A condition characterized by an abnormally elevated concentration of KETONE BODIES in the blood (acetonemia) or urine (acetonuria). It is a sign of DIABETES COMPLICATION, starvation, alcoholism or a mitochondrial metabolic disturbance (e.g., MAPLE SYRUP URINE DISEASE).
| Excerpt | Reference |
|---|
| "lipacidemia and ketosis) are prevented." | ( Anschütz, A; Förster, H; Quadbeck, R, 1979) |
| "Thus, ketosis is viewed as the result of increased mobilization of free fatty acids from adipose tissue (site 1) to the liver (site 2), coupled with simultaneous enhancement of the liver's capacity to convert these substrates into acetoacetic and beta-hydroxybutyric acids." | ( Foster, DW; McGarry, JD, 1977) |
| "Post-exercise ketosis is known to be suppressed by physical training and by a high carbohydrate diet." | ( Adams, JH; Koeslag, JH, 1989) |
| "Post-exercise ketosis is not abolished by glucose ingestion immediately after exercise but is counteracted by simultaneous beta-adrenergic blockade." | ( J de V Lochner, J; Koeslag, JH; Vahed, YA, 1988) |
| "Diabetic ketoacidosis is often associated with a temporary increase in protein excretion, but the mechanisms are not completely known." | ( Alberti, KG; Christensen, CK; Mogensen, CE; Pedersen, EB; Schmitz, O, 1986) |
| "A mild ketosis is known to prevail in the mother, fetus, and newborn infant during the 3rd trimester and in the early neonatal period." | ( Auestad, N; Benson, J; Edmond, J; Picone, T; Rambathla, S; Wu, PY, 1986) |
| "No other cause of ketoacidosis is found." | ( Armaghanian, C; Didier, G; Fogliani, J; Fogliani, S, 1980) |
| "Susceptibility to ketosis is probably due to the combination of appetite limitation and a high degree of precedence given to the demand of the mammary gland for nutrients, in particular glucose." | ( Baird, GD, 1982) |
| "Ketosis is normal during fasting, after prolonged exercise, and when a high-fat diet is consumed." | ( Ashmarina, L; Boukaftane, Y; Kassovska-Bratinova, S; Lambert, M; Lapierre, P; Mitchell, GA; Potier, E; Robert, MF; Wang, SP, 1995) |
| "Alcoholic ketoacidosis is rare and must be considered in the differential diagnosis of any alcoholic patient with acidosis." | ( Jobard, JM, 1993) |
| "Ketosis is beneficial for seizure control, possibly through induction of cerebral acidosis." | ( Al-Mudallal, AS; Harik, SI; LaManna, JC; Lust, WD, 1996) |
| "Although ketosis is an integral aspect of these therapeutic regimens, the direct importance of ketosis to seizure control needs further investigation." | ( Comeau, F; Cunnane, S; Curtis, R; Musa-Veloso, K; Rarama, E, 2002) |
| "Ketosis is believed to be necessary to the anticonvulsant mechanism of the ketogenic diet; however, the relationship between ketosis and seizure control has not been established." | ( Musa-Veloso, K, 2004) |
| "Thus, ketosis is insufficient and a functioning leptin signaling system appears necessary for the KD to slow weight gain." | ( Erbayat-Altay, E; Rensing, N; Thio, LL; Yamada, KA, 2006) |
| "Subclinical ketosis is a metabolic disorder in high-producing dairy cattle that can be detected by ketone bodies in milk: acetone (Ac), acetoacetate (AcAc), and beta-hydroxybutyrate (BHBA)." | ( de Jong, G; de Roos, AP; Hørlyk, J; van den Bijgaart, HJ, 2007) |
| "Ketosis is a common metabolic disease, and affected dairy cows are known to have increased risk for mastitis and other infectious conditions." | ( Elazar, S; Grinberg, N; Rosenshine, I; Shpigel, NY, 2008) |
