Page last updated: 2024-08-05 14:41:36

allelochemical

A class of secondary metabolites developed by many plants to influence the behaviour, growth or survival of herbivores, and thus acting as a defence against herbivory.

ChEBI ID: 62215

Members (8)

MemberDefinitionClass
2-hydroxy-1,4-benzoxazin-3-oneA benzoxazine bearing hydroxy and oxo substituents at positions 2 and 3 respectively.HBOA
2,4-dihydroxy-1,4-benzoxazin-3-oneA lactol that consists of 1,4-benzoxazine bearing two hydroxy substituents at positions 2 and 4 as well as a keto group at position 3.DIBOA
2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-oneA lactol that is DIBOA in which the hydrogen at position 7 is replaced by a methoxy group. It has been isolated from the maize plants.DIMBOA
3-methylpentaneAn alkane that is pentane which is substituted by a methyl group at position 3. It is used as a solvent in organic synthesis, as a lubricant and as a raw material for producing carbon black.3-methylpentane
benzoxazoloneA member of the class of benzoxazoles that is 2,3-dihydro-1,3-benzoxazole carrying an oxo group at position 2.2-benzoxazolinone
catecholA benzenediol comprising of a benzene core carrying two hydroxy substituents ortho to each other.catechol
levodopaAn optically active form of dopa having L-configuration. Used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's diseaseL-dopa zwitterion; L-dopa
n-cinnamoyltyramineA member of the class of cinnamamides that is tyramine substituted by a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at the nitrogen atom. It is found in rice and exhibits an allelopathic effect to suppress the growth of weeds.N-trans-cinnamoyltyramine

Research

Studies (19,036)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19904,950 (26.00)18.7374
1990's3,380 (17.76)18.2507
2000's4,274 (22.45)29.6817
2010's4,787 (25.15)24.3611
2020's1,645 (8.64)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials1,906 (9.41%)5.53%
Reviews2,277 (11.24%)6.00%
Case Studies1,806 (8.91%)4.05%
Observational86 (0.42%)0.25%
Other14,187 (70.02%)84.16%

