Encephalitis, Herpes Simplex

An acute (or rarely chronic) inflammatory process of the brain caused by SIMPLEXVIRUS infections which may be fatal. The majority of infections are caused by human herpesvirus 1 (HERPESVIRUS 1, HUMAN) and less often by human herpesvirus 2 (HERPESVIRUS 2, HUMAN). Clinical manifestations include FEVER; HEADACHE; SEIZURES; HALLUCINATIONS; behavioral alterations; APHASIA; hemiparesis; and COMA. Pathologically, the condition is marked by a hemorrhagic necrosis involving the medial and inferior TEMPORAL LOBE and orbital regions of the FRONTAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, pp751-4)

Synonym
Encephalitis, Herpes Simplex

Excerpt	Reference
"Herpes simplex encephalitis is the most common identified cause of sporadic viral encephalitis in the United States."	( Tyler, KL, 2004)
"Herpes simplex encephalitis is a devastating disease."	( Blomqvist, P; Brytting, M; Forsgren, M; Granath, F; Hjalmarsson, A; Sköldenberg, B, 2009)
"Herpes simplex encephalitis is a diagnostic challenge and causes high morbidity and mortality in children."	( Cofré, J; Farfán, M; Izquierdo, G; Torres, JP; Venegas, G; Vergara, A, 2012)
"Herpes simplex encephalitis is associated with substantial morbidity and mortality and may be related to timely diagnosis and treatment."	( Bitnun, A; Kulik, DM; Mekky, M; Parkin, PC; Yang, M, 2012)
"Herpes simplex encephalitis is rarely caused by herpes simplex virus type 2 (HSV-2) after the neonatal period."	( Au, S; Bojanova, M; Fernandez-Gerlinger, M; Greffe, S; Grenet, J; Meffre, A; Rouveix, E; Rozenberg, F, 2015)
"Herpes simplex encephalitis is a severe neurological condition, whose outcome is improved if treated early with acyclovir."	( Benrhouma, H; Gouider-Khouja, N; Klaa, H; Kraoua, I; Nasri, A; Turki, I, 2015)
"Herpes simplex encephalitis is uncommon in children and has a severe course (especially in vertically infected infants)."	( Czupryna, P; Krawczuk, K; Moniuszko-Malinowska, A; Ołdak, E; Pancewicz, S, 2019)
"Herpes simplex encephalitis is the most common cause of sporadic viral encephalitis worldwide but presents as a diagnostic challenge at many settings due to its non-specific symptoms, which can be easily mistaken for systemic infection or metabolic encephalopathy."	( Bhalla, A; Divyashree, K; Singh, H; Suri, V, 2023)

Excerpt	Reference
"The role of acyclovir for the treatment of herpes simplex encephalitis has been well documented, but the role of surgical decompression for herpes simplex encephalitis has only rarely been mentioned."	( Yan, HJ, 2002)
"The recommended treatment for herpes simplex encephalitis (HSE) remains intravenous acyclovir."	( Chau, TT; Farrar, J; Hien, TT; Lindegardh, N; Pouplin, JN; Pouplin, T; Rogier van Doorn, H; Török, ME; Van Toi, P, 2011)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	6 (1.37)	23.3326
1990's	8 (1.83)	12.5806
2000's	175 (39.95)	18.1394
2010's	196 (44.75)	28.8240
2020's	53 (12.10)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
chlorine	low	1	0
kynurenine	low	1	0
pk 11195	low	3	0
pleconaril	low	1	0
phenytoin	low	4	0
aspirin	low	1	0
azathioprine	low	1	0
bisindolylmaleimide i	low	1	0
carbamazepine	low	5	0
clobazam	low	1	0
clonazepam	low	2	0
clonidine	low	2	0
diazepam	low	1	0
valproic acid	low	3	0
fluorouracil	low	2	0
foscarnet	low	10	0
haloperidol	low	1	0
iofetamine	low	1	0
kinetin	low	2	0
lamotrigine	low	1	0
mexiletine	low	1	0
olomoucine	low	2	0
phenobarbital	low	2	0
piracetam	low	2	0
procarbazine	low	1	0
propofol	low	1	0
propranolol	low	1	0
risperidone	low	2	0
ropinirole	low	1	0
s-methylisothiopseudouronium	low	1	0
sb 202190	low	1	0
sevoflurane	low	1	0
sulforaphane	low	1	0
sumatriptan	low	1	0
temozolomide	low	2	0
trihexyphenidyl	low	1	0
vigabatrin	low	1	0
corticosterone	low	3	0
prednisolone	low	7	0
prednisone	low	3	0
penicillin g	low	2	0
idoxuridine	low	1	0
chloramphenicol	low	1	0
levodopa	low	1	0
mannitol	low	2	0
cytarabine	low	1	0
valine	medium	11	2
tryptophan	low	1	0
methylprednisolone	low	16	0
indazoles	low	1	0
oxazoles	low	1	0
thiazoles	low	1	0
pyrazines	low	1	0
betamethasone	low	1	0
kainic acid	low	1	0
vancomycin	low	2	0
glycyrrhizic acid	low	1	0
d-alpha tocopherol	low	1	0
methylprednisolone hemisuccinate	low	1	0
vidarabine	low	5	0
n-methylaspartate	low	1	0
gadolinium	low	1	0
daunorubicin	low	1	0
isothiuronium	low	1	0
4-methoxyamphetamine	low	1	0
glutamic acid	low	1	0
amoxicillin	low	1	0
etoposide	low	1	0
epirubicin	low	1	0
captopril	low	1	0
lamivudine	low	1	0
glucose, (beta-d)-isomer	low	1	0
cephalosporin c	low	1	0
fluorodeoxyglucose f18	low	3	0
corilagin	low	1	0
atovaquone	low	1	0
d-aspartic acid	low	1	0
8-((4-chlorophenyl)thio)cyclic-3',5'-amp	low	1	0
artesunic acid	low	1	0
fingolimod hydrochloride	low	1	0
deoxyglucose	low	1	0
methotrexate	low	4	0
carbapenems	low	1	0
darunavir	low	1	0
bortezomib	low	1	0
ritonavir	low	1	0
bradykinin	low	1	0
nitroarginine	low	1	0
abacavir	low	1	0
clindamycin	low	1	0
h 89	low	1	0
bay 57-1293	low	1	0
dimethyl fumarate	low	1	0
glycosides	low	1	0
arginine vasopressin	low	1	0
mercaptopurine	low	1	0
thiopental	low	1	0
u 0126	low	1	0
myelin basic protein	low	1	0
sphingosine	low	1	0
dinoprostone	low	1	0
dinoprost	low	1	0
8-epi-prostaglandin f2alpha	low	1	0
isotretinoin	low	1	0
phenylephrine hydrochloride	low	2	0
levetiracetam	low	2	0
sirolimus	low	1	0
kaempferol 3-o-rhamnoside	low	1	0
cysteine	low	2	0
cefotaxime	low	1	0
proguanil	low	1	0
rilpivirine	low	1	0
6 beta-hydroxycortisol	low	1	0
gadolinium dtpa	low	2	0
rmp 7	low	1	0
tofacitinib	low	1	0
pazopanib	low	1	0
oxadiazoles	low	1	0
pituitrin	low	2	0
rifamycins	low	1	0
cytochrome c-t	low	1	0
dynorphins	low	1	0
bucladesine	low	1	0
ro13-9904	low	2	0
piperidines	low	1	0
natriuretic peptide, brain	low	1	0
ascorbic acid	low	1	0
oxytetracycline, anhydrous	low	1	0
warfarin	low	3	0
transforming growth factor beta	low	2	0
cyclin d1	low	1	0
amyloid beta-peptides	low	1	0
acyclovir	medium	326	5
guanine	low	1	0
neopterin	low	1	0
rifampin	low	1	0
dacarbazine	low	2	0
ganciclovir	low	7	0
valacyclovir	medium	13	2
allopurinol	low	1	0
valganciclovir	low	1	0
9-(4-hydroxybutyl)guanine	low	1	0
eye	low	2	0
ego	low	1	0
technetium tc 99m bicisate	low	2	0

Protein Targets (1,905)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	7	1	9
5-hydroxytryptamine receptor 2A	0	8	1	9
5-hydroxytryptamine receptor 1A	0	15	5	21
5-hydroxytryptamine receptor 1B	0	10	1	11
5-hydroxytryptamine receptor 1D	0	3	2	5
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 2B	0	5	1	6
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	5	1	6
Sodium-dependent serotonin transporter	0	3	0	3
5-hydroxytryptamine receptor 7	0	2	1	3
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	1	1	2
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	1	2
ATAD5 protein, partial	13	0	0	13
euchromatic histone-lysine N-methyltransferase 2	45	0	0	45
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
geminin	43	0	0	43
ATP-dependent phosphofructokinase	19	0	0	19
interleukin 8	9	0	0	9
RAR-related orphan receptor gamma	22	0	0	22
AR protein	50	0	0	50
aldehyde dehydrogenase 1 family, member A1	26	0	0	26
estrogen receptor 2 (ER beta)	15	0	0	15
nuclear receptor subfamily 1, group I, member 3	24	0	0	24
progesterone receptor	23	0	0	23
glucocorticoid receptor [Homo sapiens]	39	0	0	39
estrogen-related nuclear receptor alpha	47	0	0	47
farnesoid X nuclear receptor	21	0	0	21
estrogen nuclear receptor alpha	51	0	0	51
peroxisome proliferator activated receptor gamma	23	0	0	23
aryl hydrocarbon receptor	14	0	0	14
survival motor neuron protein isoform d	15	0	0	15
Cellular tumor antigen p53	31	0	0	31
Nuclear receptor ROR-gamma	7	0	0	7
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Thymidine kinase	0	4	0	4
Thymidine kinase, cytosolic	0	3	0	5
Thymidine kinase	0	1	0	1
Thymidine kinase	0	2	0	2
Thymidine kinase	0	2	0	2
Luciferase	11	0	0	11
cytochrome P450 family 3 subfamily A polypeptide 4	24	0	0	24
cytochrome P450 2D6	19	0	0	19
peripheral myelin protein 22	17	0	0	17
Albumin	0	0	8	11
ATP-dependent translocase ABCB1	0	11	0	16
Replicase polyprotein 1ab	0	2	0	2
Replicase polyprotein 1ab	0	3	0	3
