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aminoxyls
Radicals derived from hydroxylamines by removal of the hydrogen atom from the hydroxy group. The synonymous terms nitroxyl radicals and nitroxides erroneously suggest the presence of a nitro group.
ChEBI ID: 39477
Members (17)
| Member | Definition | Role |
|---|---|---|
| (1-oxyl-2,2,5,5-tetramethylpyrroline-3-methyl)methanethiosulfonate | An aminooxyl that is pyrroline substituted by an oxidanediyl group at position 1, by methyl groups at positions 2, 2, 5 and 5, and by a [(methylsulfonyl)sulfanyl]methyl group at position 3. It is a highly reactive thiol-specific spin label. | (1-oxyl-2,2,5,5-tetramethylpyrroline-3-methyl)methanethiosulfonate |
| 2,2,5,5-tetramethyl-1-pyrrolidinyloxy-3-carboxylic acid | 3-carboxy-PROXYL | |
| 2,2,6,6-tetramethylpiperidine-n-oxide-4-amino-4-carboxylic acid | TOAC | |
| 3-(2-iodoacetamido)-2,2,5,5-tetramethyl-1-pyrrolidinyloxyl | 3-(2-iodacetamido)-PROXYL | |
| 3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolidinyl-n-oxyl | 3-carbamoyl-PROXYL | |
| 4-maleimido-2,2,6,6-tetramethylpiperidinooxyl | A member of the class of piperidines that is TEMPO carrying a maleimido group at position 4. | 4-maleimido-TEMPO |
| 5-doxylstearate | 5-DOXYL-stearic acid | |
| di-t-butyl nitroxide | An aminoxyl that is N-tert-butyl-2-methylpropan-2-amine carrying an oxidanediyl group at the nitrogen atom. | di-tert-butyl nitroxide |
| fremy's salt | potassium nitrosodisulfonate | |
| n-(1-oxyl-2,2,5,5-tetramethyl-3-pyrrolidinyl)maleimide | 3-maleimido-PROXYL | |
| n-(1-oxyl-2,2,6,6-tetramethyl-4-piperidinyl)iodoacetamide | A piperidinecarboxamide that is TEMPO carrying an 2-iodoacetamido group at position 4. | 4-(2-iodacetamido)-TEMPO |
| proxyl nitroxide | PROXYL | |
| tempace | A piperidinecarboxamide that is TEMPO carrying an acetamido group at position 4. | 4-acetamido-TEMPO |
| tempo | A member of the class of aminoxyls that is piperidine that carries an oxidanediyl group at position 1 and methyl groups at positions 2, 2, 6, and 6, respectively. | TEMPO |
| tempo carboxylic acid | A member of the class of aminoxyls that is TEMPO carrying a carboxy group at position 4. | 4-carboxy-TEMPO |
| tempol | A member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties. | 4-hydroxy-TEMPO |
| triacetoneamine-n-oxyl | A member of the class of aminoxyls that is TEMPO carrying an oxo group at position 4. | 4-oxo-TEMPO |
Research
Studies (1,577)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 233 (14.77) | 18.7374 |
| 1990's | 298 (18.90) | 18.2507 |
| 2000's | 379 (24.03) | 29.6817 |
| 2010's | 524 (33.23) | 24.3611 |
| 2020's | 143 (9.07) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 10 (0.60%) | 5.53% |
| Reviews | 30 (1.79%) | 6.00% |
| Case Studies | 1 (0.06%) | 4.05% |
| Observational | 1 (0.06%) | 0.25% |
| Other | 1,635 (97.50%) | 84.16% |