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L-leucine derivative
A proteinogenic amino acid derivative resulting from reaction of L-leucine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-leucine by a heteroatom.
ChEBI ID: 25018
Members (9)
| Member | Definition | Role |
|---|---|---|
| acetylleucine | The N-acetyl derivative of L-leucine. | N-acetyl-L-leucine |
| aloxistatin | An L-leucine derivative that is the amide obtained by formal condensation of the carboxy group of (2S,3S)-3-(ethoxycarbonyl)oxirane-2-carboxylic acid with the amino group of N-(3-methylbutyl)-L-leucinamide. | aloxistatin |
| e 64 | E64 zwitterion; E64 | |
| leucine methyl ester | The methyl ester of L-leucine. | methyl L-leucinate |
| leucine-beta-naphthylamide | An L-leucine derivative that is the amide obtained by formal condensation of the carboxy group of L-leucine with the amino group of 2-naphthylamine. | L-leucine 2-naphthylamide |
| mln 4760 | A L-histidine derivative that is L-histidine in which a hydrogen of the primary amino group is substituted by a (1S)-1-carboxy-3-methylbutyl group and the ring NH group is substituted by a 3,5-dichlorobenzyl group. It is a potent and selective human angiotensin-converting enzyme 2 (ACE2) inhibitor (IC50 = 0.44 nM) which was in clinical development for the treatment of ulcerative colitis. | MLN-4760 |
| orlistat | A carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug. | orlistat |
| PF-00835231 | A primary alcohol resulting from the cleavage of the phosphate group of the prodrug PF-07304814. It is an inhibitor of SARS-CoV-1 and -2 main protease (3CLpro) and exhibits potent in vitro antiviral activity. | PF-00835231 |
| PF-07304814 | An indolecarboxamide resulting from the formal condensation of the carboxy group of 4-methoxy-1H-indole-2-carboxylic acid with the primary amino group of N-[(2S)-3-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]-4-(phosphonooxy)butan-2-yl]-L-leucinamide. It is the phosphate prodrug of PF-00835231, an anticoronaviral agent. | PF-07304814 |
Research
Studies (2,122)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 114 (5.37) | 18.7374 |
| 1990's | 361 (17.01) | 18.2507 |
| 2000's | 841 (39.63) | 29.6817 |
| 2010's | 622 (29.31) | 24.3611 |
| 2020's | 184 (8.67) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 276 (12.26%) | 5.53% |
| Reviews | 346 (15.37%) | 6.00% |
| Case Studies | 70 (3.11%) | 4.05% |
| Observational | 1 (0.04%) | 0.25% |
| Other | 1,558 (69.21%) | 84.16% |