An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.
ChEBI ID: 37887
| Member | Definition | Class |
|---|---|---|
| bethanidine | bethanidine | |
| bretylium | A quaternary ammonium cation having 2-bromobenzyl, ethyl and two methyl groups attached to the nitrogen. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. | bretylium |
| bretylium tosylate | The tosylate salt of bretylium. It blocks noradrenaline release from the peripheral sympathetic nervous system, and is used in emergency medicine, cardiology, and other specialties for the acute management of ventricular tachycardia and ventricular fibrillation. | bretylium tosylate |
| bupivacaine hydrochloride | A racemate composed of equimolar amounts of dextrobupivacaine hydrochloride and levobupivacaine hydrochloride. The monohydrate form is commonly used as a local anaesthetic. | 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride; bupivacaine hydrochloride (anhydrous) |
| clozapine | A benzodiazepine that is 5H-dibenzo[b,e][1,4]diazepine substituted by a chloro group at position 8 and a 4-methylpiperazin-1-yl group at position 11. It is a second generation antipsychotic used in the treatment of psychiatric disorders like schizophrenia. | clozapine |
| dihydroergocristine | Ergocristine in which a single bond replaces the double bond between positions 9 and 10. It is used as the mesylate salt for the symptomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease. | dihydroergocristine |
| guanadrel | A spiroketal resulting from the formal condensation of the keto group of cyclohexanone with the hydroxy groups of 1-(2,3-dihydroxypropyl)guanidine. A postganglionic adrenergic blocking agent formerly used (generally as the sulfate salt) for the management of hypertension, it has been largely superseded by other drugs less likely to cause orthostatic hypotension (dizzy spells on standing up or stretching). | guanadrel |
| guanadrel sulfate | An organic sulfate salt resulting from the reaction of 2 eq. guanadrel with 1 eq. sulfuric acid. A postganglionic adrenergic blocking agent formerly used for the management of hypertension, it has been largely superseded by other drugs less likely to cause orthostatic hypotension (dizzy spells on standing up or stretching). | guanadrel sulfate |
| guanethidine | A member of the class of guanidines in which one of the hydrogens of the amino group has been replaced by a 2-azocan-1-ylethyl group. | guanethidine |
| hordatine a | A member of the calss of benzofurans that is a homodimer of para-coumarylagmatine where a hydroxy group of one molecule has reacted across the other molecule's ethene double bond to combine the two molecules and form a furan ring. | hordatine A |
| levobupivacaine | The (S)-(-)-enantiomer of bupivacaine. | levobupivacaine |
| levobupivacaine hydrochloride | The monohydrochloride salt of levobupivacaine. | levobupivacaine hydrochloride (anhydrous) |
| lurasidone | An N-arylpiperazine that is (3aR,4S,7R,7aS)-2-{[(1R,2R)-2-(piperazin-1-ylmethyl)cyclohexyl]methyl}hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione in which position N4 of the piperazine ring is substituted by a 1,2-benzothiazol-3-yl group. Lurasidone is used (generally as the hydrochloride salt) as an atypical antipsychotic for the treatment of schizophrenia. | lurasidone |
| lurasidone hydrochloride | A hydrochloride obtained by reaction of lurasidone with one equivalent of hydrochloric acid. An atypical antipsychotic agent used for the treatment of schizophrenia. | lurasidone hydrochloride |
| periciazine | A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic. | periciazine |
| profenamine | A member of the class of phenothiazines that is phenothiazine in which the hydrogen attached to the nitrogen is substituted by a 2-(diethylamino)propyl group. An antimuscarinic, it is used as the hydrochloride for the symptomatic treatment of Parkinson's disease. | profenamine |
| profenamine hydrochloride | The monohydrochloride salt of profenamine. An antimuscarinic, it is used for the symptomatic treatment of Parkinson's disease. | profenamine hydrochloride |
| quetiapine | quetiapine | |
| trazodone | An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group. | trazodone |
| trazodone hydrochloride | A hydrochloride salt prepared from equimolar amounts of trazodone and hydrogen chloride. | trazodone hydrochloride |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 9,275 (18.70) | 18.7374 |
| 1990's | 5,389 (10.86) | 18.2507 |
| 2000's | 10,233 (20.63) | 29.6817 |
| 2010's | 16,770 (33.80) | 24.3611 |
| 2020's | 7,943 (16.01) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 2,461 (4.68%) | 5.53% |
| Reviews | 2,882 (5.48%) | 6.00% |
| Case Studies | 2,642 (5.02%) | 4.05% |
| Observational | 103 (0.20%) | 0.25% |
| Other | 44,547 (84.63%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 24.4442 | 1 | 5 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 6.2560 | 1 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 25.6018 | 1 | 2 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 0.0134 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 23.5676 | 1 | 4 |
| AR protein | Homo sapiens (human) | Potency | 20.5670 | 8 | 20 |
