Compounds > guttiferone a
Page last updated: 2024-12-11

guttiferone a

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Description

guttiferone A: antibacterial from Clusiaceae family; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
ClusiaceaefamilyThe mangosteen plant family (sometimes classified as Guttiferae; also known as Hypericaceae) of the order THEALES, subclass Dilleniidae, class Magnoliopsida. It includes trees and shrubs with resinous, sticky sap, usually with broad-ended, oblong, leathery leaves with a strong, central vein, flowers with many stamens.[MeSH]ClusiaceaeThe mangosteen plant family (sometimes classified as Guttiferae; also known as Hypericaceae) of the order THEALES, subclass Dilleniidae, class Magnoliopsida. It includes trees and shrubs with resinous, sticky sap, usually with broad-ended, oblong, leathery leaves with a strong, central vein, flowers with many stamens.[MeSH]

Cross-References

ID SourceID
PubMed CID5352090
CHEBI ID65990
SCHEMBL ID12634388
MeSH IDM0557599

Synonyms (8)

Synonym
NSC692993 ,
guttiferone a
nsc-692993
chebi:65990 ,
guttiferone-a
(1r,3e,5s,6r,7s)-3-[(3,4-dihydroxyphenyl)-hydroxymethylidene]-6-methyl-1,5,7-tris(3-methylbut-2-enyl)-6-(4-methylpent-3-enyl)bicyclo[3.3.1]nonane-2,4,9-trione
SCHEMBL12634388
147687-34-1

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
PapainCarica papaya (papaya)IC50 (µMol)1.90000.00201.504510.0000AID351452
Cathepsin BHomo sapiens (human)IC50 (µMol)2.10000.00021.845310.0000AID351454
Cathepsin GHomo sapiens (human)IC50 (µMol)2.70000.01372.42247.4130AID351455
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (30)

Processvia Protein(s)Taxonomy
proteolysisCathepsin BHomo sapiens (human)
thyroid hormone generationCathepsin BHomo sapiens (human)
collagen catabolic processCathepsin BHomo sapiens (human)
epithelial cell differentiationCathepsin BHomo sapiens (human)
regulation of apoptotic processCathepsin BHomo sapiens (human)
decidualizationCathepsin BHomo sapiens (human)
symbiont entry into host cellCathepsin BHomo sapiens (human)
proteolysis involved in protein catabolic processCathepsin BHomo sapiens (human)
cellular response to thyroid hormone stimulusCathepsin BHomo sapiens (human)
proteolysisCathepsin GHomo sapiens (human)
angiotensin maturationCathepsin GHomo sapiens (human)
monocyte chemotaxisCathepsin GHomo sapiens (human)
protein phosphorylationCathepsin GHomo sapiens (human)
proteolysisCathepsin GHomo sapiens (human)
immune responseCathepsin GHomo sapiens (human)
protein processingCathepsin GHomo sapiens (human)
cytokine-mediated signaling pathwayCathepsin GHomo sapiens (human)
protein metabolic processCathepsin GHomo sapiens (human)
antibacterial humoral responseCathepsin GHomo sapiens (human)
extracellular matrix disassemblyCathepsin GHomo sapiens (human)
platelet activationCathepsin GHomo sapiens (human)
purinergic nucleotide receptor signaling pathwayCathepsin GHomo sapiens (human)
neutrophil activationCathepsin GHomo sapiens (human)
positive regulation of immune responseCathepsin GHomo sapiens (human)
defense response to Gram-negative bacteriumCathepsin GHomo sapiens (human)
defense response to Gram-positive bacteriumCathepsin GHomo sapiens (human)
defense response to fungusCathepsin GHomo sapiens (human)
negative regulation of T cell activationCathepsin GHomo sapiens (human)
neutrophil-mediated killing of gram-positive bacteriumCathepsin GHomo sapiens (human)
cellular response to lipopolysaccharideCathepsin GHomo sapiens (human)
biofilm matrix disassemblyCathepsin GHomo sapiens (human)
positive regulation of platelet aggregationCathepsin GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (11)