Protein Targets (177)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency14.501512
15-lipoxygenase, partialHomo sapiens (human)Potency27.829812
activating transcription factor 6Homo sapiens (human)Potency7.093512
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency15.954112
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency14.125411
AR proteinHomo sapiens (human)Potency15.1517711
aryl hydrocarbon receptorHomo sapiens (human)Potency45.615424
arylsulfatase AHomo sapiens (human)Potency37.933011
Ataxin-2Homo sapiens (human)Potency39.810711
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency14.646212
atrial natriuretic peptide receptor 1 precursorHomo sapiens (human)Potency23.934111
Bloom syndrome protein isoform 1Homo sapiens (human)Potency30.231633
Cellular tumor antigen p53Homo sapiens (human)Potency25.185312
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency13.357412
Chain A, ATP-DEPENDENT DNA HELICASE Q1Homo sapiens (human)Potency14.219112
Chain A, Beta-lactamaseEscherichia coli K-12Potency3.092912
Chain A, HADH2 proteinHomo sapiens (human)Potency6.702625
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency37.081413
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency21.886823
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency10.226912
Chain B, HADH2 proteinHomo sapiens (human)Potency6.702625
chromobox protein homolog 1Homo sapiens (human)Potency43.122224
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency10.000022
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency44.385112
D(1A) dopamine receptorSus scrofa (pig)Potency0.926811
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency31.622811
DNA polymerase betaHomo sapiens (human)Potency39.810711
DNA polymerase eta isoform 1Homo sapiens (human)Potency23.604723
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency32.574424
DNA polymerase kappa isoform 1Homo sapiens (human)Potency21.635116
dopamine D1 receptorHomo sapiens (human)Potency8.199511
endonuclease IVEscherichia coliPotency19.952611
estrogen nuclear receptor alphaHomo sapiens (human)Potency40.5569815
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency27.926235
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency29.4223715
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency6.503615
EWS/FLI fusion proteinHomo sapiens (human)Potency0.372211
farnesoid X nuclear receptorHomo sapiens (human)Potency22.387211
flap endonuclease 1Homo sapiens (human)Potency17.922436
GABA theta subunitRattus norvegicus (Norway rat)Potency10.000011
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency10.000011
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency10.000011
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency10.000011
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency10.000011
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency10.000011
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency10.000011
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency10.000011
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency10.000011
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency10.000011
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency10.000011
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency10.000011
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency10.000011
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency10.000011
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency10.000011
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency10.000011
gemininHomo sapiens (human)Potency3.851034
GLI family zinc finger 3Homo sapiens (human)Potency1.384423
GLS proteinHomo sapiens (human)Potency24.512925
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency29.099934
glucokinase regulatory proteinHomo sapiens (human)Potency5.011911
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency54.815412
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)Homo sapiens (human)Potency13.091811
heat shock protein beta-1Homo sapiens (human)Potency13.967911
hexokinase-4 isoform 1Homo sapiens (human)Potency5.011911
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency12.589312
Histone H2A.xCricetulus griseus (Chinese hamster)Potency34.946924
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency11.294724
IDH1Homo sapiens (human)Potency10.322511
importin subunit beta-1 isoform 1Homo sapiens (human)Potency56.234111
interleukin 8Homo sapiens (human)Potency74.978011
lamin isoform A-delta10Homo sapiens (human)Potency23.350722
lethal(3)malignant brain tumor-like protein 1 isoform IHomo sapiens (human)Potency17.782811
LuciferasePhotinus pyralis (common eastern firefly)Potency32.196811
M-phase phosphoprotein 8Homo sapiens (human)Potency37.877213
Microtubule-associated protein tauHomo sapiens (human)Potency7.769022
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency0.070811
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency100.000011
NFKB1 protein, partialHomo sapiens (human)Potency2.238722
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency115.821011
Nrf2Homo sapiens (human)Potency29.295322
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency33.604346
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency0.870811
Nuclear receptor ROR-gammaHomo sapiens (human)Potency5.955711
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency56.216736
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency44.668411
ParkinHomo sapiens (human)Potency20.596212
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency68.830323
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency3.219711
peripheral myelin protein 22 isoform 1Homo sapiens (human)Potency75.686311
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency34.753622
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency17.584511
phosphoglycerate kinaseTrypanosoma brucei brucei TREU927Potency16.663234
phosphopantetheinyl transferaseBacillus subtilisPotency87.772333
plasminogen precursorMus musculus (house mouse)Potency1.778311
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency12.589311
pregnane X nuclear receptorHomo sapiens (human)Potency21.954911
pyruvate kinaseLeishmania mexicana mexicanaPotency25.118922
RAR-related orphan receptor gammaMus musculus (house mouse)Potency18.531924
ras-related protein Rab-9AHomo sapiens (human)Potency73.078011
regulator of G-protein signaling 4Homo sapiens (human)Potency18.887611
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency50.927123
serine/threonine-protein kinase mTOR isoform 1Homo sapiens (human)Potency11.535633
snurportin-1Homo sapiens (human)Potency56.234111
survival motor neuron protein isoform dHomo sapiens (human)Potency12.589311
TDP1 proteinHomo sapiens (human)Potency29.092911
thioredoxin glutathione reductaseSchistosoma mansoniPotency15.848911
thioredoxin reductaseRattus norvegicus (Norway rat)Potency18.399737
ThrombopoietinHomo sapiens (human)Potency5.011922
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency40.688824
ubiquitin carboxyl-terminal hydrolase 2 isoform aHomo sapiens (human)Potency20.749111
urokinase plasminogen activator surface receptor precursorMus musculus (house mouse)Potency1.778311
urokinase-type plasminogen activator precursorMus musculus (house mouse)Potency1.778311
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency31.270211
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency0.003511
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency54.815412
WRNHomo sapiens (human)Potency5.497922