| arylsulfatase A | Homo sapiens (human) | Potency | 11.9955 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 3.0013 | 2 | 3 |
| Ataxin-2 | Homo sapiens (human) | Potency | 20.9616 | 2 | 4 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 4.3411 | 1 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 10.5909 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 10.3992 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0035 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 21.8003 | 2 | 5 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 25.0593 | 1 | 5 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 10.6826 | 2 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 24.9054 | 2 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 29.1125 | 2 | 7 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 30.6687 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 29.1125 | 2 | 7 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 65.9163 | 2 | 5 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 10.6882 | 1 | 5 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 13.7011 | 1 | 5 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 18.3411 | 2 | 14 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 15.1004 | 2 | 9 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 4.6719 | 3 | 7 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| dopamine D1 receptor | Homo sapiens (human) | Potency | 0.0517 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 24.9092 | 7 | 22 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 37.5753 | 9 | 16 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 9.8549 | 1 | 5 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 34.6694 | 3 | 3 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 23.4106 | 2 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 24.9053 | 1 | 2 |
| G | Vesicular stomatitis virus | Potency | 38.9018 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 18.3411 | 1 | 7 |
| geminin | Homo sapiens (human) | Potency | 8.6549 | 2 | 4 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 20.2431 | 2 | 6 |
| GLS protein | Homo sapiens (human) | Potency | 21.4864 | 2 | 4 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 13.5481 | 1 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 11.4516 | 2 | 7 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 33.4915 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 18.8920 | 2 | 11 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 19.7234 | 1 | 7 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 61.9315 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 2.1314 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 10.3225 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 38.9018 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 3.3667 | 2 | 3 |
| Interferon beta | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 8.7330 | 1 | 7 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 31.6228 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 40.5334 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 18.1378 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 27.7240 | 1 | 4 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 21.1591 | 2 | 6 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 9.0216 | 2 | 5 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 1.0000 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 33.0209 | 2 | 3 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 17.9498 | 1 | 3 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 19.2872 | 3 | 5 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 20.2731 | 1 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 47.7548 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 18.5820 | 2 | 5 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 1.9162 | 2 | 2 |
| polyprotein | Zika virus | Potency | 24.9053 | 1 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 11.0475 | 1 | 4 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 12.2057 | 1 | 8 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 16.3657 | 2 | 8 |
| progesterone receptor | Homo sapiens (human) | Potency | 27.0592 | 1 | 3 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 3.4006 | 2 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 26.6795 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 29.0144 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 18.4915 | 2 | 2 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 29.9349 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 21.4411 | 1 | 7 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 12.5893 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.8406 | 2 | 29 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 32.3600 | 4 | 12 |