Processvia Protein(s)Taxonomy
cysteine-type endopeptidase activityCathepsin BHomo sapiens (human)
protein bindingCathepsin BHomo sapiens (human)
collagen bindingCathepsin BHomo sapiens (human)
peptidase activityCathepsin BHomo sapiens (human)
cysteine-type peptidase activityCathepsin BHomo sapiens (human)
proteoglycan bindingCathepsin BHomo sapiens (human)
serine-type endopeptidase activityCathepsin GHomo sapiens (human)
protein bindingCathepsin GHomo sapiens (human)
heparin bindingCathepsin GHomo sapiens (human)
peptidase activityCathepsin GHomo sapiens (human)
serine-type peptidase activityCathepsin GHomo sapiens (human)
receptor ligand activityCathepsin GHomo sapiens (human)
caspase bindingCathepsin GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (21)

Processvia Protein(s)Taxonomy
collagen-containing extracellular matrixCathepsin BHomo sapiens (human)
extracellular regionCathepsin BHomo sapiens (human)
extracellular spaceCathepsin BHomo sapiens (human)
lysosomeCathepsin BHomo sapiens (human)
external side of plasma membraneCathepsin BHomo sapiens (human)
apical plasma membraneCathepsin BHomo sapiens (human)
endolysosome lumenCathepsin BHomo sapiens (human)
melanosomeCathepsin BHomo sapiens (human)
perinuclear region of cytoplasmCathepsin BHomo sapiens (human)
collagen-containing extracellular matrixCathepsin BHomo sapiens (human)
extracellular exosomeCathepsin BHomo sapiens (human)
peptidase inhibitor complexCathepsin BHomo sapiens (human)
ficolin-1-rich granule lumenCathepsin BHomo sapiens (human)
extracellular spaceCathepsin BHomo sapiens (human)
lysosomeCathepsin BHomo sapiens (human)
collagen-containing extracellular matrixCathepsin GHomo sapiens (human)
extracellular regionCathepsin GHomo sapiens (human)
extracellular spaceCathepsin GHomo sapiens (human)
nucleusCathepsin GHomo sapiens (human)
lysosomeCathepsin GHomo sapiens (human)
cytosolCathepsin GHomo sapiens (human)
plasma membraneCathepsin GHomo sapiens (human)
cytoplasmic stress granuleCathepsin GHomo sapiens (human)
membraneCathepsin GHomo sapiens (human)
secretory granuleCathepsin GHomo sapiens (human)
azurophil granule lumenCathepsin GHomo sapiens (human)
collagen-containing extracellular matrixCathepsin GHomo sapiens (human)
extracellular exosomeCathepsin GHomo sapiens (human)
cytoplasmCathepsin GHomo sapiens (human)
intracellular membrane-bounded organelleCathepsin GHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (78)