Reverse transcriptase/RNaseH	0	4	4	8
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	7	0	9
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	11	0	0	11
Chain B, HADH2 protein	11	0	0	11
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
Chain A, Ferritin light chain	16	0	0	16
thioredoxin reductase	25	0	0	25
phosphopantetheinyl transferase	19	0	0	19
GLS protein	16	0	0	16
TDP1 protein	45	0	0	45
Smad3	5	0	0	5
thyroid stimulating hormone receptor	20	0	0	20
EWS/FLI fusion protein	26	0	0	26
arylsulfatase A	18	0	0	18
activating transcription factor 6	15	0	0	15
Histone H2A.x	11	0	0	11
Bloom syndrome protein isoform 1	23	0	0	23
hemoglobin subunit beta	5	0	0	5
atrial natriuretic peptide receptor 1 precursor	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
lamin isoform A-delta10	32	0	0	32
Solute carrier family 22 member 1	0	7	0	13
ATP-binding cassette sub-family C member 3	0	38	0	38
Multidrug resistance-associated protein 4	0	38	0	40
Solute carrier family 22 member 6	0	3	0	4
Bile salt export pump	0	9	0	9
Bile salt export pump	0	46	0	46
Purine nucleoside phosphorylase	0	3	0	3
POU domain, class 2, transcription factor 2	0	0	0	2
Cytochrome P450 2C9	0	15	0	15
Cytochrome P450 2J2	0	7	0	7
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	4	4
Solute carrier family 22 member 6	0	1	0	6
Solute carrier family 22 member 8	0	2	0	7
Canalicular multispecific organic anion transporter 1	0	38	0	39
Thymidine kinase	0	2	0	2
IDH1	16	0	0	16
transcriptional regulator ERG isoform 3	9	0	0	9
thyroid hormone receptor beta isoform 2	25	0	0	25
ras-related protein Rab-9A	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	28	0	0	28
Polyphenol oxidase 2	0	3	0	4
Voltage-dependent calcium channel gamma-2 subunit	18	0	0	18
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	3
Glutamate receptor 2	18	5	2	25
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	2	2	4
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
TAR DNA-binding protein 43	10	0	0	10
Shiga toxin subunit A	0	2	0	2
Histamine H3 receptor	0	1	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	21	0	0	21
Chain A, Beta-lactamase	12	0	0	12
Chain A, 2-oxoglutarate Oxygenase	17	0	0	17
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
apical membrane antigen 1, AMA1	5	0	0	5
Beta-lactamase	0	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	8	0	0	8
DNA polymerase eta isoform 1	7	0	0	7
DNA polymerase iota isoform a (long)	20	0	0	20
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
urokinase plasminogen activator surface receptor precursor	7	0	0	7
DNA polymerase kappa isoform 1	9	0	0	9
Beta-lactamase SHV-1	0	0	0	3
Beta-lactamase SHV-1	0	0	0	3
Beta-lactamase	0	0	0	3
Kappa-type opioid receptor	0	1	0	4
Solute carrier family 15 member 1	0	6	0	7
Solute carrier family 15 member 1	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
vitamin D3 receptor isoform VDRA	12	0	0	12
Translocator protein	0	3	3	7
Vasopressin V2 receptor	0	2	1	4
Oxytocin receptor	0	1	1	2
Vasopressin V1a receptor	0	0	2	2
Vasopressin V1a receptor	0	4	2	6
Vasopressin V1b receptor	0	1	1	2
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	1	1	3
Translocator protein	0	1	0	2
Oxytocin receptor	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	13	0	0	13
GLI family zinc finger 3	29	0	0	29
thioredoxin glutathione reductase	8	0	0	8
retinoic acid nuclear receptor alpha variant 1	31	0	0	31
vitamin D (1,25- dihydroxyvitamin D3) receptor	18	0	0	18
chromobox protein homolog 1	19	0	0	19
nuclear factor erythroid 2-related factor 2 isoform 2	14	0	0	14
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
lethal factor (plasmid)	8	0	0	8
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Alpha-2B adrenergic receptor	0	8	3	12
Spike glycoprotein	17	0	0	17
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	14	0	0	14
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	1	0	0	1
glucocerebrosidase	5	0	0	5
peroxisome proliferator-activated receptor delta	16	0	0	16
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	9	0	0	9
muscarinic acetylcholine receptor M1	12	0	0	12
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Epidermal growth factor receptor	0	6	4	10
Carbonic anhydrase 1	0	7	0	12
Carbonic anhydrase 2	0	9	1	14
Fatty acid-binding protein, liver	0	3	0	3
Integrin beta-3	6	1	1	8
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	6	1	1	8
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	6	0	6
Adenosine receptor A1	0	2	0	3
Adenosine receptor A2a	0	1	1	3
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	5	2	7
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	10	12	5	27
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	7	1	8
Sigma non-opioid intracellular receptor 1	0	3	1	4
SMAD family member 2	5	0	0	5
USP1 protein, partial	16	0	0	16
SMAD family member 3	5	0	0	5
Microtubule-associated protein tau	20	0	0	20
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	12	0	0	12
retinoid X nuclear receptor alpha	18	0	0	18
pregnane X nuclear receptor	31	0	0	31
v-jun sarcoma virus 17 oncogene homolog (avian)	12	0	0	12
Dihydroorotate dehydrogenase	0	1	0	1
cellular tumor antigen p53 isoform a	9	0	0	9
cytochrome P450 2C9 precursor	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	11	0	0	11
heat shock protein beta-1	9	0	0	9
nuclear receptor ROR-gamma isoform 1	9	0	0	9
Vpr	5	0	0	5
histone acetyltransferase KAT2A isoform 1	16	0	0	16
Cytochrome b	0	1	0	1
Dihydroorotate dehydrogenase (fumarate)	0	1	0	1
Histamine H2 receptor	9	0	0	10
Guanine nucleotide-binding protein G	3	0	0	3
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	2
Dihydroorotate dehydrogenase	0	2	0	2
Dihydroorotate dehydrogenase (quinone), mitochondrial	0	1	0	2
glp-1 receptor, partial	10	0	0	10
pregnane X receptor	6	0	0	6
Fumarate hydratase	10	0	0	10
NFKB1 protein, partial	6	0	0	6
PPM1D protein	8	0	0	8
Thrombopoietin	6	0	0	6
polyprotein	10	0	0	10
67.9K protein	10	0	0	10
Parkin	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	22	0	0	22
thyroid stimulating hormone receptor	17	0	0	17
peripheral myelin protein 22 isoform 1	13	0	0	13
huntingtin isoform 2	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	7	0	0	7
Interferon beta	22	0	0	22
Adenosine receptor A3	0	4	1	5
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
D(1A) dopamine receptor	3	1	0	4
Multidrug and toxin extrusion protein 1	0	5	0	5
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
ATPase family AAA domain-containing protein 5	17	0	0	17
Ataxin-2	21	0	0	21
G	15	0	0	15
P53	1	0	0	1
cytochrome P450 3A4 isoform 1	10	0	0	10
M-phase phosphoprotein 8	7	0	0	7
muscleblind-like protein 1 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	10	11	4	25
HLA class I histocompatibility antigen, B alpha chain	15	0	0	15
Gamma-aminobutyric acid receptor subunit beta-1	10	11	4	25
Gamma-aminobutyric acid receptor subunit delta	10	11	4	25
Gamma-aminobutyric acid receptor subunit gamma-2	10	11	5	26
Gamma-aminobutyric acid receptor subunit alpha-5	10	11	4	25
Gamma-aminobutyric acid receptor subunit alpha-3	10	11	4	25
Gamma-aminobutyric acid receptor subunit gamma-1	10	11	4	25
Gamma-aminobutyric acid receptor subunit alpha-2	10	11	4	25
Gamma-aminobutyric acid receptor subunit alpha-4	10	11	4	25
Gamma-aminobutyric acid receptor subunit gamma-3	10	11	4	25
Gamma-aminobutyric acid receptor subunit alpha-6	10	11	4	25
Gamma-aminobutyric acid receptor subunit beta-3	10	11	4	25
Gamma-aminobutyric acid receptor subunit beta-2	10	11	5	26
GABA theta subunit	10	11	4	25
Inositol hexakisphosphate kinase 1	15	0	0	15
Gamma-aminobutyric acid receptor subunit epsilon	10	11	4	25
Protein-arginine deiminase type-4	0	3	0	3
cytochrome P450 2C9, partial	15	0	0	15
Carbonic anhydrase 12	0	3	0	6
Cytochrome P450 1A2	0	5	0	5
Cytochrome P450 3A4	0	16	1	19
Cytochrome P450 2C8	0	3	0	3
Cytochrome P450 2D6	0	10	0	10
Cytochrome P450 2A6	0	3	0	3
Cytochrome P450 2B6	0	1	2	3
Cytochrome P450 2C19	0	7	0	7
Carbonic anhydrase 5A, mitochondrial	0	3	0	6
Potassium voltage-gated channel subfamily H member 2	0	14	0	14
Carbonic anhydrase 9	0	5	0	8
Carbonic anhydrase 5B, mitochondrial	0	2	0	5