| Thrombopoietin | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 22.1192 | 3 | 13 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 14.7473 | 2 | 3 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 38.7006 | 1 | 3 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 3.0761 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 7.8422 | 2 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 72.3342 | 1 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 33.4915 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Rattus norvegicus (Norway rat) | Ki | 0.0150 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | IC50 | 0.1500 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Mus musculus (house mouse) | IC50 | 2.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 1.1359 | 3 | 6 |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | Ki | 0.1820 | 17 | 25 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | Ki | 0.2292 | 9 | 11 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | IC50 | 0.5713 | 3 | 5 |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | Ki | 0.3243 | 2 | 4 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | IC50 | 0.5870 | 1 | 1 |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | Ki | 0.0232 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | IC50 | 0.5870 | 1 | 1 |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | Ki | 0.0232 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | IC50 | 0.0887 | 4 | 8 |
| 5-hydroxytryptamine receptor 2A | Mus musculus (house mouse) | IC50 | 0.0280 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.0776 | 12 | 13 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 0.0363 | 37 | 49 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | Ki | 0.0119 | 23 | 24 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 0.1074 | 2 | 6 |
| 5-hydroxytryptamine receptor 2B | Mus musculus (house mouse) | IC50 | 0.0280 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | IC50 | 0.0338 | 7 | 7 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 0.0986 | 5 | 7 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Ki | 0.0137 | 7 | 7 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | IC50 | 0.5315 | 3 | 7 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | IC50 | 0.0310 | 8 | 8 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | Ki | 0.2849 | 24 | 32 |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | Ki | 0.0135 | 10 | 10 |
| 5-hydroxytryptamine receptor 2C | Mus musculus (house mouse) | IC50 | 0.0280 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Cavia porcellus (domestic guinea pig) | IC50 | 110.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Homo sapiens (human) | Ki | 0.3348 | 3 | 3 |
| 5-hydroxytryptamine receptor 3A | Mus musculus (house mouse) | Ki | 0.0320 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | Ki | 0.0530 | 1 | 1 |
| 5-hydroxytryptamine receptor 3B | Homo sapiens (human) | Ki | 0.4091 | 2 | 2 |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | Ki | 0.0530 | 1 | 1 |
| 5-hydroxytryptamine receptor 3C | Homo sapiens (human) | Ki | 0.4091 | 2 | 2 |
| 5-hydroxytryptamine receptor 3D | Homo sapiens (human) | Ki | 0.4091 | 2 | 2 |
| 5-hydroxytryptamine receptor 3E | Homo sapiens (human) | Ki | 0.4091 | 2 | 2 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | IC50 | 0.8640 | 2 | 4 |
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | Ki | 0.4488 | 2 | 4 |
| 5-hydroxytryptamine receptor 4 | Homo sapiens (human) | Ki | 0.2239 | 1 | 1 |
| 5-hydroxytryptamine receptor 5A | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | IC50 | 0.0171 | 4 | 4 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | Ki | 0.0828 | 17 | 21 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | IC50 | 0.0157 | 1 | 1 |
| 5-hydroxytryptamine receptor 7 | Homo sapiens (human) | Ki | 0.3078 | 30 | 36 |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | Ki | 0.0094 | 2 | 2 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 437.2971 | 6 | 7 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 3,492.5171 | 6 | 7 |
| Acetylcholinesterase | Bos taurus (cattle) | IC50 | 7.0000 | 1 | 1 |
| Acetylcholinesterase | Bos taurus (cattle) | Ki | 173.2000 | 2 | 2 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 0.3530 | 1 | 1 |
| Adenylate cyclase type 1 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 2 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 3 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 4 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 5 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 6 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylate cyclase type 8 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Adenylyl cyclase 7 | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 1.4700 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 1.4580 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0816 | 8 | 9 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.0211 | 7 | 9 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.1484 | 9 | 12 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0816 | 8 | 9 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | Ki | 0.0214 | 6 | 8 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.1478 | 10 | 12 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | IC50 | 0.1322 | 1 | 3 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0816 | 8 | 9 |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | Ki | 0.0332 | 7 | 11 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.1737 | 8 | 10 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 1.1635 | 1 | 3 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 3.5772 | 2 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 0.3240 | 5 | 9 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.1161 | 6 | 8 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | IC50 | 0.1708 | 1 | 3 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 3.5772 | 2 | 2 |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | Ki | 0.2333 | 3 | 7 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.1349 | 4 | 6 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 0.7902 | 1 | 3 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 3.5772 | 2 | 2 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.2181 | 4 | 8 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.1349 | 4 | 6 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 3.0000 | 1 | 1 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | IC50 | 6.2855 | 2 | 2 |