Assay IDTitleYearJournalArticle
AID653255Antifungal activity against Candida krusei ATCC 6258 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID653250Antimicrobial activity against Pseudomonas aeruginosa ATCC 9027 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID653261Antifungal activity against Microsporum gypseum after 48 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID653253Antimicrobial activity against Proteus mirabilis ATCC 25933 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID351458Inhibition of Carica papaya papain at 50 uM preincubated for 5 mins before addition of increasing concentration of substrate Z-FR-AMC2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
Natural polyprenylated benzophenones inhibiting cysteine and serine proteases.
AID653249Antimicrobial activity against Bacillus cereus ATCC 11778 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID1320378Drug aggregation in deuterated phosphate buffer assessed as diffusion coefficient at 100 uM in presence of 0.001% TX-100 by DOSY NMR method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID757792Safety index, ratio of IC50 for african green monkey Vero cells to IC50 for bloodstream stage of Trypanosoma brucei brucei 932013European journal of medicinal chemistry, Jul, Volume: 65Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
AID351452Inhibition of Carica papaya papain by spectrofluorimetry2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
Natural polyprenylated benzophenones inhibiting cysteine and serine proteases.
AID653257Antifungal activity against Candida glabrata ATCC 90030 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID1320364Drug aggregation in Tris HCl/Tris buffer at 100 uM in presence of SIRT1 by dynamic light scattering method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320380Drug aggregation in deuterated phosphate buffer assessed as diffusion coefficient at 100 uM in presence of 1.5 uM bovine serum albumin by DOSY NMR method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320344Activation of 25 nM N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli at 100 uM using RHKK(Ac)W-NH2 as substrate after 1 hr in presence of 0.01% TX-100 by UV detection-based HPLC method relative to control2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320353Activation of 25 nM N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli at 100 uM using RHKK(Ac)W-NH2 as substrate after 1 hr in presence of 0.01% TX-100 and BSA by UV detection-based HPLC method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320377Drug aggregation in deuterated phosphate buffer assessed as diffusion coefficient at 1 mM by DOSY NMR method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID548181Antioxidant activity assessed as DPPH radical scavenging activity2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Benzophenones and biflavonoids from Rheedia edulis.
AID1320362Drug aggregation in Tris HCl/Tris buffer at 100 uM by dynamic light scattering method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320375Binding affinity to 25 to 100 nM N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli at 100 uM by 1H NMR method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320376Drug aggregation in deuterated phosphate buffer assessed as diffusion coefficient at 100 uM by DOSY NMR method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320369Drug aggregation in deuterated phosphate buffer at 100 uM in presence of 0.01% TX-100 by 1H NMR method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320379Drug aggregation in deuterated phosphate buffer assessed as diffusion coefficient at 100 uM in presence of 0.01% TX-100 by DOSY NMR method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320368Drug aggregation in deuterated phosphate buffer at 100 uM in presence of 0.001% TX-100 by 1H NMR method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320352Inhibition of 8 nM N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli assessed as remaining activity at 100 uM using RHKK(Ac)W-NH2 as substrate by UV detection-based HPLC method relative to control2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID757791Safety index, ratio of IC50 for african green monkey Vero cells to IC50 for promastigote stage of Leishmania donovani LV92013European journal of medicinal chemistry, Jul, Volume: 65Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
AID653258Antifungal activity against Candida tropicalis ATCC 750 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID757803Antitrypanosomal activity against bloodstream stage of Trypanosoma brucei brucei 93 assessed as parasite growth inhibition at 50 ug/ml after 72 hrs by resazurin reduction assay relative to control2013European journal of medicinal chemistry, Jul, Volume: 65Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
AID1235879Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay2015Journal of natural products, Aug-28, Volume: 78, Issue:8
Polycyclic Polyprenylated Xanthones from Symphonia globulifera: Isolation and Biomimetic Electrosynthesis.
AID351457Inhibition of trypsin assessed as residual enzyme activity at 10 uM after 30 mins2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
Natural polyprenylated benzophenones inhibiting cysteine and serine proteases.
