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L-leucine derivative

A proteinogenic amino acid derivative resulting from reaction of L-leucine at the amino group or the carboxy group, or from the replacement of any hydrogen of L-leucine by a heteroatom.

ChEBI ID: 25018

Members (9)

MemberDefinitionRole
acetylleucineThe N-acetyl derivative of L-leucine.N-acetyl-L-leucine
aloxistatinAn L-leucine derivative that is the amide obtained by formal condensation of the carboxy group of (2S,3S)-3-(ethoxycarbonyl)oxirane-2-carboxylic acid with the amino group of N-(3-methylbutyl)-L-leucinamide.aloxistatin
e 64E64 zwitterion; E64
leucine methyl esterThe methyl ester of L-leucine.methyl L-leucinate
leucine-beta-naphthylamideAn L-leucine derivative that is the amide obtained by formal condensation of the carboxy group of L-leucine with the amino group of 2-naphthylamine.L-leucine 2-naphthylamide
mln 4760A L-histidine derivative that is L-histidine in which a hydrogen of the primary amino group is substituted by a (1S)-1-carboxy-3-methylbutyl group and the ring NH group is substituted by a 3,5-dichlorobenzyl group. It is a potent and selective human angiotensin-converting enzyme 2 (ACE2) inhibitor (IC50 = 0.44 nM) which was in clinical development for the treatment of ulcerative colitis.MLN-4760
orlistatA carboxylic ester resulting from the formal condensation of the carboxy group of N-formyl-L-leucine with the hydroxy group of (3S,4S)-3-hexyl-4-[(2S)-2-hydroxytridecyl]oxetan-2-one. A pancreatic lipase inhibitor, it is used as an anti-obesity drug.orlistat
PF-00835231A primary alcohol resulting from the cleavage of the phosphate group of the prodrug PF-07304814. It is an inhibitor of SARS-CoV-1 and -2 main protease (3CLpro) and exhibits potent in vitro antiviral activity.PF-00835231
PF-07304814An indolecarboxamide resulting from the formal condensation of the carboxy group of 4-methoxy-1H-indole-2-carboxylic acid with the primary amino group of N-[(2S)-3-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]-4-(phosphonooxy)butan-2-yl]-L-leucinamide. It is the phosphate prodrug of PF-00835231, an anticoronaviral agent.PF-07304814

Research

Studies (2,122)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-1990114 (5.37)18.7374
1990's361 (17.01)18.2507
2000's841 (39.63)29.6817
2010's622 (29.31)24.3611
2020's184 (8.67)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials276 (12.26%)5.53%
Reviews346 (15.37%)6.00%
Case Studies70 (3.11%)4.05%
Observational1 (0.04%)0.25%
Other1,558 (69.21%)84.16%