Any fungal metabolite produced during a metabolic reaction in the mould, Aspergillus.
| Member | Definition | Class |
|---|
| (+)-(7S)-sydonic acid | A sesquiterpenoid that is benzoic acid substituted by a hydroxy group at position 3 and a (2S)-2-hydroxy-6-methylheptan-2-yl group at position 4. It has been isolated from the sea fan derived fungus Aspergillus sydowii. | (+)-(7S)-sydonic acid |
| (11S,14S)-Cyclo-(L-Trp-L-Phe) | | (11S,14S)-Cyclo-(L-Trp-L-Phe) |
| (E)-5-hydroxy-6-(3-methylbut-2-enyl)-2-(pent-1-enyl)benzofuran-4-carbaldehyde | A member of the class of 1-benzofurans that is 1-benzofuran substituted by a hydroxy group at position 5, a prenyl group at position 6 and a pent-1-en-1-yl group at position 2. Isolated from Chaetomium globosum, it exhibits radical scavenging activity. | (E)-5-hydroxy-6-(3-methylbut-2-enyl)-2-(pent-1-enyl)benzofuran-4-carbaldehyde |
| 2-pentylfuran | A member of the class of furans that is furan in which the hydrogen at position 2 is replaced by a pentyl group. It is found in many heat-processed foods and drinks. | 2-pentylfuran |
| 3-hydroxyterphenyllin | A para-terphenyl that is the 3-hydroxy derivative of terphenyllin. It has been isolated from Aspergillus taichungensis. | 3-hydroxyterphenyllin |
| 3-methylfuran | A member of the class of furans that is furan in which the hydrogen at position 3 is replaced by a methyl group. It is a chemical that is produced in foods during food processing and preservation techniques that involve heat treatment such as cooking and pasteurization. | 3-methylfuran |
| 3,5-dimethylorsellinic acid | A member of the class of dihydroxybenzoic acids that is o-orsellinic acid carrying two additional methyl substituents at positions 3 and 5. | 3,5-dimethylorsellinic acid |
| 6-methoxyspirotryprostatin b | An indole alkaloid isolated from a marine-derived fungal strain Aspergillus sydowii PFW1-13 and has been shown to exhibit cytotoxic activity. | 6-methoxyspirotryprostatin B |
| adefovir | A dimeric naphthopyran with formula C32H26O10, originally isolated from Aspergillus niger. | aurasperone A |
| aflatoxin m1 | A member of the class of aflatoxins that is aflatoxin B1 in which the hydrogen at position 9a is replaced by a hydroxy group. | aflatoxin M1 |
| aphidicolin | A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. | aphidicolin |
| aspergillide a | A macrolide that is 4,15-dioxabicyclo[9.3.1]pentadec-9-en-3-one substituted by a hydroxy group at position 14 and a methyl group at position 5 (the 1R,5S,9E,11R,14S stereoisomer). It is isolated from the marine-derived fungus Aspergillus ostianus and exhibits cytotoxic activity against mouse lymphocytic leukemia cells (L1210). | aspergillide A |
| aspergillide b | A macrolide that is 4,15-dioxabicyclo[9.3.1]pentadec-9-en-3-one substituted by a hydroxy group at position 14 and a methyl group at position 5 (the 1S,5S,9E,11R,14S stereoisomer). It is isolated from the marine-derived fungus Aspergillus ostianus and exhibits cytotoxic activity against mouse lymphocytic leukemia cells (L1210). | aspergillide B |
| asperlicin c | A member of the class of asperlicins in which the core 6,7-dihydroquinazolino[3,2-a][1,4]benzodiazepine-5,13-dione skeleton is substituted at the 7 pro-S position by an indol-3-ylmethyl group. It is a cholecystokinin antagonist. | asperlicin C |
| asperparaline a | An alkaloid isolated from Aspergillus aculeatus. | asperparaline A |
| aspirochlorine | | Aspirochlorine |
| aspulvinone E | A 4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one in which the double bond adopts a Z-configuration. It is a marine metabolite isolated from the fungus Aspergillus terreus and exhibits antiviral activity. | aspulvinone E |
| beta-amyrin | A pentacyclic triterpenoid that is oleanane substituted at the 3beta-position by a hydroxy group and containing a double bond between positions 12 and 13. It is one of the most commonly occurring triterpenoids in higher plants. | beta-amyrin |
| betaine aldehyde | A quaternary ammonium ion that is nitrogen substituted by three methyl groups and a 2-oxoethyl group. It is an intermediate in the metabolism of amino acids like glycine, serine and threonine. | betaine aldehyde |
| cerevisterol | An ergostanoid that is (22E)-ergosta-7,22-diene substituted by hydroxy groups at positions 3, 5 and 6 (the 3beta,5alpha,6beta stereoisomer). It has been isolated from the fungus, Xylaria species. | cerevisterol |
| chrysogine | | chrysogine |
| echinuline | An indole alkaloid with formula C29H39N3O2. It is a fungal metabolite found in several Aspergillus species. | echinulin |
| emindole SB | | emindole SB |
| estin | An oxaspiro compound that is 3H,4'H-spiro[[1]benzofuran-2,1'-cyclohexa[2,5]diene]-3,4'-dione substituted by methoxycarbonyl, hydroxy, chloro, methyl, methoxy and chloro groups at positions 2', 4, 5, 6, 6' and 7, respectively. It is a fungal metabolite isolated from Aspergillus terreus and Penicillium glabrum. | (+)-geodin |
| flavasperone | A naphtho-gamma-pyrone that is 4H-naphtho[1,2-b]pyran-4-one carrying a methyl substituent at position2, a hydroxy substituent at position 5 and two methoxy substotuents at positions 8 and 10. Originally isolated from Aspergillus niger. | flavasperone |
