Page last updated: 2024-09-28

Tick Toxicoses

Toxicoses caused by toxic substances secreted by the salivary glands of ticks; include tick paralysis (neurotropic toxin), sweating sickness (dermotropic toxin), and Rhipicephalus appendiculatus toxicosis (leukotropic toxin).

Synonyms(1)

Synonym
Tick Toxicoses

Research

Studies (18)

TimeframeStudies, This Condition (%)All Conditions %
pre-199018 (100.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's0 (0.00)28.8240
2020's0 (0.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
salicylic acid0low10
thiamine0low10
chlorpromazine0low10
phenoxybenzamine0low10
promethazine0low10
thymidine0low10
tubocurarine0low10
ethyl chloride0low10
phencyclidine0low10
trolamine salicylate0low10
foxes0low10
griseofulvin0low10
riboflavin0low10
ants0low20
ascorbic acid0low10
tetracycline0low10
oxytetracycline, anhydrous0low10
muramidase0low10
eye0low10

Protein Targets (524)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase4004
RAR-related orphan receptor gamma7007
GLI family zinc finger 34004
AR protein8008
thioredoxin glutathione reductase2002
cytochrome P450 family 3 subfamily A polypeptide 47007
glucocorticoid receptor [Homo sapiens]7007
retinoic acid nuclear receptor alpha variant 15005
estrogen-related nuclear receptor alpha4004
estrogen nuclear receptor alpha6006
vitamin D (1,25- dihydroxyvitamin D3) receptor4004
IDH13003
euchromatic histone-lysine N-methyltransferase 25005
chromobox protein homolog 15005
nuclear factor erythroid 2-related factor 2 isoform 22002
thyroid hormone receptor beta isoform 24004
nuclear factor erythroid 2-related factor 2 isoform 17007
lethal(3)malignant brain tumor-like protein 1 isoform I1001
geminin5005
lethal factor (plasmid)3003
lamin isoform A-delta103003
Polyphenol oxidase 20203
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0415
Spike glycoprotein5229
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Proteasome subunit beta type-110001
thioredoxin reductase4004
phosphopantetheinyl transferase3003
ATAD5 protein, partial2002
Fumarate hydratase1001
USP1 protein, partial3003
NFKB1 protein, partial1001
TDP1 protein5005
Microtubule-associated protein tau2002
Thrombopoietin1001
Smad31001
caspase 7, apoptosis-related cysteine protease2002
estrogen receptor 2 (ER beta)4004
nuclear receptor subfamily 1, group I, member 34004
progesterone receptor5005
NADPH oxidase 10101
retinoid X nuclear receptor alpha5005
farnesoid X nuclear receptor3003
pregnane X nuclear receptor4004
G2002
cytochrome P450 2D65005
polyprotein1001
67.9K protein1001
peroxisome proliferator-activated receptor delta4004
peroxisome proliferator activated receptor gamma4004
Snq2p0002
caspase-32002
Adenylate cyclase type 1 0202
thyroid stimulating hormone receptor5005
v-jun sarcoma virus 17 oncogene homolog (avian)5005
Histone H2A.x4004
Caspase-71001
Spike glycoprotein0224
Replicase polyprotein 1ab0224
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a1001
D(1A) dopamine receptor2002
vitamin D3 receptor isoform VDRA3003
potassium voltage-gated channel subfamily H member 2 isoform d3003
caspase-31001
histone deacetylase 9 isoform 31001
heat shock protein beta-13003
mitogen-activated protein kinase 12002
atrial natriuretic peptide receptor 2 precursor1001
ras-related protein Rab-9A1001
serine/threonine-protein kinase mTOR isoform 12002
DNA polymerase kappa isoform 12002
peripheral myelin protein 225005
survival motor neuron protein isoform d4004
cytochrome P450 3A4 isoform 13003
M-phase phosphoprotein 82002
histone acetyltransferase KAT2A isoform 13003
muscarinic acetylcholine receptor M11001
Gamma-aminobutyric acid receptor subunit pi3003
Proteasome subunit alpha type-70001
Solute carrier family 22 member 1 0506
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
Transmembrane protease serine 20224
Glutamate receptor ionotropic, NMDA 2D0202
ATP-binding cassette sub-family C member 30404
Multidrug resistance-associated protein 40404
Transient receptor potential cation channel subfamily V member 10101
Glutamate receptor ionotropic, NMDA 3B0202
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Bile salt export pump0202
5-hydroxytryptamine receptor 40404