| Angiotensin-converting enzyme | Oryctolagus cuniculus (rabbit) | Ki | 8.6606 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 4 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Ki | 263.5000 | 2 | 2 |
| ATP-dependent translocase ABCB1 | Mus musculus (house mouse) | Ki | 139.1000 | 2 | 2 |
| Beta-1 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 18.0000 | 2 | 2 |
| Beta-1 adrenergic receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.1500 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1400 | 1 | 1 |
| Beta-2 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Beta-3 adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 269.3700 | 5 | 12 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 196.5000 | 1 | 1 |
| Calmodulin-1 | Homo sapiens (human) | IC50 | 80.0000 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Carboxylic ester hydrolase | Equus caballus (horse) | Ki | 0.0200 | 1 | 1 |
| Cholecystokinin receptor type A | Cavia porcellus (domestic guinea pig) | Ki | 0.0600 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 0.4750 | 1 | 2 |
| Cholinesterase | Homo sapiens (human) | IC50 | 0.7033 | 3 | 3 |
| Cholinesterase | Homo sapiens (human) | Ki | 4,033.3467 | 3 | 3 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 14.1000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 0.2982 | 1 | 2 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 14.1000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 0.0170 | 1 | 2 |
| D | Bos taurus (cattle) | IC50 | 4.0900 | 2 | 2 |
| D | Rattus norvegicus (Norway rat) | IC50 | 1.0661 | 8 | 12 |
| D | Bos taurus (cattle) | Ki | 0.4200 | 8 | 13 |
| D | Rattus norvegicus (Norway rat) | Ki | 0.2369 | 13 | 16 |
| D(1A) dopamine receptor | Homo sapiens (human) | IC50 | 0.2682 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Ki | 0.4847 | 12 | 16 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9312 | 5 | 7 |
| D(1B) dopamine receptor | Homo sapiens (human) | Ki | 0.4890 | 2 | 2 |
| D(1B) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.1742 | 2 | 2 |
| D(2) dopamine receptor | Bos taurus (cattle) | IC50 | 1.8040 | 5 | 5 |
| D(2) dopamine receptor | Homo sapiens (human) | IC50 | 0.6958 | 9 | 11 |
| D(2) dopamine receptor | Mus musculus (house mouse) | IC50 | 0.2900 | 1 | 2 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.6503 | 19 | 27 |
| D(2) dopamine receptor | Bos taurus (cattle) | Ki | 0.6900 | 1 | 1 |
| D(2) dopamine receptor | Chlorocebus aethiops (grivet) | Ki | 0.2540 | 2 | 2 |
| D(2) dopamine receptor | Homo sapiens (human) | Ki | 0.1356 | 71 | 80 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.1693 | 25 | 37 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 1.4035 | 2 | 4 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9312 | 5 | 7 |
| D(3) dopamine receptor | Chlorocebus aethiops (grivet) | Ki | 0.4660 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 0.4913 | 34 | 40 |
| D(3) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.3298 | 5 | 5 |
| D(4) dopamine receptor | Homo sapiens (human) | IC50 | 0.0796 | 12 | 12 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.9312 | 5 | 7 |
| D(4) dopamine receptor | Homo sapiens (human) | Ki | 0.3045 | 51 | 55 |
| D(4) dopamine receptor | Rattus norvegicus (Norway rat) | Ki | 0.0975 | 4 | 4 |
| Dihydrofolate reductase | Bacillus anthracis | IC50 | 102.0000 | 1 | 1 |
| Endothelin receptor type B | Homo sapiens (human) | Ki | 0.0126 | 2 | 2 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Ki | 0.0126 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 2 |
| Gastrin/cholecystokinin type B receptor | Mus musculus (house mouse) | Ki | 0.0038 | 1 | 2 |
| Histamine H1 receptor | Homo sapiens (human) | IC50 | 0.1352 | 1 | 3 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 2 |
| Histamine H1 receptor | Cavia porcellus (domestic guinea pig) | Ki | 0.0692 | 1 | 2 |
| Histamine H1 receptor | Homo sapiens (human) | Ki | 0.0096 | 10 | 14 |
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | Ki | 0.0050 | 1 | 2 |
| Histamine H2 receptor | Homo sapiens (human) | IC50 | 3.6100 | 1 | 1 |
| Histamine H2 receptor | Homo sapiens (human) | Ki | 3.5500 | 1 | 1 |
| Histamine H3 receptor | Homo sapiens (human) | Ki | 0.8155 | 2 | 2 |