| fonsecin | A naphtho-gamma-pyrone that is 2,3-dihydro-4H-benzo[g]chromen-4-one bearing a methyl substituent at position 2, a methoxy substituent at position 6 and three hydroxy substituents at positions 2, 5 and 8. | fonsecin |
| fonsecinone a | A dimeric naphthopyran with formula C32H26O10, originally isolated from Aspergillus niger. | fonsecinone A |
| fumimycin | A member of the class of 1-benzofurans that is 1-benzofuran-2(3H)-one substituted by a propenyl group at position 4, hydroxy groups at positions 5 and 6, methyl group at position 3 and a [(2E)-3-carboxyprop-2-enoyl]nitrilo group at position 3. Isolated from the fermentation broth of Aspergillus fumisynnematus F746, it exhibits antibacterial activity. | fumimycin |
| fumonisin b2 | A fumonisin that is (2S,3S,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,14,15-triol in which the hydroxy groups at positions 14 and 15 have each been esterified by condensation with the 1-carboxy group of 3-carboxyglutaric acid (giving a 3-carboxyglutarate ester group with R configuration in each case). | fumonisin B2 |
| fumonisin b4 | A fumonisin that is fumonisin B2 that is lacking hydroxy group located gamma- to the amino substituent. | fumonisin B4 |
| kojic acid | A pyranone that is 4H-pyran substituted by a hydroxy group at position 5, a hydroxymethyl group at position 2 and an oxo group at position 4. It has been isolated from the fungus Aspergillus oryzae. | kojic acid |
| l 154819 | A polyketide obtained by hydrolysis of the pyranone ring of lovastatin. | mevinolinic acid |
| lovastatin | A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom). | lovastatin |
| monacolin l | A polyketide that is 1-ethyl-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalene in which one of the methyl hydrogens from the ethyl group is replaced by a 4-hydroxy-6-ketopyran-2-yl group. | monacolin L |
| n-acetyltyramine | A member of the class of tyramines that is tyramine in which one of the hydrogens of the amino group is replaced by an acetyl group. | N-acetyltyramine |
| nigerloxin | A member of the class of benzoic acids that is benzoic acid which is substituted at positions 2, 3, 4, 5, and 6 by carbamoyl, hydroxy, E)-prop-1-en-1-yl, methyl, and methoxy groups, respectively. Obtained from solid-state fermentation of Aspergillus niger CFR-W-105, it inhibits soy bean lipoxygenase-1 (LOX-1) and rat lens aldose reductase (RLAR). It also shows free radical scavenging activity. | nigerloxin |
| ochratoxin a | A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum. | ochratoxin A |
| ochratoxin b | A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid. Ochratoxin B differs from the more naturally abundant ochratoxin A in the absence of the dihydroisocoumarin chlorine atom. It has cytotoxic effects on kidney and liver cells in vitro but only minor effects in vivo, due to its rapid metabolism and excretion. It inhibits cell proliferation of human liver HepG2 cells at doses as low as 1 mug/ ml but lacks the genotoxic activity of ochratoxin A, even at higher concentrations. | ochratoxin B |
| ochratoxin c | A phenylalanine derivative that is the ethyl ester of ochratoxin A. | ochratoxin C |
| orcinol | A 5-alkylresorcinol in which the alkyl group is specified as methyl. | orcinol |
| patulin | A furopyran and lactone that is (2H-pyran-3(6H)-ylidene)acetic acid which is substituted by hydroxy groups at positions 2 and 4 and in which the hydroxy group at position 4 has condensed with the carboxy group to give the corresponding bicyclic lactone. A mycotoxin produced by several species of Aspergillus and Penicillium, it has antibiotic properties but has been shown to be carcinogenic and mutagenic. | patulin |
| paxilline | An indole diterpene alkaloid with formula C27H33NO4 isolated from Penicillium paxilli. It is a potent inhibitor of large conductance Ca2(+)- and voltage-activated K(+) (BK)-type channels. | paxilline |
| pentostatin | A member of the class of coformycins that is coformycin in which the hydroxy group at position 2' is replaced with a hydrogen. It is a drug used for the treatment of hairy cell leukaemia. | pentostatin |
| phenoxyacetic acid | A monocarboxylic acid that is the O-phenyl derivative of glycolic acid. A metabolite of 2-phenoxyethanol, it is used in the manufacture of pharmaceuticals, pesticides, fungicides and dyes. | phenoxyacetic acid |
| phenylacetic acid | A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group. | phenylacetic acid |
| phenylethyl alcohol | A primary alcohol that is ethanol substituted by a phenyl group at position 2. | 2-phenylethanol |
| phthioic acid | A methyl-branched fatty acid that is tricosanoic acid substituted by a methyl group at positions 3, 13 and 19. | 3,13,19-trimethyltricosanoic acid |
| pyranonigrin a | A member of the class of pyranopyrroles that is 2-[(1E)-prop-1-en-1-yl]-6,7-dihydropyrano[2,3-c]pyrrole-4,5-dione carrying two additional hydroxy substituents at positions 3 and 7. Originally isolated from Aspergillus niger. | pyranonigrin A |