Potassium channel subfamily K member 20101
Bile salt export pump0606
Epidermal growth factor receptor0101
Interferon beta2002
HLA class I histocompatibility antigen, B alpha chain 2002
Albumin0112
Albumin0011
Major prion protein0022
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10101
Receptor tyrosine-protein kinase erbB-20101
Cellular tumor antigen p535005
Major prion protein0011
Integrin beta-31001
Cytochrome P450 1A20011
Tyrosine-protein kinase Fyn0101
Procathepsin L0224
Aldo-keto reductase family 1 member B10404
Muscarinic acetylcholine receptor M20505
Muscarinic acetylcholine receptor M40404
ATP-dependent translocase ABCB10102
Muscarinic acetylcholine receptor M10112
Muscarinic acetylcholine receptor M30112
Muscarinic acetylcholine receptor M40112
Integrin alpha-IIb1001
5-hydroxytryptamine receptor 1A0101
5-hydroxytryptamine receptor 2C0101
Muscarinic acetylcholine receptor M50112
Muscarinic acetylcholine receptor M50404
Alpha-2A adrenergic receptor0404
Replicase polyprotein 1a0224
Replicase polyprotein 1ab0224
Replicase polyprotein 1ab0224
Cys-loop ligand-gated ion channel0101
Calmodulin-10314
Replicase polyprotein 1ab0224
Cytochrome P450 2D60112
Muscarinic acetylcholine receptor M20112
Muscarinic acetylcholine receptor M10404
Cytochrome P450 2C9 0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0405
5-hydroxytryptamine receptor 2A0101
Gamma-aminobutyric acid receptor subunit beta-13003
Alpha-1B adrenergic receptor0404
Sphingomyelin phosphodiesterase0101
Gamma-aminobutyric acid receptor subunit delta3003
Gamma-aminobutyric acid receptor subunit gamma-23003
Alpha-2C adrenergic receptor0404
D0303
D(3) dopamine receptor0303
5-hydroxytryptamine receptor 1A0404
Alpha-2B adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit alpha-53003
Gamma-aminobutyric acid receptor subunit alpha-33003
D(2) dopamine receptor0101
Muscarinic acetylcholine receptor M30404
Proteasome subunit beta type-10001
Substance-K receptor0202
D(1A) dopamine receptor0405
D(4) dopamine receptor0203
D(1B) dopamine receptor0102
Adenylate cyclase type 30202
Alpha-2C adrenergic receptor0202
UDP-glucuronosyltransferase 1A40001
Alpha-2A adrenergic receptor0202
Gamma-aminobutyric acid receptor subunit gamma-13003
Gamma-aminobutyric acid receptor subunit alpha-23003
Alpha-1D adrenergic receptor0404
Sodium-dependent noradrenaline transporter 0404
Sodium-dependent dopamine transporter0202
Histamine H2 receptor0404
Alpha-1D adrenergic receptor0404
D(1B) dopamine receptor0303
Proteasome subunit alpha type-10001
Proteasome subunit alpha type-20001
Proteasome subunit alpha type-30001
Proteasome subunit alpha type-40001
Adenylate cyclase type 20202
Adenylate cyclase type 40202
Proteasome subunit beta type-80001
Proteasome subunit beta type-90001
Proteasome subunit alpha type-50001
Proteasome subunit beta type-40001
Proteasome subunit beta type-60001
Proteasome subunit beta type-50001
5-hydroxytryptamine receptor 2A0404
5-hydroxytryptamine receptor 2C0404
Gamma-aminobutyric acid receptor subunit alpha-43003
Gamma-aminobutyric acid receptor subunit gamma-33003
5-hydroxytryptamine receptor 1B0404
Trypanothione reductase0404
Gamma-aminobutyric acid receptor subunit alpha-63003
D(4) dopamine receptor0303
5-hydroxytryptamine receptor 2B0101
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0404
Melanocortin receptor 40202
5-hydroxytryptamine receptor 7 0101
Melanocortin receptor 50202
Pleiotropic ABC efflux transporter of multiple drugs0204
5-hydroxytryptamine receptor 70101
Histamine H1 receptor0404
Mu-type opioid receptor0202
Glutamate receptor ionotropic, NMDA 1 0303
D(3) dopamine receptor0405
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Adenylate cyclase type 80202
Proteasome subunit beta type-100001
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2B0404
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0404
Histamine H2 receptor1001
Proteasome subunit beta type-30001
Proteasome subunit beta type-20001
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 60404
5-hydroxytryptamine receptor 70303
Cytochrome P450 2J20101
Gastrin/cholecystokinin type B receptor0101
Proteasome subunit alpha type-60012
D(2) dopamine receptor0304