nuclear receptor subfamily 1, group I, member 2	7	0	0	7
thyroid hormone receptor beta isoform a	12	0	0	12
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	8	2	15
Glycine receptor subunit alpha-1	0	8	0	8
Glycine receptor subunit beta	0	8	0	8
Glycine receptor subunit alpha-2	0	8	0	8
Glycine receptor subunit alpha-3	0	8	0	8
ORF73	0	0	1	1
Chain A, Protein kinase C, iota	0	1	0	1
regulator of G-protein signaling 4	12	0	0	12
mitogen-activated protein kinase 1	11	0	0	11
3-phosphoinositide-dependent protein kinase 1	0	1	3	4
G2/mitotic-specific cyclin-B2	0	2	0	3
G1/S-specific cyclin-E2	0	2	0	3
cAMP-dependent protein kinase catalytic subunit alpha	0	3	0	3
Protein kinase C gamma type	0	2	0	2
Protein kinase C beta type	0	2	3	5
Cyclin-dependent kinase 1	0	3	3	7
Serine/threonine-protein kinase pim-1	0	1	5	6
Cyclin-dependent kinase 4	0	2	3	5
G2/mitotic-specific cyclin-B1	0	3	0	4
Insulin receptor	0	1	0	1
Lethal factor	0	1	0	1
Protein kinase C alpha type	0	3	3	6
cAMP-dependent protein kinase catalytic subunit alpha	0	4	4	8
Glycogen synthase kinase-3 beta	0	1	0	1
Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform	0	1	0	1
cAMP-dependent protein kinase catalytic subunit gamma	0	3	2	5
cAMP-dependent protein kinase catalytic subunit beta	0	3	4	7
G1/S-specific cyclin-D1	0	2	0	2
Protein kinase C eta type	0	2	3	5
G1/S-specific cyclin-E1	0	2	0	3
Cyclin-dependent kinase 2	0	4	5	10
cAMP-dependent protein kinase catalytic subunit alpha	0	2	0	2
Protein kinase C iota type	0	2	3	5
Glycogen synthase kinase-3 beta	0	3	4	7
MO15-related protein kinase Pfmrk	0	3	0	3
Protein kinase C epsilon type	0	2	3	5
Protein kinase C theta type	0	2	4	6
Protein kinase C zeta type	0	2	1	3
Protein kinase C delta type	0	2	4	6
Peroxisome proliferator-activated receptor alpha	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	2	0	2
G2/mitotic-specific cyclin-B3	0	2	0	3
NAD-dependent protein deacetylase sirtuin-1	0	2	0	2
Serine/threonine-protein kinase LMTK3	0	1	0	1
Chain H, Proteasome component PUP1	0	1	0	1
Chain I, Proteasome component PUP3	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Chain K, Proteasome component PRE2	0	1	0	1
Chain L, Proteasome component C5	0	1	0	1
Proteasome subunit beta type-11	0	1	0	1
caspase 7, apoptosis-related cysteine protease	5	0	0	5
caspase-3	5	0	0	5
Caspase-7	4	0	0	4
caspase-3	4	0	0	4
26S proteasome non-ATPase regulatory subunit 11	0	1	0	1
26S proteasome non-ATPase regulatory subunit 12	0	1	0	1
26S proteasome non-ATPase regulatory subunit 14	0	1	0	1
Proteasome subunit alpha type-7	0	1	0	1
Histone deacetylase 3	0	4	0	4
26S proteasome non-ATPase regulatory subunit 3	0	1	0	1
Prothrombin	0	2	1	4
Chymotrypsinogen A	0	1	0	1
Carbonic anhydrase 3	0	1	0	4
Cathepsin B	0	1	0	1
Neutrophil elastase	0	1	0	1
Cathepsin G	0	2	0	2
Lysosomal protective protein	0	1	0	1
Chymotrypsinogen B	0	2	0	2
26S proteasome regulatory subunit 6A	0	1	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Proteasome subunit beta type-1	0	1	0	2
Carbonic anhydrase 4	0	3	0	6
Carbonic anhydrase 6	0	1	0	4
Chymase	0	1	0	1
Proteasome subunit alpha type-1	0	1	0	1
Proteasome subunit alpha type-2	0	1	0	1
Proteasome subunit alpha type-3	0	1	0	1
Proteasome subunit alpha type-4	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-8	0	1	0	1
Proteasome subunit beta type-9	0	1	0	1
Proteasome subunit alpha type-5	0	1	0	1
Proteasome subunit beta type-4	0	1	0	1
Proteasome subunit beta type-6	0	1	0	1
Proteasome subunit beta type-5	0	2	0	3
26S proteasome regulatory subunit 7	0	1	0	1
Lon protease homolog, mitochondrial	0	1	0	1
Proteasome subunit beta type-10	0	1	0	1
Carbonic anhydrase 7	0	1	0	4
26S proteasome regulatory subunit 6B	0	1	3	4
26S proteasome non-ATPase regulatory subunit 8	0	1	0	1
Proteasome subunit beta type-3	0	1	0	1
Proteasome subunit beta type-2	0	1	0	2
26S proteasome non-ATPase regulatory subunit 7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 4	0	1	0	1
26S proteasome complex subunit SEM1	0	1	0	1
Proteasome subunit alpha type-6	0	1	0	1
26S proteasome regulatory subunit 4	0	1	0	1
26S proteasome regulatory subunit 8	0	1	0	1
26S proteasome regulatory subunit 10B	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
26S proteasome non-ATPase regulatory subunit 2	0	1	0	1
Histone deacetylase 1	0	5	0	5
26S proteasome non-ATPase regulatory subunit 6	0	1	0	1
Proteasomal ubiquitin receptor ADRM1	0	1	0	1
ATP-dependent Clp protease proteolytic subunit	0	1	1	2
Carbonic anhydrase 13	0	1	0	1
NACHT, LRR and PYD domains-containing protein 3	0	1	0	1
Proteasome subunit alpha-type 8	0	1	0	1
Histone deacetylase 2	0	4	0	4
Proteasome subunit beta type-7	0	1	0	1
26S proteasome non-ATPase regulatory subunit 1	0	1	0	1
Carbonic anhydrase 15	0	2	0	4
Histone deacetylase 8	0	5	0	5
Histone deacetylase 6	0	5	0	5
Carbonic anhydrase 14	0	1	0	4
26S proteasome non-ATPase regulatory subunit 13	0	1	0	1
Angiotensin-converting enzyme	0	3	1	5
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	3	1	6
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	1	1	2
vasopressin V1b receptor	1	0	0	1
cAMP-dependent protein kinase type I-alpha regulatory subunit	0	0	1	1
cAMP-dependent protein kinase type II-beta regulatory subunit	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta isoform 1	0	0	1	1
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
neuropeptide S receptor isoform A	4	0	0	4
cAMP-dependent protein kinase catalytic subunit beta isoform 3	0	0	1	1
Chain A, angiotensin converting enzyme	0	1	0	1
Chain A, angiotensin converting enzyme	0	1	0	1
15-lipoxygenase, partial	9	0	0	9
Metallo-beta-lactamase type 2	0	1	1	4
transient receptor potential cation channel subfamily V member 1	2	0	0	2
Renin	0	1	0	1
Neprilysin	0	1	0	1
Neprilysin	0	1	0	1
Leukotriene A-4 hydrolase	0	2	1	3
EEF1AKMT4-ECE2 readthrough transcript protein	0	1	0	1
Angiotensin-converting enzyme	0	5	0	6
Leukotriene A-4 hydrolase	0	1	0	1
Thymidine phosphorylase	0	0	1	2
Endothelin-converting enzyme 1	0	1	0	1
Succinyl-diaminopimelate desuccinylase	0	2	0	2
Angiotensin-converting enzyme	0	2	0	2
Beta-lactamase TEM	0	2	0	3
Mu-type opioid receptor	0	1	1	2
Beta-lactamase	0	2	0	3
Beta-lactamase	0	2	0	2
Angiotensin-converting enzyme 2	0	1	0	1
Beta-lactamase class B VIM-2	0	1	1	4
Albumin	0	0	5	5
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	4	0	4
Sodium channel protein type 3 subunit alpha	0	3	0	3
UDP-glucuronosyltransferase 2B7	0	2	0	6
Sodium channel protein type 4 subunit alpha	0	5	0	8
Sodium channel protein type 9 subunit alpha	0	7	0	7
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	2
Solute carrier family 22 member 7	0	1	0	3
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	2
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Solute carrier family 22 member 11	0	1	0	4
Solute carrier family 22 member 8	0	2	0	3
Beta-lactamase VIM-1	0	0	0	2
Solute carrier family 22 member 7	0	1	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
streptokinase A precursor	0	0	3	3
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Carbonic anhydrase	0	1	0	3
Gamma-aminobutyric acid receptor subunit pi	0	6	0	6
Gamma-aminobutyric acid receptor subunit delta	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	5
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	5
Neuronal acetylcholine receptor subunit alpha-4	2	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	5
Neuronal acetylcholine receptor subunit beta-2	2	2	0	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	7	4	11
Gamma-aminobutyric acid receptor subunit beta-1	0	6	2	8
Gamma-aminobutyric acid receptor subunit gamma-2	0	7	3	10
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	5
Gamma-aminobutyric acid receptor subunit beta-3	0	7	3	10
Translocator protein	0	2	0	2
Translocator protein	0	4	1	6
Cholecystokinin receptor type A	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	6	4	10
Gamma-aminobutyric acid receptor subunit alpha-3	0	6	3	9
Gamma-aminobutyric acid receptor subunit alpha-2	0	6	3	9
Gamma-aminobutyric acid receptor subunit beta-2	0	6	3	9
Gamma-aminobutyric acid receptor subunit alpha-4	0	6	2	8
Gamma-aminobutyric acid receptor subunit epsilon	0	6	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	0	6	2	8
Gamma-aminobutyric acid receptor subunit gamma-1	0	6	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	0	6	0	6
Gamma-aminobutyric acid receptor subunit theta	0	6	0	6
Chain A, Cruzipain	6	0	0	6
Beta-1 adrenergic receptor	0	1	2	4
Alpha-1B adrenergic receptor	0	0	1	1
cytochrome P450 2D6 isoform 1	8	0	0	8
cytochrome P450 2C19 precursor	6	0	0	6
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Solute carrier family 22 member 3	0	4	0	4
5-hydroxytryptamine receptor 1A	0	8	3	11
Alpha-2A adrenergic receptor	0	8	3	12
Alpha-1B adrenergic receptor	0	11	1	12
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-2C adrenergic receptor	0	7	3	11
D	0	4	0	4
D(3) dopamine receptor	0	6	0	6
Alpha-2B adrenergic receptor	0	5	1	6
Amine oxidase [flavin-containing] A	0	1	0	1
Alpha-2C adrenergic receptor	0	5	1	6
Alpha-2A adrenergic receptor	0	5	1	6
Alpha-1D adrenergic receptor	0	9	1	10
Alpha-1D adrenergic receptor	0	6	2	9
D(1B) dopamine receptor	0	3	0	3
Amine oxidase [flavin-containing] B	0	1	0	1
Adenosine receptor A2b	0	0	1	1
Alpha-2B adrenergic receptor	0	0	0	1
D(4) dopamine receptor	0	3	0	3
Delta-type opioid receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	6	3	10
Alpha-1B adrenergic receptor	0	3	2	6
Alpha-1A adrenergic receptor	0	11	2	13
5-hydroxytryptamine receptor 7	0	3	0	3
D(2) dopamine receptor	0	7	0	7
Inositol monophosphatase 1	5	0	0	5
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Nischarin	0	2	0	2
Solute carrier family 22 member 1	0	3	0	3
Nischarin	0	1	0	1
Protein kinase C alpha type	0	3	0	3
Protein kinase C delta type	0	3	0	3
Protein kinase C epsilon type	0	3	0	3
Protein kinase C zeta type	0	3	0	3
DNA topoisomerase 1	0	2	0	3
DNA repair protein RAD52 homolog	0	1	0	1
Squalene monooxygenase	0	1	0	1
Protein kinase C gamma type	0	3	0	3
Protein kinase C beta type	0	3	0	3
Protein kinase C eta type	0	3	0	3
RNA-directed RNA polymerase	0	2	1	3
Protein kinase C theta type	0	3	0	3
GALC protein	3	0	0	3
nonstructural protein 1	4	0	0	4
Solute carrier family 22 member 2	0	3	0	5
Solute carrier family 22 member 3	0	1	0	1
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	2	0	2
Mineralocorticoid receptor	0	2	2	4
Androgen receptor	0	4	0	4
C-8 sterol isomerase	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	2	0	2
Solute carrier family 22 member 2	0	2	0	2
endonuclease IV	9	0	0	9
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidylate synthase	0	3	0	4
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	3	4
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
importin subunit beta-1 isoform 1	8	0	0	8
snurportin-1	8	0	0	8
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Metabotropic glutamate receptor 6	0	1	3	5
Glutamate transporter homolog	0	0	1	1
Excitatory amino acid transporter 1	0	3	0	4
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
Matrix metalloproteinase-9	0	1	0	1
Isocitrate lyase	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
Chain A, Pol Polyprotein	0	1	0	1
Chain B, Pol Polyprotein	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, protease	0	1	0	1
Chain B, protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease (Retropepsin)	0	0	1	1
Chain B, Protease (Retropepsin)	0	0	1	1
Chain A, Protease (Retropepsin)	0	0	1	1
Chain B, Protease (Retropepsin)	0	0	1	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, HIV-1 Protease	0	1	0	1
Chain B, HIV-1 Protease	0	1	0	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, HIV-1 protease	0	0	1	1
Chain B, HIV-1 protease	0	0	1	1
Chain A, HIV-1 protease	0	0	1	1
Chain B, HIV-1 protease	0	0	1	1
Chain A, HIV-1 Protease	0	0	1	1
Chain B, HIV-1 Protease	0	0	1	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, Protease	0	1	0	1
Chain B, Protease	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, HIV-1 protease	0	1	0	1
Chain B, HIV-1 protease	0	1	0	1
Chain A, Protease	0	0	1	1
Chain B, Protease	0	0	1	1
Chain A, Pol polyprotein	0	1	0	1
Chain B, Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	2	0	2
Gag-Pol polyprotein	0	1	1	2
Potassium voltage-gated channel subfamily E member 1	0	2	0	2
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	9	1	10
Sodium channel protein type 5 subunit alpha	0	7	0	7
Protease	0	6	1	11
Gag-Pol polyprotein	0	1	0	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Protease	0	4	3	8
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	0	0	4
Transthyretin	0	1	0	1
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
DNA topoisomerase 2-alpha	0	1	4	11
Carbonyl reductase [NADPH] 1	0	0	0	2
Glutamate receptor 1	1	5	2	8
Glutamate receptor 3	1	5	2	8
Glutamate receptor 4	1	5	2	8
Platelet-activating factor receptor	1	0	0	1
Multidrug resistance-associated protein 1	0	2	0	4
Gamma-aminobutyric acid	0	2	1	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	6	1	7
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	6	1	7
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	6	1	7
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Gamma-aminobutyric acid receptor subunit pi	0	2	1	3
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	1	3
Kelch-like ECH-associated protein 1	0	1	3	4
Nuclear factor erythroid 2-related factor 2	0	1	3	5
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	3	2	5
Prostaglandin E2 receptor EP4 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	2	4
Prostaglandin E2 receptor EP3 subtype	0	3	2	5
Prostaglandin E2 receptor EP2 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	3	1	4
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Prostaglandin D2 receptor	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
prostaglandin E2 receptor EP2 subtype	1	0	0	3
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	1	0	2
Mas-related G-protein coupled receptor member X2	0	0	1	1
Genome polyprotein	0	1	0	1
Tyrosine-protein kinase Fyn	0	2	4	6
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	4	0	4
DNA topoisomerase 2	0	0	0	1
ATP-dependent translocase ABCB1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	1	0	2
Serum paraoxonase/arylesterase 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	7	3	14
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	7	3	14
Glutamate receptor ionotropic, NMDA 2B	0	8	3	15
Glutamate receptor ionotropic, NMDA 2C	0	7	3	14
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	4	11
Glutamate receptor ionotropic, NMDA 2D	0	7	3	14
Tubulin beta-2B chain	0	1	0	1
Integrase	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	7	3	14
Solute carrier organic anion transporter family member 1B3	0	7	0	9
Glutamate receptor ionotropic, NMDA 3A	0	7	3	14
Sphingosine 1-phosphate receptor 1	0	0	1	1
RCG53912, isoform CRA_a	0	0	0	1
Sphingosine kinase 1	0	0	0	1
Sphingosine kinase 2	0	1	0	2
Sphingosine kinase 1	0	1	0	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
flap endonuclease 1	10	0	0	10
Solute carrier family 22 member 8	0	1	0	4
Amyloid-beta precursor protein	1	1	0	2
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, probable fosfomycin resistance protein	0	0	1	1
Chain B, probable fosfomycin resistance protein	0	0	1	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
DNA polymerase delta catalytic subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	3	4
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
D(1A) dopamine receptor	8	0	0	8
Gamma-aminobutyric acid type B receptor subunit 2	0	1	1	2
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	3	0	3
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	3	0	3
Sodium- and chloride-dependent GABA transporter 3	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	3	0	3
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	1	0	1
Histone deacetylase 7	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	1	2
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
ClpP	2	0	0	2
Transitional endoplasmic reticulum ATPase	0	1	0	1
Glycogen phosphorylase, muscle form	0	2	0	2
Asialoglycoprotein receptor 1	0	1	1	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	5	2	7
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	3	2	5
Metabotropic glutamate receptor 5	0	1	2	4