| Histamine H4 receptor | Homo sapiens (human) | Ki | 0.1925 | 3 | 3 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 4 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 0.6609 | 3 | 4 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 0.2014 | 5 | 9 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 0.2047 | 7 | 11 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Ki | 0.0136 | 2 | 2 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | IC50 | 1.9104 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 0.2453 | 5 | 7 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | Ki | 0.6031 | 2 | 4 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | Ki | 0.0356 | 2 | 2 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 0.0780 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 0.2453 | 5 | 7 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 0.3570 | 2 | 3 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | IC50 | 0.8118 | 1 | 2 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 0.2453 | 5 | 7 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | Ki | 0.2365 | 3 | 6 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | IC50 | 1.5068 | 1 | 2 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 0.2453 | 5 | 7 |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | Ki | 0.8049 | 2 | 4 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | Ki | 0.0251 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | IC50 | 10.5710 | 1 | 1 |
| Nuclear receptor subfamily 3 group C member 3 | Bos taurus (cattle) | Ki | 8.6606 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 109.5438 | 17 | 25 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 9.9601 | 5 | 5 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | IC50 | 2.2482 | 1 | 2 |
| Sigma non-opioid intracellular receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | Ki | 3.4633 | 2 | 3 |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | IC50 | 16.9000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | IC50 | 5.7544 | 1 | 2 |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | Ki | 0.2392 | 4 | 5 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 0.0210 | 1 | 2 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 1.4700 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 1.4580 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.3690 | 1 | 2 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 5.5730 | 2 | 4 |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | Ki | 0.0210 | 1 | 1 |
| Solute carrier family 22 member 1 | Homo sapiens (human) | IC50 | 20.4600 | 1 | 1 |
| Transporter | Rattus norvegicus (Norway rat) | Ki | 0.5890 | 2 | 3 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1F | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | EC50 | 0.7850 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | EC50 | 0.0200 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | Kd | 0.1259 | 1 | 2 |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | EC50 | 0.2500 | 1 | 1 |
| Albumin | Rattus norvegicus (Norway rat) | Kd | 43.3750 | 1 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5129 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5129 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 0.5129 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 20.4174 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 20.4174 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Kd | 20.4174 | 1 | 1 |
| Calmodulin | Bos taurus (cattle) | Kd | 61.0000 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | EC50 | 0.0004 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | Kd | 0.0031 | 1 | 1 |
| Histamine H4 receptor | Homo sapiens (human) | Kd | 0.0294 | 4 | 4 |
| HLA class I histocompatibility antigen, A alpha chain | Homo sapiens (human) | Kd | 2.5000 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 2 |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| short transient receptor potential channel 6 isoform 1 | Mus musculus (house mouse) | EC50 | 15.8500 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Activity | 0.0054 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | INH | 0.0054 | 1 | 1 |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | INH | 0.0064 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | Km | 35.1500 | 1 | 2 |
| Cytochrome P450 2C19 | Homo sapiens (human) | Km | 25.3000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Km | 25.3000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Km | 43.7667 | 3 | 3 |
| Cytochrome P450 2J2 | Homo sapiens (human) | Km | 25.3000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Km | 45.2400 | 4 | 5 |
| D(1A) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(1B) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Activity | 0.2560 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(2) dopamine receptor | Homo sapiens (human) | pKi | 0.0069 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | pKi | 0.0066 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | Kb | 10.0000 | 1 | 1 |
| D(4) dopamine receptor | Homo sapiens (human) | pKi | 0.0073 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | Activity | 0.0012 | 1 | 1 |
| Histamine H1 receptor | Homo sapiens (human) | INH | 0.0012 | 1 | 1 |
| Nitric oxide synthase, brain | Rattus norvegicus (Norway rat) | Activity | 0.1000 | 1 | 2 |
| Nitric oxide synthase, inducible | Homo sapiens (human) | Activity | 0.1000 | 1 | 2 |
| UDP-glucuronosyltransferase 1A4 | Homo sapiens (human) | Km | 62.0000 | 1 | 1 |