Calmodulin 0123
Gamma-aminobutyric acid receptor subunit alpha-13003
Gamma-aminobutyric acid receptor subunit beta-33003
Gamma-aminobutyric acid receptor subunit beta-23003
Aldehyde oxidase 10101
Glutamate receptor ionotropic, NMDA 2A 0303
Glutamate receptor ionotropic, NMDA 2B0303
Glutamate receptor ionotropic, NMDA 2C0304
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Sodium-dependent dopamine transporter 0202
Adenylate cyclase type 60202
Adenylate cyclase type 50202
Glutamate receptor ionotropic, NMDA 10303
Aldehyde oxidase0202
Potassium voltage-gated channel subfamily H member 20202
Glutamate receptor ionotropic, NMDA 2A0303
Glutamate receptor ionotropic, NMDA 2B0303
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Glutamate receptor ionotropic, NMDA 2C0202
Sodium channel protein type 9 subunit alpha0101
Glutamate receptor ionotropic, NMDA 2D0303
Nuclear receptor subfamily 3 group C member 3 0202
Adenylyl cyclase 7 0202
Proteasome subunit alpha-type 80001
Glutamate receptor ionotropic, NMDA 3A0202
Glutamate receptor ionotropic, NMDA 3B0303
GABA theta subunit3003
Inositol hexakisphosphate kinase 12002
Canalicular multispecific organic anion transporter 10404
D0101
Sodium channel protein type 2 subunit alpha0101
Proteasome subunit beta type-70001
Ataxin-23003
Sigma non-opioid intracellular receptor 10505
Angiotensin-converting enzyme 2 0224
Gamma-aminobutyric acid receptor subunit epsilon3003
Sodium channel protein type 3 subunit alpha0101
Glutamate receptor ionotropic, NMDA 3A0303
Sodium channel protein type 11 subunit alpha0101
Sodium channel protein type 8 subunit alpha0101
Histamine H3 receptor0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial2002
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase3003
Chain A, Cruzipain1001
pregnane X receptor1001
SMAD family member 22002
SMAD family member 32002
aldehyde dehydrogenase 1 family, member A16006
thyroid stimulating hormone receptor1001
aryl hydrocarbon receptor4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a1001
activating transcription factor 62002
nuclear receptor subfamily 1, group I, member 21001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 14004
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
urokinase plasminogen activator surface receptor precursor1001
DNA dC->dU-editing enzyme APOBEC-3G isoform 12002
Heme oxygenase 1 0101
Heme oxygenase 20101
Nuclear receptor ROR-gamma1001
Lanosterol 14-alpha demethylase0101
ATPase family AAA domain-containing protein 51001
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Beta-lactamase1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, JmjC domain-containing histone demethylation protein 3A1001
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
WRN1001
GLS protein3003
Valosin-containing protein0101
apical membrane antigen 1, AMA11001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
regulator of G-protein signaling 43003
bromodomain adjacent to zinc finger domain 2B1001
lysosomal alpha-glucosidase preproprotein1001
thyroid hormone receptor beta isoform a2002
transcriptional regulator ERG isoform 31001
microphthalmia-associated transcription factor isoform 90101
importin subunit beta-1 isoform 11001
DNA polymerase beta1001
flap endonuclease 12002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
serine/threonine-protein kinase PLK11001
snurportin-11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 11001
DNA polymerase eta isoform 11001
DNA polymerase iota isoform a (long)1001
eukaryotic translation initiation factor 4E isoform 10101
muscleblind-like protein 1 isoform 11001
Rap guanine nucleotide exchange factor 31001
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Serum paraoxonase/arylesterase 10101
phosphoglycerate kinase1001
Chain A, Immunoglobulin0011
Chain B, Immunoglobulin0011
Muscarinic acetylcholine receptor M10012
Cytochrome P450 2B60101
Sodium-dependent serotonin transporter0101
Muscarinic acetylcholine receptor M40012
Delta-type opioid receptor0001
Kappa-type opioid receptor0001
Lysosomal Pro-X carboxypeptidase0101
Mu-type opioid receptor0001
Cholinesterase0101
Muscarinic acetylcholine receptor M50012
