Hyperargininemia

A rare autosomal recessive disorder of the urea cycle. It is caused by a deficiency of the hepatic enzyme ARGINASE. Arginine is elevated in the blood and cerebrospinal fluid, and periodic HYPERAMMONEMIA may occur. Disease onset is usually in infancy or early childhood. Clinical manifestations include seizures, microcephaly, progressive mental impairment, hypotonia, ataxia, spastic diplegia, and quadriparesis. (From Hum Genet 1993 Mar;91(1):1-5; Menkes, Textbook of Child Neurology, 5th ed, p51)

Synonym
Hyperargininemia

Excerpt	Reference
"Hyperargininemia is a metabolic disorder biochemically characterized by tissue accumulation of arginine and other guanidino compounds."	( Bavaresco, CS; Delwing, D; Hagen, ME; Severo Dutra-Filho, C; Wajner, M; Wannmacher, CM; Wyse, AT, 2001)
"Hyperargininemia is a rare autosomal disorder that results from a deficiency in hepatic type I arginase."	( Ash, DE; Emig, FA; Lavulo, LT, 2002)
"Hyperargininemia is an inherited neurometabolic disorder biochemically characterized by tissue accumulation of arginine and clinically by severe neurological symptoms whose pathophysiology is poorly understood."	( Delwing, D; Dutra-Filho, CS; Wajner, M; Wannmacher, CM; Wyse, AT, 2002)
"Hyperargininemia is a metabolic disorder caused by deficiency of arginase activity resulting in tissue accumulation of arginine and neurological dysfunction."	( Bavaresco, CS; Calcagnotto, T; Delwing, D; Lamers, ML; Tagliari, B; Wajner, M; Wannmacher, CM; Wyse, AT, 2003)
"Hyperargininemia is a rare inborn error of metabolism due to arginase deficiency, which is inherited in an autossomal recessive manner."	( Gomes Martins, E; Santos Silva, E; Saudubray, JM; Vilarinho, L; Vilarinho, S, 2010)
"Hyperargininemia is a very rare progressive neurometabolic disorder caused by deficiency of hepatic cytosolic arginase I, resulting from mutations in the ARG1 gene."	( Abdul Razak, C; Boon Hock, C; Haniffa, M; Hayati, F; Mohd Rawi, R; Mohseni, J; Ngu, LH; Othman, SN; Peitee, WO; Sasongko, TH; Zilfalil, BA, 2014)
"Hyperargininemia is caused by deficiency of arginase 1, which catalyzes the hydrolysis of L-arginine to urea as the final enzyme in the urea cycle."	( Ensenauer, R; Häussinger, D; Mayatepek, E; Schlune, A; Vom Dahl, S, 2015)
"Hyperargininemia is currently included as a secondary target on the U."	( Cederbaum, SD; Currier, R; Grimm, M; Lapidus, D; Therrell, BL, 2017)
"Hyperargininemia is a urea cycle disorder that has rarely been reported in adults."	( Amalakanti, S; Daggumati, R; Nagarjunakonda, S, 2020)
"Hyperargininemia is an autosomal recessive disorder caused by a defect in the arginase I enzyme."	( Afrantou, T; Bakirtzis, C; Boziki, MK; Grigoriadis, N; Smyrni, N, 2021)

Excerpt	Reference
"In Japan, hyperargininemia has been reported in only 5 unrelated families and four patients are alive at present."	( Aono, S; Hayakawa, C; Ikemoto, M; Kashiwamata, S; Keino, H; Mizutani, N; Murachi, T; Totani, M; Watanabe, K, 1991)
"Patients with hyperargininemia have an arginase deficiency which leads to blockade of the urea cycle in the last step with several clinical symptoms."	( De Deyn, PP; Lowenthal, A; Marescau, B; Wiechert, P, 1989)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	49 (36.03)	23.3326
1990's	21 (15.44)	12.5806
2000's	25 (18.38)	18.1394
2010's	29 (21.32)	28.8240
2020's	12 (8.82)	9.53