AID1320365Drug aggregation in Tris HCl/Tris buffer at 100 uM in presence of 0.01% TX-100 by dynamic light scattering method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID757794Cytotoxicity against african green monkey Vero cells assessed as growth inhibition at 10'-5 M after 72 hrs by MTS assay relative to control2013European journal of medicinal chemistry, Jul, Volume: 65Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
AID1320372Drug aggregation in deuterated phosphate buffer at 100 uM in presence of 0.2% glycerol by 1H NMR method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320347Activation of 25 nM N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli at 100 uM using RHKK(Ac)W-NH2 as substrate after 1 hr in presence of 0.01% CHAPS by UV detection-based HPLC method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID652972Antimicrobial activity against Staphylococcus aureus ATCC 6538 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID351455Inhibition of cathepsin G by spectrofluorimetry2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
Natural polyprenylated benzophenones inhibiting cysteine and serine proteases.
AID397756Therapeutic index, ratio of cytotoxicity against human CEM-SS cells to EC50 for HIV12001Journal of natural products, Feb, Volume: 64, Issue:2
Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program.
AID653254Antifungal activity against Candida albicans ATCC 09548 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID653252Antimicrobial activity against Escherichia coli ATCC 25922 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID1320340Inhibition of 250 nM N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli at 100 uM using RHKK(Ac)W-NH2 as substrate after 5 to 10 mins by UV detection-based HPLC method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320357Inhibition of 500 to 2000 nM bovine pancreas trypsin at 100 uM using c[YKDEGLEE]-NH2 as substrate in presence of 0.01% TX-100 by UV detection-based HPLC method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID757796Leishmanicidal activity against promastigote stage of Leishmania donovani LV9 assessed as cell viability by MTT assay2013European journal of medicinal chemistry, Jul, Volume: 65Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
AID1320343Activation of 50 nM N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli at 100 uM using RHKK(Ac)W-NH2 as substrate after 30 mins in presence of 0.01% TX-100 by UV detection-based HPLC method relative to control2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID397755Antiviral activity against HIV1 in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect2001Journal of natural products, Feb, Volume: 64, Issue:2
Natural product-based anti-HIV drug discovery and development facilitated by the NCI developmental therapeutics program.
AID757799Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia infected in human erythrocytes assessed as parasite growth inhibition at 10 ug/ml after 24 hrs by [3H]-hypoxanthine incorporation assay relative to control2013European journal of medicinal chemistry, Jul, Volume: 65Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
AID1320356Inhibition of 500 to 2000 nM bovine pancreas trypsin at 100 uM using c[YKDEGLEE]-NH2 as substrate by UV detection-based HPLC method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID653256Antifungal activity against Candida parapsilosis ATCC 69548 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID1320371Drug aggregation in deuterated phosphate buffer at 100 uM in presence of 0.01% CHAPS by 1H NMR method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID757798Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia infected in human erythrocytes assessed as parasite growth inhibition at 1 ug/ml after 24 hrs by [3H]-hypoxanthine incorporation assay relative to control2013European journal of medicinal chemistry, Jul, Volume: 65Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
AID653263Ratio of MIC100 for chloramphenicol to MIC100 of compound for Staphylococcus aureus ATCC 6538 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID1320342Inhibition of 25 nM N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli at 100 uM using RHKK(Ac)W-NH2 as substrate after 1 hr by UV detection-based HPLC method relative to control2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID652973Antimicrobial activity against Staphylococcus epidermidis ATCC 12228 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID1320370Drug aggregation in deuterated phosphate buffer at 100 uM in presence of 0.01% Tween 20 by 1H NMR method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID653251Antimicrobial activity against Salmonella typhimurium ATCC 14028 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID757801Antitrypanosomal activity against bloodstream stage of Trypanosoma brucei brucei 93 assessed as parasite growth inhibition at 1 ug/ml after 72 hrs by resazurin reduction assay relative to control2013European journal of medicinal chemistry, Jul, Volume: 65Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
AID1320374Binding affinity to 150 nM to 1.5 uM bovine serum albumin at 100 uM by 1H NMR method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID548182Antioxidant activity assessed as ABTS radical scavenging activity2010Journal of natural products, Nov-29, Volume: 73, Issue:11
Benzophenones and biflavonoids from Rheedia edulis.
