An EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen) inhibitor that interferes with the action of steroid 11beta-monooxygenase (EC 1.14.15.4).
ChEBI ID: 76798
| Member | Definition | Class |
|---|---|---|
| metyrapone | An aromatic ketone that is 3,3-dimethylbutan-2-one in which the methyl groups at positions 1 and 4 are replaced by pyridin-3-yl groups. A steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitor, it is used in the diagnosis of adrenal insufficiency. | metyrapone |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,182 (68.32) | 18.7374 |
| 1990's | 427 (13.37) | 18.2507 |
| 2000's | 295 (9.24) | 29.6817 |
| 2010's | 238 (7.45) | 24.3611 |
| 2020's | 52 (1.63) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 128 (3.75%) | 5.53% |
| Reviews | 147 (4.30%) | 6.00% |
| Case Studies | 192 (5.62%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 2,948 (86.33%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 1.2589 | 2 | 2 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 7.7619 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 1.2589 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 0.1188 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 31.6228 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Aromatase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 229.0000 | 1 | 1 |
| Cytochrome P450 11B1, mitochondrial | Homo sapiens (human) | IC50 | 0.0181 | 10 | 10 |
| Cytochrome P450 11B1, mitochondrial | Rattus norvegicus (Norway rat) | IC50 | 4.7357 | 3 | 3 |
| Cytochrome P450 11B1, mitochondrial | Bos taurus (cattle) | IC50 | 7.8300 | 1 | 1 |
| Cytochrome P450 11B2, mitochondrial | Homo sapiens (human) | IC50 | 0.0838 | 9 | 9 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 4.8000 | 2 | 2 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Cytochrome P450 2C8 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 4.6000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 2.8659 | 2 | 2 |
| Steroid 17-alpha-hydroxylase/17,20 lyase | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |