1,6-hexanedithiol profile

1,6-Hexanedithiol is a bifunctional thiol compound. It is a colorless liquid with a strong odor. It is commonly synthesized by the reaction of 1,6-dibromohexane with sodium hydrosulfide in ethanol. 1,6-Hexanedithiol has a variety of applications, including as a cross-linking agent for polymers, a building block for organic synthesis, and a component of biocompatible materials. It is also being studied for its potential applications in the development of new drugs and therapies.'
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1,6-hexanedithiol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	14491
CHEBI ID	173638
SCHEMBL ID	64527
MeSH ID	M0486199

Synonym
CHEBI:173638
nsc-29031
usaf uctl-72
1,6-hexanedithiol
1,6-hexanedimercaptan
wln: sh6sh
1,6-dimercaptohexane
nsc29031
1191-43-1
brn 1732507
hexamethylene dimercaptan
fema no. 3495
ndr-139
einecs 214-735-1
nsc 29031
hexane-1,6-dithiol
1,6-hexamethylenedithiol
1,6-hexanedithiol, >=97%, fg
1,6-hexanedithiol, 96%
inchi=1/c6h14s2/c7-5-3-1-2-4-6-8/h7-8h,1-6h2
srzxcowfgpicga-uhfffaoysa-
H0334
A804205
unii-rwn7rm884e
1,6-hexane dithiol
rwn7rm884e ,
4-01-00-02559 (beilstein handbook reference)
FT-0607015
AKOS015897443
1,6-hexanedithiol [fhfi]
1,6- dimercaptohexane
SCHEMBL64527
Q-100088
hexanedithiol-(1,6)
DTXSID60152317
mfcd00004910
1,6-hexanedithiol, 99.5%
hexamethylendithiol
fema 3495
1, 6-hexanedimercaptan
Q27288323
D90840
AS-57326

Class	Description
alkanethiol	An alkanethiol is a compound in which a sulfanyl group, -SH, is attached to an alkyl group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	8 (33.33)	29.6817
2010's	16 (66.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	24 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methane Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).	2.51	2	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas
3,4-dihydroxyphenylacetic acid 3,4-Dihydroxyphenylacetic Acid: A deaminated metabolite of LEVODOPA.. (3,4-dihydroxyphenyl)acetic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.. dihydroxyphenylacetic acid : A dihydroxy monocarboxylic acid consisting of phenylacetic acid having two phenolic hydroxy substituents.	2.06	1	catechols; dihydroxyphenylacetic acid	human metabolite
glycine [no description available]	2.06	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
2,2'-dipyridyl 2,2'-Dipyridyl: A reagent used for the determination of iron.. 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.	2.1	1	bipyridine	chelator; ferroptosis inhibitor
cystamine [no description available]	2.06	1	organic disulfide; primary amino compound	EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor
3-mercaptopropionic acid 3-Mercaptopropionic Acid: An inhibitor of glutamate decarboxylase. It decreases the GAMMA-AMINOBUTYRIC ACID concentration in the brain, thereby causing convulsions.. 3-mercaptopropanoic acid : A mercaptopropanoic acid that is propanoic acid carrying a sulfanyl group at position 3.	2.73	3	mercaptopropanoic acid	algal metabolite
dilactide dilactide: structure given in first source	2.1	1	dioxanes
triethylene glycol dimethacrylate [no description available]	2.02	1
vinyl ether vinyl ether: major descriptor (65-85); on-line search VINYL COMPOUNDS (66-85); Index Medicus search VINYL ETHER (65-85)	2.02	1	ether
1-hexanol 1-hexanol: RN given refers to parent cpd. hexanol : A fatty alcohol consisting of a hydroxy function at any position of an unbranched saturated chain of six carbon atoms.. hexan-1-ol : A primary alcohol that is hexane substituted by a hydroxy group at position 1.	2.77	3	hexanol; primary alcohol	alarm pheromone; antibacterial agent; fragrance; plant metabolite
luminol Luminol: 5-Amino-2,3-dihydro-1,4-phthalazinedione. Substance that emits light on oxidation. It is used in chemical determinations.	2.17	1
zinc oxide Zinc Oxide: A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.	2.05	1	zinc molecular entity
bisphenol a-glycidyl methacrylate Bisphenol A-Glycidyl Methacrylate: The reaction product of bisphenol A and glycidyl methacrylate that undergoes polymerization when exposed to ultraviolet light or mixed with a catalyst. It is used as a bond implant material and as the resin component of dental sealants and composite restorative materials.	2.02	1	diarylmethane
platinum Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae.	2.43	2	elemental platinum; nickel group element atom; platinum group metal atom
gold Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.	4.36	19	copper group element atom; elemental gold
2,2'-dipyridyl disulfide 2,2'-dipyridyl disulfide: disulfide is an important moiety in this cpd. aldrithiol : A member of the class of pyridines that is pyridine which is substituted by a pyridin-2-yldisulfanediyl group at position 2. It is a reagent used in molecular biology as an oxidizing agent. Also used in peptide synthesis and for detecting thiols.	2.1	1	organic disulfide; pyridines	oxidising agent
pentaerythritol tetra(3-mercaptopropionate) pentaerythritol tetra(3-mercaptopropionate): structure in first source	2.43	2
hexacyanoferrate iii hexacyanoferrate III: RN given refers to parent cpd	2.11	1
11-mercaptoundecanoic acid [no description available]	2.46	2
6-mercapto-1-hexanol [no description available]	2.47	2
16-mercaptohexadecanoic acid [no description available]	2.03	1
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.06	1	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
thrombin aptamer thrombin aptamer: nucleotide sequence given in first source; a synthetic polynucleotide	2.05	1

Condition	Relationship Strength	Studies
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	3.44	7
Breast Cancer [description not available]	2.11	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.11	1
Cardiovascular Stroke [description not available]	2.06	1
Myocardial Infarction NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).	2.06	1

1,6-hexanedithiol

Description

Cross-References

Synonyms (43)

Drug Classes (1)

Research

Studies (24)

Market Indicators

Research Demand Index: 27.24

Study Types