| "Hyperketonemia is increasingly being identified in type 2 diabetic patients in addition to those with type 1 diabetes." | ( Jain, SK; Rains, JL, 2011) |
| "Physiological ketosis is a hallmark of metabolism in suckling infants." | ( Khazipov, R; Minlebaev, M, 2011) |
| "Ketosis is a common metabolic disease in dairy cows." | ( Buttchereit, N; Gronwald, W; Immervoll, AK; Junge, W; Klein, MS; Louis, C; Miemczyk, SP; Oefner, PJ; Thaller, G; Wiedemann, S, 2012) |
| "Ketosis is a metabolic disorder closely associated with both lipid and carbohydrate metabolism." | ( Sun, ZL; Xiao, HB; Zhou, N, 2012) |
| "Alcohol ketoacidosis is a frequently missed diagnosis, but is well described in the literature." | ( Dwyer, JB; Tamama, K, 2013) |
| "This degree of ketonemia is estimated to contribute up to 8% to 9% of brain energy metabolism." | ( Castellano, CA; Chouinard-Watkins, R; Courchesne-Loyer, A; Cunnane, SC; Fortier, M; Nugent, S; Roy, M; Tremblay-Mercier, J, 2013) |
| "Ketosis is estimated to affect 15% of early lactation dairy cows." | ( Gordon, JL; Karcher, EL; Shire, J, 2013) |
| "Subclinical ketosis is a metabolic disorder which often goes undiagnosed and leads to constricted performance and an impairment of general condition." | ( Dänicke, S; Frahm, J; Kersten, S; Meyer, U; Rehage, J; Reiche, D; Schulz, K, 2014) |
| "KME-induced hyperketonemia is robust, convenient, and safe, and the ester can be taken as an oral supplement without changing the habitual diet." | ( Kashiwaya, Y; King, MT; Newport, MT; VanItallie, TB; Veech, RL, 2015) |
| "Subclinical ketosis is one of the most prevalent metabolic disorders in high-producing dairy cows during early lactation." | ( Ehret, A; Gronwald, W; Hochstuhl, D; Klein, MS; Krattenmacher, N; Tetens, J; Thaller, G, 2015) |
| "Ketosis is a common disease in dairy cattle, especially in the days after calving, and it is often undiagnosed." | ( Huzzey, JM; Itle, AJ; von Keyserlingk, MA; Weary, DM, 2015) |
| "Ketosis is associated with many transition cow diseases and the subclinical form has been found to be a common condition in high-producing dairy cows." | ( Bemers, R; Berge, AC; Papen, J; Vanholder, T; Vertenten, G, 2015) |
| "Subclinical ketosis is common and is significantly associated with reproductive performance in mainly pasture-fed New Zealand dairy cattle." | ( Compton, CW; McDougall, S; Young, L, 2015) |
| "Ketosis is also produced during fasting periods, which is known as fasting ketosis (FK)." | ( Forzani, ES; Jackemeyer, D; Prabhakar, A; Quach, A; Tao, N; Terrera, M; Tsow, F; Xian, X; Zhang, H, 2015) |
| "Ketoacidosis is a potential complication of type 1 diabetes." | ( Häring, HU; Heni, M; Hudak, SK; Overkamp, D; Wagner, R, 2015) |
| "If alcoholic ketoacidosis is suspected, dextrose-containing fluids are recommended over normal saline." | ( Adkins, DA; Cook, AM; Flannery, AH, 2016) |
| "Hyperketonemia is a condition with elevated blood levels of acetoacetate, 3-β-hydroxybutyrate, and acetone." | ( Jain, SK; Kanikarla-Marie, P, 2016) |
| "Starvation ketoacidosis is a rare cause of metabolic acidosis and is a phenomenon that occurs normally during fasting, as the body switches from carbohydrate to lipid energy sources." | ( Augsburger, M; Burkhardt, S; Lardi, C; Palmiere, C; Sabatasso, S; Tettamanti, C; Werner, D, 2016) |
| "Ketoacidosis is an important but under-recognized complication of neuromuscular disease, in particular spinal muscular atrophy." | ( Furlong, MJ; Gleeson, S; Mulroy, E, 2016) |
| "Dairy cows with ketosis are characterized by oxidative stress, hepatic damage, and hyperketonemia." | ( Du, X; Li, X; Liu, G; Peng, Z; Shi, Z; Wang, Z; Zhang, Y; Zhao, C, 2017) |
| "Ketosis is a very frequent metabolic disease in dairy cows, resulting in lower milk production, impaired fertility and increased frequency of other diseases." | ( Belić, B; Cincović, MR; Djoković, R; Ježek, J; Klinkon, M; Nemec, M; Starič, J, 2017) |
| "Ketosis is a common condition found in the initial stages of lactation in high-yielding dairy cows." | ( Brodzki, A; Brodzki, P; Kurek, Ł; Marczuk, J, 2018) |
| "Ketoacidosis is an under-recognized entity in patients with neuromuscular diseases and requires a high index of suspicion for prompt diagnosis and management." | ( El Chediak, A; Hashash, JG; Koubar, SH; Lakkis, B, 2018) |
| "Neuroprotection by ketosis is thought to be associated with improved mitochondrial function, decreased reactive oxygen species (ROS) and apoptotic and inflammatory mediators, and increased protective pathways." | ( Kerwin, T; LaManna, JC; Puchowicz, M; Xu, K; Zhang, Y, 2018) |
| "Subclinical ketosis is a common metabolic disorder affecting dairy cattle that results in a greater risk for the development of subsequent metabolic and infectious disease." | ( Duffield, TF; Kelton, DF; Renaud, DL, 2019) |
| "Ketoacidosis is attributed in part to the massive release of ketone bodies (e." | ( Kaphalia, BS; Segar, L; Shawky, NM; Srinivasan, MP; Thangaraju, M, 2019) |
| "Ketosis is a metabolic disorder that has an important impact on health and productivity in dairy cattle during early lactation." | ( Garzón-Audor, A; Oliver-Espinosa, O, 2019) |
| "Ketoacidosis is uncommon in non-diabetic women, but occurs in the postpartum period as a rare complication of continuing to breastfeed during periods of acute illness." | ( Azzam, O; Prentice, D, 2019) |
| "Diabetic ketoacidosis is defined as hyperglycemia >250 mg/dL with metabolic acidosis of arterial pH <7." | ( Bennett, A; Geehan, D; Moncure, M; Segebrecht, R; Van Way, CW; Weide, L, 2019) |
| "Ketosis is a condition where ketone bodies are produced as an alternative energy source, due to insufficient glucose for energy production so that the body switches from carbohydrate metabolism to mostly fat metabolism." | ( Do Park, K; Kang, DY; Lee, HK; Song, KD; Sp, N; Yang, YM, 2019) |
| "Ketosis is a major metabolic disorder of high-yielding dairy cows during the transition period." | ( Coleman, DN; Jia, H; Li, X; Liu, G; Loor, JJ; Ma, L; Wang, Y; Xu, C; Xu, Q, 2019) |
| "Ketosis is a metabolic state in which the body uses ketones derived from breakdown of fatty acids as the primary mitochondrial fuel source instead of glucose." | ( Campbell, H; Campbell, I, 2019) |
| "Ketosis is an important metabolic disease that can negatively affect the production efficiency of dairy cows." | ( Du, X; Fang, Z; Li, X; Liu, G; Loor, JJ; Shen, T; Shi, Z; Wang, X; Xing, D; Zhu, Y, 2019) |
| "Ketoacidosis is a dangerous complication of diabetes mellitus in which plasma levels of ketone bodies can reach 20-25 mM." | ( Adamovich, KV; Adamovich, TV; Dubouskaya, TG; Fedorovich, SV; Hrynevich, SV; Voronina, PP; Waseem, TV, 2020) |
| "Lactation ketoacidosis is an extremely rare type of high anion gap metabolic acidosis." | ( Al Alawi, AM; Al Amri, U; Falhammar, H, 2019) |
| "Hyperketonemia is a metabolic disease in dairy cows, associated with negative nutrition balance (NNB) induced by low dry matter intake (DMI) and increased nutrient requirements." | ( Abdelatty, AM; Du, X; Li, G; Li, X; Liu, G; Mohamed, FF; Peng, Z; Sun, X; Wang, Z; Xu, Q; Zhao, C, 2020) |
| "Ketosis is a metabolic disorder often triggered by anorexia in animals fed on high energy diets." | ( Bochmann, M; Clauss, M; Hatt, JM; Hetzel, U; Riond, B; Schmid, NS, 2020) |
| "Ketosis is a metabolic disease of dairy cows often characterized by high concentrations of ketone bodies and fatty acids, but low milk protein and milk production." | ( Chen, X; Dong, J; Fang, Z; Guan, Y; Jia, H; Li, X; Liu, G; Loor, JJ; Shu, X; Wang, Y; Zuo, R, 2020) |
| "Ketosis is a metabolic disorder of increasing importance in high-yielding dairy cows, but accurate population-wide binary health trait recording is difficult to implement." | ( Klein, SL; König, S; May, K; Scheper, C, 2020) |
| "Ketosis is a serious metabolic disorder characterized by systemic and hepatic oxidative stress, inflammation, and apoptosis, as well as reduced milk yield." | ( Cao, Z; Jia, H; Jiang, C; Liang, Y; Loor, JJ; Luo, S; Shao, G; Sun, X; Tang, Y; Xu, C; Xu, Q; Zhao, C, 2021) |
| "Clinical ketosis is common during the dairy cows' transition period and is responsible for considerable economic loss." | ( Bannert, E; Baumgartner, W; Kadáši, M; Kaiser, A; Klein, R; Köller, G; Leonhardt, AS; Pietsch, F; Rachidi, F; Schären, M; Snedec, T; Spilke, J; Starke, A; Theile, S; Theinert, K, 2021) |
| "Ketosis is a common metabolic disorder in high-producing dairy cows during the peripartal period." | ( Du, X; Feng, X; Li, C; Li, N; Li, X; Liang, Y; Liu, G; Loor, JJ; Shu, X; Song, Y; Wang, Z; Yang, Y, 2021) |
| "Ketosis is one of the most frequent metabolic diseases in high-yielding dairy cows and is characterized by high concentrations of ketone bodies in blood, urine, and milk, causing high economic losses." | ( Duffield, T; Schenkel, F; Soares, RAN; Squires, EJ; Vargas, G, 2021) |
| "Starvation ketosis is usually a benign entity, however when combined with factors such as stress of critical illness, can produce metabolic acidosis which at times can be severe." | ( Barnett, R; Khanin, Y; Parikh, R; Sharma, P; Wanchoo, R, 2022) |
| "Fasting ketoacidosis is especially an underdiagnosed problem in patients with neuro-muscular disease with severely depleted muscular mass." | ( Grady, BP; Kemming, JL; Koop, K; van Dam, M; Vissers, LATM, 2021) |
| "Key Message: Ketoacidosis is a major feature of common clinical conditions to include diabetic ketoacidosis, alcoholic ketoacidosis, salicylate intoxication, SGLT2 inhibitor therapy, and calorie sufficient but carbohydrate-restricted diets." | ( Clegg, DJ; Palmer, BF, 2021) |
| "Ketoacidosis is a potentially fatal complication that often presents as euglycaemic ketoacidosis during SGLT2 inhibitor treatment." | ( Iwasaki, Y; Karita, K; Kuratani, N; Seki, H; Shiga, T; Yasuda, K; Yorozu, T, 2021) |
| "Ketoacidosis is relatively common and should be considered as a cause of sudden death, especially in alcoholic patients and patients with diabetes with no clear cause of death at autopsy." | ( Beresford, P; Davidson, F; Gallagher, PJ; Gwiti, P, 2023) |
| "Lactation ketoacidosis is a very rare cause of metabolic acidosis in breastfeeding patients." | ( Oliver, JJ; Osborne, KC, 2022) |