AID653262Cytotoxicity against human PBMC after 48 hrs by MTT assay2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID351456Inhibition of Carica papaya papain assessed as residual enzyme activity at 9 uM after 30 mins2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
Natural polyprenylated benzophenones inhibiting cysteine and serine proteases.
AID351454Inhibition of cathepsin B by spectrofluorimetry2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
Natural polyprenylated benzophenones inhibiting cysteine and serine proteases.
AID757802Antitrypanosomal activity against bloodstream stage of Trypanosoma brucei brucei 93 assessed as parasite growth inhibition at 10 ug/ml after 72 hrs by resazurin reduction assay relative to control2013European journal of medicinal chemistry, Jul, Volume: 65Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
AID757795Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 72 hrs by MTS assay2013European journal of medicinal chemistry, Jul, Volume: 65Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
AID757797Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia infected in human erythrocytes assessed as parasite growth inhibition after 24 hrs by [3H]-hypoxanthine incorporation assay2013European journal of medicinal chemistry, Jul, Volume: 65Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
AID1320363Drug aggregation in Tris HCl/Tris buffer at 100 uM in presence of BSA by dynamic light scattering method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320366Drug aggregation in deuterated phosphate buffer up to 100 uM by 1H NMR method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID757804Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia infected in human erythrocytes assessed as parasite growth inhibition at 50 ug/ml after 24 hrs by [3H]-hypoxanthine incorporation assay relative to control2013European journal of medicinal chemistry, Jul, Volume: 65Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
AID1320346Activation of 25 nM N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli at 100 uM using RHKK(Ac)W-NH2 as substrate after 1 hr in presence of 0.01% Tween 20 by UV detection-based HPLC method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID351453Inhibition of trypsin by spectrofluorimetry2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
Natural polyprenylated benzophenones inhibiting cysteine and serine proteases.
AID757800Antitrypanosomal activity against bloodstream stage of Trypanosoma brucei brucei 93 assessed as parasite growth inhibition after 72 hrs by resazurin reduction assay2013European journal of medicinal chemistry, Jul, Volume: 65Synthesis of novel guttiferone A derivatives: in-vitro evaluation toward Plasmodium falciparum, Trypanosoma brucei and Leishmania donovani.
AID1320341Inhibition of 50 nM N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli at 100 uM using RHKK(Ac)W-NH2 as substrate after 30 mins by UV detection-based HPLC method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID351461Inhibition of Carica papaya papain at 50 uM preincubated before DTT addition by fluorescence measurement2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
Natural polyprenylated benzophenones inhibiting cysteine and serine proteases.
AID653259Antifungal activity against Cryptococcus neoformans ATCC 90012 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
AID1320339Inhibition of N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli at 32 uM using RHKK(Ac)W-NH2 as substrate by UV detection-based HPLC method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320367Drug aggregation in deuterated phosphate buffer at 200 uM in presence of 0.01% TX-100 by 1H NMR method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID351459Inhibition of trypsin at 50 uM preincubated for 5 mins before addition of increasing concentration of substrate Z-FR-AMC2009European journal of medicinal chemistry, Mar, Volume: 44, Issue:3
Natural polyprenylated benzophenones inhibiting cysteine and serine proteases.
AID1320348Activation of 25 nM N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli at 100 uM using RHKK(Ac)W-NH2 as substrate after 1 hr in presence of 0.4% glycerol by UV detection-based HPLC method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320355Activation of 8 nM N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli at 100 uM using RHKK(Ac)W-NH2 as substrate in presence of 0.01% TX-100 by UV detection-based HPLC method relative to control2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320354Inhibition of 25 nM N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli at 100 uM using RHKK(Ac)W-NH2 as substrate after 1 hr in presence of BSA by UV detection-based HPLC method2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID1320345Activation of 50 nM N-terminal His6-tagged recombinant human SIRT1 expressed in Escherichia coli at low micromolar concentration using RHKK(Ac)W-NH2 as substrate after 30 mins in presence of 0.01% TX-100 by UV detection-based HPLC method relative to contr2016Journal of medicinal chemistry, Oct-27, Volume: 59, Issue:20
Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity.
AID653260Antifungal activity against Trichophyton tonsurans after 48 hrs by broth microdilution method2012Bioorganic & medicinal chemistry, Apr-15, Volume: 20, Issue:8
Semisynthesis and antimicrobial activity of novel guttiferone-A derivatives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (10.00)29.6817
2010's16 (80.00)24.3611
2020's2 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.17