Glutamate receptor ionotropic, kainate 2	0	5	3	8
Glutamate receptor 1	0	3	2	5
Glutamate receptor 2	0	3	2	5
Glutamate receptor 3	0	1	2	3
Glutamate receptor ionotropic, kainate 3	0	5	0	5
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	3	1	4
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	4	0	4
Glutamate receptor ionotropic, kainate 4	0	5	0	5
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	3	2	5
Glutamate receptor ionotropic, kainate 3	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	3	0	3
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, kainate 5	0	5	0	5
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Pancreatic alpha-amylase	0	1	0	1
Beta-glucuronidase	0	1	0	1
Beta-glucuronidase	0	1	0	1
High mobility group protein B1	0	0	2	2
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	1	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	1	2
High mobility group protein B1	0	0	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 2	0	1	1	2
Canalicular multispecific organic anion transporter 1	0	2	0	3
Solute carrier organic anion transporter family member 1B1	0	6	0	7
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Guanine deaminase	0	0	0	1
Chain E, C-amp-dependent Protein Kinase	0	1	0	1
Chain I, Protein Kinase Inhibitor Peptide	0	1	0	1
Chain E, C-amp-dependent Protein Kinase	0	1	0	1
Chain E, C-amp-dependent Protein Kinase	0	1	0	1
Chain I, Protein Kinase Inhibitor Peptide	0	1	0	1
Rho-associated protein kinase 2	0	2	4	6
Ribosomal protein S6 kinase alpha-5	0	2	4	6
Serine/threonine-protein kinase D3	0	1	4	5
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	1	0	1
cAMP-dependent protein kinase catalytic subunit beta	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	1	2
Myosin light chain kinase, smooth muscle	0	1	3	4
Casein kinase II subunit alpha'	0	1	4	5
Ribosomal protein S6 kinase beta-1	0	2	3	5
cAMP-dependent protein kinase type II-beta regulatory subunit	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	5	4	9
RAC-beta serine/threonine-protein kinase	0	1	4	5
G protein-coupled receptor kinase 6	0	1	2	3
Casein kinase I isoform alpha	0	1	3	4
Casein kinase I isoform delta	0	2	4	6
Casein kinase I isoform epsilon	0	1	4	5
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	3	4
Casein kinase I isoform gamma-2	0	1	4	5
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	1	3	4
cGMP-dependent protein kinase 1	0	1	4	5
Serine/threonine-protein kinase D1	0	1	3	4
Myosin light chain kinase, smooth muscle	0	1	4	5
Myosin light chain kinase 3	0	1	3	4
Calcium/calmodulin-dependent protein kinase kinase 2	0	1	4	5
Casein kinase I isoform gamma-1	0	1	4	5
RAC-gamma serine/threonine-protein kinase	0	1	4	5
Adenylate cyclase type 1	0	1	0	1
Cocaine esterase	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
UDP-glucuronosyltransferase 1A9	0	1	0	4
5-hydroxytryptamine receptor 4	0	8	0	8
Potassium channel subfamily K member 2	0	2	0	2
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	5	0	5
Muscarinic acetylcholine receptor M2	0	5	1	6
Muscarinic acetylcholine receptor M4	0	4	0	4
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M5	0	5	0	5
Beta-2 adrenergic receptor	0	4	0	5
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M1	0	6	1	7
Integrin alpha-4	0	1	0	1
D(2) dopamine receptor	0	7	3	12
Beta-1 adrenergic receptor	0	4	1	6
D(2) dopamine receptor	0	3	0	3
Muscarinic acetylcholine receptor M3	0	6	1	7
D(1A) dopamine receptor	0	5	2	8
D(4) dopamine receptor	0	3	2	7
D(1B) dopamine receptor	0	2	1	4
Adenylate cyclase type 3	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Sodium-dependent noradrenaline transporter	0	4	0	4
Sodium-dependent dopamine transporter	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
Histamine H2 receptor	0	4	0	4
Beta-3 adrenergic receptor	0	3	0	3
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 2A	0	8	2	10
5-hydroxytryptamine receptor 2C	0	9	1	10
Histamine H1 receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	3
Mu-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 7	0	4	1	5
Kappa-type opioid receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Histamine H1 receptor	0	4	0	4
Mu-type opioid receptor	0	5	2	7
D(3) dopamine receptor	0	5	2	9
Sodium channel protein type 1 subunit alpha	0	4	0	4
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2B	0	12	1	13
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 6	0	4	1	5
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Adenylate cyclase type 6	0	1	0	1
Adenylate cyclase type 5	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	1	4
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	2	0	2
Cholecystokinin receptor type A	0	1	0	1
Adenylyl cyclase 7	0	1	0	1
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	5	0	5
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	5	0	5
Sodium channel protein type 11 subunit alpha	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	2	0	2
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	3	0	3
Thymidine kinase	0	0	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
DNA repair and recombination protein RadA	0	0	1	1
Heat shock protein HSP 90-alpha	0	0	1	1
Indoleamine 2,3-dioxygenase 1	0	1	1	3
Cyclin-A2	0	2	0	2
Nitric oxide synthase, brain	0	4	0	4
Cyclin-A1	0	2	0	2
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
Sodium/myo-inositol cotransporter 2	0	1	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	1	0	1
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	2	4	6
Retinoic acid receptor RXR-alpha	0	1	0	1
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Mitogen-activated protein kinase 14	0	5	4	9
Rap guanine nucleotide exchange factor 4	1	0	0	1
Nitric oxide synthase, inducible	0	4	0	4
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain A, Glutamate receptor 2	0	0	1	1
Chain C, Glutamate receptor 2	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
Glutamate receptor ionotropic, kainate 4	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
Endochitinase	0	1	0	1
7,8-dihydro-8-oxoguanine triphosphatase	0	1	0	1
Endochitinase A1	0	1	0	1
Acidic mammalian chitinase	0	1	0	1
Capsid protein	0	1	1	2
Dihydrofolate reductase	0	4	2	6
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Synaptic vesicle glycoprotein 2A	0	2	0	2
dopamine D1 receptor	2	0	0	2
WRN	2	0	0	2
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	1	0	0	1
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Plasma kallikrein	0	0	0	2
Tyrosine-protein kinase Lck	0	3	4	7
Carbonic anhydrase	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	3	0	3
SLC16A10 protein	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	0	0	2
Monocarboxylate transporter 10	0	0	0	2
Carbonic anhydrase 13	0	0	0	3
phosphoglycerate kinase	2	0	0	2
UDP-glucose 6-dehydrogenase	0	1	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
acid sphingomyelinase	2	0	0	2
Thymidylate synthase	0	1	0	1
alpha-galactosidase	3	0	0	3
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
DNA polymerase beta	4	0	0	4
caspase-1 isoform alpha precursor	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	2	5	7
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	5	5
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Potassium channel subfamily K member 3	0	1	0	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	2	0	2
Cytochrome P450 3A5	0	2	0	2
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
NAD-dependent protein deacetylase	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Nitric oxide synthase, endothelial	0	2	0	2
Nitric oxide synthase, endothelial	0	3	0	3
Nitric oxide synthase, brain	0	2	0	2
Nitric oxide synthase, inducible	0	3	0	3
Nitric oxide synthase, inducible	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Chain A, MAP KINASE P38	0	1	0	1
Chain A, PROTEIN (MAP KINASE P38)	0	1	0	1
Chain A, PROTEIN (MAP KINASE P38)	0	1	0	1
Chain A, Protein (map Kinase P38)	0	1	0	1
Chain A, Extracellular Regulated Kinase 2	0	1	0	1
Chain A, Extracellular Regulated Kinase 2	0	1	0	1
lysosomal alpha-glucosidase preproprotein	3	0	0	3
G2/mitotic-specific cyclin-B	0	1	0	1
Mitogen-activated protein kinase 3	0	1	4	5