| "Ketosis is an alternative route for energy supply and provides the same metabolic effects as insulin but at the metabolic or primitive control level, which bypasses the complex signaling pathway of insulin." | ( Grande, G; Milardi, D; Zolla, L, 2022) |
| "Ketosis is a common metabolic disorder in peripartal dairy cows that is caused by excessive mobilization of fat and incomplete hepatic metabolism of fatty acids (FFA)." | ( Fan, W; Gao, C; Jiang, Q; Li, M; Loor, JJ; Tian, Y; Wang, S; Xu, C; Yang, M; Yang, W; Zhang, B, 2022) |
| "Ketosis is one of the most important health problems in dairy sheep." | ( Faillace, V; Fiore, E; Fiore, F; Harvatine, K; Laghi, L; Lisuzzo, A; Mazzotta, E; Moscati, L; Spissu, N; Zhu, C, 2022) |
| "Ketosis is a metabolic disease of dairy cows in the perinatal period, β-hydroxybutyrate (β-HB) is the main component of ketosis." | ( Chen, M; Gao, X; Hong, H; Jiang, L; Jiang, Y; Jin, Q; Jin, Z; Liu, W; Qian, Y; Wei, Z; Xu, J; Yang, Z; Zhang, H; Zhang, X, 2023) |
| "Ketosis is a metabolic disease of dairy cows in the perinatal period, β-hydroxybutyrate (β-HB) is the main component of ketosis." | ( Chen, M; Gao, X; Hong, H; Jiang, L; Jiang, Y; Jin, Q; Jin, Z; Liu, W; Qian, Y; Wei, Z; Xu, J; Yang, Z; Zhang, H; Zhang, X, 2023) |
| "Ketosis is a common nutritional metabolic disease during the perinatal period in dairy cows." | ( Cao, J; Dai, D; Fang, L; Liu, H; Ning, M; Wang, B; Yao, C; Zhang, Y; Zhao, Y, 2023) |
| Excerpt | Reference |
|---|
| "The hyperenzymemia in ketosis-affected animals, in animals with liver injuries as well as in cows subjected to starving or prednisolon treatment was substantiated by the higher activity of SGOT." | ( Vasilov, B, 1977) |
| "One cow on treatment 2 developed ketosis, but not fatty liver, after only 4 d of feed restriction." | ( Drackley, JK; Richard, MJ; Veenhuizen, JJ; Young, JW, 1991) |
| "Eight cows were treated for clinical ketosis." | ( Halse, K; Refsdal, AO; Ropstad, E, 1989) |
| "Treatment of ketosis resulted in complete recovery from impairments of metabolism in liver." | ( Beitz, DC; Mills, SE; Young, JW, 1986) |
| "Cows with ketonuria (from ++ up to + positive results with the nitroprusside tests) and hydroglycaemia (blood sugar up to 30 mg) were treated with monensine at the rate of 125 mg, in the morning and in the evening or with nicotinic acid at 3 g and the same frequency for 6-7 consecutive days." | ( Gabrovski, P; Goranov, Kh; Popgeorgieva, M; Zheliazkov, S, 1984) |
| "The treatment did not prevent clinical ketosis." | ( Miettinen, PV, 1995) |
| "In this study, treatment of ketosis in dairy cattle with a corticosteriod alone was less efficacious than treatment with glucose and a corticosteroid." | ( Avidar, Y; Bogin, E; Chen, R; Shpigel, NY, 1996) |
| "The duration of subclinical ketosis for cows that had been treated with monensin was also shorter than that for cows treated with the placebo." | ( Bagg, R; Dick, P; Duffield, TF; Leslie, KE; Lissemore, K; Lumsden, JH; McBride, BW; Sandals, D, 1998) |
| "A consistently strong ketosis (beta-hydroxybutyrate of >3 mmol/L) seemed to be important for maintaining the efficacy of the diet therapy." | ( Kang, du C; Kang, HC; Kim, HD; Ko, TS; Lee, HS; You, SJ, 2007) |
| "Cows in the ketosis-induction group were fed at 50% of day 4 intake until they developed signs of clinical ketosis, and cows in the control group were fed ad libitum throughout the treatment period." | ( Bionaz, M; Dann, HM; Drackley, JK; Everts, RE; Lewin, HA; Loor, JJ; Morin, DE; Oliveira, R; Rodriguez-Zas, SL, 2007) |