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.17 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index5.26 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.17)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (4.76%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (95.24%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gallic acid
gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.		2.0510trihydroxybenzoic acidantineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.0810aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
benzophenone
benzophenone : The simplest member of the class of benzophenones, being formaldehyde in which both hydrogens are replaced by phenyl groups.		7.4720benzophenonesphotosensitizing agent;
plant metabolite
fluconazole
Fluconazole: Triazole antifungal agent that is used to treat oropharyngeal CANDIDIASIS and cryptococcal MENINGITIS in AIDS.. fluconazole : A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It is an antifungal drug used for the treatment of mucosal candidiasis and for systemic infections including systemic candidiasis, coccidioidomycosis, and cryptococcosis.		2.5220conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug		environmental contaminant;
P450 inhibitor;
xenobiotic
miltefosine
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.		2.0810phosphocholines;
phospholipid		anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor
omeprazole
Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.. omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.. 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.		2.0710aromatic ether;
benzimidazoles;
pyridines;
sulfoxide
pentamidine
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.		2.0810aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
chloramphenicol
Amphenicol: Chloramphenicol and its derivatives.		2.0710C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor
thiazoles
[no description available]		2.07101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.		2.0610dialdehydebiomarker
stavudine
Stavudine: A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.. stavudine : A nucleoside analogue obtained by formal dehydration across positions 2 and 3 of thymidine. An inhibitor of HIV-1 reverse transcriptase		3.110dihydrofuran;
nucleoside analogue;
organic molecular entity		antimetabolite;
antiviral agent;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor
zalcitabine
Zalcitabine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication at low concentrations, acting as a chain-terminator of viral DNA by binding to reverse transcriptase. Its principal toxic side effect is axonal degeneration resulting in peripheral neuropathy.. zalcitabine : A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.		3.110pyrimidine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
nitidine chloride
[no description available]		3.110
glutamic acid
Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.		2.0710glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
nigericin
Nigericin: A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus. (From Merck Index, 11th ed). nigericin : A polyether antibiotic which affects ion transport and ATPase activity in mitochondria. It is produced by Streptomyces hygroscopicus.		3.110polycyclic etherantibacterial agent;
antimicrobial agent;
bacterial metabolite;
potassium ionophore
zidovudine
Zidovudine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia.. zidovudine : A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.		3.110azide;
pyrimidine 2',3'-dideoxyribonucleoside		antimetabolite;
antiviral drug;
HIV-1 reverse transcriptase inhibitor
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
[no description available]		2.0510chromanol;
monocarboxylic acid;
phenols		antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radical scavenger;
Wnt signalling inhibitor
lamivudine
[no description available]		3.110monothioacetal;
nucleoside analogue;
oxacycle;
primary alcohol		allergen;
anti-HBV agent;
antiviral drug;
EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor;
HIV-1 reverse transcriptase inhibitor;
prodrug
kynostatin 272
kynostatin 272: structure given in first source; contains allophenylnorstatine as a transition-state mimic		3.110peptide
thiazolyl blue
thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.		2.0710organic bromide saltcolorimetric reagent;
dye
calanolide a
calanolide A: NSC 661122 and costatolide are isomers; a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum (Clusiaceae); structure in first source. (+)-calanolide A : An organic heterotetracyclic compound that is 11,12-dihydro-2H,6H,10H-dipyrano[2,3-f:2',3'-h]chromen-2-one substituted by a hydroxy group at position 12, methyl groups at positions 6, 6, 10 and 11 and a propyl group at position 4 (the 10R,11S,12S stereoisomer). Isolated from Calophyllum lanigerum var austrocoriaceum and Calophyllum brasiliense, it exhibits potent activity against HIV-1 reverse transcriptase.		3.110cyclic ether;
delta-lactone;
organic heterotetracyclic compound;
secondary alcohol		HIV-1 reverse transcriptase inhibitor;