G1/S-specific cyclin-D3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	2	3	5
Mitogen-activated protein kinase 1	0	1	0	1
Cyclin-dependent kinase 6	0	1	3	4
Cyclin-dependent-like kinase 5	0	2	4	6
Voltage-dependent N-type calcium channel subunit alpha-1B	0	0	1	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
Cyclin-dependent kinase 1	0	1	0	1
Valosin-containing protein	0	1	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Leukotriene C4 synthase	0	0	2	2
tyrosine-protein kinase Yes	3	0	0	3
Bone morphogenetic protein receptor type-1B	0	0	3	3
Membrane-associated progesterone receptor component 1	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	2	2
Serine/threonine-protein kinase PLK4	0	0	4	4
Serine/threonine-protein kinase 25	0	0	3	3
ATP-dependent RNA helicase DDX3X	0	0	3	3
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	2	2
Pyridoxal kinase	0	0	3	3
Citron Rho-interacting kinase	0	0	4	4
Serine/threonine-protein kinase RIO3	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 7	0	1	2	3
Serine/threonine-protein kinase Chk1	0	1	4	5
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	2	2
Peripheral plasma membrane protein CASK	0	0	2	2
Aurora kinase A	0	0	4	4
Cyclin-G-associated kinase	0	0	4	4
Serine/threonine-protein kinase DCLK1	0	0	3	3
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	2	2
Muscle, skeletal receptor tyrosine-protein kinase	0	0	3	3
Ephrin type-B receptor 6	0	0	3	3
Peroxisomal acyl-coenzyme A oxidase 3	0	0	3	3
Mitogen-activated protein kinase 13	0	2	2	4
Mitogen-activated protein kinase kinase kinase 13	0	0	2	2
Death-associated protein kinase 3	0	0	3	3
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 2	0	0	4	4
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	3	3
NUAK family SNF1-like kinase 1	0	0	3	3
Dynamin-like 120 kDa protein, mitochondrial	0	0	3	3
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	2	2
Tyrosine-protein kinase JAK2	0	4	5	11
Serine/threonine-protein kinase ULK1	0	0	3	3
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	3	3
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	3	3
Ribosomal protein S6 kinase alpha-4	0	0	4	4
Serine/threonine-protein kinase 16	0	0	4	4
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	2	2
Serine/threonine-protein kinase PAK 3	0	0	3	3
Cyclin-dependent kinase-like 5	0	0	3	3
Serine/threonine-protein kinase 17B	0	0	3	3
Serine/threonine-protein kinase 10	0	0	4	4
Cyclin-dependent kinase 14	0	0	3	3
Structural maintenance of chromosomes protein 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 6	0	0	3	3
Serine/threonine-protein kinase OSR1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	4	4
Serine/threonine-protein kinase LATS1	0	0	4	4
Serine/threonine-protein kinase PAK 4	0	0	4	4
Serine/threonine-protein kinase Chk2	0	0	2	2
RAF proto-oncogene serine/threonine-protein kinase	0	1	3	4
Receptor tyrosine-protein kinase erbB-2	0	1	3	4
High affinity nerve growth factor receptor	0	0	4	4
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
ADP/ATP translocase 2	0	0	3	3
Insulin receptor	0	1	4	5
Glycogen phosphorylase, liver form	0	0	3	3
Tyrosine-protein kinase Fes/Fps	0	0	4	4
Macrophage colony-stimulating factor 1 receptor	0	1	3	4
Tyrosine-protein kinase Yes	0	0	4	4
Tyrosine-protein kinase Lyn	0	0	4	4
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	4	4
Insulin-like growth factor 1 receptor	0	0	4	4
Signal recognition particle receptor subunit alpha	0	0	3	3
Cytochrome c1, heme protein, mitochondrial	0	0	3	3
Hepatocyte growth factor receptor	0	0	4	4
Tyrosine-protein kinase HCK	0	0	4	4
Proto-oncogene tyrosine-protein kinase ROS	0	0	3	3
Platelet-derived growth factor receptor beta	0	1	4	5
Tyrosine-protein kinase Fgr	0	0	4	4
Wee1-like protein kinase 2	0	0	2	2
Uncharacterized serine/threonine-protein kinase SBK3	0	0	2	2
Serine/threonine-protein kinase A-Raf	0	0	3	3
Mast/stem cell growth factor receptor Kit	0	1	3	4
Glycogen phosphorylase, brain form	0	0	3	3
Breakpoint cluster region protein	0	0	3	3
Fibroblast growth factor receptor 1	0	1	4	5
ADP/ATP translocase 3	0	0	3	3
Inosine-5'-monophosphate dehydrogenase 2	0	0	2	2
Proto-oncogene tyrosine-protein kinase Src	0	0	4	4
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	2	2
Insulin receptor-related protein	0	0	3	3
Serine/threonine-protein kinase B-raf	0	1	4	5
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	4	4
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	3	3
Platelet-derived growth factor receptor alpha	0	1	3	4
Tyrosine-protein kinase Fer	0	0	4	4
Vascular endothelial growth factor receptor 1	0	1	3	4
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	3	3
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	3	3
Serine/threonine-protein kinase MAK	0	0	2	2
Cyclin-dependent kinase 11B	0	0	3	3
Ephrin type-A receptor 1	0	0	4	4
Fibroblast growth factor receptor 2	0	1	3	4
Receptor tyrosine-protein kinase erbB-3	0	0	2	2
Multifunctional protein ADE2	0	0	3	3
Acetylcholinesterase	0	1	0	1
Fibroblast growth factor receptor 4	0	0	3	3
Fibroblast growth factor receptor 3	0	0	3	3
Ferrochelatase, mitochondrial	0	0	3	3
Tyrosine-protein kinase JAK1	0	4	5	11
Beta-adrenergic receptor kinase 1	0	0	3	3
Probable ATP-dependent RNA helicase DDX6	0	0	3	3
Activin receptor type-2A	0	0	3	3
MAP/microtubule affinity-regulating kinase 3	0	0	4	4
Ephrin type-A receptor 2	0	0	4	4
Ephrin type-A receptor 3	0	0	3	3
Ephrin type-A receptor 8	0	0	3	3
Ephrin type-B receptor 2	0	0	4	4
Leukocyte tyrosine kinase receptor	0	0	3	3
Non-receptor tyrosine-protein kinase TYK2	0	3	5	10
Phosphatidylethanolamine-binding protein 1	0	0	2	2
Wee1-like protein kinase	0	0	4	4
Heme oxygenase 2	0	0	3	3
Tyrosine-protein kinase receptor UFO	0	0	3	3
Mitogen-activated protein kinase 4	0	0	3	3
S-adenosylmethionine synthase isoform type-2	0	0	3	3
DnaJ homolog subfamily A member 1	0	0	3	3
G protein-coupled receptor kinase 4	0	0	2	2
Dual specificity protein kinase TTK	0	0	4	4
DNA replication licensing factor MCM4	0	0	2	2
Tyrosine-protein kinase receptor Tie-1	0	0	3	3
Vascular endothelial growth factor receptor 3	0	1	3	4
Dual specificity mitogen-activated protein kinase kinase 2	0	1	4	5
Receptor-type tyrosine-protein kinase FLT3	0	0	4	4
Bone morphogenetic protein receptor type-1A	0	0	4	4
Activin receptor type-1B	0	0	4	4
TGF-beta receptor type-1	0	0	4	4
Serine/threonine-protein kinase receptor R3	0	0	4	4
TGF-beta receptor type-2	0	0	4	4
Tyrosine-protein kinase CSK	0	1	4	5
Glycine--tRNA ligase	0	0	3	3
Exosome RNA helicase MTR4	0	0	3	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	3	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	2	2
Serine/threonine-protein kinase mTOR	0	1	3	4
Megakaryocyte-associated tyrosine-protein kinase	0	0	2	2
Tyrosine-protein kinase Tec	0	1	4	5
Tyrosine-protein kinase TXK	0	1	3	4
Tyrosine-protein kinase ABL2	0	1	4	5
Tyrosine-protein kinase FRK	0	0	4	4
Tyrosine-protein kinase ZAP-70	0	0	3	3
Tyrosine-protein kinase SYK	0	0	4	4
Mitogen-activated protein kinase 8	0	1	4	5
Mitogen-activated protein kinase 9	0	0	4	4
Dual specificity mitogen-activated protein kinase kinase 4	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 3	0	0	4	4
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	2	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	0	2	2
MAP kinase-activated protein kinase 2	0	1	4	5
Cyclin-dependent kinase 8	0	0	3	3
Elongation factor Tu, mitochondrial	0	0	3	3
Cysteine--tRNA ligase, cytoplasmic	0	0	3	3
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	3	3
Dual specificity protein kinase CLK1	0	0	4	4
Dual specificity protein kinase CLK2	0	0	4	4
Dual specificity protein kinase CLK3	0	0	4	4
Glycogen synthase kinase-3 alpha	0	0	4	4
Cyclin-dependent kinase 7	0	0	4	4
Cyclin-dependent kinase 9	0	0	4	4
Ras-related protein Rab-27A	0	0	2	2
Tyrosine-protein kinase Blk	0	1	3	4
Interleukin-1 receptor-associated kinase 1	0	0	3	3
Ribosomal protein S6 kinase alpha-3	0	1	4	5
Cytoplasmic tyrosine-protein kinase BMX	0	1	3	4
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	3	3
Serine/threonine-protein kinase Nek2	0	0	4	4
Serine/threonine-protein kinase Nek3	0	0	3	3
Serine/threonine-protein kinase Nek4	0	0	2	2
