factor	0	3	0	3
Carbonic anhydrase	0	1	0	5
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	0	0	4
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	5
Equilibrative nucleoside transporter 4	0	0	0	1
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 13	0	1	0	4
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	2
Coagulation factor XII	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Protein-glutamine gamma-glutamyltransferase 2	0	1	0	1
Cruzipain	0	1	0	1
Secreted chorismate mutase	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endonuclease 8-like 1	0	1	0	1
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	3	1	4
Beta-2 adrenergic receptor	0	2	0	2
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	2	2
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Beta-2 adrenergic receptor	0	1	1	2
Taste receptor type 2 member 42	0	0	1	1
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	2	3
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Chain A, Glutamate receptor 2	0	0	1	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain C, Glutamate receptor 2	0	0	1	1
Glutamate receptor ionotropic, kainate 4	0	1	0	1
Synaptic vesicular amine transporter	0	4	1	5
Aryl hydrocarbon receptor	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
G protein-coupled receptor GPR35	0	0	1	1
Vesicular glutamate transporter 3	0	1	0	1
G-protein coupled receptor 35	0	2	1	3
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
Catechol O-methyltransferase	0	1	0	1
5-hydroxytryptamine receptor 1E	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	3	0	3
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Aldehyde oxidase 1	0	1	0	1
Dopamine beta-hydroxylase	0	2	0	2
Lactoperoxidase	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 3B	0	4	0	4
Endothelin-1 receptor	0	2	1	3
Type-2 angiotensin II receptor	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
G-protein coupled receptor	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Histidine decarboxylase	0	0	3	3
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
D-amino-acid oxidase	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
kappa-type opioid receptor isoform 1	0	1	0	1
Beta-galactosidase	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	3
Nociceptin receptor	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	4
Hormone-sensitive lipase	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	4
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Caspase-9	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 1	0	3	0	4
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Collagenase 3	0	1	0	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	2	0	2
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
NAD-dependent protein deacetylase	0	1	0	1
Interstitial collagenase	0	2	0	2
Leukotriene A-4 hydrolase	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-4	0	1	0	1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	1	0	1
Voltage-dependent calcium channel gamma-3 subunit	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1H	0	1	0	1
Cannabinoid receptor 1	0	4	0	4
Voltage-dependent L-type calcium channel subunit beta-3	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	2	0	3
Voltage-dependent calcium channel gamma-7 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel gamma-1 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-2	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	3	0	3
Voltage-dependent R-type calcium channel subunit alpha-1E	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-4	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Voltage-dependent calcium channel subunit alpha-2/delta-3	0	1	0	1
Voltage-dependent calcium channel gamma-8 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-6 subunit	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	2	0	2
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
Voltage-dependent calcium channel gamma-4 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-5 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	0	1	0	1
Lysine-specific demethylase 4C	0	4	0	4
G-protein coupled receptor 55	0	1	0	1
Platelet-activating factor receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Thromboxane-A synthase	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	4	0	5
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Casein kinase II subunit alpha'	0	1	0	1
cAMP-dependent protein kinase catalytic subunit gamma	0	1	0	1
cAMP-dependent protein kinase catalytic subunit beta	0	1	0	1
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	0	2
Interleukin-6 receptor subunit alpha	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Thyrotropin-releasing hormone receptor	0	1	0	1
Glycine receptor subunit alpha-4	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, L-ARGININE\\:GLYCINE AMIDINOTRANSFERASE	0	1	0	1
polyadenylate-binding protein 1	0	1	0	1
bcl-2-related protein A1	0	1	0	1
Oxytocin receptor	0	0	1	1
Type II pantothenate kinase	0	0	0	1
Type III pantothenate kinase	0	0	0	1
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
CREB-binding protein	1	0	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	2
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	2
rac GTPase-activating protein 1 isoform a	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Synaptic vesicle glycoprotein 2A	0	1	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Beta-casein	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-mannosidase 2C1	0	0	1	1
Bromodomain-containing protein 2	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	2	0	2
Type-1 angiotensin II receptor	0	1	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Chloroquine resistance transporter	0	1	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	3	3
Pyridoxal kinase	0	0	0	1
hemoglobin subunit beta	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Quinolone resistance protein NorA	0	1	0	2
DNA topoisomerase 1	0	1	0	1
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
inositol monophosphatase 1	1	0	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Calpain-2 catalytic subunit	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Transporter	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
DNA topoisomerase 2-alpha	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Pyruvate kinase PKM	0	1	0	1
Sulfate anion transporter 1	0	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Glycine receptor subunit beta	0	1	0	1
Chain A, Protein (aspartate Aminotransferase)	0	0	1	1
Chain A, Aspartate Aminotransferase	0	0	1	1
Lysine-specific demethylase 4E	0	1	0	1
Delta-aminolevulinic acid dehydratase	0	1	0	1
NADP-dependent malic enzyme, mitochondrial	0	0	0	1
Solute carrier family 13 member 3	0	1	0	1
Methyl-accepting chemotaxis protein NahY	0	0	1	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Solute carrier organic anion transporter family member 1A4	0	1	0	3
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Peroxisome proliferator-activated receptor gamma	0	0	4	4
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Endolysin	0	0	1	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Genome polyprotein	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	2	0	3
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Ubiquitin carboxyl-terminal hydrolase 1	0	1	0	1
Lysozyme C-1	0	1	0	1
Glycoprotein hormones alpha chain	1	0	0	1
Protein kinase C alpha type	0	1	0	1
Beta-glucuronidase	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Protein kinase C eta type	0	1	0	1
Calcium-dependent protein kinase 4	0	1	0	1
WD repeat-containing protein 48	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
Protein kinase C theta type	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Vif	0	2	0	2
Tat	0	1	0	1
Strictosidine synthase	0	0	0	1
Cathepsin K	0	1	0	1
Cytochrome P450 2A13	0	1	1	2
5-hydroxytryptamine receptor 5A	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Stromelysin-1	0	1	0	1
SLC16A10 protein	0	0	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Alcohol Withdrawal Associated Autonomic Hyperactivity

Synonyms(7)

Research Excerpts

Overview

Context

Treatment

Research

Studies (922)

Protein Targets (1,648)

Alcohol Withdrawal Associated Autonomic Hyperactivity

Synonyms(7)

Research Excerpts

Overview

Context

Treatment

Research

Studies (922)

Drugs Studied (347)

Protein Targets (1,648)