plant metabolite
kynostatin 227
kynostatin 227: structure given in first source; contains allophenylnorstatine as a transition-state mimic		3.110
lodenosine
lodenosine: anti-HIV nucleoside analog, the flourine atom on lodenosine is located at 2-arabinoside location, while 2'-fluoro-2',3'-dideoxyadenosine has the flourine residue at the 2-ribose sugar location		3.110
leupeptin
[no description available]		2.0510aldehyde;
tripeptide		bacterial metabolite;
calpain inhibitor;
cathepsin B inhibitor;
EC 3.4.21.4 (trypsin) inhibitor;
serine protease inhibitor
e 64
E 64: cysteine protease inhibitor of microbial origin, which inhibits cathepsin B (EC 3.4.22.1) and cathepsin L (EC 3.4.22.-)		2.0510dicarboxylic acid monoamide;
epoxy monocarboxylic acid;
guanidines;
L-leucine derivative;
zwitterion		antimalarial;
antiparasitic agent;
protease inhibitor
fenton's reagent
Fenton's reagent: used for oxidizing sugars & alcohols		2.0710
hyperforin
hyperforin: a prenylated acylphloroglucinol derivative; antibiotic component of novoimanine; psychoactive agent in St. John's wort; Russian; structure;. hyperforin : A cyclic terpene ketone that is a prenylated carbobicyclic acylphloroglucinol derivative produced by St. John's Wort, Hypericum perforatum.		2.1310
resveratrol
trans-resveratrol : A resveratrol in which the double bond has E configuration.		2.1310resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
12-deoxyphorbol 13-acetate
[no description available]		3.110phorbol estermetabolite
michellamine c
michellamine A: atropisomeric naphthylisoquinoline anti-HIV cytopathic alkaloid dimers; from tropical plant Ancistrocladus abbreviatus; structure given in first source. michellamine A : A dimeric isoquinoline alkaloid isolated from Ancistrocladus abbreviatus and has been shown to exhibit anti-HIV activity.		3.110
costatolide
(-)-calanolide B : An organic heterotetracyclic compound that is 11,12-dihydro-2H,6H,10H-dipyrano[2,3-f:2',3'-h]chromen-2-one substituted by a hydroxy group at position 12, methyl groups at positions 6, 6, 10 and 11 and a propyl group at position 4 (the 10S,11R,12S stereoisomer). Isolated from Calophyllum lanigerum var austrocoriaceum and Calophyllum brasiliense, it exhibits potent activity against HIV-1 reverse transcriptase.		3.110cyclic ether;
delta-lactone;
organic heterotetracyclic compound;
secondary alcohol		HIV-1 reverse transcriptase inhibitor;
plant metabolite
nemorosone
[no description available]		2.4920
1,1-diphenyl-2-picrylhydrazyl
1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)		2.0710
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.4820antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
fumarprotocetraric acid
fumarprotocetraric acid: RN given refers to (E)-isomer; structure given in first source		3.110carbonyl compound
deoxyribose
[no description available]		2.0610deoxypentosehuman metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
pepstatin
pepstatin: inhibits the aspartic protease endothiapepsin		3.110pentapeptide;
secondary carboxamide		bacterial metabolite;
EC 3.4.23.* (aspartic endopeptidase) inhibitor
indigo carmine
3,5-di-O-(E)-caffeoylquinic acid: from roots of Lychnophora ericoides; structure in first source. 3,5-di-O-caffeoyl quinic acid : A carboxylic ester that is the diester obtained by the condensation of the hydroxy groups at positions 3 and 5 of (-)-quinic acid with the carboxy group of trans-caffeic acid. Isolated from Brazilian propolis and Suaeda glauca, it exhibits hepatoprotective and cytotoxic activities.		3.110
oblongifolin c
oblongifolin C: has antineoplastic activity; isolated from Garcinia yunnanensis; structure in first source		2.1310
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		2.0610organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		2.0610ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
aristoforin
Aristoforin: derivative of hyperforin, is a potent anticancer agent; structure in first source		2.1310
didanosine
Didanosine: A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA by binding to reverse transcriptase; ddI is then metabolized to dideoxyadenosine triphosphate, its putative active metabolite.. didanosine : A purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS.		3.110purine 2',3'-dideoxyribonucleosideantimetabolite;
antiviral drug;
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor;
geroprotector;
HIV-1 reverse transcriptase inhibitor
conocurvone
conocurvone: a trimeric naphthoquinone derivative; extracted from Conospermum incurvum; structure given in first source		3.110organic heterotricyclic compound;
organooxygen compound
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.4820
Ache
[description not available]		02.0710
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		02.0710
Curling Ulcer
Acute stress DUODENAL ULCER, usually observed in patients with extensive third-degree burns.		02.0710
Gastric Ulcer
[description not available]		02.0710
Duodenal Ulcer
A PEPTIC ULCER located in the DUODENUM.		02.0710
Stomach Ulcer
Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).		02.0710