Tyrosine-protein kinase JAK3	0	4	4	11
Dual specificity mitogen-activated protein kinase kinase 6	0	0	4	4
Serine/threonine-protein kinase PLK1	0	0	4	4
Death-associated protein kinase 1	0	0	3	3
LIM domain kinase 1	0	0	4	4
LIM domain kinase 2	0	0	4	4
Mitogen-activated protein kinase 12	0	2	3	5
Mitogen-activated protein kinase 10	0	0	4	4
Tyrosine--tRNA ligase, cytoplasmic	0	0	3	3
5'-AMP-activated protein kinase subunit gamma-1	0	0	3	3
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	3	3
Ephrin type-B receptor 3	0	0	4	4
Ephrin type-A receptor 5	0	0	4	4
Ephrin type-B receptor 4	0	0	4	4
Ephrin type-B receptor 1	0	0	3	3
Ephrin type-A receptor 4	0	0	4	4
Adenylate kinase 2, mitochondrial	0	0	3	3
Adenosine kinase	0	0	3	3
Hormonally up-regulated neu tumor-associated kinase	0	0	2	2
Serine/threonine-protein kinase SIK1	0	0	3	3
Receptor-interacting serine/threonine-protein kinase 4	0	0	2	2
Ras-related protein Rab-10	0	0	3	3
Cell division control protein 2 homolog	0	0	2	2
Actin-related protein 3	0	0	3	3
Actin-related protein 2	0	0	2	2
Calcium-dependent protein kinase 1	0	0	2	2
GTP-binding nuclear protein Ran	0	0	3	3
Tubulin alpha-1A chain	0	0	3	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	3	3
SRSF protein kinase 2	0	0	3	3
Mitogen-activated protein kinase kinase kinase 9	0	0	3	3
Serine/threonine-protein kinase PknB	0	0	2	2
Cyclin-dependent kinase 3	0	0	3	3
Cyclin-dependent kinase-like 1	0	0	2	2
Cyclin-dependent kinase 16	0	0	4	4
Cyclin-dependent kinase 17	0	0	4	4
ATP-dependent 6-phosphofructokinase, platelet type	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 1	0	1	4	5
Angiopoietin-1 receptor	0	0	3	3
Mitogen-activated protein kinase kinase kinase 10	0	0	3	3
Activin receptor type-1	0	0	4	4
Macrophage-stimulating protein receptor	0	0	3	3
Focal adhesion kinase 1	0	0	4	4
Tyrosine-protein kinase BTK	0	1	4	5
Tyrosine-protein kinase receptor TYRO3	0	0	3	3
Cyclin-dependent kinase 18	0	0	4	4
Activated CDC42 kinase 1	0	0	4	4
Epithelial discoidin domain-containing receptor 1	0	0	4	4
Tyrosine-protein kinase ITK/TSK	0	1	3	4
Myotonin-protein kinase	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	3	3
Mitogen-activated protein kinase kinase kinase 12	0	0	2	2
Tyrosine-protein kinase Mer	0	0	4	4
Serine/threonine-protein kinase 4	0	0	4	4
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	4	4
Serine/threonine-protein kinase PAK 1	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 5	0	0	3	3
Mitogen-activated protein kinase 7	0	0	4	4
Serine/threonine-protein kinase PAK 2	0	0	4	4
Serine/threonine-protein kinase 3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 1	0	0	3	3
cGMP-dependent protein kinase 2	0	0	3	3
Integrin-linked protein kinase	0	0	3	3
Rho-associated protein kinase 1	0	0	3	3
Non-receptor tyrosine-protein kinase TNK1	0	0	4	4
Serine/threonine-protein kinase PRP4 homolog	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 1	0	1	3	4
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	4	4
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	4	4
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	3	3
Activin receptor type-2B	0	0	4	4
Bone morphogenetic protein receptor type-2	0	0	4	4
Protein-tyrosine kinase 6	0	0	4	4
Cyclin-dependent kinase 13	0	0	3	3
Calcium/calmodulin-dependent protein kinase type 1	0	0	3	3
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	4	4
Protein-tyrosine kinase 2-beta	0	0	4	4
Maternal embryonic leucine zipper kinase	0	0	4	4
Structural maintenance of chromosomes protein 1A	0	0	2	2
Chromodomain-helicase-DNA-binding protein 4	0	0	3	3
Peroxisomal acyl-coenzyme A oxidase 1	0	0	2	2
Serine/threonine-protein kinase 38	0	0	2	2
Receptor tyrosine-protein kinase erbB-4	0	1	2	3
Ribosomal protein S6 kinase alpha-2	0	0	3	3
Ephrin type-A receptor 7	0	0	3	3
Delta(24)-sterol reductase	0	0	2	2
Ribosomal protein S6 kinase alpha-1	0	0	4	4
Dual specificity testis-specific protein kinase 1	0	0	4	4
Mitogen-activated protein kinase 11	0	2	4	6
Serine/threonine-protein kinase STK11	0	0	4	4
Rhodopsin kinase GRK1	0	0	2	2
NT-3 growth factor receptor	0	0	3	3
Serine/threonine-protein kinase N1	0	0	4	4
Serine/threonine-protein kinase N2	0	0	4	4
Calcium/calmodulin-dependent protein kinase type IV	0	0	4	4
Mitogen-activated protein kinase kinase kinase 11	0	0	4	4
BDNF/NT-3 growth factors receptor	0	0	3	3
Mitogen-activated protein kinase 6	0	0	3	3
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	3	3
Discoidin domain-containing receptor 2	0	1	4	5
AP2-associated protein kinase 1	0	0	4	4
Receptor protein-tyrosine kinase	0	1	0	1
Serine/threonine-protein kinase SBK1	0	0	2	2
Mitogen-activated protein kinase kinase kinase 19	0	0	2	2
Putative heat shock protein HSP 90-beta 2	0	0	3	3
Serine/threonine-protein kinase TNNI3K	0	0	3	3
Rab-like protein 3	0	0	2	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	2	2
Serine/threonine-protein kinase MRCK alpha	0	0	4	4
Serine/threonine-protein kinase MRCK gamma	0	0	4	4
Acyl-CoA dehydrogenase family member 10	0	0	3	3
Serine/threonine-protein kinase Nek5	0	0	3	3
Serine/threonine-protein kinase N3	0	0	2	2
Serine/threonine-protein kinase ULK3	0	0	3	3
Dual serine/threonine and tyrosine protein kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 15	0	0	2	2
Uncharacterized protein FLJ45252	0	0	3	3
Acyl-CoA dehydrogenase family member 11	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	3	3
Serine/threonine-protein kinase MARK2	0	0	4	4
ATP-dependent RNA helicase DHX30	0	0	3	3
Serine/threonine-protein kinase TAO1	0	0	3	3
STE20-related kinase adapter protein alpha	0	0	3	3
Myosin-14	0	0	3	3
AarF domain-containing protein kinase 1	0	0	3	3
Serine/threonine-protein kinase tousled-like 2	0	0	3	3
Serine/threonine-protein kinase 32C	0	0	3	3
Serine/threonine-protein kinase pim-3	0	0	3	3
ATP-dependent RNA helicase DDX42	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	2	2
Myosin light chain kinase family member 4	0	0	3	3
Homeodomain-interacting protein kinase 1	0	0	2	2
Calcium/calmodulin-dependent protein kinase type 1D	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	4	4
Cyclin-dependent kinase-like 3	0	0	2	2
MAP kinase-activated protein kinase 5	0	2	4	6
Serine/threonine-protein kinase BRSK2	0	0	3	3
Serine/threonine-protein kinase NIM1	0	0	2	2
Serine/threonine-protein kinase ULK2	0	0	2	2
Misshapen-like kinase 1	0	0	3	3
Serine/threonine-protein kinase DCLK2	0	0	3	3
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	3	3
Casein kinase I isoform alpha-like	0	0	3	3
Homeodomain-interacting protein kinase 4	0	0	2	2
Myosin-IIIa	0	0	3	3
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	3	3
Serine/threonine-protein kinase Nek11	0	0	2	2
Atypical kinase COQ8A, mitochondrial	0	0	4	4
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	3	3
Mitogen-activated protein kinase 15	0	0	4	4
Serine/threonine-protein kinase Nek9	0	0	4	4
Serine/threonine-protein kinase BRSK1	0	0	3	3
Serine/threonine-protein kinase 35	0	0	2	2
Serine/threonine-protein kinase Nek7	0	0	3	3
Rhodopsin kinase GRK7	0	0	2	2
Serine/threonine-protein kinase 32A	0	0	2	2
Myosin-IIIb	0	0	3	3
ATP-dependent RNA helicase DDX1	0	0	3	3
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	2	2
Cyclin-dependent kinase-like 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	4	4
Serine/threonine-protein kinase Sgk3	0	0	2	2
Atypical kinase COQ8B, mitochondrial	0	0	3	3
Aurora kinase B	0	0	4	4
MAP/microtubule affinity-regulating kinase 4	0	0	4	4
Calcium/calmodulin-dependent protein kinase type 1G	0	0	4	4
Serine/threonine-protein kinase Nek1	0	0	4	4
Cyclin-dependent kinase 15	0	0	2	2
EKC/KEOPS complex subunit TP53RK	0	0	3	3
SRSF protein kinase 1	0	0	3	3
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	4	4
Mitogen-activated protein kinase kinase kinase 5	0	0	4	4
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	3	3
Mitogen-activated protein kinase kinase kinase 3	0	0	3	3
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	3	3
Serine/threonine-protein kinase RIO1	0	0	3	3
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	3	3
Serine/threonine-protein kinase RIO2	0	0	2	2
Cyclin-dependent kinase 19	0	0	3	3