| rubrofusarin B | A benzochromenone that is rubrofusarin in which the hydroxy group at position 6 has been converted to the corresponding methyl ether. | rubrofusarin B |
| terphenyllin | A para-terphenyl that is 1,1':4',1''-terphenyl substituted by methoxy groups at positions 3' and 6' and hydroxy groups at positions 2', 4 and 4''. It has been isolated from Aspergillus taichungensis. | terphenyllin |
| terreic acid | | terreic acid |
| ustiloxin b | A heterodetic cyclic peptide with formula C26H39N5O12S produced by Ustilaginoidea virens fungi. It is an inhibitor of microtubule assembly. | ustiloxin B |
| variecolin | | Variecolin |
| verruculogen | An organic heterohexacyclic compound that is a mycotoxic indole alkaloid isolated from Penicillium and Aspergillus species. | verruculogen |
| versicolorin a | An organic heteropentacyclic compound that is 3a,12a-dihydroanthra[2,3-b]furo[3,2-d]furan-5,10-dione carrying three hydroxy substituents at positions 4, 6 and 8. | versicolorin A |
| versicolorin c | An organic heteropentacyclic compound that is 2,3,3a,12a-tetrahydroanthra[2,3-b]furo[3,2-d]furan-5,10-dione carrying three hydroxy substituents at positions 4, 6 and 8. | versicolorin B |
| viridicatin | A hydroxyquinolone that is 3-hydroxyuinolin-2(1H)-one which is substituted at position 4 by a phenyl groups. Isolated from the mycelium of several Penicillium species, it exhibits strong antibiotic activity against M. tuberculosis and also against B. subtilis, S. aureus and S. cerevisiae. | viridicatin |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 28.3708 | 1 | 2 |
| 67.9K protein | Vaccinia virus | Potency | 11.2202 | 2 | 3 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 49.1558 | 1 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 33.5520 | 1 | 2 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 27.7170 | 2 | 2 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 8.9125 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 26.5117 | 11 | 24 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 10.3183 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 37.9330 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 74.8688 | 1 | 3 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 46.4129 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 46.4129 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 49.6036 | 3 | 7 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 10.2663 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 36.1377 | 1 | 4 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 25.2300 | 1 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 25.1189 | 1 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 26.6514 | 1 | 2 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 67.8334 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 34.2834 | 3 | 7 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 8.5336 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 55.7562 | 1 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 79.9598 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 26.3114 | 1 | 3 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 10.0000 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 12.7496 | 2 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 22.4419 | 1 | 4 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 64.7949 | 2 | 2 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 45.8577 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 29.9944 | 11 | 33 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 23.9761 | 2 | 7 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 19.6227 | 6 | 18 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 20.0743 | 1 | 6 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 15.4576 | 4 | 4 |
| eyes absent homolog 2 isoform a | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 31.8430 | 5 | 7 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 10.0000 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 4.4976 | 2 | 9 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 31.5422 | 2 | 11 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 32.5368 | 5 | 12 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 14.7157 | 2 | 4 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 14.1254 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 24.8401 | 1 | 2 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 49.7955 | 2 | 5 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 33.9972 | 1 | 2 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 37.6460 | 1 | 2 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 11.8054 | 2 | 3 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 59.8918 | 2 | 3 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 20.6847 | 3 | 5 |