| "This article provides an update on ketosis treatment regimens." | ( Duffield, TF; Gordon, JL; Leblanc, SJ, 2013) |
| "Early induction of ketosis may be a novel strategy to effectively treat super-refractory status epilepticus." | ( Chan, OW; Hsia, SH; Lin, JJ; Lin, KL; Wang, HS, 2015) |
| "Treating ketosis with natural substances is preferable, because they are unlikely to cause side-effects." | ( Byun, HJ; Cho, KH; Darvin, P; Do, CH; Joung, YH; Kang, DY; Park, KD; Park, MN; S P, N; Yang, YM, 2017) |
| "The development of non-hyperglycemic ketoacidosis should be monitored following the discontinuation of SGLT2 inhibitors, especially in patients who start to feel unwell and exhibit protracted hyperglycosuria after the discontinuation of treatment." | ( Fukagawa, M; Miyauchi, M; Toyoda, M, 2017) |
| "In all patients, ketoacidosis receded on glucose infusion and renal replacement therapy." | ( Eisner, F; Eller, K; Eller, P; Lind, A; Mader, JK; Pieber, TR; Plank, J; Schilcher, G; Schwetz, V, 2017) |
| "Euglycaemic ketoacidosis has been reported after sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment." | ( Baek, SI; Choi, SH; Jang, HC; Kim, KM; Lee, DH; Lim, S; Min, SH; Moon, JH; Oh, TJ; Park, KS, 2018) |
| "This is a first report of ketonuria in a MS-patient with T1D treated with DMF." | ( Jarosz-Chobot, P; Krzystanek, E, 2018) |
| "Effect of treatment on ketonemia and prevalence of HYK were evaluated for 4 specific time periods: 1 to 3, 4 to 7, 8 to 17, and 18 to 26 DIM." | ( Chorfi, Y; Dubuc, J; Dufour, S; Krug, C; Lacasse, P; Morin, PA; Roy, JP; Santschi, DE, 2018) |
| "Hyperosmolar coma with ketoacidosis is a rare side-effect of diazoxide therapy, documented even in patients with persistent hyperinsulinemic hypoglycemia of infancy." | ( Bhatia, V; Ellard, S; Flanagan, SE; Hussain, K; Mangla, P, 2018) |
| "Therein, the level of ketosis must be regulated tightly to ensure an effective therapy." | ( Geidl, B; Gerber, PA; Güntner, AT; Kohler, M; Kompalla, JF; Landis, H; Pratsinis, SE; Sievi, NA; Theodore, SJ, 2018) |
| "The ketogenic diet (KD) induces ketosis and is an effective treatment for medically resistant epilepsy." | ( Campbell, H; Campbell, I, 2019) |
| "Nutritional ketosis, induced via either the classical ketogenic diet or the use of emulsified medium-chain triglycerides, is an established treatment for pharmaceutical resistant epilepsy in children and more recently in adults." | ( Berk, M; Carvalho, AF; Maes, M; Morris, G; Puri, BK, 2020) |
| "In ketogenic therapies, ketosis is achieved by either a ketogenic diet or by the administration of exogenous ketone bodies." | ( Doche, E; Guigonis, JM; Kotchetkov, P; Lindenthal, S; Osman, O; Pourcher, T; Suissa, L, 2021) |
| "Key Message: Ketoacidosis is a major feature of common clinical conditions to include diabetic ketoacidosis, alcoholic ketoacidosis, salicylate intoxication, SGLT2 inhibitor therapy, and calorie sufficient but carbohydrate-restricted diets." | ( Clegg, DJ; Palmer, BF, 2021) |
| "Treatment in HG cows decreased clinical ketosis, increased milk production in the fifth week of lactation for multiparous cows, and tended to increase 305-d mature-equivalent milk yield (305ME) for primiparous cows compared with untreated cows with the same metabolic profile." | ( Aldridge, BM; Canisso, IF; Coelho, WM; Hubner, AM; Lima, FS; Peixoto, PM; Ribeiro, L, 2022) |