Any gamma-lactone having the lactone moiety derived from 4-hydroxybutanoic acid.
ChEBI ID: 22950
| Member | Definition | Role |
|---|---|---|
| 4-butyrolactone | A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2. | gamma-butyrolactone |
| 4-hexanolide | A gamma-lactone that is oxolan-2-one substituted by an ethyl group at position 5. | gamma-caprolactone |
| a-factor (streptomyces) | A butan-4-olide that is gamma-butyrolactone with a 6-methylheptanoyl substituent at position 3 and a hydroxymethyl substituent at position 4 (the 3R,4R-stereoisomer). | (3R,4R)-4-(hydroxymethyl)-3-(6-methylheptanoyl)oxolan-2-one |
| alpha-methylene gamma-butyrolactone | A butan-4-olide having a methylene group at the 3-position. | alpha-methylene gamma-butyrolactone |
| anthecotulide | anthecotulide | |
| bursehernin | A butan-4-olide that is (-)-pluviatolide in which the phenolic hydroxy group has been converted to the corresponding methyl ether. | (-)-bursehernin |
| gamma-valerolactone | A butan-4-olide that is dihydrofuran-2(3H)-one substituted by a methyl group at position 5. It has been found in the urine samples of humans exposed to n-hexane. | gamma-valerolactone |
| pantolactone | A butan-4-olide that is dihydrofuran-2(3H)-one substituted by a hydroxy group at position 3 and two methyl groups at position 4 (the R-stereoisomer). | (R)-pantolactone |
| pluviatolide | A butan-4-olide that is dihydrofuran-2(3H)-one which is substituted by a vanillyl group at position 3 and by a 3,4-methylenedioxybenzyl group at position 4 (the R,R stereoisomer). | (-)-pluviatolide |
| ribonolactone | A five-membered form of ribonolactone having D-configuration. | D-ribono-1,4-lactone |
| yatein | A member of the class of butan-4-olides carrying 3,4,5-trimethoxybenzyl and (1,3-benzodioxol-5-yl)methyl substituents at positions 3 and 4 respectively. | dihydroanhydropodorhizol |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 388 (8.62) | 18.7374 |
| 1990's | 453 (10.07) | 18.2507 |
| 2000's | 1,583 (35.19) | 29.6817 |
| 2010's | 1,691 (37.59) | 24.3611 |
| 2020's | 384 (8.54) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 82 (1.68%) | 5.53% |
| Reviews | 293 (6.02%) | 6.00% |
| Case Studies | 73 (1.50%) | 4.05% |
| Observational | 4 (0.08%) | 0.25% |
| Other | 4,419 (90.72%) | 84.16% |