Drug	Relationship Strength	Studies	Trials
ammonium hydroxide	low	34	0
benzoic acid	low	1	0
carnitine	low	1	0
choline	low	1	0
gamma-guanidinobutyric acid	low	1	0
alpha-keto-delta-guanidinovaleric acid	low	1	0
creatine	low	3	0
lactic acid	low	1	0
glycine	low	2	0
glycocyamine	low	2	0
orotic acid	low	4	0
uracil	low	1	0
urea	low	33	0
baclofen	low	1	0
valproic acid	low	3	0
eperisone	low	1	0
guanidine	low	1	0
4-phenylbutyric acid	low	1	0
alanine	low	1	0
aspartic acid	low	2	0
glutamine	low	6	0
lysine	low	5	0
ethinyl estradiol	low	1	0
adenosine diphosphate	low	2	0
uridine	low	1	0
phenylephrine	low	1	0
adenosine monophosphate	low	2	0
leucine	low	1	0
chloroform	low	1	0
ornithine	low	11	0
medroxyprogesterone acetate	low	1	0
arginine	medium	81	1
homoarginine	low	2	0
citrulline	low	8	0
d-alpha tocopherol	low	4	0
pseudouridine	low	1	0
manganese	low	4	0
ethinyl estradiol-norgestrel combination	low	1	0
s-adenosylmethionine	low	1	0
ng-nitroarginine methyl ester	low	5	0
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	low	1	0
n-acetylaspartic acid	low	1	0
homocitrulline	low	1	0
n-acetyl-l-arginine	low	2	0
beta-hydroxyisovaleric acid	low	1	0
cobalt	low	1	0
valerates	low	1	0
argininic acid	low	1	0
sodium benzoate	low	3	0
tamoxifen	low	1	0
bilirubin	low	1	0
vitamin k semiquinone radical	low	1	0
ellagic acid	low	1	0
tetrodotoxin	low	1	0
oligonucleotides	low	1	0
picrotoxin	low	1	0
guanidinosuccinic acid	low	1	0
ascorbic acid	low	3	0
norgestrel	low	1	0
exudates	low	1	0