Muscarinic acetylcholine receptor M30012
Muscarinic acetylcholine receptor M20012
Sigma non-opioid intracellular receptor 10202
EWS/FLI fusion protein2002
arylsulfatase A1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
Solute carrier family 22 member 20202
Solute carrier family 22 member 30101
ATP-dependent phosphofructokinase2002
glucocerebrosidase1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
huntingtin isoform 21001
Inositol monophosphatase 12002
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Chloroquine resistance transporter0101
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain A, Breast cancer type 1 susceptibility protein1001
Chain H, Immunoglobulin Igg1 Heavy chain0011
Chain L, Immunoglobulin Igg1 Lambda Light Chain0011
Chain A, DODECIN0011
Chain A, DODECIN0011
Chain C, DODECIN0011
Chain E, DODECIN0011
15-lipoxygenase, partial1001
hypoxia-inducible factor 1 alpha subunit1001
NPYLR7B0011
thyrotropin-releasing hormone receptor1001
tumor necrosis factor1001
nuclear factor NF-kappa-B p105 subunit isoform 11001
caspase-1 isoform alpha precursor1001
Riboflavin-binding protein0112
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Caspase-71001
10 kDa heat shock protein, mitochondrial0101
Thiosulfate sulfurtransferase0101
60 kDa chaperonin 0101
10 kDa chaperonin 0101
chaperonin-containing TCP-1 beta subunit homolog1001
Estrogen receptor beta0001
Inhibitor of nuclear factor kappa-B kinase subunit beta0001
Solute carrier family 22 member 60101
Carbonic anhydrase 120101
5'-AMP-activated protein kinase subunit beta-20001
Carbonic anhydrase 10303
Carbonic anhydrase 20303
Polymerase acidic protein0011
Carbonic anhydrase 30101
Stromelysin-10112
Tyrosine-protein phosphatase YopH0101
High mobility group protein B10011
Aldo-keto reductase family 1 member B10101
Prolyl 4-hydroxylase subunit alpha-10101
Tyrosine-protein phosphatase non-receptor type 10103
Estrogen receptor0001
Acetylcholinesterase0101
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60202
Cystathionine gamma-lyase0101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20101
Carbonic anhydrase 70101
5'-AMP-activated protein kinase subunit gamma-10001
5'-AMP-activated protein kinase catalytic subunit alpha-20001
Xanthine dehydrogenase/oxidase0101
5'-AMP-activated protein kinase catalytic subunit alpha-10001
Carbonic anhydrase 90101
Carbonic anhydrase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Nicotinate phosphoribosyltransferase0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 80102
Solute carrier family 22 member 60101
Ubiquitin-like domain-containing CTD phosphatase 10101
Carbonic anhydrase 150101
Carbonic anhydrase 130101
5'-AMP-activated protein kinase subunit gamma-30001
5'-AMP-activated protein kinase subunit gamma-20001
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
5'-AMP-activated protein kinase subunit beta-10001
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Tetracycline resistance protein, class B0001
72 kDa type IV collagenase0101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
Multidrug transporter MdfA0101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Neutrophil collagenase0101
Alpha-synuclein0101
Collagenase 30101
Cannabinoid receptor 10101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Integrase 0101
P2Y purinoceptor 120101
Solute carrier family 22 member 110001
Protein-arginine deiminase type-40101
Solute carrier family 22 member 70001
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Transketolase0011
Thiamine-binding periplasmic protein0011
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
Thymidine kinase 0102
Thymidine kinase, cytosolic0204
Thymidine kinase0102
Thymidylate synthase0001
Thymidine phosphorylase0001
Polyunsaturated fatty acid 5-lipoxygenase0101
Glucose-6-phosphate 1-dehydrogenase0101
Thymidine phosphorylase0001
Thymidylate kinase0101
Thymidine kinase, cytosolic 0002
Thymidine kinase0001
Thymidylate kinase0101
Thymidine kinase 0102
Sterol O-acyltransferase 10101
Thymidine kinase0001
Thymidine kinase0001
Multidrug and toxin extrusion protein 20101
Multidrug and toxin extrusion protein 10101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]