| IDH1 | Homo sapiens (human) | Potency | 14.0081 | 1 | 3 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 62.3032 | 2 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 17.7828 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| isocitrate dehydrogenase 1, partial | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 5.8793 | 1 | 3 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 37.9330 | 1 | 1 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 14.6985 | 2 | 7 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 35.7168 | 2 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 25.1189 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 36.6442 | 4 | 11 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 23.1093 | 1 | 1 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 63.7207 | 2 | 2 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 19.1112 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 9.4658 | 2 | 5 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 43.8842 | 3 | 8 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| Parkin | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 45.8577 | 1 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 16.1366 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 34.4372 | 5 | 9 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 20.7848 | 3 | 6 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 59.6649 | 1 | 2 |
| PINK1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 0.8913 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 27.3964 | 3 | 4 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 44.6684 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 35.5118 | 2 | 4 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 8.2550 | 2 | 11 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 38.6289 | 3 | 6 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 20.0029 | 4 | 9 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 23.7781 | 1 | 1 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 46.9446 | 2 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 46.9446 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 17.4228 | 1 | 4 |
| snurportin-1 | Homo sapiens (human) | Potency | 62.3032 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 1.5218 | 2 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 7.4918 | 1 | 5 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 17.6219 | 1 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 13.3102 | 2 | 16 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 44.6684 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 94.5626 | 1 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 42.1515 | 3 | 11 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 19.3492 | 2 | 3 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 28.2814 | 3 | 4 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 41.3778 | 2 | 2 |
| tumor susceptibility gene 101 protein | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 0.8913 | 1 | 1 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 0.8913 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 47.2780 | 2 | 3 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 32.6148 | 2 | 4 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 28.7439 | 4 | 6 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 35.8157 | 1 | 4 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 14.9125 | 1 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) | IC50 | 4.0109 | 10 | 10 |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Rattus norvegicus (Norway rat) | IC50 | 0.0529 | 9 | 10 |
| Acyl-CoA:cholesterol acyltransferase | Oryctolagus cuniculus (rabbit) | IC50 | 16.8000 | 1 | 1 |
| Adenosine deaminase | Homo sapiens (human) | Ki | 0.0001 | 8 | 8 |
| Adenosine deaminase | Bos taurus (cattle) | Ki | 0.0000 | 2 | 3 |
| Adenosine deaminase | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 0.0041 | 2 | 2 |
| Adenosine receptor A1 | Homo sapiens (human) | IC50 | 26.7200 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 15.5860 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 96.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 54.3765 | 2 | 2 |
| Aldo-keto reductase family 1 member B1 | Sus scrofa (pig) | IC50 | 160.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | Ki | 253.0000 | 1 | 3 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 8.6800 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | IC50 | 8.3300 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 30.1640 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 20.1100 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | IC50 | 50.0200 | 5 | 5 |
| bcl-2-related protein A1 | Mus musculus (house mouse) | IC50 | 100.0000 | 2 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 57.2000 | 2 | 3 |
| BZLF2 | Human herpesvirus 4 type 2 (Epstein-Barr virus type 2) | IC50 | 2.0300 | 1 | 1 |
| C-C chemokine receptor type 5 | Homo sapiens (human) | IC50 | 9.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 95.5000 | 2 | 2 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 7.0500 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 2.2400 | 1 | 1 |
| Chain A, Antigen Cd11a (p180) | Homo sapiens (human) | IC50 | 2.4000 | 1 | 1 |
| Chain A, RNA-directed RNA polymerase NS5 | Dengue virus 2 16681-PDK53 | IC50 | 38.1400 | 1 | 1 |
| Choline trimethylamine-lyase | Oleidesulfovibrio alaskensis G20 | IC50 | 26.0000 | 1 | 1 |