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
3-dehydroquinate synthaseEscherichia coli K-12Ki755.000022
Adenosine receptor A1Rattus norvegicus (Norway rat)Ki20.666733
Adenosine receptor A2aRattus norvegicus (Norway rat)Ki381.450022
Arginase-1Bos taurus (cattle)IC50123.000011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000011
Autoinducer 2-binding periplasmic protein LuxPVibrio harveyiIC5059.000011
Bile salt export pumpHomo sapiens (human)IC50133.000011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000011
Carbonic anhydraseDicentrarchus labrax (European seabass)Ki14.800011
Carbonic anhydrase 1Homo sapiens (human)IC505.790011
Carbonic anhydrase 1Homo sapiens (human)Ki1,418.87221027
Carbonic anhydrase 12Homo sapiens (human)Ki401.3500314
Carbonic anhydrase 13Mus musculus (house mouse)Ki401.8214314
Carbonic anhydrase 14Homo sapiens (human)Ki407.0643314
Carbonic anhydrase 15Mus musculus (house mouse)Ki10.200011
Carbonic anhydrase 2Homo sapiens (human)IC505.790011
Carbonic anhydrase 2Homo sapiens (human)Ki531.51701027
Carbonic anhydrase 3Bos taurus (cattle)IC505.790011
Carbonic anhydrase 3Bos taurus (cattle)Ki675.511736
Carbonic anhydrase 3Homo sapiens (human)Ki401.9357314
Carbonic anhydrase 4Homo sapiens (human)Ki596.8437724
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ki407.9500314
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Ki400.6786314
Carbonic anhydrase 6Homo sapiens (human)IC505.790011
Carbonic anhydrase 6Homo sapiens (human)Ki603.2875620
Carbonic anhydrase 7Homo sapiens (human)Ki502.0786314
Carbonic anhydrase 9Homo sapiens (human)Ki396.4067415
Cytochrome P450 1A2Homo sapiens (human)IC50370.000011
E3 ubiquitin-protein ligase Mdm2Homo sapiens (human)IC50100.000011
Epidermal growth factor receptorHomo sapiens (human)IC50309.641023
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)IC5066.893333
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)IC50100.000011
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)IC500.680011
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)IC50100.000011
Glutaminyl-peptide cyclotransferaseHomo sapiens (human)IC505.000011
integrase, partialHuman immunodeficiency virus 1IC500.593922
Large neutral amino acids transporter small subunit 1Homo sapiens (human)IC50100.000011
lens epithelium-derived growth factor p75Homo sapiens (human)IC500.593922
Matrix metalloproteinase-9Homo sapiens (human)IC5023.367011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)IC5033.000011
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)IC501.563012
Prolyl 4-hydroxylase subunit alpha-1Gallus gallus (chicken)Ki25.000011
Solute carrier family 15 member 1Homo sapiens (human)IC50141,200.000011
TyrosinaseHomo sapiens (human)IC508,400.000011
Tyrosine-protein kinase FynHomo sapiens (human)IC509.788512
Tyrosine-protein kinase LckHomo sapiens (human)IC503.729011
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitHomo sapiens (human)IC5011.900011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain A, Neutrophil gelatinase-associated lipocalinHomo sapiens (human)Kd0.000411

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
3-dehydroquinate synthaseEscherichia coli K-12Km17.000022
Adenosine receptor A1Rattus norvegicus (Norway rat)KA11.400011
Adenosine receptor A2aRattus norvegicus (Norway rat)KA11.400012
Carbonic anhydraseCandida albicans SC5314KA0.960011
Carbonic anhydraseMethanosarcina thermophilaKA39.000011
Carbonic anhydraseMethanothermobacter thermautotrophicus str. Delta HKa11.400011
Carbonic anhydraseSaccharomyces cerevisiae S288CKa90.000022
Carbonic anhydrase Cryptococcus neoformans var. grubiiKA43.300011
Carbonic anhydrase Nakaseomyces glabratus CBS 138Ka23.300011
Carbonic anhydrase 1Homo sapiens (human)KA3.10001111
Carbonic anhydrase 12Homo sapiens (human)KA1.670011
Carbonic anhydrase 13Mus musculus (house mouse)KA43.000011
Carbonic anhydrase 14Homo sapiens (human)KA12.100011
Carbonic anhydrase 15Mus musculus (house mouse)KA6.500011
Carbonic anhydrase 2Homo sapiens (human)Ka11.40001313
Carbonic anhydrase 3Homo sapiens (human)KA13.500022
Carbonic anhydrase 4Homo sapiens (human)KA15.300022
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)KA0.036011
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)KA0.063011
Carbonic anhydrase 6Homo sapiens (human)KA18.000022
Carbonic anhydrase 7Homo sapiens (human)KA58.300011
Carbonic anhydrase 9Homo sapiens (human)KA51.300011
Carbonic anhydrase-like protein, putativeTrypanosoma cruzi strain CL BrenerKA0.830011
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)KA58.300011
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)KA58.300011
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)KA58.300011
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)KA58.300011
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)KA58.300011
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)KA58.300011
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)KA58.300011
Monocarboxylate transporter 10Rattus norvegicus (Norway rat)Km6,430.000011
Plasma kallikreinHomo sapiens (human)KA0.063011
Polyphenol oxidase 2Agaricus bisporusKm860.000011
Potassium-transporting ATPase alpha chain 1Sus scrofa (pig)Km16.000011
Potassium-transporting ATPase subunit betaSus scrofa (pig)Km16.000011
SLC16A10 proteinHomo sapiens (human)Km1,212.500011