Transient receptor potential cation channel subfamily M member 6	0	0	2	2
Testis-specific serine/threonine-protein kinase 1	0	0	3	3
Serine/threonine-protein kinase 33	0	0	3	3
Nucleolar GTP-binding protein 1	0	0	3	3
Serine/threonine-protein kinase D2	0	0	4	4
Serine/threonine-protein kinase DCLK3	0	0	3	3
NUAK family SNF1-like kinase 2	0	0	3	3
RNA cytidine acetyltransferase	0	0	3	3
Serine/threonine-protein kinase SIK2	0	0	4	4
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	3	3
STE20-like serine/threonine-protein kinase	0	0	4	4
Serine/threonine-protein kinase TAO3	0	0	3	3
Homeodomain-interacting protein kinase 2	0	0	2	2
Tyrosine-protein kinase Srms	0	0	3	3
Homeodomain-interacting protein kinase 3	0	0	2	2
Serine/threonine-protein kinase PLK3	0	0	3	3
dCTP pyrophosphatase 1	0	0	3	3
Dual specificity protein kinase CLK4	0	0	4	4
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	3	3
Serine/threonine-protein kinase Nek6	0	0	3	3
Serine/threonine-protein kinase PAK 6	0	0	3	3
SNF-related serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase LATS2	0	0	3	3
Serine/threonine-protein kinase 36	0	0	3	3
Phenylalanine--tRNA ligase beta subunit	0	0	3	3
Isoleucine--tRNA ligase, mitochondrial	0	0	2	2
BMP-2-inducible protein kinase	0	0	4	4
Obg-like ATPase 1	0	0	2	2
Midasin	0	0	3	3
Interleukin-1 receptor-associated kinase 4	0	0	3	3
Serine/threonine-protein kinase 32B	0	0	3	3
Mitogen-activated protein kinase kinase kinase 20	0	0	4	4
Cyclin-dependent kinase 12	0	0	3	3
Serine/threonine-protein kinase PLK2	0	0	2	2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	2	2
Serine/threonine-protein kinase MARK1	0	0	3	3
Serine/threonine-protein kinase pim-2	0	0	3	3
Serine/threonine-protein kinase PAK 5	0	0	3	3
Serine/threonine-protein kinase 26	0	0	4	4
eIF-2-alpha kinase GCN2	0	0	3	3
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	3	3
Serine/threonine-protein kinase NLK	0	0	4	4
Phosphatidylinositol 4-kinase beta	0	0	2	2
Serine/threonine-protein kinase 17A	0	0	3	3
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	2	2
Ephrin type-A receptor 6	0	0	3	3
5'-AMP-activated protein kinase subunit gamma-2	0	0	3	3
Serine/threonine-protein kinase TBK1	0	1	3	4
Septin-9	0	0	3	3
Death-associated protein kinase 2	0	0	3	3
Ribosomal protein S6 kinase alpha-6	0	0	4	4
TRAF2 and NCK-interacting protein kinase	0	0	4	4
Serine/threonine-protein kinase tousled-like 1	0	0	3	3
Serine/threonine-protein kinase TAO2	0	0	3	3
Long-chain-fatty-acid--CoA ligase 5	0	0	2	2
ALK tyrosine kinase receptor	0	0	3	3
SRSF protein kinase 3	0	0	2	2
Serine/threonine-protein kinase ICK	0	0	3	3
Cyclin-dependent kinase 11A	0	0	3	3
Aurora kinase C	0	0	3	3
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	3	3
Serine/threonine-protein kinase 38-like	0	0	3	3
Microtubule-associated serine/threonine-protein kinase 1	0	0	2	2
Serine/threonine-protein kinase SIK3	0	0	3	3
Mitogen-activated protein kinase kinase kinase 2	0	0	3	3
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	4	4
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 3	0	0	3	3
Serine/threonine-protein kinase MRCK beta	0	0	4	4
Interleukin-1 receptor-associated kinase 3	0	0	4	4
Serine/threonine-protein kinase 24	0	0	4	4
Casein kinase I isoform gamma-3	0	0	4	4
Mitogen-activated protein kinase kinase kinase 4	0	0	4	4
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase OXA-10	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
Beta-lactamase	0	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Genome polyprotein	0	0	1	1
Genome polyprotein	0	0	1	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	1	2	3
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Trace amine-associated receptor 5	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	3
Beta-3 adrenergic receptor	0	2	1	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
5-hydroxytryptamine receptor 1B	0	4	2	6
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Delta-type opioid receptor	0	1	1	2
Kappa-type opioid receptor	0	3	1	4
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Beta-2 adrenergic receptor	0	1	1	3
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	4	0	4
NH(3)-dependent NAD(+) synthetase	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	2	0	2
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	1	0	1
Alpha-synuclein	1	1	0	2
Solute carrier organic anion transporter family member 1A2	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	2	0	2
Glutathione S-transferase omega-1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Thiosulfate sulfurtransferase	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Gag-Pol polyprotein	0	2	0	2
Reverse transcriptase	0	1	0	1
Reverse transcriptase	0	0	1	1
Glycine receptor subunit alpha-1	0	0	1	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Multidrug and toxin extrusion protein 2	0	2	0	2
Transporter	0	2	0	2
Histamine H3 receptor	0	1	0	1
Chain A, HIV-1 PROTEASE	0	1	0	1
Chain B, HIV-1 PROTEASE	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, POL polyprotein	0	1	0	1
Chain B, POL polyprotein	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Chain A, Endothiapepsin	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Substance-K receptor	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Gag-Pol polyprotein	0	1	0	1
Thromboxane-A synthase	0	0	0	1
Plasmepsin V	0	1	0	1
Bromodomain-containing protein 4	0	1	1	2
Tyrosinase	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Bromodomain testis-specific protein	0	1	0	1
Tau-tubulin kinase 1	0	1	0	1
Tau-tubulin kinase 2	0	1	0	1
large T antigen	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Cell division cycle 7-related protein kinase	0	0	1	1
Eukaryotic translation initiation factor 5B	0	0	1	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Eukaryotic translation initiation factor 4E	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Ras-related protein Rab-6A	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
UMP-CMP kinase	0	0	1	1
Myosin-10	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	2	2
Programmed cell death protein 4	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
PAS domain-containing serine/threonine-protein kinase	0	0	2	2
Dual specificity testis-specific protein kinase 2	0	0	2	2
Target of rapamycin complex subunit LST8	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Thyroid hormone receptor-associated protein 3	0	0	2	2
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
bcl-2-related protein A1	0	1	0	1
Endoglycoceramidase II	0	0	0	1
Estrogen receptor	0	0	1	1
Estrogen receptor beta	0	0	1	1
Transcription regulator protein BACH1	0	1	0	1
Transcription factor MafK	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
NAD	0	0	0	1
Quinone oxidoreductase	0	0	0	3
Nuclear factor erythroid 2-related factor 2	0	0	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	1
Kelch-like ECH-associated protein 1	0	0	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Carboxypeptidase M	0	1	0	1
5-hydroxytryptamine receptor 1D	0	2	1	4
5-hydroxytryptamine receptor 1E	0	1	0	1
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
5-hydroxytryptamine receptor 1B	0	1	0	1
polyadenylate-binding protein 1	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase	0	1	0	1
Chain A, Tyrosine-protein kinase JAK2	0	1	0	1
Serine/threonine-protein kinase Sgk1	0	1	0	1
Serine/threonine-protein kinase ATR	0	0	1	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
Tyrosine-protein kinase JAK2	0	1	0	1
Tyrosine-protein kinase JAK3	0	1	0	1
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Phospholipase A-2-activating protein	0	1	0	1
Malate dehydrogenase	0	1	0	1
Valacyclovir hydrolase	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
Dipeptidyl peptidase 4	0	1	0	1
Adenosylhomocysteinase	0	1	0	1
Adenosine deaminase	0	0	0	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Encephalitis, Herpes Simplex

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (438)

Protein Targets (1,905)

Encephalitis, Herpes Simplex

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (438)

Drugs Studied (169)

Protein Targets (1,905)