| Cysteine protease | Trypanosoma brucei rhodesiense | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 12.4446 | 1 | 2 |
| D-amino-acid oxidase | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| D-amino-acid oxidase | Sus scrofa (pig) | IC50 | 2.0000 | 1 | 1 |
| DNA polymerase alpha catalytic subunit | Homo sapiens (human) | IC50 | 5.1500 | 6 | 6 |
| DNA polymerase beta | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| DNA polymerase beta | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| DNA polymerase catalytic subunit | Human alphaherpesvirus 1 strain 17 | IC50 | 0.5000 | 1 | 1 |
| DNA polymerase catalytic subunit | Human alphaherpesvirus 1 strain KOS | IC50 | 0.4380 | 1 | 1 |
| DNA polymerase catalytic subunit | Human herpesvirus 3 strain Dumas | IC50 | 1.6000 | 1 | 2 |
| DNA polymerase catalytic subunit | Human herpesvirus 5 strain AD169 | IC50 | 0.4435 | 2 | 2 |
| DNA polymerase catalytic subunit | Human herpesvirus 6 (strain Uganda-1102) | IC50 | 0.4000 | 1 | 1 |
| DNA polymerase delta catalytic subunit | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| DNA polymerase lambda | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| DNA polymerase subunit gamma-1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Female germline-specific tumor suppressor gld-1 | Caenorhabditis elegans | IC50 | 2.9570 | 1 | 1 |
| G-protein coupled receptor 55 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Genome polyprotein | | IC50 | 3.8000 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 11.9110 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 25.9330 | 1 | 1 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 16.2850 | 1 | 1 |
| Insulin receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
| Integrin alpha-L | Homo sapiens (human) | IC50 | 3.0900 | 2 | 2 |
| Integrin beta-2 | Homo sapiens (human) | IC50 | 3.0900 | 2 | 2 |
| Intercellular adhesion molecule 1 | Homo sapiens (human) | IC50 | 3.7800 | 1 | 1 |
| L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase | Mycobacterium tuberculosis H37Rv | IC50 | 2,500.0000 | 1 | 1 |
| Lanosterol 14-alpha demethylase | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | IC50 | 129.0225 | 3 | 4 |
| Lysosomal alpha-glucosidase | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Lysosomal alpha-glucosidase | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| Maltase-glucoamylase, intestinal | Homo sapiens (human) | IC50 | 138.6967 | 2 | 3 |
| Maltase-glucoamylase, intestinal | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| N-arachidonyl glycine receptor | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Neutrophil elastase | Homo sapiens (human) | IC50 | 0.0270 | 1 | 1 |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| Polymerase acidic protein | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 12.4446 | 1 | 2 |
| Polyphenol oxidase 1 | Agaricus bisporus | IC50 | 20.1350 | 2 | 2 |
| Polyphenol oxidase 1 | Agaricus bisporus | Ki | 12.2000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 63.2557 | 107 | 108 |
| Polyphenol oxidase 2 | Agaricus bisporus | Ki | 82.3278 | 9 | 9 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Probable maltase-glucoamylase 2 | Homo sapiens (human) | IC50 | 138.6967 | 2 | 3 |
| Probable maltase-glucoamylase 2 | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| Prolyl 4-hydroxylase subunit alpha-1 | Gallus gallus (chicken) | Ki | 20,000.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| Rev | Human immunodeficiency virus 1 | IC50 | 16.2410 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 5.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 10.1040 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 8.0280 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 8.7530 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 8.6800 | 1 | 1 |
| Solute carrier family 22 member 20 | Mus musculus (house mouse) | Ki | 48.9890 | 1 | 2 |
| Solute carrier family 22 member 6 | Mus musculus (house mouse) | Ki | 6.2548 | 1 | 2 |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | IC50 | 16.0000 | 1 | 2 |
| Substance-K receptor | Homo sapiens (human) | IC50 | 28.2240 | 1 | 1 |
| Substance-K receptor | Homo sapiens (human) | Ki | 9.4080 | 1 | 1 |
| Sucrase-isomaltase, intestinal | Homo sapiens (human) | IC50 | 138.6967 | 2 | 3 |
| Sucrase-isomaltase, intestinal | Homo sapiens (human) | Ki | 1.5000 | 1 | 1 |
| TPA: protein transporter TIM10 | Saccharomyces cerevisiae S288C | IC50 | 33.5500 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 1,014.7415 | 19 | 20 |
| Tyrosinase | Mus musculus (house mouse) | IC50 | 716.9000 | 3 | 3 |
| Tyrosinase | Priestia megaterium | IC50 | 52.0000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | Ki | 350.0000 | 1 | 1 |
| Tyrosinase | Mus musculus (house mouse) | Ki | 5,500.0000 | 1 | 1 |
| Tyrosinase | Danio rerio (zebrafish) | IC50 | 12,550.0000 | 2 | 2 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Uncharacterized protein YOR062C | Saccharomyces cerevisiae S288C | IC50 | 19.0000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 18.1500 | 1 | 2 |