Protein Targets (743)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	9	0	0	9
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE	0	0	1	1
mitogen-activated protein kinase 1	2	0	0	2
survival motor neuron protein isoform d	1	0	0	1
Histone deacetylase 3	0	4	0	4
Histone deacetylase 4	0	4	0	4
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	4	0	4
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	4	0	4
Chain A, Beta-lactamase	5	0	0	5
GLS protein	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	13	0	0	13
geminin	12	0	0	12
Polyphenol oxidase 2	0	3	0	3
Acetylcholinesterase	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Sodium-dependent dopamine transporter	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
regulator of G-protein signaling 4	5	0	0	5
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	2	2	4
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	4	1	5
Delta-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	4	1	5
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	2	2
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	2	2
P2Y purinoceptor 1	0	0	2	2
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	3	0	0	3
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	2	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
Chain A, Glycogen Phosphorylase B	0	0	1	1
Chain B, Glycogen Phosphorylase B	0	0	1	1
Chain A, ADP-dependent glucokinase	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, phosphodiesterase-nucleotide pyrophosphatase	0	1	0	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain B, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
RAR-related orphan receptor gamma	11	0	0	11
AR protein	10	0	0	10
glucocorticoid receptor [Homo sapiens]	8	0	0	8
estrogen-related nuclear receptor alpha	12	0	0	12
v-jun sarcoma virus 17 oncogene homolog (avian)	8	0	0	8
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	1	1
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
L-lactate dehydrogenase A chain	0	1	1	2
Adenylate kinase isoenzyme 1	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	3
Fructose-1,6-bisphosphatase 1	0	1	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Cytochrome P450 2C9	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
5'-nucleotidase	0	1	0	2
Choline O-acetyltransferase	0	1	0	1
Adenylate kinase 2, mitochondrial	0	1	0	2
GTP:AMP phosphotransferase AK3, mitochondrial	0	0	0	1
Adenosine receptor A1	0	2	1	3
Adenylate kinase isoenzyme 1	0	1	0	2
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	0	1
Glycine--tRNA ligase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Adenosine deaminase-like protein	0	0	0	1
Protease	0	1	1	2
Histamine H3 receptor	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
5'-AMP-activated protein kinase subunit beta-1	0	0	2	2
ATP-dependent phosphofructokinase	8	0	0	8
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Carbonic anhydrase 1	0	2	0	5
Carbonic anhydrase 2	0	2	0	5
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	4	1	5
Proton-coupled amino acid transporter 1	0	5	0	6
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
thioredoxin reductase	6	0	0	6
phosphopantetheinyl transferase	8	0	0	8
NFKB1 protein, partial	3	0	0	3
thyroid stimulating hormone receptor	4	0	0	4
alpha-galactosidase	1	0	0	1
cytochrome P450 2C19 precursor	3	0	0	3
chromobox protein homolog 1	6	0	0	6
flap endonuclease 1	4	0	0	4
DNA polymerase iota isoform a (long)	6	0	0	6
muscarinic acetylcholine receptor M1	2	0	0	2
lethal factor (plasmid)	8	0	0	8
Cytochrome P450 3A4	0	2	0	3
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	2	0	3
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Cationic amino acid transporter 3	0	2	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	4	0	0	4
GLI family zinc finger 3	10	0	0	10
thioredoxin glutathione reductase	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	6	0	0	6
retinoic acid nuclear receptor alpha variant 1	10	0	0	10
estrogen nuclear receptor alpha	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
IDH1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 2	3	0	0	3
thyroid hormone receptor beta isoform 2	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	7	0	0	7
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lamin isoform A-delta10	11	0	0	11
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Alpha-2B adrenergic receptor	0	5	1	6
Spike glycoprotein	3	0	1	4
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Ferritin light chain	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
arylsulfatase A	4	0	0	4
Bloom syndrome protein isoform 1	4	0	0	4
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	3	1	4
Glutamate receptor ionotropic, NMDA 2B	0	3	1	4
Glutamate receptor ionotropic, NMDA 2C	0	3	1	4
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	3	1	4
Glutamate receptor ionotropic, NMDA 3B	0	3	1	4
Glutamate receptor ionotropic, NMDA 3A	0	3	1	4
ATAD5 protein, partial	2	0	0	2
67.9K protein	4	0	0	4
activating transcription factor 6	5	0	0	5
D(1A) dopamine receptor	3	0	0	3
cytochrome P450 3A4 isoform 1	4	0	0	4
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	4	1	0	5
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	4
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Bile salt export pump	0	7	0	7
Gamma-aminobutyric acid receptor subunit beta-1	4	1	0	5
Gamma-aminobutyric acid receptor subunit delta	4	1	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	4	1	1	6
Gamma-aminobutyric acid receptor subunit alpha-5	4	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	4	1	0	5
Gamma-aminobutyric acid receptor subunit gamma-1	4	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	4	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	4	1	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	4	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	4	1	0	5
Gamma-aminobutyric acid receptor subunit alpha-1	4	1	1	6
Gamma-aminobutyric acid receptor subunit beta-3	4	1	0	5
Gamma-aminobutyric acid receptor subunit beta-2	4	1	1	6
GABA theta subunit	4	1	0	5
Canalicular multispecific organic anion transporter 1	0	4	0	4
Gamma-aminobutyric acid receptor subunit epsilon	4	1	0	5
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Chain A, Oxygen-insensitive Nad(p)h Nitroreductase	0	1	0	1
Chain B, Oxygen-insensitive Nad(p)h Nitroreductase	0	1	0	1
Luciferase	5	0	0	5
estrogen receptor 2 (ER beta)	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
D-amino-acid oxidase	0	0	1	1
Cellular tumor antigen p53	8	0	0	8
Neuronal acetylcholine receptor subunit alpha-4	1	2	0	3
Neuronal acetylcholine receptor subunit beta-2	1	2	0	3
D-amino-acid oxidase	0	2	1	3
Metabotropic glutamate receptor 5	0	0	1	1
Alpha-glucosidase MAL12	0	1	0	1
Monocarboxylate transporter 1	0	0	0	1
Beta-lactamase	0	1	1	2
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
D-aspartate oxidase	0	1	0	1
Serine racemase	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
Chain A, Cruzipain	2	0	0	2
USP1 protein, partial	6	0	0	6
Microtubule-associated protein tau	5	0	0	5
vitamin D3 receptor isoform VDRA	4	0	0	4
DNA polymerase kappa isoform 1	3	0	0	3
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	3
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
interleukin 8	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
progesterone receptor	5	0	0	5
retinoid X nuclear receptor alpha	6	0	0	6
peroxisome proliferator-activated receptor delta	4	0	0	4
Histone H2A.x	4	0	0	4
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Glutamate receptor 2	6	0	0	6
Nuclear receptor ROR-gamma	4	0	0	4
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	2
Solute carrier family 22 member 1	0	0	0	1
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	3	0	5
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	3	0	5
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
General amino-acid permease GAP1	0	0	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
heat shock protein beta-1	4	0	0	4
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	5	0	0	5
Glutathione S-transferase P	0	2	0	2
Alpha-tocopherol transfer protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, Casein kinase II subunit alpha	0	1	0	1
endonuclease IV	1	0	0	1
15-lipoxygenase, partial	2	0	0	2
Mcl-1	0	1	0	1
acetyl-CoA acetyltransferase/HMG-CoA reductase	0	1	0	1
TDP1 protein	4	0	0	4
apical membrane antigen 1, AMA1	2	0	0	2
bromodomain adjacent to zinc finger domain 2B	2	0	0	2
unnamed protein product	0	1	0	1
heat shock 70kDa protein 1A	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
Aldehyde oxidase 1	0	1	0	1
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
cytochrome P450 2C9 precursor	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
fructose-bisphosphate aldolase A	1	0	0	1
thyroid hormone receptor beta isoform a	3	0	0	3
core-binding factor subunit beta isoform 2	1	0	0	1
glyceraldehyde-3-phosphate dehydrogenase isoform 1	1	0	0	1
DNA polymerase beta	1	0	0	1
dual specificity protein phosphatase 3	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
mothers against decapentaplegic homolog 3 isoform 1	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	1	0	0	1
heat shock cognate 71 kDa protein isoform 1	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
Vif	0	1	0	1
Tat	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
dual specificity protein phosphatase 6	0	1	0	1
heat shock cognate 71 kDa protein isoform 2	0	1	0	1
Serine/threonine-protein kinase PLK4	0	1	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	1	0	1
Aurora kinase A	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Acetylcholinesterase	0	1	0	2
Carbonic anhydrase 12	0	1	0	1
NUAK family SNF1-like kinase 1	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	3
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Renin	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	2	0	2
Amyloid-beta precursor protein	0	1	0	1
Insulin receptor	0	1	0	1
Nucleophosmin	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	1	0	1
Insulin-like growth factor 1 receptor	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Hepatocyte growth factor receptor	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	0	1
Cytochrome P450 2D6	0	3	0	3
Glutathione S-transferase Mu 1	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Cyclin-dependent kinase 4	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Macrophage migration inhibitory factor	0	2	0	2
Serine/threonine-protein kinase B-raf	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Casein kinase II subunit alpha'	0	1	0	1
Cyclin-A2	0	1	0	1
Amine oxidase [flavin-containing] A	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	1	0	1
cAMP-dependent protein kinase catalytic subunit beta	0	1	0	1
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase 6	0	1	0	1
G1/S-specific cyclin-D1	0	1	0	1
Cyclin-dependent kinase 2	0	1	0	1
Adenosine receptor A1	0	1	0	1
Cruzipain	0	1	0	1
Adenosine receptor A2a	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
Mitogen-activated protein kinase kinase kinase 8	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Histamine H2 receptor	2	0	0	2
Glycogen synthase kinase-3 beta	0	1	0	1
Squalene monooxygenase	0	1	0	1
Serine/threonine-protein kinase PLK1	0	1	0	1
Ephrin type-B receptor 4	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 1	0	1	0	1
Beta-secretase 1	0	1	0	1
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	2	0	2
Cyclin-A1	0	1	0	1
Lactoperoxidase	0	0	0	1
Cholinesterase	0	0	0	1
DNA primase	0	1	0	1
Angiopoietin-1 receptor	0	1	0	1
Focal adhesion kinase 1	0	1	0	1
Tyrosine-protein kinase Lyn	0	1	0	1
Polypeptide N-acetylgalactosaminyltransferase 2	0	1	1	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
ELAV-like protein 3	0	1	0	1
Carbonic anhydrase 9	0	2	0	2
Thioredoxin reductase 1, cytoplasmic	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
5'-nucleotidase	0	1	0	1
Tyrosine-protein kinase Fgr	0	1	0	1
Integrase	0	1	0	1
Thioredoxin reductase 3	0	1	0	1
Glutathione S-transferase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Aurora kinase B	0	1	0	1
Translin-associated protein X	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
Thioredoxin reductase 2, mitochondrial	0	1	0	1
Carbonic anhydrase 14	0	1	0	1
ALK tyrosine kinase receptor	0	1	0	1
DNA polymerase iota	0	1	0	1
DNA polymerase eta	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
Cysteine protease ATG4B	0	1	0	1
phosphoglycerate kinase	1	0	0	1
M17 leucyl aminopeptidase	0	1	0	1
likely tRNA 2'-phosphotransferase	0	1	0	1
Muscarinic acetylcholine receptor M2	0	4	0	4
Sigma non-opioid intracellular receptor 1	0	4	0	4
pregnane X receptor	3	0	0	3
Fumarate hydratase	2	0	0	2
PPM1D protein	2	0	0	2
caspase 7, apoptosis-related cysteine protease	3	0	0	3
farnesoid X nuclear receptor	4	0	0	4
pregnane X nuclear receptor	4	0	0	4
G	2	0	0	2
polyprotein	2	0	0	2
peroxisome proliferator activated receptor gamma	5	0	0	5
caspase-3	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
thyroid stimulating hormone receptor	4	0	0	4
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
Vpr	1	0	0	1
peripheral myelin protein 22	2	0	0	2
Cytochrome P450 2B1	0	1	0	1
Interferon beta	3	0	0	3
HLA class I histocompatibility antigen, B alpha chain	2	0	0	2
Estrogen receptor	0	5	3	9
Glucocorticoid receptor	0	4	1	5
Sex hormone-binding globulin	0	0	2	2
Glycine receptor subunit alpha-1	0	4	0	4
Aldo-keto reductase family 1 member B1	0	5	0	5
Adenosine receptor A3	0	4	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Androgen receptor	0	6	0	6
Alpha-1B adrenergic receptor	0	5	0	5
Glycine receptor subunit beta	0	4	0	4
Cytochrome P450 2B6	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
Glycine receptor subunit alpha-2	0	4	0	4
Sodium-dependent noradrenaline transporter	0	4	0	4
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Glycine receptor subunit alpha-3	0	4	0	4
Adenosine receptor A2a	0	4	0	4
Sodium-dependent serotonin transporter	0	4	0	4
Alpha-1A adrenergic receptor	0	5	0	5
Sulfotransferase 1A1	0	2	1	4
Sodium-dependent dopamine transporter	0	4	0	4
Aldehyde oxidase	0	1	0	1
TAR DNA-binding protein 43	2	0	0	2
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Inositol hexakisphosphate kinase 1	2	0	0	2
Estrogen receptor beta	0	4	3	7
Multidrug and toxin extrusion protein 1	0	1	0	1
cytochrome P450 2C9, partial	2	0	0	2
Chain A, Glutamine Binding Protein	0	0	1	1
peripheral myelin protein 22 isoform 1	1	0	0	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Olfactory receptor 51E2	0	0	2	2
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Solute carrier family 22 member 3	0	2	0	2
Intestinal-type alkaline phosphatase	0	2	0	2
Phospholipase A-2-activating protein	0	2	0	2
cytochrome P450 2D6	1	0	0	1
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
SMAD family member 2	2	0	0	2
SMAD family member 3	2	0	0	2
PINK1	1	0	0	1
nonstructural protein 1	2	0	0	2
Parkin	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
transcriptional regulator ERG isoform 3	3	0	0	3
neuropeptide S receptor isoform A	1	0	0	1
Progesterone receptor	0	3	1	4
Mineralocorticoid receptor	0	1	0	1
Androgen receptor	0	2	2	4
Androgen receptor	0	0	1	1
Histamine H2 receptor	0	4	0	4
5-hydroxytryptamine receptor 1B	0	3	0	3
Alpha-synuclein	2	0	0	2
Aldo-keto reductase family 1 member C3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
EWS/FLI fusion protein	2	0	0	2
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Collagenase 3	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, L-ARGININE\\:GLYCINE AMIDINOTRANSFERASE	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
dopamine D1 receptor	1	0	0	1
glp-1 receptor, partial	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
Alpha-1B adrenergic receptor	0	0	1	1
ras-related protein Rab-9A	2	0	0	2
Beta-2 adrenergic receptor	0	0	1	1
Beta-1 adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	3	1	4
Beta-3 adrenergic receptor	0	2	1	3
POU domain, class 2, transcription factor 1	0	0	0	1
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Met repressor	0	0	2	2
Protein arginine N-methyltransferase 5	0	0	1	1
Histone H3K27 methylase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	0	1	2
S-adenosylmethionine decarboxylase proenzyme	0	1	0	2
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	0	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Methylosome protein 50	0	0	1	1
Carbonic anhydrase	0	1	0	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
glucocerebrosidase	1	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Caspase-7	1	0	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
cytochrome P450 2D6 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
interferon gamma precursor	0	0	0	1
caspase-3	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
M-phase phosphoprotein 8	1	0	0	1
streptokinase A precursor	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
5-hydroxytryptamine receptor 4	0	2	0	2
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	0	1	1
Muscarinic acetylcholine receptor M4	0	2	0	2
ATP-dependent translocase ABCB1	0	2	1	3
Muscarinic acetylcholine receptor M5	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Angiotensin-converting enzyme	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Protein kinase C alpha type	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Substance-K receptor	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Thromboxane-A synthase	0	1	0	1
Protein kinase C eta type	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	1	3
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Emopamil-binding protein-like	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Chain A, Uracil-DNA Glycosylase	0	1	0	1
Protein cereblon	0	4	0	4
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, Cytidine Deaminase	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Cytidine deaminase	0	1	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Solute carrier family 28 member 3	0	2	0	2
Carbonic anhydrase	0	1	0	1
Cocaine esterase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	1	0	2
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (136)

Protein Targets (743)

Hyperargininemia

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (136)

Drugs Studied (72)

Protein Targets (743)